Home Amines 86-42-0
86-42-0,MFCD00552927
Catalog No.:AA01CBPU

86-42-0 | 4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol

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1g
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$37.00   $26.00
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5g
95%
in stock  
$79.00   $55.00
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25g
95%
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$203.00   $142.00
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100g
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01CBPU
Chemical Name:
4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol
CAS Number:
86-42-0
Molecular Formula:
C20H22ClN3O
Molecular Weight:
355.8612
MDL Number:
MFCD00552927
SMILES:
CCN(Cc1cc(ccc1O)Nc1ccnc2c1ccc(c2)Cl)CC
NSC Number:
13453
Properties
Computed Properties
 
Complexity:
406  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.6  

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Journal: Parasitology 20111001

Title: Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda.

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Title: Buchwald reaction as the key step for the synthesis of metabolically more stable analogs of amodiaquine.

Journal: European journal of medicinal chemistry 20110701

Title: Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Journal: Drug metabolism and pharmacokinetics 20110601

Title: Therapeutic efficacies of artemisinin-based combination therapies in Nigerian children with uncomplicated falciparum malaria during five years of adoption as first-line treatments.

Journal: The American journal of tropical medicine and hygiene 20110601

Title: Therapeutic efficacy and effects of artemether-lumefantrine and artesunate-amodiaquine coformulated or copackaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in Southwest Nigeria.

Journal: The American journal of tropical medicine and hygiene 20110505

Title: Use of area under the curve to evaluate the effects of antimalarial drugs on malaria-associated anemia after treatment.

Journal: American journal of therapeutics 20110501

Title: Malaria in pregnancy: the difficulties in measuring birthweight.

Journal: BJOG : an international journal of obstetrics and gynaecology 20110501

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Journal: Antimicrobial agents and chemotherapy 20110501

Title: Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria.

Journal: European journal of medicinal chemistry 20110501

Title: Quinine-resistant malaria in traveler returning from French Guiana, 2010.

Journal: Emerging infectious diseases 20110501

Title: The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial.

Journal: PLoS medicine 20110501

Title: A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening.

Journal: International journal of pharmaceutics 20110415

Title: Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

Journal: PLoS genetics 20110401

Title: The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.

Journal: Journal of inorganic biochemistry 20110301

Title: Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers.

Journal: European journal of clinical pharmacology 20110301

Title: Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants.

Journal: The Journal of infectious diseases 20110215

Title: Intermittent preventive treatment to reduce the burden of malaria in children: new evidence on integration and delivery.

Journal: PLoS medicine 20110201

Title: Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trial.

Journal: PLoS medicine 20110201

Title: Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Mali: a randomised, double-blind, placebo-controlled trial.

Journal: PLoS medicine 20110201

Title: Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial.

Journal: PLoS medicine 20110201

Title: Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana.

Journal: The Journal of infectious diseases 20110115

Title: Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs.

Journal: Experimental parasitology 20110101

Title: Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110101

Title: Is parasite clearance clinically important after malaria treatment in a high transmission area? A 3-month follow-up of home-based management with herbal medicine or ACT.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20110101

Title: An in vitro, high throughput, seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS.

Journal: Drug metabolism letters 20110101

Title: Changes in health workers' malaria diagnosis and treatment practices in Kenya.

Journal: Malaria journal 20110101

Title: A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia.

Journal: Malaria journal 20110101

Title: Exploring provider and community responses to the new malaria diagnostic and treatment regime in Solomon Islands.

Journal: Malaria journal 20110101

Title: Using rapid diagnostic tests as source of malaria parasite DNA for molecular analyses in the era of declining malaria prevalence.

Journal: Malaria journal 20110101

Title: Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs.

Journal: Malaria journal 20110101

Title: Hepatitis C virus infection may lead to slower emergence of P. falciparum in blood.

Journal: PloS one 20110101

Title: Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial.

Journal: PloS one 20110101

Title: Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan.

Journal: Malaria journal 20110101

Title: Evaluation of prevalence's of pfdhfr and pfdhps mutations in Angola.

Journal: Malaria journal 20110101

Title: Access to artesunate-amodiaquine, quinine and other anti-malarials: policy and markets in Burundi.

Journal: Malaria journal 20110101

Title: Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008.

Journal: Malaria journal 20110101

Title: A systematic review and meta-analysis of the efficacy and safety of intermittent preventive treatment of malaria in children (IPTc).

Journal: PloS one 20110101

Title: A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa.

Journal: PloS one 20110101

Title: Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.

Journal: Malaria journal 20110101

Title: Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children.

Journal: Malaria journal 20110101

Title: Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection.

Journal: Malaria journal 20110101

Title: Clearance of asymptomatic P. falciparum Infections Interacts with the number of clones to predict the risk of subsequent malaria in Kenyan children.

Journal: PloS one 20110101

Title: Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study.

Journal: Malaria journal 20110101

Title: Natural products as starting points for future anti-malarial therapies: going back to our roots?

Journal: Malaria journal 20110101

Title: To what extent can traditional medicine contribute a complementary or alternative solution to malaria control programmes?

Journal: Malaria journal 20110101

Title: Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?

Journal: Malaria journal 20110101

Title: A 'reverse pharmacology' approach for developing an anti-malarial phytomedicine.

Journal: Malaria journal 20110101

Title: Prevalence of molecular markers of anti-malarial drug resistance in Plasmodium vivax and Plasmodium falciparum in two districts of Nepal.

Journal: Malaria journal 20110101

Title: Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan Africa.

Journal: Malaria journal 20110101

Title: Increasing malaria hospital admissions in Uganda between 1999 and 2009.

Journal: BMC medicine 20110101

Title: Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children.

Journal: PloS one 20110101

Title: Protective efficacy of malaria case management and intermittent preventive treatment for preventing malaria mortality in children: a systematic review for the Lives Saved Tool.

Journal: BMC public health 20110101

Title: Knowledge and behaviour as determinants of anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya.

Journal: Malaria journal 20110101

Title: A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine.

Journal: Malaria journal 20110101

Title: Modelling the protective efficacy of alternative delivery schedules for intermittent preventive treatment of malaria in infants and children.

Journal: PloS one 20110101

Title: Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand.

Journal: Malaria journal 20110101

Title: Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data.

Journal: Malaria journal 20110101

Title: Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.

Journal: PloS one 20110101

Title: High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children.

Journal: Malaria journal 20110101

Title: Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana.

Journal: Malaria journal 20110101

Title: Prevalence and risk factors of malaria among children in southern highland Rwanda.

Journal: Malaria journal 20110101

Title: The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership.

Journal: Malaria journal 20110101

Title: Innovative public-private partnerships to maximize the delivery of anti-malarial medicines: lessons learned from the ASAQ Winthrop experience.

Journal: Malaria journal 20110101

Title: High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: an urgent need to re-examine malaria drug policy.

Journal: Parasites & vectors 20110101

Title: Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau: a randomized controlled trial.

Journal: Malaria journal 20110101

Title: Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

Journal: PloS one 20110101

Title: Treatment of uncomplicated malaria at public health facilities and medicine retailers in south-eastern Nigeria.

Journal: Malaria journal 20110101

Title: Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections.

Journal: Malaria journal 20110101

Title: Increasing Access to Subsidized Artemisinin-based Combination Therapy through Accredited Drug Dispensing Outlets in Tanzania.

Journal: Health research policy and systems 20110101

Title: Acridine and acridinones: old and new structures with antimalarial activity.

Journal: The open medicinal chemistry journal 20110101

Title: Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan.

Journal: Malaria journal 20110101

Title: Efficacy of PermaNet® 2.0 and PermaNet® 3.0 against insecticide-resistant Anopheles gambiae in experimental huts in Côte d'Ivoire.

Journal: Malaria journal 20110101

Title: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria.

Journal: Malaria journal 20110101

Title: Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro.

Journal: Malaria journal 20110101

Title: Increase in EPI vaccines coverage after implementation of intermittent preventive treatment of malaria in infant with Sulfadoxine -pyrimethamine in the district of Kolokani, Mali: results from a cluster randomized control trial.

Journal: BMC public health 20110101

Title: Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies.

Journal: PloS one 20110101

Title: Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal.

Journal: Malaria journal 20110101

Title: Taking stock: provider prescribing practices in the presence and absence of ACT stock.

Journal: Malaria journal 20110101

Title: Exposure to anti-malarial drugs and monitoring of adverse drug reactions using toll-free mobile phone calls in private retail sector in Sagamu, Nigeria: implications for pharmacovigilance.

Journal: Malaria journal 20110101

Title: Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial.

Journal: Malaria journal 20110101

Title: Saleability of anti-malarials in private drug shops in Muheza, Tanzania: a baseline study in an era of assumed artemisinin combination therapy (ACT).

Journal: Malaria journal 20110101

Title: Feasibility and acceptability of ACT for the community case management of malaria in urban settings in five African sites.

Journal: Malaria journal 20110101

Title: Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine.

Journal: Malaria journal 20110101

Title: Malaria morbidity in children in the year after they had received intermittent preventive treatment of malaria in Mali: a randomized control trial.

Journal: PloS one 20110101

Title: Morbidity from malaria in children in the year after they had received intermittent preventive treatment of malaria: a randomised trial.

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Title: A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania.

Journal: Malaria journal 20110101

Title: Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations.

Journal: Malaria journal 20110101

Title: Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola.

Journal: Malaria journal 20110101

Title: Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites.

Journal: Malaria journal 20110101

Title: Evaluating health workers' potential resistance to new interventions: a role for discrete choice experiments.

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Title: Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: provider knowledge and acceptability.

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Title: PfMDR1: mechanisms of transport modulation by functional polymorphisms.

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Title: Protein-based signatures of functional evolution in Plasmodium falciparum.

Journal: BMC evolutionary biology 20110101

Title: Reduced in vitro susceptibility to artemisinin derivatives associated with multi-resistance in a traveller returning from South-East Asia.

Journal: Malaria journal 20110101

Title: Cost analysis of school-based intermittent screening and treatment of malaria in Kenya.

Journal: Malaria journal 20110101

Title: Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali.

Journal: Malaria journal 20110101

Title: Genetic polymorphism of merozoite surface protein-1 and merozoite surface protein-2 in Plasmodium falciparum isolates from Brazzaville, Republic of Congo.

Journal: Malaria journal 20110101

Title: Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya.

Journal: Malaria journal 20110101

Title: A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes.

Journal: Malaria journal 20110101

Title: Prospective study on severe malaria among in-patients at Bombo regional hospital, Tanga, north-eastern Tanzania.

Journal: BMC infectious diseases 20110101

Title: Management of uncomplicated malaria in children under 13 years of age at a district hospital in Senegal: from official guidelines to usual practices.

Journal: Malaria journal 20110101

Title: Serological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, equatorial Guinea.

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Title: Risk factors for Plasmodium falciparum hyperparasitaemia in malarious children.

Journal: BMC infectious diseases 20110101

Title: Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats.

Journal: Malaria journal 20110101

Title: Falciparum malaria in young children of rural Burkina Faso: comparison of survey data in 1999 with 2009.

Journal: Malaria journal 20110101

Title: What clinicians who practice in countries reaching malaria elimination should be aware of: lessons learnt from recent experience in Sri Lanka.

Journal: Malaria journal 20110101

Title: A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon.

Journal: Malaria journal 20110101

Title: Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs.

Journal: Malaria journal 20110101

Title: Five years of antimalarial resistance marker surveillance in Gaza Province, Mozambique, following artemisinin-based combination therapy roll out.

Journal: PloS one 20110101

Title: Malaria drug resistance: new observations and developments.

Journal: Essays in biochemistry 20110101

Title: Accessibility, availability and affordability of anti-malarials in a rural district in Kenya after implementation of a national subsidy scheme.

Journal: Malaria journal 20110101

Title: Effect of acute Plasmodium falciparum malaria on reactivation and shedding of the eight human herpes viruses.

Journal: PloS one 20110101

Title: Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei.

Journal: PloS one 20110101

Title: The ACTwatch project: methods to describe anti-malarial markets in seven countries.

Journal: Malaria journal 20110101

Title: Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries.

Journal: Malaria journal 20110101

Title: Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use.

Journal: BMC infectious diseases 20110101

Title: Metal complexes of diisopropylthiourea: synthesis, characterization and antibacterial studies.

Journal: International journal of molecular sciences 20110101

Title: A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response.

Journal: PloS one 20110101

Title: Coverage, adherence and costs of intermittent preventive treatment of malaria in children employing different delivery strategies in Jasikan, Ghana.

Journal: PloS one 20110101

Title: Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator.

Journal: Malaria journal 20110101

Title: Drugs for malaria: something old, something new, something borrowed.

Journal: F1000 biology reports 20110101

Title: Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.

Journal: PloS one 20110101

Title: Quantifying the importance of MSP1-19 as a target of growth-inhibitory and protective antibodies against Plasmodium falciparum in humans.

