108433-95-0,MFCD00133522
Catalog No.:AA01CP36

108433-95-0 | Magainin II

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥97% (HPLC)
in stock  
$397.00   $278.00
- +
5mg
≥97% (HPLC)
in stock  
$1,415.00   $990.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01CP36
Chemical Name:
Magainin II
CAS Number:
108433-95-0
Molecular Formula:
C114H180N30O29S
Molecular Weight:
2466.8976
MDL Number:
MFCD00133522
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)CC(=O)N)CCSC)[C@H](CC)C)CCC(=O)O)C(C)C)Cc1ccccc1)C)CCCCN)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](CC)C)NC(=O)CN)CCCCN)Cc1ccccc1)CC(C)C)Cc1nc[nH]c1)CO)C)CCCCN
Properties
Computed Properties
 
Complexity:
5180  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
21  
Heavy Atom Count:
174  
Hydrogen Bond Acceptor Count:
36  
Hydrogen Bond Donor Count:
33  
Rotatable Bond Count:
86  
XLogP3:
-7.4  

Literature

Title: Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II.

Journal: Peptides 20120201

Title: Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2.

Journal: The Biochemical journal 20110615

Title: Monitoring membrane binding and insertion of peptides by two-color fluorescent label.

Journal: Biochimica et biophysica acta 20110101

Title: Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts.

Journal: Experimental parasitology 20100801

Title: Molecular interactions between magainin 2 and model membranes in situ.

Journal: The journal of physical chemistry. B 20090910

Title: Evidence of pores and thinned lipid bilayers induced in oriented lipid membranes interacting with the antimicrobial peptides, magainin-2 and aurein-3.3.

Journal: Biochimica et biophysica acta 20090701

Title: The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains.

Journal: Journal of medical microbiology 20090701

Title: Magainin 2 revisited: a test of the quantitative model for the all-or-none permeabilization of phospholipid vesicles.

Journal: Biophysical journal 20090107

Title: Protective effects of the combination of alpha-helical antimicrobial peptides and rifampicin in three rat models of Pseudomonas aeruginosa infection.

Journal: The Journal of antimicrobial chemotherapy 20081201

Title: Physico-chemical and biophysical study of the interaction of hexa- and heptaacyl lipid A from Erwinia carotovora with magainin 2-derived antimicrobial peptides.

Journal: Biochimica et biophysica acta 20081001

Title: Design and synthesis of novel antibacterial peptide-resin conjugates.

Journal: Bioorganic & medicinal chemistry letters 20071101

Title: Transdermal delivery enhanced by magainin pore-forming peptide.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20071008

Title: Action mechanism of PEGylated magainin 2 analogue peptide.

Journal: Biochimica et biophysica acta 20071001

Title: Structure of magainin and alamethicin in model membranes studied by x-ray reflectivity.

Journal: Biophysical journal 20061101

Title: Amphibian peptides prevent endotoxemia and bacterial translocation in bile duct-ligated rats.

Journal: Critical care medicine 20060901

Title: Can the ravages of uncontrolled systemic inflammatory response be regulated by amphibian antimicrobial peptides?

Journal: Critical care medicine 20060901

Title: Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines.

Journal: European urology 20060701

Title: Solid-state NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from magainin 2 and melittin.

Journal: Biophysical journal 20060701

Title: Effect of MUC7 peptides on the growth of bacteria and on Streptococcus mutans biofilm.

Journal: The Journal of antimicrobial chemotherapy 20060601

Title: Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro.

Journal: Biochemical pharmacology 20060428

Title: Single giant unilamellar vesicle method reveals effect of antimicrobial peptide magainin 2 on membrane permeability.

Journal: Biochemistry 20051206

Title: Implicit solvent simulations of peptide interactions with anionic lipid membranes.

Journal: Proteins 20050215

Title: Membrane translocation mechanism of the antimicrobial peptide buforin 2.

Journal: Biochemistry 20041214

Title: Binding and insertion of alpha-helical anti-microbial peptides in POPC bilayers studied by molecular dynamics simulations.

Journal: Chemistry and physics of lipids 20041101

Title: Structure-antiviral activity relationships of cecropin A-magainin 2 hybrid peptide and its analogues.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20040501

Title: Membrane-mediated capillary electrophoresis: interaction of cationic peptides with bicelles.

Journal: Electrophoresis 20040501

Title: Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides.

Journal: Biotechnology letters 20040201

Title: The anti-infective activity of human milk is potentially greater than the sum of its microbicidal components.

Journal: Advances in experimental medicine and biology 20040101

Title: Bilayer localization of membrane-active peptides studied in biomimetic vesicles by visible and fluorescence spectroscopies.

Journal: European journal of biochemistry 20031101

Title: Helical peptoid mimics of magainin-2 amide.

Journal: Journal of the American Chemical Society 20031008

Title: Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles.

Journal: Biopolymers 20030401

Title: Magainin 2 channel formation in planar lipid membranes: the role of lipid polar groups and ergosterol.

