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479501-40-1
Catalog No.:AA01E4GZ

479501-40-1 | RK20448-Trihydrochloride

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$120.00   $84.00
- +
5mg
≥98%
in stock  
$488.00   $341.00
- +
10mg
≥98%
in stock  
$850.00   $595.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E4GZ
Chemical Name:
RK20448-Trihydrochloride
CAS Number:
479501-40-1
Molecular Formula:
C29H34N6O
Molecular Weight:
482.6199
SMILES:
CN1CCN(CC1)[C@@H]1CC[C@@H](CC1)n1cc(c2c1ncnc2N)c1ccc(cc1)Oc1ccccc1
Properties
Computed Properties
 
Complexity:
679  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
4.5  

Literature

Title: An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.

Journal: Oncogene 20081127

Title: SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.

Journal: Cancer research 20040901

Title: Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

Journal: Oncogene 20021121

Title: Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

Journal: Bioorganic & medicinal chemistry letters 20020617

Title: Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.

Journal: Bioorganic & medicinal chemistry letters 20020617

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SDS
Tags:479501-40-1 Molecular Formula|479501-40-1 MDL|479501-40-1 SMILES|479501-40-1 RK20448-Trihydrochloride