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52286-59-6,MFCD00133369
Catalog No.:AA00I99Y

52286-59-6 | Ginsenoside re

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1mg
≥95%
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$46.00   $32.00
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5mg
98% by HPLC
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10mg
98% by HPLC
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25mg
98% by HPLC
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$174.00   $122.00
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50mg
>95.0%(HPLC)(qNMR)
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$194.00   $136.00
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100mg
98% by HPLC
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$386.00   $270.00
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500mg
98% by HPLC
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1000mg
98% by HPLC
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I99Y
Chemical Name:
Ginsenoside re
CAS Number:
52286-59-6
Molecular Formula:
C48H82O18
Molecular Weight:
947.1539
MDL Number:
MFCD00133369
SMILES:
OC[C@H]1O[C@@H](O[C@H]2C[C@]3(C)[C@@H]([C@@]4([C@@H]2C(C)(C)[C@@H](O)CC4)C)C[C@H]([C@H]2[C@@]3(C)CC[C@@H]2[C@@](O[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)(CCC=C(C)C)C)O)[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Properties
Properties
 
BP:
1011.8±65.0°C at 760 mmHg  
Form:
Solid  
MP:
>185°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
1700  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
26  
Heavy Atom Count:
66  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
12  
XLogP3:
1.6  

Literature

Title: Ginsenoside Re protects against phencyclidine-induced behavioral changes and mitochondrial dysfunction via interactive modulation of glutathione peroxidase-1 and NADPH oxidase in the dorsolateral cortex of mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171201

Title: Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C δ in human neuroblastoma dopaminergic SH-SY5Y cell lines.

Journal: Journal of applied toxicology : JAT 20150801

Title: Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3.

Journal: British journal of pharmacology 20150201

Title: Ginsenosides may enhance the functionality of human embryonic stem cell-derived cardiomyocytes in vitro.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20141001

Title: Effects of ginsenosides on opioid-induced hyperalgesia in mice.

Journal: Neuroreport 20140709

Title: Effects of ginsenoside Re on rat jejunal contractility.

Journal: Journal of natural medicines 20140701

Title: Dissecting active ingredients of Chinese medicine by content-weighted ingredient-target network.

Journal: Molecular bioSystems 20140701

Title: Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene.

Journal: Molecular neurobiology 20140601

Title: Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism.

Journal: Journal of natural medicines 20140401

Title: Ginsenoside Re and Rd enhance the expression of cholinergic markers and neuronal differentiation in Neuro-2a cells.

Journal: Biological & pharmaceutical bulletin 20140101

Title: Enhancement of protective immune response to recombinant Toxoplasma gondii ROP18 antigen by ginsenoside Re.

Journal: Experimental parasitology 20131001

Title: Ginsenoside Re reduces insulin resistance through activation of PPAR-γ pathway and inhibition of TNF-α production.

Journal: Journal of ethnopharmacology 20130520

Title: Rescue of PINK1 protein null-specific mitochondrial complex IV deficits by ginsenoside Re activation of nitric oxide signaling.

Journal: The Journal of biological chemistry 20121228

Title: Increase in antioxidant effect of ginsenoside Re-alanine mixture by Maillard reaction.

Journal: Food chemistry 20121215

Title: Th1 immunity induction by ginsenoside Re involves in protection of mice against disseminated candidiasis due to Candida albicans.

Journal: International immunopharmacology 20121201

Title: Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.

Journal: Metabolism: clinical and experimental 20121101

Title: Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages.

Journal: Journal of agricultural and food chemistry 20120926

Title: Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice.

Journal: Journal of ethnopharmacology 20120626

Title: Ginsenosides Rg1 and Re act as adjuvant via TLR4 signaling pathway.

Journal: Vaccine 20120608

Title: Development of a secondary antibody thio-functionalized microcantilever immunosensor and an ELISA for measuring ginsenoside Re content in the herb ginseng.

Journal: Analytical chemistry 20120515

Title: Inhibition of inflammations and macrophage activation by ginsenoside-Re isolated from Korean ginseng (Panax ginseng C.A. Meyer).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

Title: Effect of ginsenoside Re on depression- and anxiety-like behaviors and cognition memory deficit induced by repeated immobilization in rats.

Journal: Journal of microbiology and biotechnology 20120501

Title: Ginsenoside Re attenuates diabetes-associated cognitive deficits in rats.

Journal: Pharmacology, biochemistry, and behavior 20120301

Title: Separation and purification of ginsenoside Re from ginseng bud by selective adsorption of active carbon and preparative high-performance liquid chromatography.

Journal: Natural product research 20120101

Title: Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice.

Journal: International journal of molecular medicine 20120101

Title: Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells.

Journal: BMC complementary and alternative medicine 20120101

Title: Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Journal: Journal of ethnopharmacology 20111011

Title: A novel ginsenosidase from an Aspergillus strain hydrolyzing 6-O-multi-glycosides of protopanaxatriol-type ginsenosides, named ginsenosidase type IV.

Journal: Journal of microbiology and biotechnology 20111001

Title: Mucilaginibacter composti sp. nov., with ginsenoside converting activity, isolated from compost.

Journal: Journal of microbiology (Seoul, Korea) 20110601

Title: [Protective effect of ginsenoside Re on myocardial cells of neonatal SD rat subjected to hypoxia injury].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20110601

Title: Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.

Journal: Diabetes care 20110501

Title: Effect of ginsenosides Rg3 and Re on glucose transport in mature 3T3-L1 adipocytes.

Journal: Phytotherapy research : PTR 20110501

Title: Bioactivity of American ginseng by knockout extract preparation using monoclonal antibody.

Journal: Current drug discovery technologies 20110301

Title: [Determination of ginsenosides Rg1, Re and Rb1 in Panax quinquefolium by micellar electrokinetic capillary chromatography].

Journal: Se pu = Chinese journal of chromatography 20110301

Title: [Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

Title: Study on the interactions between ginsenosides and lysozyme under acidic condition by ESI-MS and molecular docking.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110201

Title: Single-chain variable fragment antibody against ginsenoside Re as an effective tool for the determination of ginsenosides in various ginsengs.

Journal: Journal of natural medicines 20110101

Title: Efficient silkworm expression of single-chain variable fragment antibody against ginsenoside Re using Bombyx mori nucleopolyhedrovirus bacmid DNA system and its application in enzyme-linked immunosorbent assay for quality control of total ginsenosides.

Journal: Journal of biochemistry 20100901

Title: [Culture of hairy roots of Panax japonicus and ginsenoside re synthesis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

Title: Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts.

Journal: Fitoterapia 20100601

Title: Ginsenoside Re enhances survival of human CD4+ T cells through regulation of autophagy.

Journal: International immunopharmacology 20100501

Title: Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Enhancement of immune responses to influenza vaccine (H3N2) by ginsenoside Re.

Journal: International immunopharmacology 20100301

Title: Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: [Determination of effective components in different positions of Panax notoginseng by HPLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091201

Title: In vivo metabolism study of ginsenoside Re in rat using high-performance liquid chromatography coupled with tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20091101

Title: [Structure and vibrational spectroscopy of ginsenoside Re: density functional theory study].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20091001

Title: [Study on extraction and purification process of total ginsenosides from Radix Ginseng].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091001

Title: [Quantitative determination of ginsenoside Re and Rg1 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901

Title: Quantitative analysis of ginsenosides Rb1, Rg1, and Re in American ginseng berry and flower samples by ELISA using monoclonal antibodies.

Journal: Journal of natural medicines 20090701

Title: [Metabolic study of ginsenoside Re in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601

Title: [Protective effect of ginsenoside Re on isoproterenol-induced triggered ventricular arrhythmia in rabbits].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090501

Title: [Effects of culture conditions on biomass and active components of suspension cells of Panax quinquefolium].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

Title: Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20080801

Title: Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats.

Journal: Journal of Asian natural products research 20080101

Title: Antioxidant protection by American ginseng in pancreatic beta-cells.

Journal: The American journal of Chinese medicine 20080101

Title: [Studies on chemical constituents from rhizomes of Panax notoginseng].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071101

Title: Study on the noncovalent complexes of ginsenoside and cytochrome c by electrospray ionization mass spectrometry.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071001

Title: The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways.

Journal: The journal of medical investigation : JMI 20070801

Title: Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.

Journal: Journal of natural products 20070701

Title: Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor.

Journal: FEBS letters 20070529

Title: Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway.

Journal: Molecular reproduction and development 20070401

Title: [Comparative study on quality of Tongrentang red ginseng and Korean red ginseng--determination of ginsenosides and polysaccharides].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Stability of angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng: in vitro and in vivo studies.

Journal: International journal of pharmaceutics 20070110

Title: Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones.

Journal: Molecular pharmacology 20061201

Title: Protective effect of ginsenoside-Re against cerebral ischemia/reperfusion damage in rats.

Journal: Biological & pharmaceutical bulletin 20061201

Title: Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS.

Journal: Journal of ethnopharmacology 20061124

Title: Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats.

Journal: European journal of pharmacology 20061121

Title: Ginsenoside Re attenuate beta-amyloid and serum-free induced neurotoxicity in PC12 cells.

Journal: Journal of ethnopharmacology 20060811

Title: Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect.

Journal: Chemistry & biodiversity 20060701

Title: The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models.

Journal: Planta medica 20060301

Title: Antioxidant effects of ginsenoside Re in cardiomyocytes.

Journal: European journal of pharmacology 20060227

Title: Ginsenoside R(e) increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase.

Journal: Archives of pharmacal research 20060201

Title: Detection and quantification of ginsenoside Re in ginseng samples by a chromatographic immunostaining method using monoclonal antibody against ginsenoside Re.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

Title: Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect.

Journal: Biological & pharmaceutical bulletin 20051001

Title: [Study on the extraction recovery of ginsenoside Re in plasma by different solid-phase cartridges].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001

Title: American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats.

Journal: Cancer chemotherapy and pharmacology 20050701

Title: Anti-diabetic effect of ginsenoside Re in ob/ob mice.

Journal: Biochimica et biophysica acta 20050610

Title: Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model.

Journal: Journal of Asian natural products research 20050601

Title: Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms.

Journal: Biotechnology letters 20050601

Title: A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration.

Journal: Pharmaceutical research 20050401

Title: [Pharmacokinetics of ginsenosides Rg1 and Re in Shenmai injection].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050401

Title: [Evaluation of measurement uncertainty for the determination of ginsenosides in Radix ginseng by HPLC].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050101

Title: Embryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20041101

Title: Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry.

Journal: Journal of agricultural and food chemistry 20040811

Title: Roles of ginsenosides on morphine-induced hyperactivity and rewarding effect in mice.

Journal: Planta medica 20040701

Title: Nitric oxide-dependent modulation of the delayed rectifier K+ current and the L-type Ca2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes.

Journal: British journal of pharmacology 20040601

Title: [Research of ginsenosides in kou zi qi using HPLC-MS-MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040501

Title: [Studies on influence of fungal elicitor on hairy root of Panax ginseng biosynthesis ginseng saponin and biomass].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040401

Title: Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities.

Journal: International archives of allergy and immunology 20040201

Title: [Identification of Panax notoginseng and its preparations by LC/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: [Optimization of the circulatory percolation process for extraction of radix ginseng rubra].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040101

Title: [Determination of ginsenosides Re, Rb1 in Panax quinquefolius by micellar electrokinetic chromatography].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201

Title: Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes.

Journal: European journal of pharmacology 20030822

Title: Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.

Journal: Journal of natural products 20030701

Title: [Study on the chemical constituents of the roots of commercial ginseng].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030601

Title: [Study on the culture of crown gall from Panax quinquefolium and the prouction of its secondary metabolites--Ginsenosides Re and Rg1].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20030501

Title: Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells.

Journal: Archives of pharmacal research 20030101

Title: Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.

Journal: Journal of natural products 20020901

Title: Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.

Journal: Diabetes 20020601

Title: Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation.

Journal: Planta medica 20020601

Title: Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro.

Journal: Experimental neurology 20020201

Title: Effect of ginsenoside Re on cardiomyocyte apoptosis and expression of Bcl-2/Bax gene after ischemia and reperfusion in rats.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

Title: Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide.

Journal: British journal of pharmacology 20011101

Title: Enzymatic synthesis of two ginsenoside Re-beta-xylosides.

Journal: Bioscience, biotechnology, and biochemistry 20010501

Title: Triterpene saponins from Vietnamese ginseng (Panax vietnamensis) and their hepatocytoprotective activity.

Journal: Journal of natural products 20010401

Title: In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.

Journal: Planta medica 20010401

Title: Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes.

Journal: Bioscience, biotechnology, and biochemistry 19961201

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Cao G, et al. Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells. Eur J Pharmacol. 2016 Dec 15;793:101-108.

Title: Su F, et al. Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to Toll-like receptor 4. Antimicrob Agents Chemother. 2015 Sep;59(9):5654-63.

Title: Zhang Z, et al. Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB. Mol Endocrinol. 2008 Jan;22(1):186-95.

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