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[1]CurrentPatentAssignee:CHINESEACADEMYOFMEDICALSCIENCES-EP2789612,2014,A1Locationinpatent:Paragraph0055
[2]CurrentPatentAssignee:CHINESEACADEMYOFMEDICALSCIENCES-US2015/31717,2015,A1Locationinpatent:Paragraph0030;0085;0086
[3]Zhang,Zhi-Hui;Yan,Yu;Deng,An-Jun;Zhang,Hai-Jing;Li,Zhi-Hong;Yuan,Tian-Yi;Fang,Lian-Hua;Wu,Lian-Qiu;Du,Guan-Hua;Qin,Hai-Lin[ChineseChemicalLetters,2018,vol.29,#1,p.131-135]
[1]CurrentPatentAssignee:CHINESEACADEMYOFMEDICALSCIENCES-EP2789612,2014,A1Locationinpatent:Paragraph0056
[2]CurrentPatentAssignee:CHINESEACADEMYOFMEDICALSCIENCES-US2015/31717,2015,A1Locationinpatent:Paragraph0030;0087;0088
[3]Zhang,Zhi-Hui;Yan,Yu;Deng,An-Jun;Zhang,Hai-Jing;Li,Zhi-Hong;Yuan,Tian-Yi;Fang,Lian-Hua;Wu,Lian-Qiu;Du,Guan-Hua;Qin,Hai-Lin[ChineseChemicalLetters,2018,vol.29,#1,p.131-135]
Title: Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.
Journal: Analytica chimica acta 20121017
Title: Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.
Journal: Analytica chimica acta 20120806
Title: Design, synthesis and multidrug resistance reversal activity evaluation of 8-oxocoptisine derivatives.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701
Title: Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.
Journal: Atherosclerosis 20120501
Title: Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method.
Journal: Journal of pharmaceutical and biomedical analysis 20120223
Title: Coptisine inhibits RANKL-induced NF-κB phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL and OPG gene expression in osteoblastic cells.
Journal: Journal of natural medicines 20120101
Title: Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings.
Journal: The American journal of Chinese medicine 20120101
Title: [Preparation and stuctural behavior of the inclusion complex of beta-cyclodextrin and coptisine hydrochloride].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120101
Title: Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription.
Journal: Fitoterapia 20111201
Title: Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids.
Journal: Talanta 20110715
Title: [Quantitative analysis of four alkaloids in Xianglian preparations by QAMS method].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601
Title: Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect.
Journal: Journal of natural products 20110425
Title: Application of 1H-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma.
Journal: Journal of natural medicines 20110401
Title: Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401
Title: [Simultaneous determination of six alkaloids in Coptis chinensis of different regions by RP-HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001
Title: Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity.
Journal: Bioorganic & medicinal chemistry letters 20100801
Title: Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis.
Journal: Journal of applied microbiology 20091001
Title: Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC.
Journal: Journal of separation science 20090501
Title: [Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201
Title: Development of a rapid resolution liquid chromatographic method for simultaneous analysis of four alkaloids in Rhizoma coptidis under different cultivation conditions.
Journal: Journal of AOAC International 20090101
Title: Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.
Journal: Phytochemical analysis : PCA 20090101
Title: Covalent bonding of azoles to quaternary protoberberine alkaloids.
Journal: Magnetic resonance in chemistry : MRC 20081201
Title: [Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101
Title: Simultaneous quantification of three alkaloids of Coptidis Rhizoma in rat urine by high-performance liquid chromatography: application to pharmacokinetic study.
Journal: Biopharmaceutics & drug disposition 20071201
Title: [Absorption of coptisine chloride and berberrubine across human intestinal epithelial by using human Caco-2 cell monolayers].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201
Title: Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry.
Journal: Journal of chromatography. A 20070803
Title: High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.
Journal: Journal of separation science 20070401
Title: Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060501
Title: Simultaneous determination of four active alkaloids from a traditional Chinese medicine Corydalis saxicola Bunting. (Yanhuanglian) in plasma and urine samples by LC-MS-MS.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
Title: [Studies on the alkaloids from herb of Corydalis adunca].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101
Title: [Quality assessment of Coptis chinensis in China].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401
Title: [Establishment of the control substance of plant drug and fingerprints of Coptis chinensis].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201
Title: Improved detection of Coptidis alkaloids by field-amplified sample stacking in capillary electrophoresis.
Journal: Journal of pharmaceutical and biomedical analysis 20040921
Title: Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth.
Journal: Clinical and experimental pharmacology & physiology 20040101
Title: [Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701
Title: Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids.
Journal: Bioscience, biotechnology, and biochemistry 20021101
Title: Inhibition of type A monoamine oxidase by coptisine in mouse brain.
Journal: Life sciences 20011228
Title: Gastric-mucous membrane protection activity of coptisine derivatives.
Journal: Biological & pharmaceutical bulletin 20011101
Title: In vitro cytotoxicity of the protoberberine-type alkaloids.
Journal: Journal of natural products 20010701
Title: Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine.
Journal: Farmaco (Societa chimica italiana : 1989) 20010101
Title: Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.
Journal: Cell biology and toxicology 20010101
Title: Analysis of coptisine, berberine and palmatine in adulterated Chinese medicine by capillary electrophoresis-electrospray ion trap mass spectrometry.
Journal: Journal of chromatography. A 20000114
Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal: Journal of natural products 19910101
Title: Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.
Title: He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.
Title: Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.
Title: Zhou X, et al. Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1. Sci Rep. 2017 Nov 14;7(1):15549.