Journal: PloS one 20110101

Title: Knowledge and practices relating to malaria in a semi-urban area of Cameroon: choices and sources of antimalarials, self-treatment and resistance.

Journal: The Pan African medical journal 20110101

Title: Poor quality vital anti-malarials in Africa - an urgent neglected public health priority.

Journal: Malaria journal 20110101

Title: Impact of combining intermittent preventive treatment with home management of malaria in children less than 10 years in a rural area of Senegal: a cluster randomized trial.

Journal: Malaria journal 20110101

Title: Prescription practices and availability of artemisinin monotherapy in India: where do we stand?

Journal: Malaria journal 20110101

Title: The use of paediatric artemisinin combinations in sub-Saharan Africa: a snapshot questionnaire survey of health care personnel.

Journal: Malaria journal 20110101

Title: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges.

Journal: Malaria journal 20110101

Title: Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America.

Journal: Malaria journal 20110101

Title: The effectiveness and perception of the use of sulphadoxine-pyrimethamine in intermittent preventive treatment of malaria in pregnancy programme in Offinso district of Ashanti region, Ghana.

Journal: Malaria journal 20110101

Title: Severe idiosyncratic drug reactions with epidermal necrolysis: A 5-year study.

Journal: Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20110101

Title: Implementation of artemether-lumefantrine treatment policy for malaria at health facilities in Tanzania.

Journal: Risk management and healthcare policy 20110101

Title: Pattern of the Antimalarials Prescription during Pregnancy in Bangui, Central African Republic.

Journal: Malaria research and treatment 20110101

Title: Malaria treatment policy change and implementation: the case of Uganda.

Journal: Malaria research and treatment 20110101

Title: Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals.

Journal: Malaria research and treatment 20110101

Title: Media, health workers, and policy makers' relationship and their impact on antimalarial policy adoption: a population genetics perspective.

Journal: Malaria research and treatment 20110101

Title: Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum.

Journal: Scientific reports 20110101

Title: A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.

Journal: The American journal of tropical medicine and hygiene 20101206

Title: In Vitro Anti-plasmodial activity of Trigonella foenum-graecum L.

Journal: Evidence-based complementary and alternative medicine : eCAM 20101201

Title: Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance.

Journal: Journal of tropical pediatrics 20101201

Title: In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.

Journal: Antimicrobial agents and chemotherapy 20101201

Title: Alternative visual displays of metaanalysis of malaria treatment trials to facilitate translation of research into policy.

Journal: Diagnostic microbiology and infectious disease 20101201

Title: Malaria: an evaluation of the current state of research on pathogenesis and antimalarial drugs.

Journal: The Yale journal of biology and medicine 20101201

Title: Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy.

Journal: Emerging infectious diseases 20101101

Title: Stress, drugs and the evolution of reproductive restraint in malaria parasites.

Journal: Proceedings. Biological sciences 20101022

Title: N-[(2-Chloro-3-quinol-yl)meth-yl]-4-fluoro-aniline.

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial.

Journal: The Lancet. Infectious diseases 20100909

Title: Redetermination of {5-[(7-chloro-quinolinium-4-yl)amino]-2-hy-droxy-benz-yl}diethyl-ammonium dichloride dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans.

Journal: Rapid communications in mass spectrometry : RCM 20100830

Title: Fixed artesunate-amodiaquine combined pre-formulation study for the treatment of malaria.

Journal: International journal of pharmaceutics 20100816

Title: Quinolines and structurally related heterocycles as antimalarials.

Journal: European journal of medicinal chemistry 20100801

Title: Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701

Title: Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.

Journal: The Journal of antimicrobial chemotherapy 20100701

Title: Extensive drug resistance in malaria and tuberculosis.

Journal: Emerging infectious diseases 20100701

Title: Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from Cameroon with uncomplicated falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20100601

Title: In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).

Journal: African health sciences 20100601

Title: Minimizing analyte electrolysis in electrospray ionization mass spectrometry using a redox buffer coated emitter electrode.

Journal: Rapid communications in mass spectrometry : RCM 20100515

Title: Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20100501

Title: Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus) versus artemether-lumefantrine (Coartem) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast.

Journal: Tropical medicine & international health : TM & IH 20100501

Title: Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.

Journal: Antimicrobial agents and chemotherapy 20100501

Title: Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

Journal: PLoS pathogens 20100501

Title: The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections.

Journal: PLoS pathogens 20100501

Title: Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso.

Journal: Acta tropica 20100401

Title: Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication.

Journal: PLoS neglected tropical diseases 20100401

Title: Design of a fixed-dose paediatric combination of artesunate and amodiaquine hydrochloride.

Journal: International journal of pharmaceutics 20100315

Title: The effect of point mutations in dihydrofolate reductase genes and multidrug resistance gene 1-86 on treatment of falciparum malaria in Sudan.

Journal: Journal of infection in developing countries 20100308

Title: In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.

Journal: Antimicrobial agents and chemotherapy 20100301

Title: Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children.

Journal: Antimicrobial agents and chemotherapy 20100301

Title: In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea.

Journal: Tropical medicine & international health : TM & IH 20100301

Title: A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia.

Journal: The American journal of tropical medicine and hygiene 20100301

Title: Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua New Guinea.

Journal: The Journal of infectious diseases 20100201

Title: Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20100101

Title: Role of reactive metabolites in drug-induced hepatotoxicity.

Journal: Handbook of experimental pharmacology 20100101

Title: Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance.

Journal: Malaria journal 20100101

Title: Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali.

Journal: Malaria journal 20100101

Title: Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: user acceptability.

Journal: Malaria journal 20100101

Title: Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay.

Journal: BMC biochemistry 20100101

Title: Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone.

Journal: Malaria journal 20100101

Title: Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity to reduce the burden of malaria?

Journal: Malaria journal 20100101

Title: Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy.

Journal: Malaria journal 20100101

Title: The coming-out of malaria gametocytes.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Evaluating different dimensions of programme effectiveness for private medicine retailer malaria control interventions in Kenya.

Journal: PloS one 20100101

Title: Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria.

Journal: Malaria journal 20100101

Title: Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children.

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Title: Achieving a dream: meeting policy goals related to improving drug access.

Journal: The open AIDS journal 20100101

Title: Retail sector distribution chains for malaria treatment in the developing world: a review of the literature.

Journal: Malaria journal 20100101

Title: Evaluation of chloroquine therapy for vivax and falciparum malaria in southern Sumatra, western Indonesia.

Journal: Malaria journal 20100101

Title: Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children.

Journal: Malaria journal 20100101

Title: Update on the efficacy, effectiveness and safety of artemether-lumefantrine combination therapy for treatment of uncomplicated malaria.

Journal: Therapeutics and clinical risk management 20100101

Title: Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon.

Journal: Malaria journal 20100101

Title: Factors influencing implementation of the Ministry of Health-led private medicine retailer programmes on malaria in Kenya.

Journal: BMC public health 20100101

Title: Malaria prevention with IPTp during pregnancy reduces neonatal mortality.

Journal: PloS one 20100101

Title: Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity.

Journal: PloS one 20100101

Title: Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates.

Journal: Malaria journal 20100101

Title: Evaluation of Interceptor long-lasting insecticidal nets in eight communities in Liberia.

Journal: Malaria journal 20100101

Title: Availability of antimalarial drugs and evaluation of the attitude and practices for the treatment of uncomplicated malaria in bangui, central african republic.

Journal: Journal of tropical medicine 20100101

Title: Evidence for perinatal and child health care guidelines in crisis settings: can Cochrane help?

Journal: BMC public health 20100101

Title: Intermittent preventive treatment in infants for the prevention of malaria in rural Western kenya: a randomized, double-blind placebo-controlled trial.

Journal: PloS one 20100101

Title: Active case detection, treatment of falciparum malaria with combined chloroquine and sulphadoxine/pyrimethamine and vivax malaria with chloroquine and molecular markers of anti-malarial resistance in the Republic of Vanuatu.

Journal: Malaria journal 20100101

Title: Absorption, distribution, excretion, and pharmacokinetics of 14C-pyronaridine tetraphosphate in male and female Sprague-Dawley rats.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Sustainable development of a GCP-compliant clinical trials platform in Africa: the malaria clinical trials alliance perspective.

Journal: Malaria journal 20100101

Title: Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial.

Journal: Malaria journal 20100101

Title: Bayesian modelling of the effect of climate on malaria in Burundi.

Journal: Malaria journal 20100101

Title: In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense.

Journal: Malaria journal 20100101

Title: Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs.

Journal: Malaria journal 20100101

Title: Barriers to prompt and effective malaria treatment among the poorest population in Kenya.

Journal: Malaria journal 20100101

Title: A typology of intellectual property management for public health innovation and access: design considerations for policymakers.

Journal: The open AIDS journal 20100101

Title: Anti-malarial drug quality in Lagos and Accra - a comparison of various quality assessments.

Journal: Malaria journal 20100101

Title: Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions -- a user perspective.

Journal: Malaria journal 20100101

Title: Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug dispensing outlets - a provider perspective.

Journal: Malaria journal 20100101

Title: Analysis of an ordinal outcome in a multicentric randomized controlled trial: application to a 3- arm anti- malarial drug trial in Cameroon.

Journal: BMC medical research methodology 20100101

Title: Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene.

Journal: Malaria journal 20100101

Title: Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance.

Journal: Malaria journal 20100101

Title: Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009.

Journal: Malaria journal 20100101

Title: A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children.

Journal: PloS one 20100101

Title: Prevention of the recurrence of anaemia in Gambian children following discharge from hospital.

Journal: PloS one 20100101

Title: WHO policy development processes for a new vaccine: case study of malaria vaccines.

Journal: Malaria journal 20100101

Title: A pharmacy too far? Equity and spatial distribution of outcomes in the delivery of subsidized artemisinin-based combination therapies through private drug shops.

Journal: BMC health services research 20100101

Title: Importance of strategic management in the implementation of private medicine retailer programmes: case studies from three districts in Kenya.

Journal: BMC health services research 20100101

Title: Methods for evaluating delivery systems for scaling-up malaria control intervention.

Journal: BMC health services research 20100101

Title: Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine.

Journal: Malaria journal 20100101

Title: Heritability of the human infectious reservoir of malaria parasites.

Journal: PloS one 20100101

Title: Community perceptions of malaria and malaria treatment behaviour in a rural district of Ghana: implications for artemisinin combination therapy.

Journal: BMC public health 20100101

Title: Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies.

Journal: BMC genetics 20100101

Title: Experience of safety monitoring in the context of a prospective observational study of artemether-lumefantrine in rural Tanzania: lessons learned for pharmacovigilance reporting.

Journal: Malaria journal 20100101

Title: Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi.

Journal: Malaria journal 20100101

Title: A progressive declining in the burden of malaria in north-eastern Tanzania.

Journal: Malaria journal 20100101

Title: Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.

Journal: PloS one 20100101

Title: Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.

Journal: Malaria journal 20100101

Title: Retinopathy in severe malaria in Ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria.

Journal: Malaria journal 20100101

Title: An economic evaluation of home management of malaria in Uganda: an interactive Markov model.

Journal: PloS one 20100101

Title: Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

Journal: BMC systems biology 20100101

Title: Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children.

Journal: PloS one 20100101

Title: Clustering of childhood mortality in the Kintampo Health and Demographic Surveillance System in Ghana.

Journal: Global health action 20100101

Title: Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance.

Journal: PloS one 20100101

Title: Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.

Journal: BMC genomics 20100101

Title: The Health and Demographic Surveillance System (HDSS) in Nouna, Burkina Faso, 1993-2007.

Journal: Global health action 20100101

Title: The use of insecticide-treated nets for reducing malaria morbidity among children aged 6-59 months, in an area of high malaria transmission in central Côte d'Ivoire.

Journal: Parasites & vectors 20100101

Title: A cohort study of Plasmodium falciparum infection dynamics in Western Kenya Highlands.

Journal: BMC infectious diseases 20100101

Title: Vasorelaxation induced by amodiaquine in rat superior mesenteric arteries: in vivo and in vitro studies.

Journal: Acta poloniae pharmaceutica 20100101

Title: Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology.

Journal: Malaria journal 20100101

Title: Improving educational achievement and anaemia of school children: design of a cluster randomised trial of school-based malaria prevention and enhanced literacy instruction in Kenya.

Journal: Trials 20100101

Title: Changing malaria intervention coverage, transmission and hospitalization in Kenya.

Journal: Malaria journal 20100101

Title: Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.

Journal: PloS one 20100101

Title: Artesunate-mefloquine combination therapy in acute Plasmodium falciparum malaria in young children: a field study regarding neurological and neuropsychiatric safety.

Journal: Malaria journal 20100101

Title: Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar.

Journal: PloS one 20100101

Title: Performance of HRP-2 based rapid diagnostic test for malaria and its variation with age in an area of intense malaria transmission in southern Tanzania.

Journal: Malaria journal 20100101

Title: Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren.

Journal: PloS one 20100101

Title: Factors determining anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya.

Journal: Malaria journal 20100101

Title: Impact of national malaria control scale-up programmes in Africa: magnitude and attribution of effects.

