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3486-66-6,MFCD03792689
Catalog No.:AA00BXGB

3486-66-6 | Coptisine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98%
1 week  
$69.00   $48.00
- +
25mg
98%
1 week  
$115.00   $81.00
- +
50mg
98%
1 week  
$188.00   $132.00
- +
100mg
98%
1 week  
$321.00   $225.00
- +
250mg
98%
1 week  
$546.00   $382.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BXGB
Chemical Name:
Coptisine
CAS Number:
3486-66-6
Molecular Formula:
C19H14NO4+
Molecular Weight:
320.3188
MDL Number:
MFCD03792689
SMILES:
C1Oc2c(O1)cc1c(c2)CC[n+]2c1cc1ccc3c(c1c2)OCO3
Properties
Computed Properties
 
Complexity:
502  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Downstream Synthesis Route

[1]Chemicalandpharmaceuticalbulletin,1982,vol.30,p.3446-3449

[1]Hanaoka,Miyoji;Sakurai,Shun-ichiro;Ohshima,Takeshi;Yasuda,Shingo;Mukai,Chisato[Chemicalandpharmaceuticalbulletin,1982,vol.30,#9,p.3446-3449]

[1]Hanaoka,Miyoji;Yoshida,Shuji;Annen,Masami;Mukai,Chisato[ChemistryLetters,1986,p.739-742]

[1]Hanaoka,Miyoji;Yoshida,Shuji;Annen,Masami;Mukai,Chisato[ChemistryLetters,1986,p.739-742]

Literature

Title: Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.

Title: He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.

Title: Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.

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SDS
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Tags:3486-66-6 Molecular Formula|3486-66-6 MDL|3486-66-6 SMILES|3486-66-6 Coptisine
Catalog No.: AA00BXGB
3486-66-6,MFCD03792689
3486-66-6 | Coptisine
Pack Size： 10mg
Purity： 98%
1 week
$69.00 $48.00
Pack Size： 25mg
Purity： 98%
1 week
$115.00 $81.00
Pack Size： 50mg
Purity： 98%
1 week
$188.00 $132.00
Pack Size： 100mg
Purity： 98%
1 week
$321.00 $225.00
Pack Size： 250mg
Purity： 98%
1 week
$546.00 $382.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BXGB
Chemical Name: Coptisine
CAS Number: 3486-66-6
Molecular Formula: C19H14NO4+
Molecular Weight: 320.3188
MDL Number: MFCD03792689
SMILES: C1Oc2c(O1)cc1c(c2)CC[n+]2c1cc1ccc3c(c1c2)OCO3
Properties
Complexity: 502  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 1  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Downstream Synthesis Route
2086-83-1    3486-66-6 

[1]Chemicalandpharmaceuticalbulletin,1982,vol.30,p.3446-3449

3486-66-6    84229-86-7 

[1]Hanaoka,Miyoji;Sakurai,Shun-ichiro;Ohshima,Takeshi;Yasuda,Shingo;Mukai,Chisato[Chemicalandpharmaceuticalbulletin,1982,vol.30,#9,p.3446-3449]

3486-66-6    77-78-1    107651-12-7 

[1]Hanaoka,Miyoji;Yoshida,Shuji;Annen,Masami;Mukai,Chisato[ChemistryLetters,1986,p.739-742]

3486-66-6    107651-13-8 

[1]Hanaoka,Miyoji;Yoshida,Shuji;Annen,Masami;Mukai,Chisato[ChemistryLetters,1986,p.739-742]

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