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123583-37-9,MFCD00165623
Catalog No.:AA01EAPB

123583-37-9 | Peptide YY (3-36) (human) trifluoroacetate salt H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 trifluoroacetate salt

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1mg
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5mg
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10mg
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EAPB
Chemical Name:
Peptide YY (3-36) (human) trifluoroacetate salt H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 trifluoroacetate salt
CAS Number:
123583-37-9
Molecular Formula:
C87H136N22O30
Molecular Weight:
1970.1401
MDL Number:
MFCD00165623
SMILES:
NCCCCC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(Cc1ccc(cc1)O)C)CCCNC(=N)N)CC(=O)N)CC(C)C)CCC(=O)O)CCC(=O)O)CO)C)CC(=O)O)CCC(=O)O)C)CCC(=O)O)NC(=O)CC(CC)C
Properties
Computed Properties
 
Complexity:
9890  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
35  
Heavy Atom Count:
287  
Hydrogen Bond Acceptor Count:
61  
Hydrogen Bond Donor Count:
61  
Rotatable Bond Count:
133  
XLogP3:
-14.9  

Literature

Title: Role of Peptide YY3-36 and Glucose-Dependent Insulinotropic Polypeptide in Anorexia Induction by Trichothecences T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170901

Title: Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin).

Journal: Archives of toxicology 20170101

Title: Comparison of anorectic and emetic potencies of deoxynivalenol (vomitoxin) to the plant metabolite deoxynivalenol-3-glucoside and synthetic deoxynivalenol derivatives EN139528 and EN139544.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20141101

Title: Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140401

Title: Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice.

Journal: American journal of physiology. Endocrinology and metabolism 20120901

Title: Dipeptidyl peptidase IV regulates proliferation of preglomerular vascular smooth muscle and mesangial cells.

Journal: Hypertension (Dallas, Tex. : 1979) 20120901

Title: Selective ablation of peptide YY cells in adult mice reveals their role in beta cell survival.

Journal: Gastroenterology 20120801

Title: Effect of isotonic solutions and peptide adsorption on zeta potential of porous silicon nanoparticle drug delivery formulations.

Journal: International journal of pharmaceutics 20120715

Title: Role of Y(2) receptors in the regulation of gastric tone in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120401

Title: Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass.

Journal: International journal of obesity (2005) 20120301

Title: Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake.

Journal: The British journal of nutrition 20111201

Title: Impaired postprandial releases/syntheses of ghrelin and PYY(3-36) and blunted responses to exogenous ghrelin and PYY(3-36) in a rodent model of diet-induced obesity.

Journal: Journal of gastroenterology and hepatology 20110401

Title: Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats.

Journal: Behavioural brain research 20110301

Title: Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors.

Journal: Peptides 20110201

Title: Salivary PYY: a putative bypass to satiety.

Journal: PloS one 20110101

Title: Effects of albumin-conjugated PYY on food intake: the respective roles of the circumventricular organs and vagus nerve.

Journal: The European journal of neuroscience 20100901

Title: PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans.

Journal: Diabetes 20100701

Title: Application of arginine as an efficient eluent in cation exchange chromatographic purification of a PEGylated peptide.

Journal: Journal of chromatography. A 20100611

Title: NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice.

Journal: Peptides 20100401

Title: Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100101

Title: Pancreatic islet isolation after gastric bypass in a rat model: technique and initial results for a promising research tool.

Journal: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 20100101

Title: [Effect of sibutramine (meridia) on body composition, peptide YY3-36 and serotonin levels in patients with exogenous constitutional obesity].

Journal: Terapevticheskii arkhiv 20100101

Title: Comparable effects of moderate intensity exercise on changes in anorectic gut hormone levels and energy intake to high intensity exercise.

Journal: The Journal of endocrinology 20091201

Title: Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man.

Journal: Regulatory peptides 20091127

Title: Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial.

Journal: Journal of psychopharmacology (Oxford, England) 20090901

Title: The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity.

Journal: American journal of physiology. Endocrinology and metabolism 20090601

Title: Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels.

Journal: Annals of surgery 20090601

Title: Reducing dietary fat from a meal increases the bioavailability of exogenous carbohydrate without altering plasma glucose concentration.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20090101

Title: Synthesis & biological evaluation of PYY(3-36) analogs substituted with alanine.

Journal: Advances in experimental medicine and biology 20090101

Title: The satiety hormone peptide YY as a regulator of appetite.