Journal: Malaria journal 20100101

Title: Anti-bacterial activity of intermittent preventive treatment of malaria in pregnancy: comparative in vitro study of sulphadoxine-pyrimethamine, mefloquine, and azithromycin.

Journal: Malaria journal 20100101

Title: Influences of intermittent preventive treatment and persistent multiclonal Plasmodium falciparum infections on clinical malaria risk.

Journal: PloS one 20100101

Title: Safety, immunogenicity and duration of protection of the RTS,S/AS02(D) malaria vaccine: one year follow-up of a randomized controlled phase I/IIb trial.

Journal: PloS one 20100101

Title: Heme and blood-feeding parasites: friends or foes?

Journal: Parasites & vectors 20100101

Title: Plasmodium falciparum clearance with artemisinin-based combination therapy (ACT) in patients with glucose-6-phosphate dehydrogenase deficiency in Mali.

Journal: Malaria journal 20100101

Title: From fever to anti-malarial: the treatment-seeking process in rural Senegal.

Journal: Malaria journal 20100101

Title: Early variations in plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin-based combinations: implications on delayed parasite clearance.

Journal: Malaria journal 20100101

Title: Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya.

Journal: Malaria journal 20100101

Title: Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum.

Journal: Malaria journal 20100101

Title: New emerging drug-resistant malaria.

Journal: International journal of general medicine 20100101

Title: Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy.

Journal: Malaria journal 20100101

Title: Science-based health innovation in Ghana: health entrepreneurs point the way to a new development path.

Journal: BMC international health and human rights 20100101

Title: Anti-malarial drugs and the prevention of malaria in the population of malaria endemic areas.

Journal: Malaria journal 20100101

Title: Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children.

Journal: Malaria journal 20100101

Title: The 'hidden' burden of malaria: cognitive impairment following infection.

Journal: Malaria journal 20100101

Title: Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea.

Journal: Malaria journal 20100101

Title: Cost comparison of microscopy vs. empiric treatment for malaria in Southwestern Nigeria: a prospective study.

Journal: Malaria journal 20100101

Title: Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type.

Journal: Malaria journal 20100101

Title: Chloroquine-induced Pruritus.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours).

Journal: Malaria journal 20100101

Title: Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trial.

Journal: PloS one 20100101

Title: Malaria: prevention in travellers.

Journal: BMJ clinical evidence 20100101

Title: A comparative analysis of the Libyan national essential medicines list and the WHO model list of essential medicines.

Journal: The Libyan journal of medicine 20100101

Title: 7-Chloro-4-[(E)-N'-(4-fluoro-benzyl-idene)hydrazin-yl]quinoline monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: Acquired resistance of malarial parasites against artemisinin-based drugs: social and economic impacts.

Journal: Infection and drug resistance 20100101

Title: Structural modifications of quinoline-based antimalarial agents: Recent developments.

Journal: Journal of pharmacy & bioallied sciences 20100101

Title: Treatment of uncomplicated malaria in Africa: evaluation of randomized clinical trials.

Journal: Nigerian quarterly journal of hospital medicine 20100101

Title: Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda: a prospective cohort study.

Journal: The Pan African medical journal 20100101

Title: Additive in vitro antiplasmodial effect of N-alkyl and N-benzyl-1,10-phenanthroline derivatives and cysteine protease inhibitor e64.

Journal: Malaria research and treatment 20100101

Title: Knowledge, Attitudes, and Practices about Malaria and Its Control in Rural Northwest Tanzania.

Journal: Malaria research and treatment 20100101

Title: Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants.

Journal: Evidence-based complementary and alternative medicine : eCAM 20091201

Title: Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20091201

Title: A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity.

Journal: European journal of medicinal chemistry 20091201

Title: Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.

Journal: The Journal of infectious diseases 20091201

Title: Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.

Journal: The Lancet. Infectious diseases 20091201

Title: Possible interruption of malaria transmission, highland Kenya, 2007-2008.

Journal: Emerging infectious diseases 20091201

Title: Influenza in Africa.

Journal: PLoS medicine 20091201

Title: Cytochrome P450 enzymes and genotype-guided drug therapy.

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Title: [Molecular markers of Plasmodium falciparum drug resistance].

Journal: Medecine tropicale : revue du Corps de sante colonial 20091201

Title: Comparative study of artesunate, ACTs and their combinants on the hormonal parameters of the male guinea pig.

Journal: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20091201

Title: 4-[(2-Chloro-ethyl)amino]quinolinium chloride monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: 7-Chloro-4-[(E)-(3-chloro-benzyl-idene)hydrazinyl]-1λ-quinolinium 3-chloro-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: 3-[(E)-(7-Chloro-4-quinol-yl)hydrazono-meth-yl]benzonitrile monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Efavirenz: a decade of clinical experience in the treatment of HIV.

Journal: The Journal of antimicrobial chemotherapy 20091101

Title: Epidemic of Plasmodium falciparum malaria involving substandard antimalarial drugs, Pakistan, 2003.

Journal: Emerging infectious diseases 20091101

Title: Metabolomics in drug intolerance.

Journal: Current drug metabolism 20091101

Title: Human CYP2C8: structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms.

Journal: Current drug metabolism 20091101

Title: Artemisinin resistance on the Thai-Cambodian border.

Journal: Lancet (London, England) 20091024

Title: Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic area of Pakistan.

Journal: The American journal of tropical medicine and hygiene 20090901

Title: Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose.

Journal: Ghana medical journal 20090901

Title: Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers.

Journal: European journal of clinical pharmacology 20090801

Title: Artemisinin-based combination therapy for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20090708

Title: Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

Journal: Experimental parasitology 20090701

Title: Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial.

Journal: The Journal of infectious diseases 20090701

Title: Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice.

Journal: Archives of toxicology 20090701

Title: Intermittent preventive treatment using artemisinin-based combination therapy reduces malaria morbidity among school-aged children in Mali.

Journal: Tropical medicine & international health : TM & IH 20090701

Title: Adherence to artesunate-amodiaquine combination therapy for uncomplicated malaria in children in Zanzibar, Tanzania.

Journal: Tropical medicine & international health : TM & IH 20090701

Title: Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.

Journal: PLoS neglected tropical diseases 20090701

Title: Focusing on quality patient care in the new global subsidy for malaria medicines.

Journal: PLoS medicine 20090701

Title: A microfluidic chip for electrochemical conversions in drug metabolism studies.

Journal: Lab on a chip 20090621

Title: In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.

Journal: The Journal of infectious diseases 20090601

Title: Impact of ministry of health interventions on private medicine retailer knowledge and practices on anti-malarial treatment in Kenya.

Journal: The American journal of tropical medicine and hygiene 20090601

Title: Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite.

Journal: The American journal of tropical medicine and hygiene 20090601

Title: Severe idiosyncratic drug reaction (Lyells syndrome) after ingesting dihydroartemisinin.

Journal: Nigerian journal of clinical practice 20090601

Title: Comparative study of artesunate, ACTs and their combinants on the spermatic parameters of the male guinea pig.

Journal: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20090601

Title: Discovery of dual function acridones as a new antimalarial chemotype.

Journal: Nature 20090514

Title: Bioelimination of histamine in epithelia of the porcine proximal colon of pigs.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090501

Title: Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam.

Journal: Tropical medicine & international health : TM & IH 20090501

Title: High prevalence of CYP2A6*4 and CYP2A6*9 alleles detected among a Malaysian population.

Journal: Clinica chimica acta; international journal of clinical chemistry 20090501

Title: Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable 'back-up' compound for N-tert-butyl isoquine.

Journal: Journal of medicinal chemistry 20090409

Title: Biological measure of compliance to Artesunate plus Amodiaquine association: interest in a Mono-Desethyl-Amodiaquine blood assay?

Journal: Acta tropica 20090401

Title: Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity.

Journal: ChemMedChem 20090401

Title: A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090401

Title: Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

Journal: PLoS medicine 20090401

Title: Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation study.

Journal: PLoS medicine 20090401

Title: Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione.

Journal: The Journal of biological chemistry 20090320

Title: Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

Journal: Journal of medicinal chemistry 20090312

Title: Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090301

Title: In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya.

Journal: Tropical medicine & international health : TM & IH 20090301

Title: Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance.

Journal: The Journal of infectious diseases 20090301

Title: Guidelines for field surveys of the quality of medicines: a proposal.

Journal: PLoS medicine 20090301

Title: Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215

Title: Amodiaquine-induced oxidative stress in a hepatocyte inflammation model.

Journal: Toxicology 20090204

Title: Efficacy of monotherapies and artesunate-based combination therapies in children with uncomplicated malaria in Somalia.

Journal: Acta tropica 20090201

Title: [Permanent deafness following typhoid fever: case report from Dakar, Senegal].

Journal: Medecine tropicale : revue du Corps de sante colonial 20090201

Title: Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20090201

Title: Intermittent preventive treatment with antimalarial drugs.

Journal: Lancet (London, England) 20090103

Title: Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

Journal: Journal of pharmaceutical sciences 20090101

Title: Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20090101

Title: Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children.

Journal: Acta tropica 20090101

Title: [Two cases of fulminant hepatitis during a curative treatment with an artesunate-amodiaquine combination].

Journal: Medecine et maladies infectieuses 20090101

Title: Dosing accuracy of artesunate and amodiaquine as treatment for falciparum malaria in Casamance, Senegal.

Journal: Tropical medicine & international health : TM & IH 20090101

Title: Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy.

Journal: Malaria journal 20090101

Title: Mefloquine--an aminoalcohol with promising antischistosomal properties in mice.

Journal: PLoS neglected tropical diseases 20090101

Title: Effect of removing direct payment for health care on utilisation and health outcomes in Ghanaian children: a randomised controlled trial.

Journal: PLoS medicine 20090101

Title: Artemisinin-based combinations versus amodiaquine plus sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali.

Journal: Malaria journal 20090101

Title: Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women.

Journal: Malaria journal 20090101

Title: Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya.

Journal: PloS one 20090101

Title: Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria.

Journal: Malaria journal 20090101

Title: Clinical trials to estimate the efficacy of preventive interventions against malaria in paediatric populations: a methodological review.

Journal: Malaria journal 20090101

Title: Estimating the burden of malaria in pregnancy: a case study from rural Madhya Pradesh, India.

Journal: Malaria journal 20090101

Title: Polymorphism of PfATPase in Niger: detection of three new point mutations.

Journal: Malaria journal 20090101

Title: Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger.

Journal: Malaria journal 20090101

Title: A 10 year study of the cause of death in children under 15 years in Manhiça, Mozambique.

Journal: BMC public health 20090101

Title: High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581.

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Title: Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali.

Journal: Malaria journal 20090101

Title: Extended high efficacy of the combination sulphadoxine-pyrimethamine with artesunate in children with uncomplicated falciparum malaria on the Benin coast, West Africa.

Journal: Malaria journal 20090101

Title: Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar.

Journal: Malaria journal 20090101

Title: The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum.

Journal: Malaria journal 20090101

Title: Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination.

Journal: Malaria journal 20090101

Title: Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.

Journal: PloS one 20090101

Title: Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.

Journal: Malaria journal 20090101

Title: Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor.

Journal: Malaria journal 20090101

Title: Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children.

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Title: Efficacy and safety of a fixed dose artesunate-sulphamethoxypyrazine-pyrimethamine compared to artemether-lumefantrine for the treatment of uncomplicated falciparum malaria across Africa: a randomized multi-centre trial.

Journal: Malaria journal 20090101

Title: The effect of varying analytical methods on estimates of anti-malarial clinical efficacy.

Journal: Malaria journal 20090101

Title: Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2).

Journal: Malaria journal 20090101

Title: In vitro activity of pyronaridine against Plasmodium falciparum and comparative evaluation of anti-malarial drug susceptibility assays.

Journal: Malaria journal 20090101

Title: Anti-malarial prescriptions in three health care facilities after the emergence of chloroquine resistance in Niakhar, Senegal (1992-2004).

Journal: Malaria journal 20090101

Title: A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria.

Journal: Malaria journal 20090101

Title: Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial.

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Title: Chloroquine resistance before and after its withdrawal in Kenya.

Journal: Malaria journal 20090101

Title: Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India.

Journal: Malaria journal 20090101

Title: Malaria vectors and transmission dynamics in Goulmoun, a rural city in south-western Chad.

Journal: BMC infectious diseases 20090101

Title: Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development.

Journal: PloS one 20090101

Title: Factors related to compliance to anti-malarial drug combination: example of amodiaquine/sulphadoxine-pyrimethamine among children in rural Senegal.

Journal: Malaria journal 20090101

Title: Randomized, multicentre assessment of the efficacy and safety of ASAQ--a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria.

Journal: Malaria journal 20090101

Title: Plasmodium falciparum genotypes diversity in symptomatic malaria of children living in an urban and a rural setting in Burkina Faso.

Journal: Malaria journal 20090101

Title: Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial.