Journal: European biophysics journal : EBJ 20030301

Title: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.

Journal: British journal of cancer 20030224

Title: Enhanced membrane permeabilization and antibacterial activity of a disulfide-dimerized magainin analogue.

Journal: Biochemistry 20030121

Title: Influence on the plasma membrane of Candida albicans by HP (2-9)-magainin 2 (1-12) hybrid peptide.

Journal: Biochemical and biophysical research communications 20021004

Title: Parallel and antiparallel dimers of magainin 2: their interaction with phospholipid membrane and antibacterial activity.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20021001

Title: Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides.

Journal: Journal of the American Chemical Society 20020626

Title: Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides.

Journal: Biochimica et biophysica acta 20020503

Title: Thermodynamics of the coil-alpha-helix transition of amphipathic peptides in a membrane environment: the role of vesicle curvature.

Journal: Biophysical chemistry 20020502

Title: Conjugation of a magainin analogue with lipophilic acids controls hydrophobicity, solution assembly, and cell selectivity.

Journal: Biochemistry 20020219

Title: Salt resistance and synergistic effect with vancomycin of alpha-helical antimicrobial peptide P18.

Journal: Biochemical and biophysical research communications 20020111

Title: Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin.

Journal: Biophysical journal 20011101

Title: Embryotoxicity of magainin-2-amide and its enhancement by cyclodextrin, albumin, hydrogen peroxide and acidification.

Journal: Human reproduction (Oxford, England) 20010701

Title: The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: implication to their mode of action.

Journal: Biochemistry 20010529

Title: Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.

Journal: Antimicrobial agents and chemotherapy 20001201

Title: Synergistic effects of low doses of histatin 5 and its analogues on amphotericin B anti-mycotic activity.

Journal: Antonie van Leeuwenhoek 20000801

Title: In vitro anticryptosporidial activity of ranalexin alone and in combination with other peptides and with hydrophobic antibiotics.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19991101

Title: In-vitro activity of polycationic peptides against Cryptosporidium parvum, Pneumocystis carinii and yeast clinical isolates.

Journal: The Journal of antimicrobial chemotherapy 19990901

Title: In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii.

Journal: The Journal of antimicrobial chemotherapy 19981001

Title: Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19870801

Title: M Zasloff, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.

Title: K Matsuzaki, et al. Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta. 1998 Nov 10;1376(3):391-400.

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SDS
Tags:108433-95-0 Molecular Formula|108433-95-0 MDL|108433-95-0 SMILES|108433-95-0 Magainin II
Catalog No.: AA01CP36
108433-95-0,MFCD00133522
108433-95-0 | Magainin II
Pack Size: 1mg
Purity: ≥97% (HPLC)
in stock
$397.00 $278.00
Pack Size: 5mg
Purity: ≥97% (HPLC)
in stock
$1,415.00 $990.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01CP36
Chemical Name: Magainin II
CAS Number: 108433-95-0
Molecular Formula: C114H180N30O29S
Molecular Weight: 2466.8976
MDL Number: MFCD00133522
SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)CC(=O)N)CCSC)[C@H](CC)C)CCC(=O)O)C(C)C)Cc1ccccc1)C)CCCCN)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](CC)C)NC(=O)CN)CCCCN)Cc1ccccc1)CC(C)C)Cc1nc[nH]c1)CO)C)CCCCN
Properties
Complexity: 5180  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 21  
Heavy Atom Count: 174  
Hydrogen Bond Acceptor Count: 36  
Hydrogen Bond Donor Count: 33  
Rotatable Bond Count: 86  
XLogP3: -7.4  
Literature fold

Title: Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II.

Journal: Peptides20120201

Title: Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2.

Journal: The Biochemical journal20110615

Title: Monitoring membrane binding and insertion of peptides by two-color fluorescent label.

Journal: Biochimica et biophysica acta20110101

Title: Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts.

Journal: Experimental parasitology20100801

Title: Molecular interactions between magainin 2 and model membranes in situ.

Journal: The journal of physical chemistry. B20090910

Title: Evidence of pores and thinned lipid bilayers induced in oriented lipid membranes interacting with the antimicrobial peptides, magainin-2 and aurein-3.3.

Journal: Biochimica et biophysica acta20090701

Title: The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains.

Journal: Journal of medical microbiology20090701

Title: Magainin 2 revisited: a test of the quantitative model for the all-or-none permeabilization of phospholipid vesicles.

Journal: Biophysical journal20090107

Title: Protective effects of the combination of alpha-helical antimicrobial peptides and rifampicin in three rat models of Pseudomonas aeruginosa infection.

Journal: The Journal of antimicrobial chemotherapy20081201

Title: Physico-chemical and biophysical study of the interaction of hexa- and heptaacyl lipid A from Erwinia carotovora with magainin 2-derived antimicrobial peptides.

Journal: Biochimica et biophysica acta20081001

Title: Design and synthesis of novel antibacterial peptide-resin conjugates.

Journal: Bioorganic & medicinal chemistry letters20071101

Title: Transdermal delivery enhanced by magainin pore-forming peptide.