Journal: Journal of clinical pathology 20080501

Title: Co-administration of SR141716 with peptide YY3-36 or oxyntomodulin has additive effects on food intake in mice.

Journal: Diabetes, obesity & metabolism 20080201

Title: PYY(3-36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of rats.

Journal: Peptides 20080101

Title: Variation of postprandial PYY 3-36 response following ingestion of differing macronutrient meals in obese females.

Journal: Annals of nutrition & metabolism 20080101

Title: Combination therapy with amylin and peptide YY[3-36] in obese rodents: anorexigenic synergy and weight loss additivity.

Journal: Endocrinology 20071201

Title: Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa.

Journal: Journal of psychiatric research 20071101

Title: A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Comparison of the metabolic effects of GIP receptor antagonism and PYY(3-36) receptor activation in high fat fed mice.

Journal: Peptides 20071101

Title: Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20071024

Title: Peptide YY(3-36)-induced inhibition of food intake in female monkeys.

Journal: Brain research 20071017

Title: Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedback.

Journal: Endocrinology 20071001

Title: Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors.

Journal: Neuropharmacology 20070501

Title: Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.

Journal: American journal of physiology. Endocrinology and metabolism 20070401

Title: The pancreatic polypeptide family and the migrating motor complex of the rat: differential effects in the duodenum and jejunum.

Journal: Regulatory peptides 20070301

Title: Identification of selective neuropeptide Y2 peptide agonists.

Journal: Bioorganic & medicinal chemistry letters 20070115

Title: Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice.

Journal: American journal of physiology. Endocrinology and metabolism 20070101

Title: Modulation of contractile function through neuropeptide Y receptors during development of cardiomyocyte hypertrophy.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060801

Title: Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery.

Journal: Journal of pharmaceutical sciences 20060601

Title: Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions.

Journal: Obesity surgery 20060501

Title: Peptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: implications for hypothalamic regulation of energy homeostasis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051109

Title: Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques.

Journal: Diabetes 20051101

Title: Peptide YY (3 -36) inhibits dopamine and norepinephrine release in the hypothalamus.

Journal: European journal of pharmacology 20050905

Title: Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice.

Journal: Endocrinology 20050901

Title: Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050810

Title: Neuropeptide Y induced modulation of dopamine synthesis in the striatum.

Journal: Regulatory peptides 20050715

Title: Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour.

Journal: Journal of neuroendocrinology 20050701

Title: Central responsiveness to a ghrelin mimetic (GHRP-6) is rapidly altered by acute changes in nutritional status in rats.

Journal: Journal of neuroendocrinology 20050601

Title: The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway.

Journal: Brain research 20050517

Title: Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake.

Journal: Brain research 20050510

Title: Y2 receptor-selective agonist delays the estrogen-induced luteinizing hormone surge in ovariectomized ewes, but y1-receptor-selective agonist stimulates voluntary food intake.

Journal: Endocrinology 20050201

Title: Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats.

Journal: Endocrinology 20050201

Title: Endogenous neuropeptide Y depresses the afferent signaling of gastric acid challenge to the mouse brainstem via neuropeptide Y type Y2 and Y4 receptors.

Journal: Neuroscience 20050101

Title: The electrophysiology of feeding circuits.

Journal: Trends in endocrinology and metabolism: TEM 20041201

Title: Effects of PYY[3-36] in rodent models of diabetes and obesity.

Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20040801

Title: PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet.

Journal: Diabetes 20040801

Title: Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20040801

Title: When enough is too much: new strategies to treat obesity.

Journal: Chemistry & biology 20040801

Title: Functional autoradiography of neuropeptide Y Y1 and Y2 receptor subtypes in rat brain using agonist stimulated [35S]GTPgammaS binding.

Journal: Journal of chemical neuroanatomy 20031101

Title: The ability of neuropeptide Y to mediate responses in the murine cutaneous microvasculature: an analysis of the contribution of Y1 and Y2 receptors.

Journal: British journal of pharmacology 20030901

Title: Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.

Journal: British journal of pharmacology 20030601

Title: Obesity drug pipeline not so fat.

Journal: Science (New York, N.Y.) 20030207

Title: Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice.

Journal: Diabetes 20021201

Title: Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism.

Journal: Molecular and cellular endocrinology 20011220

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SDS
Tags:123583-37-9 Molecular Formula|123583-37-9 MDL|123583-37-9 SMILES|123583-37-9 Peptide YY (3-36) (human) trifluoroacetate salt H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 trifluoroacetate salt