Journal: Malaria journal 20090101

Title: A comparative, randomized clinical trial of artemisinin/naphtoquine twice daily one day versus artemether/lumefantrine six doses regimen in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire.

Journal: Malaria journal 20090101

Title: Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area.

Journal: Malaria journal 20090101

Title: Fever treatment in the absence of malaria transmission in an urban informal settlement in Nairobi, Kenya.

Journal: Malaria journal 20090101

Title: Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.

Journal: BMJ (Clinical research ed.) 20090101

Title: A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR - implications for therapeutic failure and drug resistance.

Journal: Malaria journal 20090101

Title: Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in rural health facilities in southern Cameroon.

Journal: Malaria journal 20090101

Title: Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon.

Journal: Malaria journal 20090101

Title: Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis.

Journal: PloS one 20090101

Title: Longitudinal survey of malaria morbidity over 10 years in Saharevo (Madagascar): further lessons for strengthening malaria control.

Journal: Malaria journal 20090101

Title: Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings.

Journal: Malaria journal 20090101

Title: Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies.

Journal: Malaria journal 20090101

Title: Artemisinin-naphthoquine combination (ARCO) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: a preliminary report on safety and efficacy.

Journal: Malaria journal 20090101

Title: Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.

Journal: PloS one 20090101

Title: Population pharmacokinetics of artesunate and amodiaquine in African children.

Journal: Malaria journal 20090101

Title: Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis.

Journal: Malaria journal 20090101

Title: No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used.

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Title: Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania.

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Title: Bioavailability of a co-formulated combination of amodiaquine and artesunate under fed and fasted conditions. A randomised, open-label crossover study.

Journal: Arzneimittel-Forschung 20090101

Title: PfHRP2 and PfLDH antigen detection for monitoring the efficacy of artemisinin-based combination therapy (ACT) in the treatment of uncomplicated falciparum malaria.

Journal: Malaria journal 20090101

Title: Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children.

Journal: Malaria journal 20090101

Title: Socio-cultural predictors of health-seeking behaviour for febrile under-five children in Mwanza-Neno district, Malawi.

Journal: Malaria journal 20090101

Title: Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children.

Journal: PloS one 20090101

Title: Epidemiology of malaria in the forest-savanna transitional zone of Ghana.

Journal: Malaria journal 20090101

Title: Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, Indonesia.

Journal: Malaria journal 20090101

Title: Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial.

Journal: PloS one 20090101

Title: Simple field assays to check quality of current artemisinin-based antimalarial combination formulations.

Journal: PloS one 20090101

Title: Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children.

Journal: PloS one 20090101

Title: Ongoing challenges in the management of malaria.

Journal: Malaria journal 20090101

Title: The clinical efficacy of artemether/lumefantrine (Coartem).

Journal: Malaria journal 20090101

Title: Safety profile of Coartem: the evidence base.

Journal: Malaria journal 20090101

Title: Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia.

Journal: Malaria journal 20090101

Title: Ofloxacin induced leucopenia in complicated falciparum malaria: a case report.

Journal: Cases journal 20090101

Title: Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting.

Journal: BMC microbiology 20090101

Title: The use of schools for malaria surveillance and programme evaluation in Africa.

Journal: Malaria journal 20090101

Title: Artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria.

Journal: Therapeutics and clinical risk management 20090101

Title: Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial.

Journal: Malaria journal 20090101

Title: A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies.

Journal: Malaria journal 20090101

Title: Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets.

Journal: Malaria journal 20090101

Title: Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda.

Journal: Malaria journal 20090101

Title: Self-reported data: a major tool to assess compliance with anti-malarial combination therapy among children in Senegal.

Journal: Malaria journal 20090101

Title: Access to malaria treatment in young children of rural Burkina Faso.

Journal: Malaria journal 20090101

Title: Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial.

Journal: PloS one 20090101

Title: Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal.

Journal: Malaria journal 20090101

Title: Ranking malaria risk factors to guide malaria control efforts in African highlands.

Journal: PloS one 20090101

Title: Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children.

Journal: Malaria journal 20090101

Title: Quality of malaria case management at outpatient health facilities in Angola.

Journal: Malaria journal 20090101

Title: Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base.

Journal: Malaria journal 20090101

Title: Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control.

Journal: Malaria journal 20090101

Title: A comparative study of a flow-cytometry-based assessment of in vitro Plasmodium falciparum drug sensitivity.

Journal: Malaria journal 20090101

Title: Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance.

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Title: Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children.

Journal: Malaria journal 20090101

Title: Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.

Journal: Malaria journal 20090101

Title: Use and limitations of malaria rapid diagnostic testing by community health workers in war-torn Democratic Republic of Congo.

Journal: Malaria journal 20090101

Title: Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy.

Journal: Malaria journal 20090101

Title: Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients.

Journal: European journal of drug metabolism and pharmacokinetics 20090101

Title: Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa).

Journal: Journal of tropical medicine 20090101

Title: Adherence to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana: A Randomised Trial of Supervised versus Unsupervised Drug Administration.

Journal: Journal of tropical medicine 20090101

Title: Covalent protein modification by reactive drug metabolites using online electrochemistry/liquid chromatography/mass spectrometry.

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Title: Relationships between anaemia and parasitic infections in Kenyan schoolchildren: a Bayesian hierarchical modelling approach.

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Title: Single-dose pharmacokinetic interaction between artesunate and amodiaquine: assembling the clues for the purported interaction.

Journal: European journal of clinical pharmacology 20081201

Title: Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children.

Journal: Memorias do Instituto Oswaldo Cruz 20081201

Title: Plasmodium falciparum: high frequency of pfcrt point mutations and emergence of new mutant haplotypes in Colombia.

Journal: Biomedica : revista del Instituto Nacional de Salud 20081201

Title: Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax.

Journal: The Journal of infectious diseases 20081115

Title: pfmdr1 mutations in imported African Plasmodium falciparum isolates.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20081101

Title: Intermittent preventive antimalarial treatment to children (IPTc): firebreak or fire trap?

Journal: Trends in parasitology 20081101

Title: Gametocytes: insights gained during a decade of molecular monitoring.

Journal: Trends in parasitology 20081101

Title: Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria.

Journal: PLoS medicine 20081101

Title: Comparing highly efficacious antimalarial drugs.

Journal: PLoS medicine 20081101

Title: dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo.

Journal: Tropical medicine & international health : TM & IH 20081101

Title: Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity.

Journal: PLoS medicine 20081101

Title: (3RS,4SR)-Methyl 4-(2-chloro-5,8-di-methoxy-quinolin-3-yl)-1-phenyl-pyrrolidine-3-carboxyl-ate.

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Title: A randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana.

Journal: The Journal of infectious diseases 20081015

Title: Drugs for treating uncomplicated malaria in pregnant women.

Journal: The Cochrane database of systematic reviews 20081008

Title: Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions.

Journal: British journal of clinical pharmacology 20081001

Title: A randomized, comparative study of supervised and unsupervised artesunate-amodiaquine, for the treatment of uncomplicated malaria in Ghana.

Journal: Annals of tropical medicine and parasitology 20081001

Title: Monitoring Plasmodium falciparum chloroquine resistance in Yunnan Province, China, 1981-2006.

Journal: Acta tropica 20081001

Title: Deforestation and vectorial capacity of Anopheles gambiae Giles mosquitoes in malaria transmission, Kenya.

Journal: Emerging infectious diseases 20081001

Title: Amodiaquine pharmacogenetics.

Journal: Pharmacogenomics 20081001

Title: Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal.

Journal: Parasitology research 20080901

Title: Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models.

Journal: Biopharmaceutics & drug disposition 20080901

Title: Lysosomotropic drugs inhibit maturation of transforming growth factor-beta.

Journal: Canadian journal of physiology and pharmacology 20080901

Title: Synthesis and antimalarial activity of new amino analogues of amodiaquine.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20080901

Title: Effects of amodiaquine hydrochloride and artemisinin on indomethacin-induced lipid peroxidation in rats.

Journal: Pakistan journal of biological sciences : PJBS 20080901

Title: Molecular markers of in vivo Plasmodium vivax resistance to amodiaquine plus sulfadoxine-pyrimethamine: mutations in pvdhfr and pvmdr1.

Journal: The Journal of infectious diseases 20080801

Title: Adherence and effectiveness of drug combination in curative treatment among children suffering uncomplicated malaria in rural Senegal.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20080801

Title: Artemisinin derivatives and malaria: useful, in combination with other antimalarials.

Journal: Prescrire international 20080801

Title: Novel amodiaquine congeners as potent antimalarial agents.

Journal: Bioorganic & medicinal chemistry 20080715

Title: Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial.

Journal: Lancet (London, England) 20080712

Title: Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20080701

Title: Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers.

Journal: European journal of clinical pharmacology 20080701

Title: Investigation of amodiaquine bulk drug impurities by liquid chromatography/ion trap mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20080701

Title: Dihydrofolate reductase I164L mutation in Plasmodium falciparum, Madagascar.

Journal: Emerging infectious diseases 20080701

Title: Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.

Journal: Tanzania journal of health research 20080701

Title: In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes.

Journal: International journal for parasitology 20080601

Title: Effects of revised diagnostic recommendations on malaria treatment practices across age groups in Kenya.

Journal: Tropical medicine & international health : TM & IH 20080601

Title: Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea.

Journal: PLoS medicine 20080601

Title: Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia.

Journal: PLoS medicine 20080601

Title: New medicines for tropical diseases in pregnancy: catch-22.

Journal: PLoS medicine 20080601

Title: Effects of artesunate-cotrimoxazole and amodiaquine-artesunate against asexual and sexual stages of Plasmodium falciparum malaria in Nigerian children.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080601

Title: [Gametocytemia in falciparum malaria treated with amodiaquine or artesunate].

Journal: Biomedica : revista del Instituto Nacional de Salud 20080601

Title: [In vitro susceptibility of Colombian Plasmodium falciparum isolates to different antimalarial drugs].

Journal: Biomedica : revista del Instituto Nacional de Salud 20080601

Title: Performance of the OptiMAL dipstick in the diagnosis of malaria infection in pregnancy.

Journal: Therapeutics and clinical risk management 20080601

Title: The Efficacy of Amodiaquine plus Artesunate Combination in Ghana.

Journal: Ghana medical journal 20080601

Title: Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

Journal: Parasitology research 20080501

Title: High efficacy of two artemisinin-based combinations (artemether-lumefantrine and artesunate plus amodiaquine) for acute uncomplicated malaria in Ibadan, Nigeria.

Journal: Tropical medicine & international health : TM & IH 20080501

Title: Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa.

Journal: PLoS pathogens 20080501

Title: Health facility and health worker readiness to deliver new national treatment policy for malaria in Kenya.

Journal: East African medical journal 20080501

Title: Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Journal: Journal of medicinal chemistry 20080410

Title: Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein.

Journal: Bioorganic & medicinal chemistry 20080401

Title: The use of artemether-lumefantrine by febrile children following national implementation of a revised drug policy in Kenya.

Journal: Tropical medicine & international health : TM & IH 20080401

Title: Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.

Journal: Chemical research in toxicology 20080401

Title: Research in complex humanitarian emergencies: the Médecins Sans Frontières/Epicentre experience.

Journal: PLoS medicine 20080401

Title: Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.

Journal: Parasitology 20080401

Title: High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

Title: Disease and drug interactions: treating malaria with artesunate plus amodiaquine in patients also receiving treatment for concomitant HIV infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

Title: Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.

Journal: Prescrire international 20080401

Title: [Assessing the application of Rwanda's national protocol for uncomplicated malaria treatment in healthcare institutions in Kigali City, Rwanda].

Journal: Medecine et maladies infectieuses 20080301

Title: Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae.

Journal: The American journal of tropical medicine and hygiene 20080301

Title: Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali.

Journal: The American journal of tropical medicine and hygiene 20080301

Title: Clinical diagnosis of malaria and the risk of chloroquine self-medication in rural health centres in Burkina Faso.

Journal: Tropical medicine & international health : TM & IH 20080301

Title: Impact of placental Plasmodium falciparum malaria on pregnancy and perinatal outcome in sub-Saharan Africa: part III: placental malaria, maternal health, and public health.

Journal: The Yale journal of biology and medicine 20080301

Title: [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006].

Journal: Biomedica : revista del Instituto Nacional de Salud 20080301

Title: Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215

Title: Synthesis and antimalarial activity of new analogues of amodiaquine.

Journal: European journal of medicinal chemistry 20080201

Title: Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201

Title: Antimalarial resistance and DHFR/DHPS genotypes of Plasmodium falciparum three years after introduction of sulfadoxine-pyrimethamine and amodiaquine in rural Tanzania.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20080201

Title: Access and barriers to measures targeted to prevent malaria in pregnancy in rural Kenya.

Journal: Tropical medicine & international health : TM & IH 20080201

Title: Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.

Journal: Tropical medicine & international health : TM & IH 20080201

Title: Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment.

Journal: Memorias do Instituto Oswaldo Cruz 20080201

Title: Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity.