Journal: Journal of controlled release : official journal of the Controlled Release Society20071008

Title: Action mechanism of PEGylated magainin 2 analogue peptide.

Journal: Biochimica et biophysica acta20071001

Title: Structure of magainin and alamethicin in model membranes studied by x-ray reflectivity.

Journal: Biophysical journal20061101

Title: Amphibian peptides prevent endotoxemia and bacterial translocation in bile duct-ligated rats.

Journal: Critical care medicine20060901

Title: Can the ravages of uncontrolled systemic inflammatory response be regulated by amphibian antimicrobial peptides?

Journal: Critical care medicine20060901

Title: Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines.

Journal: European urology20060701

Title: Solid-state NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from magainin 2 and melittin.

Journal: Biophysical journal20060701

Title: Effect of MUC7 peptides on the growth of bacteria and on Streptococcus mutans biofilm.

Journal: The Journal of antimicrobial chemotherapy20060601

Title: Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro.

Journal: Biochemical pharmacology20060428

Title: Single giant unilamellar vesicle method reveals effect of antimicrobial peptide magainin 2 on membrane permeability.

Journal: Biochemistry20051206

Title: Implicit solvent simulations of peptide interactions with anionic lipid membranes.

Journal: Proteins20050215

Title: Membrane translocation mechanism of the antimicrobial peptide buforin 2.

Journal: Biochemistry20041214

Title: Binding and insertion of alpha-helical anti-microbial peptides in POPC bilayers studied by molecular dynamics simulations.

Journal: Chemistry and physics of lipids20041101

Title: Structure-antiviral activity relationships of cecropin A-magainin 2 hybrid peptide and its analogues.

Journal: Journal of peptide science : an official publication of the European Peptide Society20040501

Title: Membrane-mediated capillary electrophoresis: interaction of cationic peptides with bicelles.

Journal: Electrophoresis20040501

Title: Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides.

Journal: Biotechnology letters20040201

Title: The anti-infective activity of human milk is potentially greater than the sum of its microbicidal components.

Journal: Advances in experimental medicine and biology20040101

Title: Bilayer localization of membrane-active peptides studied in biomimetic vesicles by visible and fluorescence spectroscopies.

Journal: European journal of biochemistry20031101

Title: Helical peptoid mimics of magainin-2 amide.

Journal: Journal of the American Chemical Society20031008

Title: Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles.

Journal: Biopolymers20030401

Title: Magainin 2 channel formation in planar lipid membranes: the role of lipid polar groups and ergosterol.

Journal: European biophysics journal : EBJ20030301

Title: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.

Journal: British journal of cancer20030224

Title: Enhanced membrane permeabilization and antibacterial activity of a disulfide-dimerized magainin analogue.

Journal: Biochemistry20030121

Title: Influence on the plasma membrane of Candida albicans by HP (2-9)-magainin 2 (1-12) hybrid peptide.

Journal: Biochemical and biophysical research communications20021004

Title: Parallel and antiparallel dimers of magainin 2: their interaction with phospholipid membrane and antibacterial activity.

Journal: Journal of peptide science : an official publication of the European Peptide Society20021001

Title: Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides.

Journal: Journal of the American Chemical Society20020626

Title: Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides.

Journal: Biochimica et biophysica acta20020503

Title: Thermodynamics of the coil-alpha-helix transition of amphipathic peptides in a membrane environment: the role of vesicle curvature.

Journal: Biophysical chemistry20020502

Title: Conjugation of a magainin analogue with lipophilic acids controls hydrophobicity, solution assembly, and cell selectivity.

Journal: Biochemistry20020219

Title: Salt resistance and synergistic effect with vancomycin of alpha-helical antimicrobial peptide P18.

Journal: Biochemical and biophysical research communications20020111

Title: Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin.

Journal: Biophysical journal20011101

Title: Embryotoxicity of magainin-2-amide and its enhancement by cyclodextrin, albumin, hydrogen peroxide and acidification.

Journal: Human reproduction (Oxford, England)20010701

Title: The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: implication to their mode of action.

Journal: Biochemistry20010529

Title: Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.

Journal: Antimicrobial agents and chemotherapy20001201

Title: Synergistic effects of low doses of histatin 5 and its analogues on amphotericin B anti-mycotic activity.

Journal: Antonie van Leeuwenhoek20000801

Title: In vitro anticryptosporidial activity of ranalexin alone and in combination with other peptides and with hydrophobic antibiotics.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology19991101

Title: In-vitro activity of polycationic peptides against Cryptosporidium parvum, Pneumocystis carinii and yeast clinical isolates.

Journal: The Journal of antimicrobial chemotherapy19990901

Title: In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii.

Journal: The Journal of antimicrobial chemotherapy19981001

Title: Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

Journal: Proceedings of the National Academy of Sciences of the United States of America19870801

Title: M Zasloff, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.

Title: K Matsuzaki, et al. Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta. 1998 Nov 10;1376(3):391-400.

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