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Home Amines 213743-31-8
213743-31-8,MFCD04974490
Catalog No.:AA00BJVG

213743-31-8 | 7-Cyclopentyl-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-ylamine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$23.00   $16.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BJVG
Chemical Name:
7-Cyclopentyl-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-ylamine
CAS Number:
213743-31-8
Molecular Formula:
C23H22N4O
Molecular Weight:
370.4470
MDL Number:
MFCD04974490
SMILES:
Nc1ncnc2c1c(cn2C1CCCC1)c1ccc(cc1)Oc1ccccc1
Properties
Properties
 
Form:
Solid  
Storage:
Light sensitive;Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
497  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
4.6  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.2167-2170

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.2171-2174

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.2167-2170

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.2167-2170

2-cyclopentylamino-1-(4-phenoxy-phenyl)-ethanone 
  213743-31-8 

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.2167-2170

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.

Journal: Protein science : a publication of the Protein Society 20100301

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

Journal: Bioorganic & medicinal chemistry letters 20020617

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.

Journal: Bioorganic & medicinal chemistry letters 20001002

Title: Arnold LD, et al. Pyrrolo,3-dpyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70.

Title: Seo HH, et al. 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo,3-d pyrimidin-4-ylamine inhibits the proliferation and migration of vascular smooth muscle cells by suppressing ERK and Akt pathways. Eur J Pharmacol. 2017 Mar 5;798:35-42.

Title: Burchat AF, et al. Pyrrolo,3-dpyrimidines containing an extended 5-substituent as potent and selective inhibitorsof lck II. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2171-4.

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Tags:213743-31-8 Molecular Formula|213743-31-8 MDL|213743-31-8 SMILES|213743-31-8 7-Cyclopentyl-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-ylamine