Journal: Cell biology and toxicology 20080101

Title: The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania.

Journal: Malaria journal 20080101

Title: Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites.

Journal: Malaria journal 20080101

Title: Malaria risk and access to prevention and treatment in the paddies of the Kilombero Valley, Tanzania.

Journal: Malaria journal 20080101

Title: Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated falciparum malaria.

Journal: Malaria journal 20080101

Title: A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.

Journal: PloS one 20080101

Title: From chloroquine to artemether-lumefantrine: the process of drug policy change in Zambia.

Journal: Malaria journal 20080101

Title: Clinical malaria in African pregnant women.

Journal: Malaria journal 20080101

Title: Why don't health workers prescribe ACT? A qualitative study of factors affecting the prescription of artemether-lumefantrine.

Journal: Malaria journal 20080101

Title: Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: a randomized trial to guide national policy.

Journal: Malaria journal 20080101

Title: Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi.

Journal: PloS one 20080101

Title: Household cost of malaria overdiagnosis in rural Mozambique.

Journal: Malaria journal 20080101

Title: Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

Journal: PloS one 20080101

Title: Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment.

Journal: Tropical medicine & international health : TM & IH 20080101

Title: Translation of artemether-lumefantrine treatment policy into paediatric clinical practice: an early experience from Kenya.

Journal: Tropical medicine & international health : TM & IH 20080101

Title: Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine.

Journal: Malaria journal 20080101

Title: Malaria in rural Mozambique. Part I: children attending the outpatient clinic.

Journal: Malaria journal 20080101

Title: Malaria in rural Mozambique. Part II: children admitted to hospital.

Journal: Malaria journal 20080101

Title: Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria.

Journal: PloS one 20080101

Title: Guidelines and mindlines: why do clinical staff over-diagnose malaria in Tanzania? A qualitative study.

Journal: Malaria journal 20080101

Title: Can changes in malaria transmission intensity explain prolonged protection and contribute to high protective efficacy of intermittent preventive treatment for malaria in infants?

Journal: Malaria journal 20080101

Title: Assessment of the efficacy of antimalarial drugs recommended by the National Malaria Control Programme in Madagascar: up-dated baseline data from randomized and multi-site clinical trials.

Journal: Malaria journal 20080101

Title: A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic.

Journal: PloS one 20080101

Title: Enhanced efficacy of amodiaquine and chlorpheniramine combination over amodiaquine alone in the treatment of acute uncomplicated Plasmodium falciparum malaria in children.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

Title: Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso.

Journal: Malaria journal 20080101

Title: The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea.

Journal: Malaria journal 20080101

Title: Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population.

Journal: Malaria journal 20080101

Title: Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.

Journal: PloS one 20080101

Title: Malaria treatment in the retail sector: knowledge and practices of drug sellers in rural Tanzania.

Journal: BMC public health 20080101

Title: Duration of protection against malaria and anaemia provided by intermittent preventive treatment in infants in Navrongo, Ghana.

Journal: PloS one 20080101

Title: Plasmodium vivax trophozoites insensitive to chloroquine.

Journal: Malaria journal 20080101

Title: Substandard anti-malarial drugs in Burkina Faso.

Journal: Malaria journal 20080101

Title: A qualitative study of the feasibility and community perception on the effectiveness of artemether-lumefantrine use in the context of home management of malaria in south-west Nigeria.

Journal: BMC health services research 20080101

Title: Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.

Journal: PloS one 20080101

Title: Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children.

Journal: Malaria journal 20080101

Title: Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda.

Journal: Malaria journal 20080101

Title: Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children.

Journal: Chemotherapy 20080101

Title: Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite.

Journal: PloS one 20080101

Title: An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

Journal: PloS one 20080101

Title: Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique.

Journal: Malaria journal 20080101

Title: Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali.

Journal: Malaria journal 20080101

Title: Antimalarial drug use in general populations of tropical Africa.

Journal: Malaria journal 20080101

Title: Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials.

Journal: Malaria journal 20080101

Title: Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up.

Journal: Malaria journal 20080101

Title: Modelling the epidemiological impact of intermittent preventive treatment against malaria in infants.

Journal: PloS one 20080101

Title: Presumptive treatment of fever cases as malaria: help or hindrance for malaria control?

Journal: Malaria journal 20080101

Title: Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.

Journal: PloS one 20080101

Title: Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria.

Journal: Malaria journal 20080101

Title: Utilization of insecticide-treated nets by under-five children in Nigeria: assessing progress towards the Abuja targets.

Journal: Malaria journal 20080101

Title: Molecular epidemiology of drug-resistant malaria in western Kenya highlands.

Journal: BMC infectious diseases 20080101

Title: From strategy development to routine implementation: the cost of Intermittent Preventive Treatment in Infants for malaria control.

Journal: BMC health services research 20080101

Title: [Efficacy of artemether in the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6-60 months of age in Bangui (Central African Republic)].

Journal: Sante (Montrouge, France) 20080101

Title: Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

Journal: Malaria journal 20080101

Title: Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate.

Journal: BMC genomics 20080101

Title: Reduced paediatric hospitalizations for malaria and febrile illness patterns following implementation of community-based malaria control programme in rural Rwanda.

Journal: Malaria journal 20080101

Title: Spontaneous adverse drug reaction reporting in rural districts of Mozambique.

Journal: Drug safety 20080101

Title: Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine.

Journal: Malaria journal 20080101

Title: Efficacy, safety and tolerability of artesunate-mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria.

Journal: Malaria journal 20080101

Title: Obstacles to prompt and effective malaria treatment lead to low community-coverage in two rural districts of Tanzania.

Journal: BMC public health 20080101

Title: Malaria case-management under artemether-lumefantrine treatment policy in Uganda.

Journal: Malaria journal 20080101

Title: Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: a report from three study sites in sub-Saharan Africa.

Journal: Malaria journal 20080101

Title: Costs and cost-effectiveness of delivering intermittent preventive treatment through schools in western Kenya.

Journal: Malaria journal 20080101

Title: Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon.

Journal: Malaria journal 20080101

Title: Impact of training in clinical and microscopy diagnosis of childhood malaria on antimalarial drug prescription and health outcome at primary health care level in Tanzania: a randomized controlled trial.

Journal: Malaria journal 20080101

Title: Predicting Global Fund grant disbursements for procurement of artemisinin-based combination therapies.

Journal: Malaria journal 20080101

Title: Implementation of Home based management of malaria in children reduces the work load for peripheral health facilities in a rural district of Burkina Faso.

Journal: Malaria journal 20080101

Title: Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands.

Journal: Malaria journal 20080101

Title: A nationwide survey of the quality of antimalarials in retail outlets in Tanzania.

Journal: PloS one 20080101

Title: Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review.

Journal: Malaria journal 20080101

Title: Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal.

Journal: Malaria journal 20080101

Title: Social and cultural aspects of 'malaria' and its control in central Côte d'Ivoire.

Journal: Malaria journal 20080101

Title: Willingness and ability to pay for artemisinin-based combination therapy in rural Tanzania.

Journal: Malaria journal 20080101

Title: Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria.

Journal: Malaria journal 20080101

Title: Implementation of intermittent preventive treatment in pregnancy with sulphadoxine/pyrimethamine (IPTp-SP) at a district health centre in rural Senegal.

Journal: Malaria journal 20080101

Title: Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola.

Journal: Malaria journal 20080101

Title: A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya.

Journal: Malaria journal 20080101

Title: Dispensary level pilot implementation of rapid diagnostic tests: an evaluation of RDT acceptance and usage by providers and patients--Tanzania, 2005.

Journal: Malaria journal 20080101

Title: The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: a review of the evidence.

Journal: Malaria journal 20080101

Title: Malaria treatment-seeking behaviour and recovery from malaria in a highland area of Kenya.

Journal: Malaria journal 20080101

Title: Evaluation of the efficacy and safety of artemether-lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in Nigerian infants and children.

Journal: Malaria journal 20080101

Title: Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda.

Journal: Wiener klinische Wochenschrift 20080101

Title: Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20080101

Title: Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy.

Journal: Malaria journal 20080101

Title: Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya.

Journal: Malaria journal 20080101

Title: Does the drug sensitivity of malaria parasites depend on their virulence?

Journal: Malaria journal 20080101

Title: The role of anti-malarial drugs in eliminating malaria.

Journal: Malaria journal 20080101

Title: Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria.

Journal: Malaria journal 20080101

Title: Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial.

Journal: PloS one 20080101

Title: A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children.

Journal: Malaria journal 20080101

Title: A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in children in western Kenya.

Journal: Malaria journal 20080101

Title: High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.

Journal: PloS one 20080101

Title: Use of integrated malaria management reduces malaria in Kenya.

Journal: PloS one 20080101

Title: The effect of administration of amodiaquine on some parameters of neurobehaviour of Wistar rats.

Journal: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20080101

Title: Malaria: uncomplicated, caused by Plasmodium falciparum.

Journal: BMJ clinical evidence 20080101

Title: Protective effect of Garcinia kola (kolaviron) extract on predisposition of rats to cardiovascular diseases following separate administration of amodiaquine and artesunate.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20080101

Title: Formulation and Evaluation of Tramadol hydrochloride Rectal Suppositories.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Challenges Associated with Scaling up Artemisinin Combination Therapy in Sub-Saharan Africa A Review Article.

Journal: The Libyan journal of medicine 20080101

Title: Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201

Title: Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

Title: Intensity of malaria transmission and the spread of Plasmodium falciparum resistant malaria: a review of epidemiologic field evidence.

Journal: The American journal of tropical medicine and hygiene 20071201

Title: Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.

Journal: The American journal of tropical medicine and hygiene 20071201

Title: Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

Journal: Clinical pharmacology and therapeutics 20071101

Title: A field-adapted HPLC method for determination of amodiaquine and its metabolite in whole blood dried on filter paper.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101

Title: Comparison of the therapeutic efficacy of chloroquine and sulphadoxine-pyremethamine in children and pregnant women.

Journal: Tropical medicine & international health : TM & IH 20071101

Title: The safety of amodiaquine use in pregnant women.

Journal: Expert opinion on drug safety 20071101

Title: Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea.

Journal: The American journal of tropical medicine and hygiene 20071101

Title: Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar.

Journal: PLoS medicine 20071101

Title: Clinical symptoms, treatment and outcome of highlands malaria in Eldoret (2420 m a.s.l.) and comparison to malaria in hyper-immune population in endemic region of Southern Sudan.

Journal: Neuro endocrinology letters 20071101

Title: Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.

Journal: Journal of pharmacokinetics and pharmacodynamics 20071001

Title: Access to health care in contexts of livelihood insecurity: a framework for analysis and action.

Journal: PLoS medicine 20071001

Title: Development and validation of a liquid chromatography-mass spectrometry assay for the determination of pyronaridine in human blood for application to clinical pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis 20070921

Title: Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070901

Title: Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo).

Journal: Acta tropica 20070901

Title: Generation and identification of reactive metabolites by electrochemistry and immobilized enzymes coupled on-line to liquid chromatography/mass spectrometry.

Journal: Analytical chemistry 20070901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070901

Title: Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.

Journal: Clinical pharmacology and therapeutics 20070801

Title: Cardiotoxicity of antimalarial drugs.

Journal: The Lancet. Infectious diseases 20070801

Title: Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria.

Journal: The American journal of tropical medicine and hygiene 20070801

Title: A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

Journal: Experimental parasitology 20070701

Title: The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.

Journal: Annals of tropical medicine and parasitology 20070701

Title: In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies.

Journal: Journal of mass spectrometry : JMS 20070701

Title: Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

Journal: Molecular microbiology 20070701

Title: Artesunate-amodiaquine for the treatment of uncomplicated malaria.

Journal: Expert opinion on investigational drugs 20070701

Title: Emergency liver transplantation in amodiaquine-induced fulminant hepatitis.

Journal: The American journal of tropical medicine and hygiene 20070701

Title: Amodiaquine in future combination treatment of malaria in Ghana.

Journal: Tropical doctor 20070701

Title: Development and validation of a liquid chromatography-mass spectrometry assay for the determination of pyronaridine in human urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Shed some light on darkness: will Tanzania reach the millennium development goals?

Journal: Acta paediatrica (Oslo, Norway : 1992) 20070601

Title: The great failure of malaria control in Africa: a district perspective from Burkina Faso.

Journal: PLoS medicine 20070601

Title: Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.

Journal: The American journal of tropical medicine and hygiene 20070601

Title: Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union.

Journal: Acta tropica 20070601

Title: Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo.

Journal: Memorias do Instituto Oswaldo Cruz 20070601

Title: Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum.

Journal: Parasite (Paris, France) 20070601

Title: [Polymorphisms of the pfmdr1 gene in field samples of Plasmodium falciparum and their association with therapeutic response to antimalarial drugs and severe malaria in Colombia].

Journal: Biomedica : revista del Instituto Nacional de Salud 20070601

Title: [Tolerance of amodiaquine].

Journal: Medecine tropicale : revue du Corps de sante colonial 20070601

Title: [Open radomized study comparing chloroquine and amodiaquine for treatment of uncomplicated plasmodium falciparum malaria in children in Aboisso, Cote d' Ivoire].

Journal: Medecine tropicale : revue du Corps de sante colonial 20070601

Title: Impact of placental Plasmodium falciparum malaria on pregnancy and perinatal outcome in sub-Saharan Africa: I: introduction to placental malaria.

Journal: The Yale journal of biology and medicine 20070601

Title: [A new, cheaper and simpler anti-malaria preparation].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070531

Title: Antimalarial drugs--here and on the horizon.

Journal: JAMA 20070523

Title: Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial.

Journal: JAMA 20070523

Title: Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.

Journal: Chemical research in toxicology 20070501

Title: Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau.

Journal: The American journal of tropical medicine and hygiene 20070501

Title: Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.

Journal: PLoS clinical trials 20070501

Title: Response to malaria epidemics in Africa.

Journal: Emerging infectious diseases 20070501

Title: Resistance to dihydroartemisinin.

Journal: Emerging infectious diseases 20070501

Title: Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070415

Title: A randomised trial to assess the safety and efficacy of artemether-lumefantrine (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwanda.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20070401

Title: Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20070401

Title: The novel antimalarial compound dioncophylline C forms a complex with heme in solution.

Journal: ChemMedChem 20070401

Title: Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.

Journal: The Journal of antimicrobial chemotherapy 20070401

Title: Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.

Journal: Therapeutic drug monitoring 20070401

Title: [ASAQ, a breakthrough in the fight against malaria].

Journal: Medecine tropicale : revue du Corps de sante colonial 20070401

Title: Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070315

Title: [Against malaria: ASAQ, one dollar per box].

Journal: Revue medicale suisse 20070314

Title: Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice.

Journal: European journal of pharmacology 20070308

Title: New once a day, fixed dose antimalarial is now available for adults and children.

Journal: BMJ (Clinical research ed.) 20070303

Title: Correlations between treatment outcome and both anti-MSP119 antibody response and erythrocyte-related genetic factors in Plasmodium falciparum malaria.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070301

Title: Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20070301

Title: Practical HPLC methods for the quantitative determination of common antimalarials in Africa.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

Title: Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.

Journal: Chemical research in toxicology 20070301

Title: In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe.

Journal: Tropical medicine & international health : TM & IH 20070301

Title: The comparative efficacies of malartin, with and without amodiaquine, in the treatment of Plasmodium falciparum malaria in the Buea district of Cameroon.

Journal: Annals of tropical medicine and parasitology 20070301

Title: Genome-wide linkage analysis of malaria infection intensity and mild disease.

Journal: PLoS genetics 20070301

Title: [Assessment of the efficacy of antimalarial drugs in Tarapacá, in the Colombian Amazon basin].

Journal: Biomedica : revista del Instituto Nacional de Salud 20070301

Title: Chloroquine-resistant malaria in Malawi.

Journal: The New England journal of medicine 20070222

Title: Antimalarial drug combinations in vastly different settings.

Journal: Lancet (London, England) 20070210

Title: Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial.

Journal: Lancet (London, England) 20070210

Title: Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20070201

Title: Amodiaquine combined with sulfadoxine/pyrimethamine versus artemisinin-based combinations for the treatment of uncomplicated falciparum malaria in Africa: a meta-analysis.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20070201

Title: The effects of artemether-lumefantrine vs amodiaquine-sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children.

Journal: Parasitology research 20070201

Title: CYP2C8 and antimalaria drug efficacy.

Journal: Pharmacogenomics 20070201

Title: [Benzo[c][2,7]naphthyridine-5-yl-arylamines-phenol Mannich bases of the amodiaquine-, cycloquine- and pyronaridine-type].

Journal: Die Pharmazie 20070201

Title: In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.

Journal: The Journal of biological chemistry 20070126

Title: Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use.

Journal: PloS one 20070101

Title: Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers.

Journal: PLoS clinical trials 20070101

Title: Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance.

Journal: Malaria journal 20070101

Title: Efficacies of artesunate plus either sulfadoxine-pyrimethamine or amodiaquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan.

Journal: Annals of tropical medicine and parasitology 20070101

Title: Molecular epidemiology of malaria in Cameroon. XXIV. Trends of in vitro antimalarial drug responses in Yaounde, Cameroon.

Journal: The American journal of tropical medicine and hygiene 20070101

Title: [Benzo[c][2,7]naphthyridine-5-yl-amines and benzo[h][1,6]naphthyridine-5-yl-amines--potential antimalarials].

Journal: Die Pharmazie 20070101

Title: Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?

Journal: Malaria journal 20070101

Title: A cost-effectiveness analysis of artemether lumefantrine for treatment of uncomplicated malaria in Zambia.

Journal: Malaria journal 20070101

Title: Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.

Journal: Malaria journal 20070101

Title: Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children.

Journal: Malaria journal 20070101

Title: Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea.

Journal: Malaria journal 20070101

Title: Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant.

Journal: Malaria journal 20070101

Title: Exploration of rate-limiting conformational state for 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N(omega)-oxides (tebuquine analogues) for antimalarial activity using molecular shape analysis and molecular field analysis studies.

Journal: Journal of chemical information and modeling 20070101

Title: Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparum to chloroquine: requirement of a standardized in vitro assay.

Journal: Malaria journal 20070101

Title: Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria.

Journal: Malaria journal 20070101

Title: Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children.

Journal: PloS one 20070101

Title: Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine-pyrimethamine in N'Zérékoré.

Journal: Malaria journal 20070101

Title: Antimalarial drug prescribing practice in private and public health facilities in South-east Nigeria: a descriptive study.

Journal: Malaria journal 20070101

Title: Use of over-the-counter malaria medicines in children and adults in three districts in Kenya: implications for private medicine retailer interventions.

Journal: Malaria journal 20070101

Title: Paracheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?

Journal: Malaria journal 20070101

Title: Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar.

Journal: Malaria journal 20070101

Title: The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya.

Journal: Malaria journal 20070101

Title: Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal.

Journal: Malaria journal 20070101

Title: [Place of artemisinin derivatives as anti-malarial drugs in paediatric hospitalization in Abidjan].

Journal: Therapie 20070101

Title: Understanding and improving access to prompt and effective malaria treatment and care in rural Tanzania: the ACCESS Programme.

Journal: Malaria journal 20070101

Title: Self-reported use of anti-malarial drugs and health facility management of malaria in Ghana.

Journal: Malaria journal 20070101

Title: A comparative study on the efficacy of artesunate plus sulphadoxine/pyrimethamine versus artemether-lumefantrine in eastern Sudan.

Journal: Malaria journal 20070101

Title: Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction.

Journal: Malaria journal 20070101

Title: Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana.

Journal: Malaria journal 20070101

Title: Assessing malaria control in the Kassena-Nankana district of northern Ghana through repeated surveys using the RBM tools.

Journal: Malaria journal 20070101

Title: Battling the malaria iceberg with chloroquine in India.

Journal: Malaria journal 20070101

Title: The rationale and plan for creating a World Antimalarial Resistance Network (WARN).

Journal: Malaria journal 20070101

Title: World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility.

Journal: Malaria journal 20070101

Title: World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.

Journal: Malaria journal 20070101

Title: World Antimalarial Resistance Network (WARN) IV: clinical pharmacology.

Journal: Malaria journal 20070101

Title: Acute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics.

Journal: BMC infectious diseases 20070101

Title: Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications.

Journal: Malaria journal 20070101

Title: Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate.

Journal: PloS one 20070101

Title: Antimalarial drug toxicity: a review.

Journal: Chemotherapy 20070101

Title: [Therapeutic efficacy of amodiaquine against uncomplicated malaria in Madagascar].

Journal: Sante (Montrouge, France) 20070101

Title: The effect of HIV on morbidity and mortality in children with severe malarial anaemia.

Journal: Malaria journal 20070101

Title: Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy.

Journal: Malaria journal 20070101

Title: Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania.

Journal: Malaria journal 20070101

Title: A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.

Journal: PloS one 20070101

Title: Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal.

Journal: Malaria journal 20070101

Title: The decline in paediatric malaria admissions on the coast of Kenya.

Journal: Malaria journal 20070101

Title: Pilot feasibility study of an emergency paediatric kit for intra-rectal quinine administration used by the personnel of community-based health care units in Senegal.

Journal: Malaria journal 20070101

Title: Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum.

Journal: Malaria journal 20070101

Title: Photophysical properties and photobiological behavior of amodiaquine, primaquine and chloroquine.

Journal: Photochemistry and photobiology 20070101

Title: Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs.

Journal: Malaria journal 20070101

Title: Intermittent preventive treatment for the prevention of malaria during pregnancy in high transmission areas.

Journal: Malaria journal 20070101

Title: Complement activation in Ghanaian children with severe Plasmodium falciparum malaria.

Journal: Malaria journal 20070101

Title: Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa.

Journal: Malaria journal 20070101

Title: Malaria: prevention in travellers.

Journal: BMJ clinical evidence 20070101

Title: Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20061201

Title: Continued efficacy of sulfadoxine-pyrimethamine as second line treatment for malaria in children in Guinea-Bissau.

Journal: Acta tropica 20061201

Title: Amodiaquine resistance is not related to rare findings of pfmdr1 gene amplifications in Kenya.

Journal: Tropical medicine & international health : TM & IH 20061201

Title: Rifampicin/Cotrimoxazole/Isoniazid versus mefloquine or quinine + sulfadoxine- pyrimethamine for malaria: a randomized trial.

Journal: PLoS clinical trials 20061201

Title: Erythrocyte G protein as a novel target for malarial chemotherapy.

Journal: PLoS medicine 20061201

Title: Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria.

Journal: Bulletin of the World Health Organization 20061201

Title: Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.

Journal: Memorias do Instituto Oswaldo Cruz 20061201

Title: Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: experience with fixed-dose formulation.

Journal: Acta tropica 20061101

Title: Amodiaquine, malaria, pregnancy: the old new drug.

Journal: Lancet (London, England) 20061014

Title: Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.

Journal: Lancet (London, England) 20061014

Title: Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes.

Journal: Tropical medicine & international health : TM & IH 20061001

Title: Cost-effectiveness study of three antimalarial drug combinations in Tanzania.

Journal: PLoS medicine 20061001

Title: The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060901

Title: Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change.

Journal: The American journal of tropical medicine and hygiene 20060901

Title: A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.

Journal: Tanzania health research bulletin 20060901

Title: Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

Journal: Biochemical and biophysical research communications 20060804

Title: Factors contributing to the development of anaemia in Plasmodium falciparum malaria: what about drug-resistant parasites?

Journal: Journal of tropical pediatrics 20060801

Title: High reinfection rate and treatment failures in children treated with amodiaquine for falciparum malaria in Muheza villages, Northeastern Tanzania.

Journal: The American journal of tropical medicine and hygiene 20060801

Title: Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20060701

Title: Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.

Journal: European journal of clinical pharmacology 20060701

Title: Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.

Journal: Tropical medicine & international health : TM & IH 20060701

Title: High efficacy of two artemisinin-based combinations (artesunate + amodiaquine and artemether + lumefantrine) in Caala, Central Angola.

Journal: The American journal of tropical medicine and hygiene 20060701

Title: Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.

Journal: The American journal of tropical medicine and hygiene 20060701

Title: Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.

Journal: The American journal of tropical medicine and hygiene 20060701

Title: Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum.

Journal: PLoS clinical trials 20060701

Title: Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum.

Journal: PLoS clinical trials 20060701

Title: Relationship between NMR shielding and heme binding strength for a series of 7-substituted quinolines.

Journal: The journal of physical chemistry. A 20060629

Title: Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.

Journal: The Journal of infectious diseases 20060615

Title: In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601

Title: In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum.

Journal: The Journal of antimicrobial chemotherapy 20060601

Title: Resisting resistance: dealing with the irrepressible problem of malaria.

Journal: British journal of clinical pharmacology 20060601

Title: Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.

Journal: Tropical medicine & international health : TM & IH 20060601

Title: [Knowledge and practice among health workers from the Thiès region with regard to new malaria treatment policies].

Journal: Sante publique (Vandoeuvre-les-Nancy, France) 20060601

Title: Efficacy of chloroquine, sulfadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria among children under five in Bongor and Koumra, Chad.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20060501

Title: Modelling malaria control.

Journal: PLoS medicine 20060501

Title: Potential impact of intermittent preventive treatment (IPT) on spread of drug-resistant malaria.

Journal: PLoS medicine 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults.

Journal: Tropical medicine & international health : TM & IH 20060501

Title: Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro.

Journal: Memorias do Instituto Oswaldo Cruz 20060501

Title: RTS,S/AS02A malaria vaccine does not induce parasite CSP T cell epitope selection and reduces multiplicity of infection.

Journal: PLoS clinical trials 20060501

Title: Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda.

Journal: PLoS clinical trials 20060501

Title: Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum.

