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118025-43-7,MFCD00133766
Catalog No.:AA008QZ9

118025-43-7 | PHM-27 (HUMAN)

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008QZ9
Chemical Name:
PHM-27 (HUMAN)
CAS Number:
118025-43-7
Molecular Formula:
C135H214N34O40S
Molecular Weight:
2985.4125
MDL Number:
MFCD00133766
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCSC)CC(C)C)CO)CCC(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCCN)CCCCN)C)CO)CC(C)C)CCC(=O)N)CC(C)C)CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)N)C)CC(=O)O)Cc1ccccc1)CO)CC(=O)O)Cc1ccccc1)CO
Properties
Computed Properties
 
Complexity:
6580  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
26  
Heavy Atom Count:
210  
Hydrogen Bond Acceptor Count:
46  
Hydrogen Bond Donor Count:
42  
Rotatable Bond Count:
102  
XLogP3:
-12.1  

Literature

Title: The VPAC2 agonist peptide histidine isoleucine (PHI) up-regulates glutamate transport in the corpus callosum of a rat model of amyotrophic lateral sclerosis (hSOD1G93A) by inhibiting caspase-3 mediated inactivation of GLT-1a.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001

Title: A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones.

Journal: Biochemistry 20110329

Title: Distinct expression and regulation of the glutamate transporter isoforms GLT-1a and GLT-1b in cultured astrocytes from a rat model of amyotrophic lateral sclerosis (hSOD1G93A).

Journal: Neurochemistry international 20090101

Title: Excitatory actions of peptide histidine isoleucine on thalamic relay neurons.

Journal: Neuropharmacology 20081201

Title: Newly-identified receptors for peptide histidine-isoleucine and GHRH-like peptide in zebrafish help to elucidate the mammalian secretin superfamily.

Journal: Journal of molecular endocrinology 20081101

Title: Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus.

Journal: European journal of pharmacology 20080820

Title: Activation of VIP/PACAP type 2 receptor by the peptide histidine isoleucine in astrocytes influences GLAST-mediated glutamate uptake.

Journal: Journal of neurochemistry 20080501

Title: Unconventional binding sites and receptors for VIP and related peptides PACAP and PHI/PHM: an update.

Journal: Peptides 20070901

Title: Glucagon-related peptides in the mouse retina and the effects of deprivation of form vision.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070201

Title: Effects of PACAP, VIP and related peptides on cyclic AMP formation in rat neuronal and astrocyte cultures and cerebral cortical slices.

Journal: Pharmacological reports : PR 20070101

Title: Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat.

Journal: Annals of the New York Academy of Sciences 20060701

Title: PACAP, VIP, and PHI: effects on AC-, PLC-, and PLD-driven signaling systems in the primary glial cell cultures.

Journal: Annals of the New York Academy of Sciences 20060701

Title: PACAP- and PHI-mediated sustained relaxation in circular muscle of gastric fundus: findings obtained in PACAP knockout mice.

Journal: Regulatory peptides 20060115

Title: Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum.

Journal: Pflugers Archiv : European journal of physiology 20060101

Title: VPAC2 receptors mediate vasoactive intestinal peptide-induced neuroprotection against neonatal excitotoxic brain lesions in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: The relative importance of vasoactive intestinal peptide and peptide histidine isoleucine as physiological regulators of prolactin in the domestic turkey.

Journal: General and comparative endocrinology 20050701

Title: Interindividual variation in distribution of extramural ganglion cells in the male pelvis: a semi-quantitative and immunohistochemical study concerning nerve-sparing pelvic surgery.

Journal: European urology 20050701

Title: Human H9 cells proliferation is differently controlled by vasoactive intestinal peptide or peptide histidine methionine: implication of a GTP-insensitive form of VPAC1 receptor.

Journal: Journal of neuroimmunology 20050101

Title: Neuroprotective potential of three neuropeptides PACAP, VIP and PHI.

Journal: Pharmacological reports : PR 20050101

Title: Receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in turkey cerebral cortex: characterization by [125I]-VIP binding and effects on cyclic AMP synthesis.

Journal: General and comparative endocrinology 20040601

Title: Neurotransmitters co-existing with VIP or PACAP.

Journal: Peptides 20040301

Title: [Peptide histidine-isoleucine and and its human analogue peptide histidine-methionine: localization, receptors and biological function].

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20040226

Title: Neuritogenesis induced by vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and peptide histidine methionine in SH-SY5y cells is associated with regulated expression of cytoskeleton mRNAs and proteins.

Journal: Journal of neuroscience research 20040201

Title: [Neuroprotective role of PACAP, VIP, and PHI in the central nervous system].

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20040101

Title: Disrupted circadian rhythms in VIP- and PHI-deficient mice.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20031101

Title: Peptides that regulate food intake: effect of peptide histidine isoleucine on consummatory behavior in rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030601

Title: A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus.

Journal: The European journal of neuroscience 20030601

Title: A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus.

Journal: The European journal of neuroscience 20030201

Title: Demonstration of nerve fibers immunoreactive to peptide N-terminal histidine C-terminal isoleucine (PHI) and vasoactive intestinal peptide (VIP) in the pig pineal gland.

Journal: Folia histochemica et cytobiologica 20030101

Title: Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro.

Journal: Journal of molecular neuroscience : MN 20030101

Title: Cyclic AMP formation in chicken brain: effect of vasoactive intestinal peptide, peptide histidine-isoleucine (PHI), and some PHI-related peptides.

Journal: Polish journal of pharmacology 20030101

Title: Involvement of peptide histidine isoleucine in non-adrenergic non-cholinergic relaxation of the rat gastric fundus induced by high-frequency neuronal firing.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021201

Title: Axonal neurofilament-H immunolabeling in the rabbit retina.

Journal: The Journal of comparative neurology 20021118

Title: The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.

Journal: Cell 20020517

Title: Identification of a potential receptor for both peptide histidine isoleucine and peptide histidine valine.

Journal: Endocrinology 20020401

Title: Vasoactive intestinal peptide influences neurite outgrowth in cultured rat spinal cord neurons.

Journal: Neurological research 20011201

Title: The polypeptide PHI discriminates a GTP-insensitive form of VIP receptor in liver membranes.

Journal: Neuropeptides 20010401

Title: Hair-cycle-associated remodeling of the peptidergic innervation of murine skin, and hair growth modulation by neuropeptides.

Journal: The Journal of investigative dermatology 20010201

Title: Vagus nerve modulates secretin binding sites in the rat forestomach.

Journal: The American journal of physiology 19990401

Title: Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT.

Journal: The American journal of physiology 19880801

Title: Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon--secretin family.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19811101

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Tags:118025-43-7 Molecular Formula|118025-43-7 MDL|118025-43-7 SMILES|118025-43-7 PHM-27 (HUMAN)