Catalog No.:AA00GX23

908112-43-6 | Snx-2112

Name: Name:Snx-2112
Brand: AABLOCKS
SKU: AA00GX23
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

5mg

98%

in stock

$29.00 $21.00

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10mg

98%

in stock

$48.00 $34.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA00GX23

Chemical Name:

Snx-2112

CAS Number:

908112-43-6

Molecular Formula:

C23H27F3N4O3

Molecular Weight:

464.4807

MDL Number:

MFCD16038907

SMILES:

OC1CCC(CC1)Nc1cc(ccc1C(=O)N)n1nc(c2c1CC(C)(C)CC2=O)C(F)(F)F

Properties

Computed Properties

Complexity:

754

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

3.8

Downstream Synthesis Route

crizotinib

74124-79-1

908112-43-6

(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

[1]Patent:WO2015/38649,2015,A1.Locationinpatent:Paragraph001558

74124-79-1

908112-43-6

57260-71-6

1-tert-butyl4-((1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl)piperazine-1,4-dicarboxylate

[1]Patent:WO2015/38649,2015,A1.Locationinpatent:Paragraph001581

908112-43-6

(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexylpiperazine-1-carboxylatehydrochloride

[1]Patent:WO2015/38649,2015,A1

908112-43-6

1-((1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl)4-((S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano3',4':6,7indolizino1,2-bquinolin-9-yl)piperazine-1,4-dicarboxylate

[1]Patent:WO2015/38649,2015,A1

908112-43-6

(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl((2R,3R,4R,6S)-3-hydroxy-2-methyl-6-(((1R,3R)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)carbamate

[1]Patent:WO2015/38649,2015,A1

Literature

Title: Heat shock protein 90 inhibitors induce functional inhibition of human natural killer cells in a dose-dependent manner.

Journal: Immunopharmacology and immunotoxicology 20160101

Title: Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases.

Journal: Bioorganic & medicinal chemistry letters 20140101

Title: The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways.

Journal: Chemico-biological interactions 20130905

Title: EC144 is a potent inhibitor of the heat shock protein 90.

Journal: Journal of medicinal chemistry 20120913

Title: Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110101

Title: SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Heat shock protein 90: inhibitors in clinical trials.

Journal: Journal of medicinal chemistry 20100114

Title: Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Journal: Journal of medicinal chemistry 20090723

Title: Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib.

Journal: Oncology research 20090101

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