Journal: The Journal of infectious diseases 20060415

Title: Amodiaquine polymeric membrane electrode.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.

Journal: The Journal of infectious diseases 20060401

Title: Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

Journal: Tropical medicine & international health : TM & IH 20060401

Title: Microscopy and outpatient malaria case management among older children and adults in Kenya.

Journal: Tropical medicine & international health : TM & IH 20060401

Title: Prevalence of malaria parasitemia among clients seeking treatment for fever or malaria at drug stores in rural Tanzania 2004.

Journal: Tropical medicine & international health : TM & IH 20060401

Title: The costs of changing national policy: lessons from malaria treatment policy guidelines in Tanzania.

Journal: Tropical medicine & international health : TM & IH 20060401

Title: [Thieno[3,2-c]quinoline-4-yl-amines--synthesis and investigation of activity against malaria].

Journal: Die Pharmazie 20060401

Title: Interactions between pairs of antimalarial drugs studied by experimental and ab initio (13)C NMR chemical shifts.

Journal: Magnetic resonance in chemistry : MRC 20060301

Title: Storage of antimalarials at household level and associated factors in Kiromo ward, Bagamoyo Tanzania.

Journal: African health sciences 20060301

Title: Chemoprophylaxis and malaria death rates.

Journal: Emerging infectious diseases 20060301

Title: Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20060125

Title: Carbon chemical shift tensor components in quinolines and quinoline N-oxides.

Journal: The journal of physical chemistry. A 20060112

Title: Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia.

Journal: Malaria journal 20060101

Title: [Cytochrome P-450 and the response to antimalarial drugs].

Journal: Revista panamericana de salud publica = Pan American journal of public health 20060101

Title: Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment.

Journal: Malaria journal 20060101

Title: Rapid Urban Malaria Appraisal (RUMA) III: epidemiology of urban malaria in the municipality of Yopougon (Abidjan).

Journal: Malaria journal 20060101

Title: Rapid Urban Malaria Appraisal (RUMA) II: epidemiology of urban malaria in Dar es Salaam (Tanzania).

Journal: Malaria journal 20060101

Title: Artemether-lumefantrine versus artesunate plus amodiaquine for treating uncomplicated childhood malaria in Nigeria: randomized controlled trial.

Journal: Malaria journal 20060101

Title: An improved high-performance liquid chromatographic determination of chloroquine and its major metabolite, desethylchloroquine, in human plasma.

Journal: European journal of drug metabolism and pharmacokinetics 20060101

Title: A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

Journal: Current topics in medicinal chemistry 20060101

Title: Rapid Urban Malaria Appraisal (RUMA) IV: epidemiology of urban malaria in Cotonou (Benin).

Journal: Malaria journal 20060101

Title: Pattern of cause-specific childhood mortality in a malaria endemic area of Burkina Faso.

Journal: Malaria journal 20060101

Title: A database of antimalarial drug resistance.

Journal: Malaria journal 20060101

Title: Pharmacovigilance of antimalarial treatment in Africa: is it possible?

Journal: Malaria journal 20060101

Title: From chloroquine to artemisinin-based combination therapy: the Sudanese experience.

Journal: Malaria journal 20060101

Title: Safety and efficacy of lumefantrine-artemether (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults.

Journal: Malaria journal 20060101

Title: A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan.

Journal: Annals of clinical microbiology and antimicrobials 20060101

Title: Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors.

Journal: Malaria journal 20060101

Title: Use of pre-packaged chloroquine for the home management of presumed malaria in Malagasy children.

Journal: Malaria journal 20060101

Title: Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

Journal: Malaria journal 20060101

Title: Dynamics of immune response and drug resistance in malaria infection.

Journal: Malaria journal 20060101

Title: Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania.

Journal: Malaria journal 20060101

Title: Literacy and recent history of diarrhoea are predictive of Plasmodium falciparum parasitaemia in Kenyan adults.

Journal: Malaria journal 20060101

Title: Spatial and temporal variation in malaria transmission in a low endemicity area in northern Tanzania.

Journal: Malaria journal 20060101

Title: Topography and malaria transmission heterogeneity in western Kenya highlands: prospects for focal vector control.

Journal: Malaria journal 20060101

Title: Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia.

Journal: Malaria journal 20060101

Title: Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania.

Journal: Malaria journal 20060101

Title: Early home-based recognition of anaemia via general danger signs, in young children, in a malaria endemic community in north-east Tanzania.

Journal: Malaria journal 20060101

Title: Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo.

Journal: Malaria journal 20060101

Title: The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005.

Journal: Malaria journal 20060101

Title: Caregivers' perceived treatment failure in home-based management of fever among Ugandan children aged less than five years.

Journal: Malaria journal 20060101

Title: Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice.

Journal: Antiviral chemistry & chemotherapy 20060101

Title: Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania.

Journal: Malaria journal 20060101

Title: Malaria in children: study of 160 cases at a private clinic in Mansehra.

Journal: Journal of Ayub Medical College, Abbottabad : JAMC 20060101

Title: Antimalarial drugs in pregnancy: a review.

Journal: Current drug safety 20060101

Title: Maternal malaria and gravidity interact to modify infant susceptibility to malaria.

Journal: PLoS medicine 20051201

Title: The quality of sulphadoxine-pyrimethamine and amodiaquine products in the Kenyan retail sector.

Journal: Journal of clinical pharmacy and therapeutics 20051201

Title: Falciparum malaria in the north of Laos: the occurrence and implications of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene haplotype SVMNT.

Journal: Tropical medicine & international health : TM & IH 20051201

Title: Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana.

Journal: Tropical medicine & international health : TM & IH 20051201

Title: Rolling back a malaria epidemic in South Africa.

Journal: PLoS medicine 20051101

Title: Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa.

Journal: PLoS medicine 20051101

Title: Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.

Journal: Tropical medicine & international health : TM & IH 20051101

Title: Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal.

Journal: Tropical medicine & international health : TM & IH 20051101

Title: Amodiaquine and combination chemotherapy for malaria.

Journal: The American journal of tropical medicine and hygiene 20051101

Title: Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

Journal: The American journal of tropical medicine and hygiene 20051101

Title: Differences in willingness to pay for artemisinin-based combinations or monotherapy: experiences from the United Republic of Tanzania.

Journal: Bulletin of the World Health Organization 20051101

Title: Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.

Journal: Journal of molecular biology 20051021

Title: Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20051019

Title: Atovaquone-proguanil for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20051019

Title: Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria.

Journal: The Cochrane database of systematic reviews 20051019

Title: Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051015

Title: Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.

Journal: The American journal of tropical medicine and hygiene 20051001

Title: Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative.

Journal: Acta tropica 20050901

Title: Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.

Journal: Acta tropica 20050901

Title: Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal.

Journal: Tropical medicine & international health : TM & IH 20050901

Title: Blood schizontocidal activity of azithromycin and its combination with alpha/beta arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening.

Journal: Parasitology 20050901

Title: Malaria in Kenya's western highlands.

Journal: Emerging infectious diseases 20050901

Title: [Evaluation of the therapeutic efficacy of amodiaquine versus chloroquine in the treatment of uncomplicated malaria in Abie, Côte-d'Ivoire].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20050901

Title: Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.

Journal: Biochemical pharmacology 20050815

Title: Drug-resistant malaria in Bangui, Central African Republic: an in vitro assessment.

Journal: The American journal of tropical medicine and hygiene 20050801

Title: Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy.

Journal: The American journal of tropical medicine and hygiene 20050801

Title: Safety and efficacy of artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Ethiopia.

Journal: East African medical journal 20050801

Title: Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20050701

Title: Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20050701

Title: Quinoline antimalarials decrease the rate of beta-hematin formation.

Journal: Journal of inorganic biochemistry 20050701

Title: Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.

Journal: PLoS medicine 20050701

Title: New malaria combination cheaper and easier to take.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050607

Title: Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.

Journal: Parasitology research 20050601

Title: A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria.

Journal: Tropical medicine & international health : TM & IH 20050601

Title: Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan.

Journal: Tropical medicine & international health : TM & IH 20050601

Title: Chemosusceptibility analysis of Plasmodium falciparum imported malaria in Italy.

Journal: Diagnostic microbiology and infectious disease 20050601

Title: Malaria: uncomplicated, caused by Plasmodium falciparum.

Journal: Clinical evidence 20050601

Title: New combination drug to treat malaria.

Journal: The Lancet. Infectious diseases 20050501

Title: Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.

Journal: The American journal of tropical medicine and hygiene 20050501

Title: Antimalarial drugs: QT prolongation and cardiac arrhythmias.

Journal: Expert opinion on drug safety 20050501

Title: Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria.

Journal: The American journal of tropical medicine and hygiene 20050501

Title: Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether.

Journal: PLoS medicine 20050401

Title: The benefits of artemisinin combination therapy for malaria extend beyond the individual patient.

Journal: PLoS medicine 20050401

Title: Effectiveness trials in African children with malaria?

Journal: Lancet (London, England) 20050401

Title: Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial.

Journal: Lancet (London, England) 20050401

Title: Selective inhibition of human cytochrome P4502C8 by montelukast.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301

Title: Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.

Journal: Acta tropica 20050301

Title: A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana.

Journal: Tropical medicine & international health : TM & IH 20050301

Title: The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.

Journal: British journal of clinical pharmacology 20050301

Title: CYP2C8 polymorphism frequencies among malaria patients in Zanzibar.

Journal: European journal of clinical pharmacology 20050301

Title: Evidence basis for antimalarial policy change in Sierra Leone: five in vivo efficacy studies of chloroquine, sulphadoxine-pyrimethamine and amodiaquine.

Journal: Tropical medicine & international health : TM & IH 20050201

Title: The search for effective and sustainable treatments for Plasmodium falciparum malaria in Africa: a model of the selection of resistance by antifolate drugs and their combinations.

Journal: The American journal of tropical medicine and hygiene 20050201

Title: Malaria epidemic and drug resistance, Djibouti.

Journal: Emerging infectious diseases 20050201

Title: Examination of 209 drugs for inhibition of cytochrome P450 2C8.

Journal: Journal of clinical pharmacology 20050101

Title: Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101

Title: Intermittent presumptive treatment for malaria.

Journal: PLoS medicine 20050101

Title: Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan.

Journal: Malaria journal 20050101

Title: Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes.

Journal: Pharmaceutical research 20050101

Title: The promise and potential challenges of intermittent preventive treatment for malaria in infants (IPTi).

Journal: Malaria journal 20050101

Title: Brands, costs and registration status of antimalarial drugs in the Kenyan retail sector.

Journal: Malaria journal 20050101

Title: Antimalarial prescribing practices: a challenge to malaria control in Ghana.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

Title: Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana.

Journal: Malaria journal 20050101

Title: Rapid urban malaria appraisal (RUMA) I: epidemiology of urban malaria in Ouagadougou.

Journal: Malaria journal 20050101

Title: Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug.

Journal: Malaria journal 20050101

Title: Malaria chemoprophylaxis and the serologic response to measles and diphtheria-tetanus-whole-cell pertussis vaccines.

Journal: Malaria journal 20050101

Title: Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies.

Journal: Malaria journal 20050101

Title: Bone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitaemia.

Journal: Malaria journal 20050101

Title: Parasitological and clinical efficacy of standard treatment regimens against Plasmodium falciparum, P. vivax and P. malariae in Papua New Guinea.

Journal: Papua and New Guinea medical journal 20050101

Title: Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains.

Journal: Biochemistry 20041228

Title: Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution.

Journal: Inorganic chemistry 20041213

Title: Amodiaquine during pregnancy.

Journal: The Lancet. Infectious diseases 20041201

Title: Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.

Journal: The American journal of tropical medicine and hygiene 20041201

Title: Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial.

Journal: Lancet (London, England) 20041101

Title: Comparison of the parasitologic efficacy of amodiaquine and sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria in the Bungoma District of western Kenya.

Journal: The American journal of tropical medicine and hygiene 20041101

Title: Antileishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysis.

Journal: Journal of medicinal chemistry 20041021

Title: Is amodiaquine failing in Rwanda? Efficacy of amodiaquine alone and combined with artesunate in children with uncomplicated malaria.

Journal: Tropical medicine & international health : TM & IH 20041001

Title: The difference between effectiveness and efficacy of antimalarial drugs in Kenya.

Journal: Tropical medicine & international health : TM & IH 20040901

Title: Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan.

Journal: Tropical medicine & international health : TM & IH 20040901

Title: Short report: lack of prediction of amodiaquine efficacy in treating Plasmodium falciparum malaria by in vitro tests.

Journal: The American journal of tropical medicine and hygiene 20040901

Title: Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children.

Journal: Parasitology 20040901

Title: Plasmodium falciparum hyperparasitaemia in children. Risk factors, treatment outcomes, and gametocytaemia following treatment.

Journal: Parasite (Paris, France) 20040901

Title: Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice.

Journal: The Journal of general virology 20040801

Title: The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.

Journal: Antimicrobial agents and chemotherapy 20040701

Title: [[1]Benzothieno[3,2-b]pyridin-4-yl-amine--synthesis and investigation of activity against malaria].

Journal: Die Pharmazie 20040701

Title: Validated assays for human cytochrome P450 activities.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601

Title: Retail supply of malaria-related drugs in rural Tanzania: risks and opportunities.

Journal: Tropical medicine & international health : TM & IH 20040601

Title: [Efficacy of therapeutic combinations with artemisinin derivatives in the treatment of non complicated malaria in Burundi].

Journal: Tropical medicine & international health : TM & IH 20040601

Title: Short report: High prevalence of multidrug-resistant Plasmodium falciparum malaria in the French territory of Mayotte.

Journal: The American journal of tropical medicine and hygiene 20040601

Title: [Thieno[2,3-c]quinolines - synthesis and biological investigation].

Journal: Die Pharmazie 20040601

Title: [[1]Benzofuro[3,2-b]pyridin-4-yl-amines - synthesis and investigation of activity against malaria].

Journal: Die Pharmazie 20040601

Title: [Combined antimalarial therapy using artemisinin].

Journal: Parassitologia 20040601

Title: Liquid chromatographic determination of amodiaquine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

Title: Malaria intermittent preventive treatment in infants, chemoprophylaxis, and childhood vaccinations.

Journal: Lancet (London, England) 20040424

Title: Can amodiaquine be used safely during pregnancy?

Journal: The Lancet. Infectious diseases 20040401

Title: A randomized trial of amodiaquine and artesunate alone and in combination for the treatment of uncomplicated falciparum malaria in children from Burkina Faso.

Journal: Tropical medicine & international health : TM & IH 20040401

Title: Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda.

Journal: Tropical medicine & international health : TM & IH 20040401

Title: In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand.

Journal: The American journal of tropical medicine and hygiene 20040401

Title: [Pyrido [3,2-b]indol-4-yl-amines--synthesis and investigation of activity against malaria].

Journal: Die Pharmazie 20040401

Title: Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea.

Journal: The American journal of tropical medicine and hygiene 20040301

Title: Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria.

Journal: Tropical medicine & international health : TM & IH 20040201

Title: Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children.

Journal: Tropical medicine & international health : TM & IH 20040201

Title: Malaria chemoprophylaxis: when should we use it and what are the options?

Journal: Expert review of anti-infective therapy 20040201

Title: Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105

Title: Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX.

Journal: Journal of inorganic biochemistry 20040101

Title: Human liver aldehyde oxidase: inhibition by 239 drugs.

Journal: Journal of clinical pharmacology 20040101

Title: Antimalarial drug toxicity: a review.

Journal: Drug safety 20040101

Title: Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review.

Journal: Journal of postgraduate medicine 20040101

Title: A new method for detection of pfmdr1 mutations in Plasmodium falciparum DNA using real-time PCR.

Journal: Malaria journal 20040101

Title: Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso.

Journal: Malaria journal 20040101

Title: Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya.

Journal: Malaria journal 20040101

Title: Gametocytogenesis: the puberty of Plasmodium falciparum.

Journal: Malaria journal 20040101

Title: Care-seeking patterns for fatal malaria in Tanzania.

Journal: Malaria journal 20040101

Title: Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania.

Journal: Malaria journal 20040101

Title: Association of house spraying with suppressed levels of drug resistance in Zimbabwe.

Journal: Malaria journal 20040101

Title: Oro-facial dyskinesias and amodiaquine.

Journal: Therapie 20040101

Title: [Limits of the efficacy of chloroquine and sulfadoxine-pyrimethamine in Northern Abidjan (Cote d'Ivoire): Combined in vivo and in vitro studies].

Journal: Sante (Montrouge, France) 20040101

Title: Chloroquine induced pruritus--questionnaire based epidemiological study.

Journal: African journal of health sciences 20040101

Title: Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031201

Title: Chloroquine efficacy in the treatment of uncomplicated malaria at three sentinel sites in northern Togo.

Journal: Annals of tropical medicine and parasitology 20031201

Title: Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.

Journal: Journal of medicinal chemistry 20031106

Title: Antimalarial compounds: from bench to bedside.

Journal: The Journal of experimental biology 20031101

Title: [Misunderstood neurological side effects of amodiaquine: apropos of 35 cases in children at Central University Hospital of Yopougon at Abidjan, Côte d' Ivoire].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20031101

Title: Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria.

Journal: The Journal of infectious diseases 20031015

Title: The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy.

Journal: Tropical medicine & international health : TM & IH 20031001

Title: Amodiaquine treatment of uncomplicated malaria in children, in an area of chloroquine-resistant Plasmodium falciparum in north-central Nigeria.

Journal: Annals of tropical medicine and parasitology 20031001

Title: Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data.

Journal: European journal of clinical pharmacology 20030901

Title: Rapid clearance of Plasmodium falciparum hyperparasitaemia after oral amodiaquine treatment in patients with uncomplicated malaria.

Journal: Acta tropica 20030901

Title: Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.

Journal: Biochemical pharmacology 20030901

Title: Plasmodium falciparum gametocytaemia in Nigerian children: before, during and after treatment with antimalarial drugs.

Journal: Tropical medicine & international health : TM & IH 20030901

Title: Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan.

Journal: The American journal of tropical medicine and hygiene 20030801

Title: Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.

Journal: The American journal of tropical medicine and hygiene 20030801

Title: Safety, efficacy and determinants of effectiveness of antimalarial drugs during pregnancy: implications for prevention programmes in Plasmodium falciparum-endemic sub-Saharan Africa.

Journal: Tropical medicine & international health : TM & IH 20030601

Title: Efficacy of amodiaquine alone and combined with sulfadoxine-pyrimethamine and of sulfadoxine pyrimethamine combined with artesunate.

Journal: The American journal of tropical medicine and hygiene 20030601

Title: Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo-controlled trial.

Journal: Lancet (London, England) 20030531

Title: Epidemiology of highland malaria in western Kenya.

Journal: East African medical journal 20030501

Title: Questions about the antimalarial amodiaquine.

Journal: Lancet (London, England) 20030405

Title: Antibody responses to Plasmodium falciparum merozoite surface protein-1 and efficacy of amodiaquine in Gabonese children with P. falciparum malaria.

Journal: The Journal of infectious diseases 20030401

Title: Evaluation of the quality of amodiaquine and sulphadoxine/pyrimethamine tablets sold by private wholesale pharmacies in Dar Es Salaam Tanzania.

Journal: Journal of clinical pharmacy and therapeutics 20030401

Title: Conductometric and indirect AAS determination of antimalarials.

Journal: Journal of pharmaceutical and biomedical analysis 20030326

Title: [Efficacy of amodiaquine and sulfadoxine/pyrimethamine in the treatment of malaria not complicated by Plasmodium falciparum in Nariño, Colombia, 1999-2002].

Journal: Biomedica : revista del Instituto Nacional de Salud 20030301

Title: A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

Journal: Annals of tropical medicine and parasitology 20030301

Title: Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.

Journal: The American journal of tropical medicine and hygiene 20030201

Title: Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.

Journal: The American journal of tropical medicine and hygiene 20030201

Title: High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030115

Title: Epidemiological models for the spread of anti-malarial resistance.

Journal: Malaria journal 20030101

Title: Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon.

Journal: Malaria journal 20030101

Title: Amodiaquine for treating malaria.

Journal: The Cochrane database of systematic reviews 20030101

Title: Vendor-to-vendor education to improve malaria treatment by private drug outlets in Bungoma District, Kenya.

Journal: Malaria journal 20030101

Title: The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids.

Journal: Malaria journal 20030101

Title: Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

Title: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine.

Journal: Malaria journal 20030101

Title: Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species of Plasmodium.

Journal: Redox report : communications in free radical research 20030101

Title: Drug resistant falciparum malaria and the use of artesunate-based combinations: focus on clinical trials sponsored by TDR.

Journal: Journal of vector borne diseases 20030101

Title: Polymorphisms in cg2 and pfcrt genes and resistance to chloroquine and other antimalarials in vitro in Plasmodium falciparum isolates from Colombia.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

Title: Comparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum.

Journal: Wiener klinische Wochenschrift 20030101

Title: Therapeutic efficacy of chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Papua New Guinea.

Journal: Papua and New Guinea medical journal 20030101

Title: Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.

Journal: Lancet (London, England) 20021201

Title: In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar.

Journal: Parassitologia 20021201

Title: Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.

Journal: European journal of clinical pharmacology 20021101

Title: Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

Journal: Science (New York, N.Y.) 20021004

Title: Paracellular tightness and catabolism restrict histamine permeation in the proximal colon of pigs.

Journal: Pflugers Archiv : European journal of physiology 20021001

Title: Monitoring the drug-sensitivity of Plasmodium falciparum in coastal towns in Madagascar by use of in vitro chemosensitivity and mutation detection tests.

Journal: Parasite (Paris, France) 20020901

Title: The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.

Journal: Annals of tropical medicine and parasitology 20020901

Title: The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20020701

Title: Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum must be delayed in Africa.

Journal: Trends in parasitology 20020701

Title: High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.

Journal: Carcinogenesis 20020601

Title: Molecular epidemiology of malaria in Cameroon. X. Evaluation of PFMDR1 mutations as genetic markers for resistance to amino alcohols and artemisinin derivatives.

Journal: The American journal of tropical medicine and hygiene 20020601

Title: Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial.

Journal: Lancet (London, England) 20020420

Title: [In vivo sensitivity of Plasmodium falciparum to amino-4-quinolines and sulfadoxine pyrimethamine in Agou (Ivory Coast)].

Journal: Pathologie-biologie 20020401

Title: Resistance of Plamodium falciparum to antimalarial drugs in Zaragoza (Antioquia, Colombia), 1998.

Journal: Memorias do Instituto Oswaldo Cruz 20020401

Title: A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

Journal: Annals of tropical medicine and parasitology 20020401

Title: In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs.

Journal: Tropical medicine & international health : TM & IH 20020301

Title: [Management of child fever in the battle against malaria in Brazzaville].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20020301

Title: Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Inhibition of P. falciparum by steroids isolated from Solanum nudum.

Journal: Phytotherapy research : PTR 20020201

Title: Differential effects of 4-aminoquinoline-containing antimalarial drugs on hemoglobin digestion in Plasmodium falciparum-infected erythrocytes.

Journal: Biochemical pharmacology 20020201

Title: Clinical status and implications of antimalarial drug resistance.

Journal: Microbes and infection 20020201

Title: Molecular epidemiology of malaria in cameroon. IX. Characteristics of recrudescent and persistent Plasmodium falciparum infections after chloroquine or amodiaquine treatment in children.

Journal: The American journal of tropical medicine and hygiene 20020201

Title: Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement?

Journal: BMC public health 20020101

Title: Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine.

Journal: Experimental parasitology 20020101

Title: [Which medication should be used to treat uncomplicated malaria when chloroquine becomes ineffective in Western Côte d'Ivoire?].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the sulfadoxine-pyrimethamine-amodiaquine combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon.

Journal: Bulletin of the World Health Organization 20020101

Title: [Center of multidrug-resistant malaria in a forest zone of Cameroon revisited after 14 years].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.

Journal: Malaria journal 20020101

Title: [Treatment of malaria in children: 1. Uncomplicated malaria].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: Efficacy of amodiaquine for uncomplicated Plasmodium falciparum malaria in Harper, Liberia.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101

Title: [National Network study to perpetuate the surveillance of Plasmodium falciparum sensitivity to antimalarials in Madagascar].

Journal: Archives de l'Institut Pasteur de Madagascar 20020101

Title: Cardiac effects of amodiaquine and sulfadoxine-pyrimethamine in malaria-infected African patients.

Journal: The American journal of tropical medicine and hygiene 20011201

Title: Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area.

Journal: Annals of tropical medicine and parasitology 20011001

Title: Gametocytaemia in Senegalese children with uncomplicated falciparum malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine.

Journal: Parasite (Paris, France) 20010901

Title: Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

Journal: Annals of tropical medicine and parasitology 20010901

Title: Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.

Journal: Journal of medicinal chemistry 20010816

Title: Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial.

Journal: Lancet (London, England) 20010804

Title: Ferrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum.

Journal: The Journal of antimicrobial chemotherapy 20010801

Title: 'One-pot' synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline.

Journal: Chemical & pharmaceutical bulletin 20010801

Title: [Evaluation of efficacy and tolerance of amodiaquine versus chloroquine in the treatment of uncomplicated malaria outbreak in children of Gabon].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20010801

Title: Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants.

Journal: Bioscience reports 20010601

Title: [Developments in anti-malaria agents: chemical data, structure-activity relationships].

Journal: Annales pharmaceutiques francaises 20010401

Title: Improved assay method for the determination of pyronaridine in plasma and whole blood by high-performance liquid chromatography for application to clinical pharmacokinetic studies.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010305

Title: Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101

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Tags:86-42-0 Molecular Formula|86-42-0 MDL|86-42-0 SMILES|86-42-0 4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol