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551-15-5,MFCD00210526
Catalog No.:AA00I9RB

551-15-5 | Liquiritin

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5mg
≥98%
in stock  
$98.00   $68.00
- +
10mg
98% by HPLC
in stock  
$142.00   $99.00
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25mg
98% by HPLC
in stock  
$228.00   $160.00
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50mg
98% by HPLC
in stock  
$343.00   $240.00
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100mg
98% by HPLC
in stock  
$547.00   $383.00
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500mg
98% by HPLC
in stock  
$1,622.00   $1,136.00
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1000mg
98% by HPLC
in stock  
$2,557.00   $1,790.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9RB
Chemical Name:
Liquiritin
CAS Number:
551-15-5
Molecular Formula:
C21H22O9
Molecular Weight:
418.3940
MDL Number:
MFCD00210526
SMILES:
OC[C@H]1O[C@@H](Oc2ccc(cc2)[C@@H]2CC(=O)c3c(O2)cc(cc3)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Properties
 
BP:
746.8°C at 760 mmHg  
Form:
Solid  
MP:
>207°C (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
593  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
4  
XLogP3:
0.4  

Literature

Title: Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system.

Journal: Toxicology and applied pharmacology 20180915

Title: Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.

Journal: Journal of ethnopharmacology 20130109

Title: Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo.

Journal: The Journal of pharmacy and pharmacology 20121101

Title: Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.

Journal: Molecules (Basel, Switzerland) 20121101

Title: Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury.

Journal: Fundamental & clinical pharmacology 20120801

Title: [Multiple analysis of the difference in intestinal absorption between the main components and the extract of Glycyrrhiza uralensis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120501

Title: [Influence of combination on the specific chromatogram of Glycyrrhiza in sini decoctions by HPLC].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120401

Title: [Simultaneous determination of four components in sini tang by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301

Title: Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120125

Title: Determination of 5-hydroxymethyl-2-furfural, albiflorin, paeoniflorin, liquiritin, ferulic acid, nodakenin, and glycyrrhizin by HPLC-PDA, and evaluation of the cytotoxicity of Palmul-tang, a traditional Korean herbal medicine.

Journal: Archives of pharmacal research 20120101

Title: [Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20111101

Title: [Effect of Tongfeng trace elements nutrient balance agent on growth, physiological characteristics and content of active constituents of Glycyrrhiza uralensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110501

Title: Optimization of micellar electrokinetic capillary chromatography method using central composite design for the analysis of components in Yangwei granule.

Journal: Journal of Zhejiang University. Science. B 20110301

Title: Simultaneous determination of liquiritin, hesperidin, and glycyrrhizin by HPLC-photodiode array detection and the anti-inflammatory effect of Pyungwi-san.

Journal: Archives of pharmacal research 20110201

Title: Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription.

Journal: Journal of ethnopharmacology 20110127

Title: [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

Title: Variation of glycyrrhizin and liquiritin contents within a population of 5-year-old licorice (Glycyrrhiza uralensis) plants cultivated under the same conditions.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties.

Journal: Journal of Asian natural products research 20101201

Title: Rapid profiling and target analysis of principal components in Fuling Decoctions by UFLC-DAD-ESI-MS.

Journal: Fitoterapia 20100901

Title: [In vitro absorption mechanism of strychnine and the transport interaction with liquiritin in Caco-2 cell monolayer model].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100901

Title: [Application of FTIR spectroscopy to the identification of Glycyrrhiza uralensis Fisch].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20100501

Title: [Investigation on medicinal plant resources of Glycyrrhiza uralensis in China and chemical assessment of its underground part].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

Title: Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Solid-phase extraction of liquiritin and glycyrrhizin from licorice using porous alkyl-pyridinium polymer sorbent.

Journal: Phytochemical analysis : PCA 20100101

Title: Solid-phase extraction of liquiritin and glycyrrhizic acid from licorice using ionic liquid-based silica sorbent.

Journal: Journal of separation science 20091201

Title: Effects of space flight on DNA mutation and secondary metabolites of licorice (Glycyrrhiza uralensis Fisch.).

Journal: Science in China. Series C, Life sciences 20091001

Title: Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090701

Title: Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not.

Journal: International immunopharmacology 20090501

Title: Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats.

Journal: Behavioural brain research 20081201

Title: [Fingerprint analysis of Radix Glycyrrhizae by fast HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080701

Title: [Neuroprotection and neurotrophism effects of liquiritin on primary cultured hippocampal cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

Title: Analysis of glycyrrhizic acid and liquiritin in liquorice root with microwave-assisted micellar extraction and pre-concentration.

Journal: Phytochemical analysis : PCA 20080101

Title: Simultaneous analysis of glycyrrhizin, paeoniflorin, quercetin, ferulic acid, liquiritin, formononetin, benzoic acid and isoliquiritigenin in the Chinese proprietary medicine Xiao Yao Wan by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20071105

Title: [Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071101

Title: Separation of Liquiritin by simulated moving bed chromatography.

Journal: Journal of chromatography. A 20070323

Title: [Relative adscriptions of components in the effective fractions of Yinqiao decoction and its composing individual herbs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070201

Title: Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

Title: Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine.

Journal: Chemico-biological interactions 20060610

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Transcriptional suppression of the HIV promoter by natural compounds.

Journal: Antiviral research 20030301

Title: Zeng C, et al. Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Front Physiol. 2019 Jul 3;10:833.

Title: Nakatani Y, et al. Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells. Eur J Pharmacol. 2017 Nov 15;815:381-390.

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