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3424-98-4,MFCD02683612
Catalog No.:AA00I6OP

3424-98-4 | 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

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10mg
98%
in stock  
$6.00   $4.00
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250mg
98%
in stock  
$33.00   $23.00
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1g
95%
in stock  
$56.00   $39.00
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5g
95%
in stock  
$254.00   $178.00
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10g
95%
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$469.00   $328.00
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25g
95%
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$937.00   $656.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I6OP
Chemical Name:
1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS Number:
3424-98-4
Molecular Formula:
C10H14N2O5
Molecular Weight:
242.2286
MDL Number:
MFCD02683612
SMILES:
OC[C@@H]1O[C@H](C[C@H]1O)n1cc(C)c(=O)[nH]c1=O
Properties
Computed Properties
 
Complexity:
381  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-1.2  

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Title: Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings.

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Title: Viral infection in renal transplant recipients.

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Journal: PloS one 20120101

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Journal: Antiviral therapy 20120101

Title: Cost-effectiveness analysis of antiviral treatments for HBeAg-positive chronic hepatitis B in Canada.

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Title: Effect and Predictive Elements for 52 Weeks' Telbivudine Treatment on Naïve HBeAg positive Chronic Hepatitis B.

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Journal: Antiviral therapy 20110101

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Journal: Journal of translational medicine 20110101

Title: Restored circulating invariant NKT cells are associated with viral control in patients with chronic hepatitis B.

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Title: Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

Title: Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20101201

Title: Clearance (née Rowland) concepts: a downdate and an update.

Journal: Journal of pharmacokinetics and pharmacodynamics 20101201

Title: Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.

Journal: Viruses 20101201

Title: Mutation pattern of lamivudine resistance in relation to hepatitis B genotypes: hepatitis B genotypes differ in their lamivudine resistance associated mutation pattern.

Journal: Journal of medical virology 20101101

Title: Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients.

Journal: Hepatology (Baltimore, Md.) 20101101

Title: Hepatitis B e antigen seroconversion: a critical event in chronic hepatitis B virus infection.

Journal: Digestive diseases and sciences 20101001

Title: Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses.

Journal: Gastroenterology 20101001

Title: Telbivudine: a review of its use in compensated chronic hepatitis B.

Journal: Drugs 20101001

Title: [A study on the factors correlated to virological response in chronic hepatitis B patients with telbivudine treatment].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20101001

Title: [Efficacy of antiviral treatment on patients with acute-on-chronic hepatitis B liver failure with low viral load].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20101001

Title: Safety evaluation of telbivudine.

Journal: Expert opinion on drug safety 20100901

Title: Telbivudine: an effective anti-HBV drug for chronic hepatitis B patients with early on-treatment responses.

Journal: Expert opinion on pharmacotherapy 20100901

Title: Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized study.

Journal: The Korean journal of hepatology 20100901

Title: [Programmed death-1 (PD-1) and PD-L1 expression during antiviral treatment of chronic hepatitis B].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100901

Title: [Analogs combination therapy in chronic hepatitis B: when and how?].

Journal: Gastroenterologie clinique et biologique 20100901

Title: [Long-term therapy for chronic hepatitis B in HIV co-infected patients].

Journal: Gastroenterologie clinique et biologique 20100901

Title: Efficacy of telbivudine in HBeAg-positive chronic hepatitis B patients with high baseline ALT levels.

Journal: World journal of gastroenterology 20100828

Title: Cost-effectiveness of nucleoside analog therapy for hepatitis B in China: a Markov analysis.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100801

Title: [Antiviral treatment of chronic B hepatitis; 2010 - therapeutic recommendations].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20100801

Title: Telbivudine: rhabdomyolysis and neuropathy.

Journal: Prescrire international 20100801

Title: Resistance management in chronic hepatitis B complicated by renal failure.

Journal: Clinical nephrology 20100701

Title: Telbivudine exhibits no inhibitory activity against HIV-1 clinical isolates in vitro.

Journal: Antimicrobial agents and chemotherapy 20100601

Title: [Icteric hepatitis in a patient with non-Hodgkin's lymphoma treated by rituximab-based chemotherapy].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20100601

Title: [Analysis of the prophylactic effect of nucleosides against reactivation of HBV in HBsAg-positive patients with non-hepatic tumors after chemotherapy].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100601

Title: Antiviral treatment of chronic hepatitis B virus (HBV) infections.

Journal: Viruses 20100601

Title: On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-positive chronic hepatitis B patients.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100501

Title: Treatment outcomes of clevudine versus lamivudine at week 48 in naïve patients with HBeAg positive chronic hepatitis B.

Journal: Journal of Korean medical science 20100501

Title: On-treatment monitoring of chronic hepatitis B virus infection: an Asian-Pacific perspective.

Journal: Journal of gastroenterology and hepatology 20100501

Title: Application of hepatitis B virus replication mouse model.

Journal: World journal of gastroenterology 20100428

Title: Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20100401

Title: Hepatitis B virus drug resistance in HIV-1-infected patients taking lamivudine-containing antiretroviral therapy.

Journal: AIDS patient care and STDs 20100401

Title: A 24-week, parallel-group, open-label, randomized clinical trial comparing the early antiviral efficacy of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive chronic hepatitis B virus infection in adult Chinese patients.

Journal: Clinical therapeutics 20100401

Title: [Clinical antiviral effects of telbivudine in patients with chronic hepatitis B].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100401

Title: Effect of antiviral treatment on the risk of hepatocellular carcinoma in patients with chronic hepatitis B.

Journal: World journal of hepatology 20100327

Title: Telbivudine use in a patient affected by occult hepatitis B virus and B-cell non-Hodgkin lymphoma.

Journal: Leukemia & lymphoma 20100301

Title: Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions.

Journal: Hepatology international 20100301

Title: Management of hepatitis B: Pakistan Society for the Study of Liver Diseases (PSSLD) practice guidelines.

Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20100301

Title: Management of chronic hepatitis B: experience from China.

Journal: Journal of viral hepatitis 20100301

Title: Telbivudine preserves T-helper 1 cytokine production and downregulates programmed death ligand 1 in a mouse model of viral hepatitis.

Journal: Journal of viral hepatitis 20100301

Title: Viral resistance in hepatitis B: prevalence and management.

Journal: Current gastroenterology reports 20100201

Title: [The effect of antiviral therapy for patients with HBeAg-negative cirrhosis].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20100201

Title: Effect of newer oral antiviral agents on future therapy of chronic hepatitis B.

Journal: Antiviral therapy 20100101

Title: Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.

Journal: PloS one 20100101

Title: Polymyositis in patients taking antiviral clevudine therapy: a report of two cases.

Journal: NeuroRehabilitation 20100101

Title: Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.

Journal: PloS one 20100101

Title: Cost-effectiveness analysis of roadmap models in chronic hepatitis B using tenofovir as the rescue therapy.

Journal: Antiviral therapy 20100101

Title: Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection.

Journal: Genome medicine 20100101

Title: Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.

Journal: Antiviral therapy 20100101

Title: A review of oral antiretroviral therapy for the treatment of chronic hepatitis B.

Journal: The Annals of pharmacotherapy 20100101

Title: [The efficacy of adefovir dipivoxil, entecavir and telbivudine for chronic hepatitis B treatment: a systematic review].

Journal: Revista da Sociedade Brasileira de Medicina Tropical 20100101

Title: Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment.

Journal: Virology journal 20100101

Title: Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review.

Journal: Virology journal 20100101

Title: Partial siamese twin as potential organ donor.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20100101

Title: Recent advances in managing hepatitis B.

Journal: F1000 medicine reports 20100101

Title: New approaches to optimize treatment responses in chronic hepatitis B.

Journal: Antiviral therapy 20100101

Title: Myotoxicity of telbivudine in pre-existing muscle damage.

Journal: Virology journal 20100101

Title: Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients.

Journal: Antiviral therapy 20100101

Title: Rituximab administration and reactivation of HBV.

Journal: Hepatitis research and treatment 20100101

Title: Therapeutic vaccination in chronic hepatitis B: preclinical studies in the woodchuck.

Journal: Hepatitis research and treatment 20100101

Title: The diagnostic value of ultrasound elastography in patients with hepatitis B virus infection: a prospective study.

Journal: The Journal of international medical research 20100101

Title: A pregnant female with a large intracranial mass: Reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy.

Journal: Surgical neurology international 20100101

Title: Molecular diagnosis of entecavir resistance.

Journal: Hepatitis monthly 20100101

Title: Different models of HBeAg seroconversion predicated by on-treatment ALT and HBV DNA profiles.

Journal: Journal of viral hepatitis 20091201

Title: Absence of effect of telbivudine on cardiac repolarization: results of a thorough QT/QTc study in healthy participants.

Journal: Journal of clinical pharmacology 20091201

Title: Current status of liver diseases in Korea: hepatitis B.

Journal: The Korean journal of hepatology 20091201

Title: [Chronic hepatitis B therapy].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20091201

Title: [Management of side effects during antiviral therapy].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20091201

Title: HBV and HCV therapy.

Journal: Viruses 20091201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20091101

Title: Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B.

Journal: Journal of hepatology 20091001

Title: Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.

Journal: Journal of hepatology 20091001

Title: Telbivudine for the treatment of chronic hepatitis B infection.

Journal: Health technology assessment (Winchester, England) 20091001

Title: Entecavir for the treatment of chronic hepatitis B infection.

Journal: Health technology assessment (Winchester, England) 20091001

Title: [The efficacy of nucleoside/nucleotide analogue on chronic hepatitis B].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20091001

Title: Current status of nucleoside antivirals in chronic hepatitis B.

Journal: Drugs of today (Barcelona, Spain : 1998) 20091001

Title: Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus.

Journal: Medical microbiology and immunology 20090801

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Tags:3424-98-4 Molecular Formula|3424-98-4 MDL|3424-98-4 SMILES|3424-98-4 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione