23491-44-3,MFCD00044760
Catalog No.:AA01EMZ6

23491-44-3 | Hoechst 33258

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Purity
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Price(USD)
Quantity
  
100mg
97%
in stock  
$211.00   $148.00
- +
250mg
97%
in stock  
$411.00   $288.00
- +
1g
97%
in stock  
$1,009.00   $706.00
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5g
97%
in stock  
$3,504.00   $2,453.00
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10g
97%
in stock  
$5,997.00 $4,198.00
  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA01EMZ6
Chemical Name:
Hoechst 33258
CAS Number:
23491-44-3
Molecular Formula:
C25H24N6O
Molecular Weight:
424.4977
MDL Number:
MFCD00044760
SMILES:
CN1CCN(CC1)c1ccc2c(c1)[nH]c(n2)c1ccc2c(c1)[nH]c(n2)c1ccc(cc1)O
Properties
Computed Properties
 
Complexity:
634  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4  

Literature

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Title: Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells.

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Title: Noninvasive near-infrared live imaging of human adult mesenchymal stem cells transplanted in a rodent model of Parkinson's disease.

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Title: α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase.

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Title: Escherichia coli induces apoptosis in human monocytic U937 cells through the Fas/FasL signaling pathway.

Journal: Molecular and cellular biochemistry 20111201

Title: Intracerebroventricular administration of human umbilical cord blood cells delays disease progression in two murine models of motor neuron degeneration.

Journal: Rejuvenation research 20111201

Title: Semi-quantitative detection of gene expression using bisbenzimide dye.

Journal: Genetics and molecular research : GMR 20111122

Title: Silica nanoparticles based label-free aptamer hybridization for ATP detection using hoechst33258 as the signal reporter.

Journal: Biosensors & bioelectronics 20111115

Title: Cytofluorometric detection of rodent malaria parasites using red-excited fluorescent dyes.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20111101

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Journal: Chemistry & biology 20111028

Title: Light-controlled DNA binding of bisbenzamidines.

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Title: Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells.

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Title: Detection of DNA-ligand binding oscillations by Stokes-shift measurements.

Journal: Angewandte Chemie (International ed. in English) 20110926

Title: A photoinduced pH jump applied to drug release from cucurbit[7]uril.

Journal: Chemical communications (Cambridge, England) 20110821

Title: Supramolecular assembly of Hoechst-33258 with cucurbit[7]uril macrocycle.

Journal: Physical chemistry chemical physics : PCCP 20110728

Title: Suppression of the notch signaling pathway by γ-secretase inhibitor GSI inhibits human nasopharyngeal carcinoma cell proliferation.

Journal: Cancer letters 20110701

Title: DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing.

Journal: Chemistry, an Asian journal 20110606

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Journal: Journal of photochemistry and photobiology. B, Biology 20110503

Title: Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways.

Journal: European journal of pharmacology 20110425

Title: Dimeric bisbenzimidazoles inhibit the DNA methylation catalyzed by the murine Dnmt3a catalytic domain.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110401

Title: The effects of Tag-1 on the maturation of mouse cerebellar granule neurons.

Journal: Cellular and molecular neurobiology 20110401

Title: Label-free aptamer-based sensors for L-argininamide by using nucleic acid minor groove binding dyes.

Journal: Chemical communications (Cambridge, England) 20110321

Title: Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.

Journal: Cellular and molecular neurobiology 20110301

Title: Evaluation of osteoclastic resorption activity using calcium phosphate coating combined with labeled polyanion.

Journal: Analytical biochemistry 20110301

Title: Gateways of ventral and dorsal streams in mouse visual cortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110202

Title: Neuronal apoptosis in the developing cerebellum.

Journal: Anatomia, histologia, embryologia 20110201

Title: pH and temperature dependent relaxation dynamics of Hoechst-33258: a time resolved fluorescence study.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101

Title: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.

Journal: Radiation oncology (London, England) 20110101

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Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110101

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Title: The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi.

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Journal: Vascular health and risk management 20110101

Title: MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by BCL2 insufficiency.

Journal: American journal of nephrology 20110101

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Title: Characterization of PicoGreen interaction with dsDNA and the origin of its fluorescence enhancement upon binding.

Journal: Biophysical journal 20101103

Title: Osmolyte changes the binding affinity and mode of interaction of minor groove binder hoechst 33258 with calf thymus DNA.

Journal: Chemical & pharmaceutical bulletin 20101101

Title: Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression.

Journal: Die Pharmazie 20101101

Title: Use of fluorescent probes as a useful tool to identify resistant Schistosoma mansoni isolates to praziquantel.

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Journal: Journal of experimental botany 20100701

Title: Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.

Journal: Acta pharmacologica Sinica 20100601

Title: Minor groove dimeric bisbenzimidazoles inhibit in vitro DNA binding to eukaryotic DNA topoisomerase I.

Journal: Biochemistry. Biokhimiia 20100601

Title: Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells.

Journal: Journal of Asian natural products research 20100301

Title: Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.

Journal: Journal of medicinal chemistry 20100211

Title: Collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer scaffold for nucleus pulposus tissue engineering.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20100201

Title: Molecular aspects of the interaction of Hoechst-33258 with GC-rich promoter region of c-met.

Journal: DNA and cell biology 20100201

Title: [Ru(phen)2(dppz)]2+ as an efficient optical probe for staining nuclear components.

Journal: Journal of inorganic biochemistry 20100201

Title: Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.

Journal: Journal of medicinal chemistry 20100128

Title: Triple recognition of B-DNA by a neomycin-Hoechst 33258-pyrene conjugate.

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Journal: Histology and histopathology 20091201

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Title: Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells.

Journal: European journal of pharmacology 20090610

Title: Binding of Hoechst 33258 and its derivatives to DNA.

Journal: Journal of biomolecular structure & dynamics 20090601

Title: Apparent non-statistical binding in a ditopic receptor for guanosine.

Journal: Organic & biomolecular chemistry 20090521

Title: Oxidative stress and apoptotic changes in primary cultures of rat proximal tubular cells exposed to lead.

Journal: Archives of toxicology 20090501

Title: Interaction of DNA minor groove binder Hoechst 33258 with bovine serum albumin.

Journal: Chemical & pharmaceutical bulletin 20090501

Title: Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform.

Journal: Molecular nutrition & food research 20090401

Title: Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles.

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Title: Compatibility of hyaluronic acid hydrogel and skeletal muscle myoblasts.

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Title: In vitro anti-cancer activity of two ethno-pharmacological healing plants from Guatemala Pluchea odorata and Phlebodium decumanum.

Journal: International journal of oncology 20090401

Title: Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures.

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Title: Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines.

Journal: Bioorganic & medicinal chemistry 20090315

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Title: DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes.

Journal: European journal of medicinal chemistry 20081001

Title: The dynamics of water at DNA interfaces: computational studies of Hoechst 33258 bound to DNA.

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Title: A new method for determining blood-brain barrier integrity based on intracardiac perfusion of an Evans Blue-Hoechst cocktail.

Journal: Journal of neuroscience methods 20080915

Title: Calorimetric and spectroscopic studies of Hoechst 33258: self-association and binding to non-cognate DNA.

Journal: Journal of molecular biology 20080905

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Journal: Acta biochimica et biophysica Sinica 20080901

Title: Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells).

Journal: Toxicology letters 20080828

Title: Hoechst 33258--poly(dG-dC).poly(dG-dC) complexes of three types.

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Title: Influence of DNA structure on adjacent site cooperative binding.

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Title: The effects of local DNA sequence on the interaction of ligands with their preferred binding sites.

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Title: Culture condition and embryonic stage dependent silence of glucocorticoid receptor expression in hippocampal neurons.

Journal: The Journal of steroid biochemistry and molecular biology 20080701

Title: Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma.

Journal: Cancer chemotherapy and pharmacology 20080601

Title: Influence of ionic strength on Hoechst 33258 binding with DNA.

Journal: Journal of biomolecular structure & dynamics 20080601

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Journal: Apoptosis : an international journal on programmed cell death 20080601

Title: Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD.

Journal: Biological & pharmaceutical bulletin 20080601

Title: Novel bisbenzimidazoles with antileishmanial effectiveness.

Journal: Bioorganic & medicinal chemistry letters 20080415

Title: Involvement of transcription factor activator protein-2alpha in doxazosin-induced HeLa cell apoptosis.

Journal: Acta pharmacologica Sinica 20080401

Title: Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells.

Journal: Biological & pharmaceutical bulletin 20080401

Title: Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes.

Journal: Journal of cellular and molecular medicine 20080401

Title: Apoptosis of HeLa cells induced by cisplatin and its mechanism.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080401

Title: Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells.

Journal: Acta pharmacologica Sinica 20080301

Title: Dynamics in the DNA recognition by DAPI: exploration of the various binding modes.

Journal: The journal of physical chemistry. B 20080124

Title: The flavonoid rutin induces astrocyte and microglia activation and regulates TNF-alpha and NO release in primary glial cell cultures.

Journal: Cell biology and toxicology 20080101

Title: Biosensor-surface plasmon resonance methods for quantitative analysis of biomolecular interactions.

Journal: Methods in cell biology 20080101

Title: Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells.

Journal: Cellular and molecular neurobiology 20080101

Title: Selective COX-2 inhibitor celecoxib combined with EGFR-TKI ZD1839 on non-small cell lung cancer cell lines: in vitro toxicity and mechanism study.

Journal: Medical oncology (Northwood, London, England) 20080101

Title: [Synthesis and properties of a symmetric dimeric bisbenzimidazole, a DNA-specific ligand].

Journal: Bioorganicheskaia khimiia 20080101

Title: The effects of vinblastine on endothelial cells.

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Title: Low-power laser irradiation inhibiting Abeta25-35-induced PC12 cell apoptosis via PKC activation.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

Title: Biomimetic modeling of copper complexes: a study of enantioselective catalytic oxidation on d-(+)-catechin and L-( - )-epicatechin with copper complexes.

Journal: Bioinorganic chemistry and applications 20080101

Title: Antiproliferative property and apoptotic effect of xanthorrhizol on MDA-MB-231 breast cancer cells.

Journal: Anticancer research 20080101

Title: Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.

Journal: Drug design, development and therapy 20080101

Title: Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by inhibiting caspase activation.

Journal: Journal of cellular physiology 20071201

Title: Three-dimensional cell organization leads to a different type of ionizing radiation-induced cell death: MG-63 monolayer cells undergo mitotic catastrophe while spheroids die of apoptosis.

Journal: International journal of oncology 20071201

Title: A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium.

Journal: Toxicology 20071120

Title: Nuclear condensation and free radical scavenging: a dual mechanism of bisbenzimidazoles to modulate radiation damage to DNA.

Journal: Molecular and cellular biochemistry 20071101

Title: Influence of surface shape on DNA binding of bimetallo helicates.

Journal: Journal of inorganic biochemistry 20071101

Title: Interaction of Hoechst 33258 and ethidium with histone1-DNA condensates.

Journal: Biomacromolecules 20071101

Title: Generation of human epidermal constructs on a collagen layer alone.

Journal: Tissue engineering 20071101

Title: Direct observation of essential DNA dynamics: melting and reformation of the DNA minor groove.

Journal: The journal of physical chemistry. B 20070913

Title: The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells.

Journal: Cell biology international 20070901

Title: Effect of fibroblast growth factor-2 on equine mesenchymal stem cell monolayer expansion and chondrogenesis.

Journal: American journal of veterinary research 20070901

Title: Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis.

Journal: Oncology reports 20070801

Title: Purification of the Prep1 interactome identifies novel pathways regulated by Prep1.

Journal: Proteomics 20070801

Title: Fluorescent DNA probes: study of mechanisms of changes in spectral properties and features of practical application.

Journal: Biochemistry. Biokhimiia 20070801

Title: Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitro.

Journal: Gastroenterology 20070701

Title: Multiple binding modes for dicationic Hoechst 33258 to DNA.

Journal: The journal of physical chemistry. B 20070628

Title: Concentration dependence of the mechanisms of tributyltin-induced apoptosis.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070601

Title: Cytoprotective effects of selenium on cadmium-induced LLC-PK1 cells apoptosis by activating JNK pathway.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070601

Title: Molecular modelling methods for prediction of sequence-selectivity in DNA recognition.

Journal: Methods (San Diego, Calif.) 20070601

Title: Electrochemical DNA biosensor using a disposable electrochemical printed (DEP) chip for the detection of SNPs from unpurified PCR amplicons.

Journal: The Analyst 20070501

Title: [Effects of EGb 761 on the cell apoptosis induced by H2O2 in RIN-m beta cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070401

Title: An experimental and computational analysis on the differential role of the positional isomers of symmetric bis-2-(pyridyl)-1H-benzimidazoles as DNA binding agents.

Journal: The Journal of organic chemistry 20070316

Title: Antioxidative and oxidative changes in the digestive gland cells of freshwater mussels Unio tumidus caused by selected phenolic compounds in the presence of H(2)O(2) or Cu(2+) ions.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070201

Title: In vivo transcranial imaging of connections in mouse visual cortex.

Journal: Journal of neuroscience methods 20070130

Title: Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site.

Journal: Journal of molecular biology 20070119

Title: Deregulation of AP-1 proteins in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidity.

Journal: The Journal of biological chemistry 20070105

Title: Studies on the interactions between DNA and PAMAM with fluorescent probe [Ru(phen)2 dppz]2+.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Di-(2-ethylhexyl) phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells.

Journal: Archives of toxicology 20070101

Title: Equilibrium shift by target DNA substrates for determination of DNA binding ligands.

Journal: Bioorganic & medicinal chemistry letters 20070101

Title: Bile acid-oligopeptide conjugates interact with DNA and facilitate transfection.

Journal: Molecular pharmaceutics 20070101

Title: Strategies of kinetoplastid cryptogene discovery and analysis.

Journal: Methods in enzymology 20070101

Title: Carbocyclic analogues of lexitropsin--DNA affinity and endonuclease inhibition.

Journal: Acta poloniae pharmaceutica 20070101

Title: Somatostatin receptor subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on cell proliferation in cell line NCI-H727.

Journal: Anticancer research 20070101

Title: Synthesis and evaluation of intercalating somatostatin receptor binding peptide conjugates for endoradiotherapy.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

Title: Site-specific acetylation of ISWI by GCN5.

Journal: BMC molecular biology 20070101

Title: Sensing of nucleic acid sequences using unmodified nucleic acid as a probe.

Journal: Nucleic acids symposium series (2004) 20070101

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Journal: Bioorganicheskaia khimiia 20070101

Title: Cadmium-induced apoptosis in rat hepatocytes does not necessarily involve caspase-dependent pathways.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20061201

Title: Heat shock protein 40/DjB1 is required for thermotolerance in early phase.

Journal: Journal of biochemistry 20061201

Title: The Hoechst 33258 covalent dimer covers a total turn of the double-stranded DNA.

Journal: Journal of biomolecular structure & dynamics 20061201

Title: 15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism.

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Title: Irbesartan attenuates contrast media-induced NRK-52E cells apoptosis.

Journal: Pharmacological research 20061001

Title: Crocetin prevents AGEs-induced vascular endothelial cell apoptosis.

Journal: Pharmacological research 20061001

Title: Triple helix stabilization by covalently linked DNA-bisbenzimidazole conjugate synthesized by maleimide-thiol coupling chemistry.

Journal: Bioorganic & medicinal chemistry 20060915

Title: Lipid peroxidation during human cerebral myelination.

Journal: Journal of neuropathology and experimental neurology 20060901

Title: Calcium and reactive oxygen species mediated Zn2+ -induced apoptosis in PC12 cells.

Journal: Journal of pharmacological sciences 20060901

Title: Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death.

Journal: Biochemical and biophysical research communications 20060721

Title: DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.

Journal: Bioorganic & medicinal chemistry letters 20060715

Title: Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells.

Journal: Biomaterials 20060601

Title: DNA targeted UVA photosensitization: characterization of an extremely photopotent iodinated minor groove binding DNA ligand.

Journal: Journal of photochemistry and photobiology. B, Biology 20060601

Title: Simultaneous quantitative measurement of luciferase reporter activity and cell number in two- and three-dimensional cultures of hepatitis C virus replicons.

Journal: Analytical biochemistry 20060315

Title: Responses of the surface membrane and excretory system of Schistosoma mansoni to damage and to treatment with praziquantel and other biomolecules.

Journal: Parasitology 20060301

Title: [Neuroprotection of chloride channel blockers against NMDA-induced apoptosis of cultured rat hippocampal neurons].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201

Title: Design of new bidentate ligands constructed of two Hoechst 33258 units for discrimination of the length of two A3T3 binding motifs.

Journal: The Journal of organic chemistry 20060106

Title: The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2.

Journal: Bioorganic & medicinal chemistry 20060101

Title: Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.

Journal: Experimental parasitology 20060101

Title: Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen.

Journal: Journal of endotoxin research 20060101

Title: Antitumor effects of 3,3',4,4',5,5'-hexahydroxystilbene in HL-60 human promyelocytic leukemia cells.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: Apoptosis assays.

Journal: Methods in molecular medicine 20060101

Title: Hydration changes in the association of Hoechst 33258 with DNA.

Journal: Biochemistry 20051227

Title: Recognition of a 10 base pair sequence of DNA and stereochemical control of the binding affinity of chiral hairpin polyamide-Hoechst 33258 conjugates.

Journal: Bioorganic & medicinal chemistry letters 20051215

Title: Mechanisms of induction of apoptosis by anthraquinone anticancer drugs aclarubicin and mitoxantrone in comparison with doxorubicin: relation to drug cytotoxicity and caspase-3 activation.

Journal: Apoptosis : an international journal on programmed cell death 20051201

Title: DNA breakage by decay of Auger electron emitters: experiments with 123I-iodoHoechst 33258 and plasmid DNA.

Journal: Radiation research 20051201

Title: Coordinates, DNA content and heterogeneity of cell nuclei and segments of the Caenorhabditis elegans intestine.

Journal: Histochemistry and cell biology 20051101

Title: Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis.

Journal: Biological & pharmaceutical bulletin 20051101

Title: Role of c-Fos protein on glutamate toxicity in primary neural hippocampal cells.

Journal: Journal of neuroscience research 20051001

Title: Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells.

Journal: Oncology reports 20051001

Title: The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: time- and p53 expression-dependency of anti-cancer drugs.

Journal: Oncology reports 20050901

Title: DNA labeling in living cells.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20050901

Title: Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity.

Journal: Chemical research in toxicology 20050901

Title: Nature of minor-groove binders-DNA complexes in the gas phase.

Journal: Journal of the American Chemical Society 20050824

Title: Theoretical study of molecular recognition by Hoechst 33258 derivatives.

Journal: Journal of biomolecular structure & dynamics 20050801

Title: Resistance mechanism development to the topoisomerase-I inhibitor Hoechst 33342 by Leishmania donovani.

Journal: Parasitology 20050801

Title: Association of the minor groove binding drug Hoechst 33258 with d(CGCGAATTCGCG)2: volumetric, calorimetric, and spectroscopic characterizations.

Journal: Biochemistry 20050719

Title: Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury.

Journal: Microvascular research 20050701

Title: Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis.

Journal: Thrombosis and haemostasis 20050701

Title: A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes.

Journal: Biophysical journal 20050601

Title: Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor.

Journal: Neuropharmacology 20050601

Title: Synthesis, DNA binding, topoisomerase inhibition and cytotoxic properties of 2-chloroethylnitrosourea derivatives of hoechst 33258.

Journal: Biological & pharmaceutical bulletin 20050601

Title: Determination of the exact copy numbers of particular mRNAs in a single cell by quantitative real-time RT-PCR.

Journal: The Journal of experimental biology 20050601

Title: Quantitative aspects of endocytic activity in lipid-mediated transfections.

Journal: FEBS letters 20050509

Title: Construction of an electrochemical DNA chip for simultaneous genotyping of single nucleotide polymorphisms.

Journal: The Analyst 20050501

Title: Visualization of early embryos of the butterfly Bicyclus anynana.

Journal: Zygote (Cambridge, England) 20050501

Title: Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival.

Journal: The Journal of biological chemistry 20050429

Title: Assay for the quantification of small-sized fragmented genomic DNA.

Journal: Analytical biochemistry 20050415

Title: The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression.

Journal: The journal of gene medicine 20050401

Title: Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma.

Journal: Oncology reports 20050401

Title: Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro.

Journal: Oncology reports 20050401

Title: Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis.

Journal: Antimicrobial agents and chemotherapy 20050401

Title: Retinal toxicity of commercial tissue plasminogen activator is mediated by the induction of nitric oxide in the mouse retinal primary cells.

Journal: Current eye research 20050401

Title: p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.

Journal: Journal of neuroscience research 20050315

Title: Unique cooperative binding interaction observed between a minor groove binding Pt antitumor agent and Hoechst dye 33258.

Journal: Inorganic chemistry 20050307

Title: Determination of cell concentration in a plant cell suspension using a fluorescence microplate reader.

Journal: Plant cell reports 20050301

Title: High-resolution simultaneous three-photon fluorescence and third-harmonic-generation microscopy.

Journal: Microscopy research and technique 20050301

Title: In vivo characterization of developing chronic pancreatitis in rats.

Journal: Laboratory investigation; a journal of technical methods and pathology 20050201

Title: Assessment of boar semen quality in relation to fertility with special reference to methanol stress.

Journal: Theriogenology 20050201

Title: Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.

Journal: Neuroscience research 20050201

Title: Fluorescence spectroscopic studies to characterize the internal environment of tetraethyl-orthosilicate derived sol-gel bulk and thin films with aging.

Journal: Biosensors & bioelectronics 20050115

Title: Hoechst 33258 as a pH-sensitive probe to study the interaction of amine oxide surfactants with DNA.

Journal: Chembiochem : a European journal of chemical biology 20050101

Title: Oleic acid causes apoptosis and dephosphorylates Bad.

Journal: Neurochemistry international 20050101

Title: Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells.

Journal: Journal of applied toxicology : JAT 20050101

Title: [Ligands with affinity to specific sequence of DNA base pairs. XII. The synthesis and cytological studies of dimeric Hoechst 33258 molecules].

Journal: Bioorganicheskaia khimiia 20050101

Title: Calcium alginate microencapsulation of ovarian follicles impacts FSH delivery and follicle morphology.

Journal: Reproductive biology and endocrinology : RB&E 20050101

Title: Leptin does not induce hypertrophy, cell cycle alterations, or production of MCP-1 in cultured rat and mouse cardiomyocytes.

Journal: Endocrine research 20050101

Title: Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groove binders.

Journal: Nucleic acids symposium series (2004) 20050101

Title: Heterogeneity in the radiosensitizing effects of the DNA ligand hoechst-33342 in human tumor cell lines.

Journal: Journal of cancer research and therapeutics 20050101

Title: Sister chromatid exchange.

Journal: Current protocols in cell biology 20050101

Title: Hoechst 33258 selectively inhibits group I intron self-splicing by affecting RNA folding.

Journal: Chembiochem : a European journal of chemical biology 20041203

Title: DNA ligand Hoechst-33342 enhances UV induced cytotoxicity in human glioma cell lines.

Journal: Journal of photochemistry and photobiology. B, Biology 20041202

Title: Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules.

Journal: Biomaterials 20041201

Title: DNA condensation monitoring after interaction with hoechst 33258 by atomic force microscopy and fluorescence spectroscopy.

Journal: Journal of biochemistry 20041201

Title: Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258.

Journal: Biophysical chemistry 20041101

Title: Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.

Journal: Neuropharmacology 20041101

Title: p75(NTR)-immunoreactivity in the subventricular zone of adult male rats: expression by cycling cells.

Journal: Journal of molecular histology 20041101

Title: Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041001

Title: Membrane-permeant, DNA-binding agents alter intracellular trafficking and increase the transfection efficiency of complexed plasmid DNA.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20041001

Title: Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20041001

Title: Comparative investigation of the biocompatibility of various silicon nitride ceramic qualities in vitro.

Journal: Journal of materials science. Materials in medicine 20041001

Title: Inhibition of Leishmania donovani promastigote DNA topoisomerase I and human monocyte DNA topoisomerases I and II by antimonial drugs and classical antitopoisomerase agents.

Journal: The Journal of parasitology 20041001

Title: Cytotoxic and apoptotic effects of novel heterodinucleoside phosphates consisting of 5-fluorodeoxyuridine and Ara-C in human cancer cell lines.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Layer-by-layer self-assembly of multilayer films containing DNA and Eu3+: their characteristics and interactions with small molecules.

Journal: Langmuir : the ACS journal of surfaces and colloids 20040817

Title: [Principle of determining the composition of complexes with the ratio of double peak values at double wavelengths by UV spectrophotometry].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20040801

Title: DNA sequence recognition in the minor groove by hairpin pyrrole polyamide-Hoechst 33258 analogue conjugate.

Journal: Bioorganic & medicinal chemistry letters 20040716

Title: Effect of LNA modifications on small molecule binding to nucleic acids.

Journal: Journal of biomolecular structure & dynamics 20040601

Title: Comparison of two techniques to evaluate the acrosomal status of zona pellucida bound sperm in humans.

Journal: Andrologia 20040601

Title: Specific interactions of quercetin and other flavonoids with target proteins are revealed by elicited fluorescence.

Journal: Biochemical and biophysical research communications 20040528

Title: Loss of Gli3 and Shh function disrupts olfactory axon trajectories.

Journal: The Journal of comparative neurology 20040503

Title: Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range.

Journal: Analytical biochemistry 20040501

Title: Cyclic adenosine monophosphate inhibits nitric oxide-induced apoptosis of cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner.

Journal: Immunopharmacology and immunotoxicology 20040501

Title: Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20040401

Title: Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) tethering a Hoechst 33258 analogue: triplex and duplex stabilization by simultaneous minor groove binding.

Journal: Journal of the American Chemical Society 20040331

Title: Amplification of nuclear aldolase A in mouse cell mutants resistant to Hoechst 33342.

Journal: Biochemical and biophysical research communications 20040319

Title: Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox.

Journal: Immunopharmacology and immunotoxicology 20040201

Title: Induction and detection of bystander effects after combined treatment of cells with 5-bromo-2'-deoxyurine, Hoechst 33 258 and ultraviolet A light.

Journal: International journal of radiation biology 20040201

Title: Optimization of an Acridine Orange-bisbenzimide procedure for the detection of apoptosis-associated fluorescence colour changes in etoposide-treated cell cultures.

Journal: Journal of molecular histology 20040201

Title: DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives.

Journal: Journal of the American Chemical Society 20040114

Title: Stem cells and nervous tissue repair: from in vitro to in vivo.

Journal: Progress in brain research 20040101

Title: Cell-cycle analysis of asynchronous populations.

Journal: Methods in molecular biology (Clifton, N.J.) 20040101

Title: Aromatic analogues of DNA minor groove binders--synthesis and biological evaluation.

Journal: European journal of medicinal chemistry 20040101

Title: Immunocytochemical techniques for studying apoptosis in primary sympathetic neurons.

Journal: Methods in molecular biology (Clifton, N.J.) 20040101

Title: [DNA-specific dimeric bisbenzimidazole].

Journal: Bioorganicheskaia khimiia 20040101

Title: Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action.

Journal: The Journal of international medical research 20040101

Title: Mitochondrial membrane potential change induced by Hoechst 33342 in myelogenous leukemia cell line HL-60.

Journal: Annals of clinical and laboratory science 20040101

Title: Plasmid DNA breakage by decay of DNA-associated auger emitters: experiments with 123I/125I-iodoHoechst 33258.

Journal: International journal of radiation biology 20040101

Title: Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury.

Journal: The Journal of comparative neurology 20031222

Title: Minor groove binding DNA ligands with expanded A/T sequence length recognition, selective binding to bent DNA regions and enhanced fluorescent properties.

Journal: Biochemistry 20031118

Title: Temperature induced hyperchromism exhibited by Hoechst 33258: evidence of drug aggregation from UV-melting method.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031101

Title: Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles.

Journal: European journal of cancer (Oxford, England : 1990) 20031101

Title: Fluorometric quantification of RNA and DNA in solutions containing both nucleic acids.

Journal: Analytical biochemistry 20031101

Title: Hoechst 33258 binds to G-quadruplex in the promoter region of human c-myc.

Journal: Biochemical and biophysical research communications 20031017

Title: Reaching into the major groove of B-DNA: synthesis and nucleic acid binding of a neomycin-hoechst 33258 conjugate.

Journal: Journal of the American Chemical Society 20031015

Title: Lithium inhibits apoptosis of mouse neural progenitor cells.

Journal: Neuroreport 20031006

Title: Selection of bacteriophage-resistant mutants of Streptococcus thermophilus.

Journal: Journal of microbiological methods 20031001

Title: Location of CNTFRalpha on outer segments: evidence of the site of action of CNTF in rat retina.

Journal: Brain research 20030926

Title: Hoechst 33342 alters luciferase gene expression in transfected BC3H-1 myocytes.

Journal: Archives of pathology & laboratory medicine 20030901

Title: Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20030901

Title: Influence of phenyl ring disubstitution on bisbenzimidazole and terbenzimidazole cytotoxicity: synthesis and biological evaluation as radioprotectors.

Journal: Journal of medicinal chemistry 20030828

Title: Copper complex of hydroxyl-substituted triazamacrocyclic ligand and its antitumor activity.

Journal: Bioorganic & medicinal chemistry letters 20030804

Title: Intravenously administered propidium iodide labels necrotic cells in the intact mouse brain after injury.

Journal: Cell death and differentiation 20030801

Title: Differential responses of human neural and hematopoietic stem cells to ethanol exposure.

Journal: Journal of hematotherapy & stem cell research 20030801

Title: Chemistry of minor groove binder-oligonucleotide conjugates.

Journal: Current protocols in nucleic acid chemistry 20030801

Title: Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases.

Journal: Neurochemistry international 20030701

Title: A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles.

Journal: Journal of pharmaceutical sciences 20030601

Title: Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.

Journal: Cancer gene therapy 20030601

Title: Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction.

Journal: Journal of molecular and cellular cardiology 20030601

Title: Biochemical studies of apoptosis induced by tamoxifen in estrogen receptor positive and negative breast cancer cell lines.

Journal: Clinical biochemistry 20030601

Title: Lack of inverse dose-rate effect and binding of the retinoblastoma gene product in the nucleus of human cancer T-47D cells arrested in G2 by ionizing radiation.

Journal: International journal of radiation biology 20030601

Title: Membrane changes during different stages of a freeze-thaw protocol for equine semen cryopreservation.

Journal: Theriogenology 20030415

Title: Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma.

Journal: Bulletin of experimental biology and medicine 20030401

Title: Global chromosome positions are transmitted through mitosis in mammalian cells.

Journal: Cell 20030321

Title: Synthesis and DNA binding studies of a new asymmetric cyanine dye binding in the minor groove of [poly(dA-dT)]2.

Journal: Bioorganic & medicinal chemistry 20030320

Title: Mode of cell death induced in Chinese hamster cells by sequence-selective DNA minor groove binding nitrogen mustards: comparison with untargeted mustards and with Hoechst 33342.

Journal: Oncology research 20030101

Title: Membrane status and in vitro capacitation of porcine sperm preserved in long-term extender at 16 degrees C.

Journal: Archives of andrology 20030101

Title: Human granulosa cells after ovulation induction show caspase-independent cell death.

Journal: Gynecologic and obstetric investigation 20030101

Title: Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

Journal: Biochemistry 20021217

Title: TGF-beta1 inhibits multiple caspases induced by TNF-alpha in murine osteoblastic MC3T3-E1 cells.

Journal: Biochimica et biophysica acta 20021216

Title: Apoptosis: biochemical aspects and clinical implications.

Journal: Clinica chimica acta; international journal of clinical chemistry 20021201

Title: Quantifying DNA concentrations using fluorometry: a comparison of fluorophores.

Journal: Molecular vision 20021106

Title: Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.

Journal: Journal of medicinal chemistry 20020926

Title: Targeted elimination of the follicular label-retaining cells by photo-induced cell killing caused a defect on follicular renewal on mice.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20020901

Title: Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures.

Journal: AAPS pharmSci 20020901

Title: Constitutive caspase-like machinery executes programmed cell death in plant cells.

Journal: Cell death and differentiation 20020701

Title: Synthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cells.

Journal: Biological & pharmaceutical bulletin 20020701

Title: Synergistic induction of the senescence-associated genes by 5-bromodeoxyuridine and AT-binding ligands in HeLa cells.

Journal: Experimental cell research 20020610

Title: Circular dichroism and thermal melting differentiation of Hoechst 33258 binding to the curved (A(4)T(4)) and straight (T(4)A(4)) DNA sequences.

Journal: Biochimica et biophysica acta 20020607

Title: Amyloglucosidase suppresses interference by glycogen in the quantification of DNA using the Hoechst 33258 dye.

Journal: BioTechniques 20020601

Title: Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse.

Journal: Mechanisms of development 20020601

Title: Protective effect of L-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells.

Journal: Cancer letters 20020408

Title: Evaluation of acrosome reaction and viability of human sperm with two fluorescent dyes.

Journal: Archives of gynecology and obstetrics 20020401

Title: Interaction of Hoechst 33258 and echinomycin with nucleosomal DNA fragments containing isolated ligand binding sites.

Journal: Biochemistry 20020312

Title: New lanostanoids from the fungus Ganoderma concinna.

Journal: Journal of natural products 20020301

Title: Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals.

Journal: Chromosoma 20020301

Title: Base-sequence specificity of Hoechst 33258 and DAPI binding to five (A/T)4 DNA sites with kinetic evidence for more than one high-affinity Hoechst 33258-AATT complex.

Journal: Journal of molecular biology 20020201

Title: Visualization of complexes of Hoechst 33258 and DNA duplexes in solution by atomic force microscopy.

Journal: Chemical & pharmaceutical bulletin 20020201

Title: Mechanism of tert-butylhydroperoxide induced apoptosis in rat hepatocytes: involvement of mitochondria and endoplasmic reticulum.

Journal: Biochimica et biophysica acta 20020130

Title: Immunocytochemical analysis of neuronal differentiation.

Journal: Methods in molecular biology (Clifton, N.J.) 20020101

Title: [A cross drug resistance of mammalian cells with a high efficiency of 'DNA clearing'].

Journal: Tsitologiia 20020101

Title: NMR characterization of the DNA binding properties of a novel Hoechst 33258 analogue peptide building block.

Journal: Bioconjugate chemistry 20020101

Title: Cooperativity in drug-DNA recognition: a molecular dynamics study.

Journal: Journal of the American Chemical Society 20011219

Title: Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition.

Journal: Bioorganic & medicinal chemistry 20011101

Title: Low-dose hypersensitivity in Chinese hamster V79 cells targeted with counted protons using a charged-particle microbeam.

Journal: Radiation research 20011101

Title: Texture analysis of fluorescence lifetime images of AT- and GC-rich regions in nuclei.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20011101

Title: Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells.

Journal: Journal of immunological methods 20011001

Title: Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin.

Journal: International journal of oncology 20011001

Title: Effects of humic substances on fluorometric DNA quantification and DNA hybridization.

Journal: Journal of microbiological methods 20011001

Title: Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo.

Journal: Carcinogenesis 20011001

Title: Effect of homologous preovulatory follicular fluid on in vitro maturation of equine cumulus-oocyte complexes.

Journal: Theriogenology 20010915

Title: Dentate granule neuron apoptosis and glia activation in murine hippocampus induced by trimethyltin exposure.

Journal: Brain research 20010907

Title: In situ staining with DNA-binding fluorescent dye, Hoechst 33258, to detect microorganisms in the epithelial cells of oral leukoplakia.

Journal: Oral oncology 20010901

Title: Significance of ligand tails for interaction with the minor groove of B-DNA.

Journal: Biophysical journal 20010901

Title: Combined prostaglandin and nitric oxide inhibition produces anatomic remodeling and closure of the ductus arteriosus in the premature newborn baboon.

Journal: Pediatric research 20010901

Title: Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells.

Journal: Free radical biology & medicine 20010901

Title: Synergistic effects of nicotine on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20010901

Title: Effect of antioxidants on preservation of motility,viability and acrosomal integrity of equine spermatozoa during storage at 5 degrees C.

Journal: Theriogenology 20010901

Title: Experimental precedent for the need to involve the primary hydration layer of DNA in lead drug design.

Journal: Journal of medicinal chemistry 20010802

Title: Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma.

Journal: Cancer gene therapy 20010801

Title: Synthesis of a dA-dT base pair analogue and its effects on DNA-ligand binding.

Journal: Bioorganic chemistry 20010801

Title: Implication of the small GTPase Rac1 in the apoptosis induced by UV in Rat-2 fibroblasts.

Journal: Biochemical and biophysical research communications 20010720

Title: Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E(2) production and neurodegeneration in cortical and hippocampal cell cultures.

Journal: Brain research 20010720

Title: A simple method for classification of cell death by use of thin layer collagen gel for the detection of apoptosis and/or necrosis after cancer chemotherapy.

Journal: Japanese journal of cancer research : Gann 20010701

Title: A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.

Journal: Journal of the American Chemical Society 20010627

Title: The protective role of HSP90 against 3-hydroxykynurenine-induced neuronal apoptosis.

Journal: Biochemical and biophysical research communications 20010608

Title: Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death.

Journal: Biochemical and biophysical research communications 20010601

Title: DNA minor-groove recognition by small molecules.

Journal: Natural product reports 20010601

Title: Double-stranded DNA binding characteristics and subcellular distribution of a minor groove binding diphenyl ether bisbenzimidazole.

Journal: Biochemistry 20010529

Title: Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010501

Title: Witness to a miracle: the initial cortisone trial: an interview with Richard Freyberg, MD. Interview by Mary Ellen Warner.

Journal: Mayo Clinic proceedings 20010501

Title: Analysis of sister-chromatid exchanges.

Journal: Current protocols in human genetics 20010501

Title: Quantitation of DNA and RNA with absorption and fluorescence spectroscopy.

Journal: Current protocols in immunology 20010501

Title: Serpin protein CrmA suppresses hypoxia-mediated apoptosis of ventricular myocytes.

Journal: Circulation 20010417

Title: Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs.

Journal: Molecular pharmacology 20010401

Title: Recent developments in sequence selective minor groove DNA effectors.

Journal: Current medicinal chemistry 20010401

Title: DNA minor groove alkylating agents.

Journal: Current medicinal chemistry 20010401

Title: Direct and sensitized photoprocesses of bis-benzimidazole dyes and the effects of surfactants and DNA.

Journal: Photochemistry and photobiology 20010401

Title: Hoechst 33342-induced apoptosis is associated with decreased immunoreactive topoisomerase I and topoisomerase I-DNA complex formation.

Journal: Annals of clinical and laboratory science 20010401

Title: Recognition of nine base pairs in the minor groove of DNA by a tripyrrole peptide-Hoechst conjugate.

Journal: Journal of the American Chemical Society 20010321

Title: Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro.

Journal: Clinical oral investigations 20010301

Title: Synthesis, crystal structure, spectral studies, and catechol oxidase activity of trigonal bipyramidal Cu(II) complexes derived from a tetradentate diamide bisbenzimidazole ligand.

Journal: Inorganic chemistry 20010226

Title: Cytotoxicity of fluoride on human pulp cell cultures in vitro.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010201

Title: Stimulating effect of an arteriovenous shunt on the in vivo growth of isografted fibroblasts: a preliminary report.

Journal: Tissue engineering 20010201

Title: High- and low-LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase.

Journal: International journal of radiation biology 20010201

Title: Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells.

Journal: Journal of neuropathology and experimental neurology 20010201

Title: A type 2A protein phosphatase gene from Aspergillus nidulans is involved in hyphal morphogenesis.

Journal: Current genetics 20010201

Title: Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia.

Journal: Journal of molecular neuroscience : MN 20010201

Title: Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: enzyme inhibitors which act by binding to substrate.

Journal: Biochemistry 20010123

Title: Biochemical characterization of the DNA helicase activity of the escherichia coli RecQ helicase.

Journal: The Journal of biological chemistry 20010105

Title: Hoechst 33342-induced apoptosis is associated with intracellular accumulation of E2F-1 protein in BC3H-1 myocytes and HL-60 cells.

Journal: Archives of pathology & laboratory medicine 20010101

Title: Intramitochondrial pyruvate attenuates hydrogen peroxide-induced apoptosis in bovine pulmonary artery endothelium.

Journal: Molecular and cellular biochemistry 20010101

Title: Ligand binding to oligonucleotides.

Journal: Methods in molecular biology (Clifton, N.J.) 20010101

Title: [Comparative study of DNA-specific dyes of the indole and benzimidazole derivates].

Journal: Bioorganicheskaia khimiia 20010101

Title: Binding of a porphyrin conjugate of Hoechst 33258 to DNA. I. UV-visible and melting studies detect multiple binding modes to a 12-mer nonself-complementary duplex.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Binding of a porphyrin conjugate of Hoechst 33258 to DNA. II. NMR spectroscopic studies detect multiple binding modes to a 12-mer nonself-complementary duplex DNA.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Binding of a desmetallo-porphyrin conjugate of Hoechst 33258 to DNA. III. Strong bonding to single-strand oligonucleotides.

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Tags:23491-44-3 Molecular Formula|23491-44-3 MDL|23491-44-3 SMILES|23491-44-3 Hoechst 33258
Catalog No.: AA01EMZ6
23491-44-3,MFCD00044760
23491-44-3 | Hoechst 33258
Pack Size: 100mg
Purity: 97%
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Pack Size: 250mg
Purity: 97%
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Purity: 97%
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Purity: 97%
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Technical Information
Catalog Number: AA01EMZ6
Chemical Name: Hoechst 33258
CAS Number: 23491-44-3
Molecular Formula: C25H24N6O
Molecular Weight: 424.4977
MDL Number: MFCD00044760
SMILES: CN1CCN(CC1)c1ccc2c(c1)[nH]c(n2)c1ccc2c(c1)[nH]c(n2)c1ccc(cc1)O
Properties
Complexity: 634  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4  
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Title: Di-(2-ethylhexyl) phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells.

Journal: Archives of toxicology20070101

Title: Equilibrium shift by target DNA substrates for determination of DNA binding ligands.

Journal: Bioorganic & medicinal chemistry letters20070101

Title: Bile acid-oligopeptide conjugates interact with DNA and facilitate transfection.

Journal: Molecular pharmaceutics20070101

Title: Strategies of kinetoplastid cryptogene discovery and analysis.

Journal: Methods in enzymology20070101

Title: Carbocyclic analogues of lexitropsin--DNA affinity and endonuclease inhibition.

Journal: Acta poloniae pharmaceutica20070101

Title: Somatostatin receptor subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on cell proliferation in cell line NCI-H727.

Journal: Anticancer research20070101

Title: Synthesis and evaluation of intercalating somatostatin receptor binding peptide conjugates for endoradiotherapy.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques20070101

Title: Site-specific acetylation of ISWI by GCN5.

Journal: BMC molecular biology20070101

Title: Sensing of nucleic acid sequences using unmodified nucleic acid as a probe.

Journal: Nucleic acids symposium series (2004)20070101

Title: [DNA sequence-specific ligands: XIII. New Dimeric Hoechst 33258 molecules, inhibitors of HIV-1 integrase in vitro].

Journal: Bioorganicheskaia khimiia20070101

Title: Cadmium-induced apoptosis in rat hepatocytes does not necessarily involve caspase-dependent pathways.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20061201

Title: Heat shock protein 40/DjB1 is required for thermotolerance in early phase.

Journal: Journal of biochemistry20061201

Title: The Hoechst 33258 covalent dimer covers a total turn of the double-stranded DNA.

Journal: Journal of biomolecular structure & dynamics20061201

Title: 15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism.

Journal: Toxicology and applied pharmacology20061101

Title: Irbesartan attenuates contrast media-induced NRK-52E cells apoptosis.

Journal: Pharmacological research20061001

Title: Crocetin prevents AGEs-induced vascular endothelial cell apoptosis.

Journal: Pharmacological research20061001

Title: Triple helix stabilization by covalently linked DNA-bisbenzimidazole conjugate synthesized by maleimide-thiol coupling chemistry.

Journal: Bioorganic & medicinal chemistry20060915

Title: Lipid peroxidation during human cerebral myelination.

Journal: Journal of neuropathology and experimental neurology20060901

Title: Calcium and reactive oxygen species mediated Zn2+ -induced apoptosis in PC12 cells.

Journal: Journal of pharmacological sciences20060901

Title: Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death.

Journal: Biochemical and biophysical research communications20060721

Title: DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.

Journal: Bioorganic & medicinal chemistry letters20060715

Title: Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells.

Journal: Biomaterials20060601

Title: DNA targeted UVA photosensitization: characterization of an extremely photopotent iodinated minor groove binding DNA ligand.

Journal: Journal of photochemistry and photobiology. B, Biology20060601

Title: Simultaneous quantitative measurement of luciferase reporter activity and cell number in two- and three-dimensional cultures of hepatitis C virus replicons.

Journal: Analytical biochemistry20060315

Title: Responses of the surface membrane and excretory system of Schistosoma mansoni to damage and to treatment with praziquantel and other biomolecules.

Journal: Parasitology20060301

Title: [Neuroprotection of chloride channel blockers against NMDA-induced apoptosis of cultured rat hippocampal neurons].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University20060201

Title: Design of new bidentate ligands constructed of two Hoechst 33258 units for discrimination of the length of two A3T3 binding motifs.

Journal: The Journal of organic chemistry20060106

Title: The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2.

Journal: Bioorganic & medicinal chemistry20060101

Title: Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.

Journal: Experimental parasitology20060101

Title: Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen.

Journal: Journal of endotoxin research20060101

Title: Antitumor effects of 3,3',4,4',5,5'-hexahydroxystilbene in HL-60 human promyelocytic leukemia cells.

Journal: Nucleosides, nucleotides & nucleic acids20060101

Title: Apoptosis assays.

Journal: Methods in molecular medicine20060101

Title: Hydration changes in the association of Hoechst 33258 with DNA.

Journal: Biochemistry20051227

Title: Recognition of a 10 base pair sequence of DNA and stereochemical control of the binding affinity of chiral hairpin polyamide-Hoechst 33258 conjugates.

Journal: Bioorganic & medicinal chemistry letters20051215

Title: Mechanisms of induction of apoptosis by anthraquinone anticancer drugs aclarubicin and mitoxantrone in comparison with doxorubicin: relation to drug cytotoxicity and caspase-3 activation.

Journal: Apoptosis : an international journal on programmed cell death20051201

Title: DNA breakage by decay of Auger electron emitters: experiments with 123I-iodoHoechst 33258 and plasmid DNA.

Journal: Radiation research20051201

Title: Coordinates, DNA content and heterogeneity of cell nuclei and segments of the Caenorhabditis elegans intestine.

Journal: Histochemistry and cell biology20051101

Title: Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis.

Journal: Biological & pharmaceutical bulletin20051101

Title: Role of c-Fos protein on glutamate toxicity in primary neural hippocampal cells.

Journal: Journal of neuroscience research20051001

Title: Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells.

Journal: Oncology reports20051001

Title: The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: time- and p53 expression-dependency of anti-cancer drugs.

Journal: Oncology reports20050901

Title: DNA labeling in living cells.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20050901

Title: Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity.

Journal: Chemical research in toxicology20050901

Title: Nature of minor-groove binders-DNA complexes in the gas phase.

Journal: Journal of the American Chemical Society20050824

Title: Theoretical study of molecular recognition by Hoechst 33258 derivatives.

Journal: Journal of biomolecular structure & dynamics20050801

Title: Resistance mechanism development to the topoisomerase-I inhibitor Hoechst 33342 by Leishmania donovani.

Journal: Parasitology20050801

Title: Association of the minor groove binding drug Hoechst 33258 with d(CGCGAATTCGCG)2: volumetric, calorimetric, and spectroscopic characterizations.

Journal: Biochemistry20050719

Title: Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury.

Journal: Microvascular research20050701

Title: Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis.

Journal: Thrombosis and haemostasis20050701

Title: A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes.

Journal: Biophysical journal20050601

Title: Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor.

Journal: Neuropharmacology20050601

Title: Synthesis, DNA binding, topoisomerase inhibition and cytotoxic properties of 2-chloroethylnitrosourea derivatives of hoechst 33258.

Journal: Biological & pharmaceutical bulletin20050601

Title: Determination of the exact copy numbers of particular mRNAs in a single cell by quantitative real-time RT-PCR.

Journal: The Journal of experimental biology20050601

Title: Quantitative aspects of endocytic activity in lipid-mediated transfections.

Journal: FEBS letters20050509

Title: Construction of an electrochemical DNA chip for simultaneous genotyping of single nucleotide polymorphisms.

Journal: The Analyst20050501

Title: Visualization of early embryos of the butterfly Bicyclus anynana.

Journal: Zygote (Cambridge, England)20050501

Title: Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival.

Journal: The Journal of biological chemistry20050429

Title: Assay for the quantification of small-sized fragmented genomic DNA.

Journal: Analytical biochemistry20050415

Title: The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression.

Journal: The journal of gene medicine20050401

Title: Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma.

Journal: Oncology reports20050401

Title: Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro.

Journal: Oncology reports20050401

Title: Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis.

Journal: Antimicrobial agents and chemotherapy20050401

Title: Retinal toxicity of commercial tissue plasminogen activator is mediated by the induction of nitric oxide in the mouse retinal primary cells.

Journal: Current eye research20050401

Title: p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.

Journal: Journal of neuroscience research20050315

Title: Unique cooperative binding interaction observed between a minor groove binding Pt antitumor agent and Hoechst dye 33258.

Journal: Inorganic chemistry20050307

Title: Determination of cell concentration in a plant cell suspension using a fluorescence microplate reader.

Journal: Plant cell reports20050301

Title: High-resolution simultaneous three-photon fluorescence and third-harmonic-generation microscopy.

Journal: Microscopy research and technique20050301

Title: In vivo characterization of developing chronic pancreatitis in rats.

Journal: Laboratory investigation; a journal of technical methods and pathology20050201

Title: Assessment of boar semen quality in relation to fertility with special reference to methanol stress.

Journal: Theriogenology20050201

Title: Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.

Journal: Neuroscience research20050201

Title: Fluorescence spectroscopic studies to characterize the internal environment of tetraethyl-orthosilicate derived sol-gel bulk and thin films with aging.

Journal: Biosensors & bioelectronics20050115

Title: Hoechst 33258 as a pH-sensitive probe to study the interaction of amine oxide surfactants with DNA.

Journal: Chembiochem : a European journal of chemical biology20050101

Title: Oleic acid causes apoptosis and dephosphorylates Bad.

Journal: Neurochemistry international20050101

Title: Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells.

Journal: Journal of applied toxicology : JAT20050101

Title: [Ligands with affinity to specific sequence of DNA base pairs. XII. The synthesis and cytological studies of dimeric Hoechst 33258 molecules].

Journal: Bioorganicheskaia khimiia20050101

Title: Calcium alginate microencapsulation of ovarian follicles impacts FSH delivery and follicle morphology.

Journal: Reproductive biology and endocrinology : RB&E20050101

Title: Leptin does not induce hypertrophy, cell cycle alterations, or production of MCP-1 in cultured rat and mouse cardiomyocytes.

Journal: Endocrine research20050101

Title: Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groove binders.

Journal: Nucleic acids symposium series (2004)20050101

Title: Heterogeneity in the radiosensitizing effects of the DNA ligand hoechst-33342 in human tumor cell lines.

Journal: Journal of cancer research and therapeutics20050101

Title: Sister chromatid exchange.

Journal: Current protocols in cell biology20050101

Title: Hoechst 33258 selectively inhibits group I intron self-splicing by affecting RNA folding.

Journal: Chembiochem : a European journal of chemical biology20041203

Title: DNA ligand Hoechst-33342 enhances UV induced cytotoxicity in human glioma cell lines.

Journal: Journal of photochemistry and photobiology. B, Biology20041202

Title: Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules.

Journal: Biomaterials20041201

Title: DNA condensation monitoring after interaction with hoechst 33258 by atomic force microscopy and fluorescence spectroscopy.

Journal: Journal of biochemistry20041201

Title: Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258.

Journal: Biophysical chemistry20041101

Title: Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.

Journal: Neuropharmacology20041101

Title: p75(NTR)-immunoreactivity in the subventricular zone of adult male rats: expression by cycling cells.

Journal: Journal of molecular histology20041101

Title: Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20041001

Title: Membrane-permeant, DNA-binding agents alter intracellular trafficking and increase the transfection efficiency of complexed plasmid DNA.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy20041001

Title: Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry20041001

Title: Comparative investigation of the biocompatibility of various silicon nitride ceramic qualities in vitro.

Journal: Journal of materials science. Materials in medicine20041001

Title: Inhibition of Leishmania donovani promastigote DNA topoisomerase I and human monocyte DNA topoisomerases I and II by antimonial drugs and classical antitopoisomerase agents.

Journal: The Journal of parasitology20041001

Title: Cytotoxic and apoptotic effects of novel heterodinucleoside phosphates consisting of 5-fluorodeoxyuridine and Ara-C in human cancer cell lines.

Journal: Nucleosides, nucleotides & nucleic acids20041001

Title: Layer-by-layer self-assembly of multilayer films containing DNA and Eu3+: their characteristics and interactions with small molecules.

Journal: Langmuir : the ACS journal of surfaces and colloids20040817

Title: [Principle of determining the composition of complexes with the ratio of double peak values at double wavelengths by UV spectrophotometry].

Journal: Guang pu xue yu guang pu fen xi = Guang pu20040801

Title: DNA sequence recognition in the minor groove by hairpin pyrrole polyamide-Hoechst 33258 analogue conjugate.

Journal: Bioorganic & medicinal chemistry letters20040716

Title: Effect of LNA modifications on small molecule binding to nucleic acids.

Journal: Journal of biomolecular structure & dynamics20040601

Title: Comparison of two techniques to evaluate the acrosomal status of zona pellucida bound sperm in humans.

Journal: Andrologia20040601

Title: Specific interactions of quercetin and other flavonoids with target proteins are revealed by elicited fluorescence.

Journal: Biochemical and biophysical research communications20040528

Title: Loss of Gli3 and Shh function disrupts olfactory axon trajectories.

Journal: The Journal of comparative neurology20040503

Title: Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range.

Journal: Analytical biochemistry20040501

Title: Cyclic adenosine monophosphate inhibits nitric oxide-induced apoptosis of cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner.

Journal: Immunopharmacology and immunotoxicology20040501

Title: Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity.

Journal: Cerebral cortex (New York, N.Y. : 1991)20040401

Title: Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) tethering a Hoechst 33258 analogue: triplex and duplex stabilization by simultaneous minor groove binding.

Journal: Journal of the American Chemical Society20040331

Title: Amplification of nuclear aldolase A in mouse cell mutants resistant to Hoechst 33342.

Journal: Biochemical and biophysical research communications20040319

Title: Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox.

Journal: Immunopharmacology and immunotoxicology20040201

Title: Induction and detection of bystander effects after combined treatment of cells with 5-bromo-2'-deoxyurine, Hoechst 33 258 and ultraviolet A light.

Journal: International journal of radiation biology20040201

Title: Optimization of an Acridine Orange-bisbenzimide procedure for the detection of apoptosis-associated fluorescence colour changes in etoposide-treated cell cultures.

Journal: Journal of molecular histology20040201

Title: DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives.

Journal: Journal of the American Chemical Society20040114

Title: Stem cells and nervous tissue repair: from in vitro to in vivo.

Journal: Progress in brain research20040101

Title: Cell-cycle analysis of asynchronous populations.

Journal: Methods in molecular biology (Clifton, N.J.)20040101

Title: Aromatic analogues of DNA minor groove binders--synthesis and biological evaluation.

Journal: European journal of medicinal chemistry20040101

Title: Immunocytochemical techniques for studying apoptosis in primary sympathetic neurons.

Journal: Methods in molecular biology (Clifton, N.J.)20040101

Title: [DNA-specific dimeric bisbenzimidazole].

Journal: Bioorganicheskaia khimiia20040101

Title: Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action.

Journal: The Journal of international medical research20040101

Title: Mitochondrial membrane potential change induced by Hoechst 33342 in myelogenous leukemia cell line HL-60.

Journal: Annals of clinical and laboratory science20040101

Title: Plasmid DNA breakage by decay of DNA-associated auger emitters: experiments with 123I/125I-iodoHoechst 33258.

Journal: International journal of radiation biology20040101

Title: Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury.

Journal: The Journal of comparative neurology20031222

Title: Minor groove binding DNA ligands with expanded A/T sequence length recognition, selective binding to bent DNA regions and enhanced fluorescent properties.

Journal: Biochemistry20031118

Title: Temperature induced hyperchromism exhibited by Hoechst 33258: evidence of drug aggregation from UV-melting method.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20031101

Title: Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles.

Journal: European journal of cancer (Oxford, England : 1990)20031101

Title: Fluorometric quantification of RNA and DNA in solutions containing both nucleic acids.

Journal: Analytical biochemistry20031101

Title: Hoechst 33258 binds to G-quadruplex in the promoter region of human c-myc.

Journal: Biochemical and biophysical research communications20031017

Title: Reaching into the major groove of B-DNA: synthesis and nucleic acid binding of a neomycin-hoechst 33258 conjugate.

Journal: Journal of the American Chemical Society20031015

Title: Lithium inhibits apoptosis of mouse neural progenitor cells.

Journal: Neuroreport20031006

Title: Selection of bacteriophage-resistant mutants of Streptococcus thermophilus.

Journal: Journal of microbiological methods20031001

Title: Location of CNTFRalpha on outer segments: evidence of the site of action of CNTF in rat retina.

Journal: Brain research20030926

Title: Hoechst 33342 alters luciferase gene expression in transfected BC3H-1 myocytes.

Journal: Archives of pathology & laboratory medicine20030901

Title: Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology20030901

Title: Influence of phenyl ring disubstitution on bisbenzimidazole and terbenzimidazole cytotoxicity: synthesis and biological evaluation as radioprotectors.

Journal: Journal of medicinal chemistry20030828

Title: Copper complex of hydroxyl-substituted triazamacrocyclic ligand and its antitumor activity.

Journal: Bioorganic & medicinal chemistry letters20030804

Title: Intravenously administered propidium iodide labels necrotic cells in the intact mouse brain after injury.

Journal: Cell death and differentiation20030801

Title: Differential responses of human neural and hematopoietic stem cells to ethanol exposure.

Journal: Journal of hematotherapy & stem cell research20030801

Title: Chemistry of minor groove binder-oligonucleotide conjugates.

Journal: Current protocols in nucleic acid chemistry20030801

Title: Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases.

Journal: Neurochemistry international20030701

Title: A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles.

Journal: Journal of pharmaceutical sciences20030601

Title: Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.

Journal: Cancer gene therapy20030601

Title: Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction.

Journal: Journal of molecular and cellular cardiology20030601

Title: Biochemical studies of apoptosis induced by tamoxifen in estrogen receptor positive and negative breast cancer cell lines.

Journal: Clinical biochemistry20030601

Title: Lack of inverse dose-rate effect and binding of the retinoblastoma gene product in the nucleus of human cancer T-47D cells arrested in G2 by ionizing radiation.

Journal: International journal of radiation biology20030601

Title: Membrane changes during different stages of a freeze-thaw protocol for equine semen cryopreservation.

Journal: Theriogenology20030415

Title: Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma.

Journal: Bulletin of experimental biology and medicine20030401

Title: Global chromosome positions are transmitted through mitosis in mammalian cells.

Journal: Cell20030321

Title: Synthesis and DNA binding studies of a new asymmetric cyanine dye binding in the minor groove of [poly(dA-dT)]2.

Journal: Bioorganic & medicinal chemistry20030320

Title: Mode of cell death induced in Chinese hamster cells by sequence-selective DNA minor groove binding nitrogen mustards: comparison with untargeted mustards and with Hoechst 33342.

Journal: Oncology research20030101

Title: Membrane status and in vitro capacitation of porcine sperm preserved in long-term extender at 16 degrees C.

Journal: Archives of andrology20030101

Title: Human granulosa cells after ovulation induction show caspase-independent cell death.

Journal: Gynecologic and obstetric investigation20030101

Title: Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

Journal: Biochemistry20021217

Title: TGF-beta1 inhibits multiple caspases induced by TNF-alpha in murine osteoblastic MC3T3-E1 cells.

Journal: Biochimica et biophysica acta20021216

Title: Apoptosis: biochemical aspects and clinical implications.

Journal: Clinica chimica acta; international journal of clinical chemistry20021201

Title: Quantifying DNA concentrations using fluorometry: a comparison of fluorophores.

Journal: Molecular vision20021106

Title: Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.

Journal: Journal of medicinal chemistry20020926

Title: Targeted elimination of the follicular label-retaining cells by photo-induced cell killing caused a defect on follicular renewal on mice.

Journal: Genes to cells : devoted to molecular & cellular mechanisms20020901

Title: Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures.

Journal: AAPS pharmSci20020901

Title: Constitutive caspase-like machinery executes programmed cell death in plant cells.

Journal: Cell death and differentiation20020701

Title: Synthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cells.

Journal: Biological & pharmaceutical bulletin20020701

Title: Synergistic induction of the senescence-associated genes by 5-bromodeoxyuridine and AT-binding ligands in HeLa cells.

Journal: Experimental cell research20020610

Title: Circular dichroism and thermal melting differentiation of Hoechst 33258 binding to the curved (A(4)T(4)) and straight (T(4)A(4)) DNA sequences.

Journal: Biochimica et biophysica acta20020607

Title: Amyloglucosidase suppresses interference by glycogen in the quantification of DNA using the Hoechst 33258 dye.

Journal: BioTechniques20020601

Title: Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse.

Journal: Mechanisms of development20020601

Title: Protective effect of L-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells.

Journal: Cancer letters20020408

Title: Evaluation of acrosome reaction and viability of human sperm with two fluorescent dyes.

Journal: Archives of gynecology and obstetrics20020401

Title: Interaction of Hoechst 33258 and echinomycin with nucleosomal DNA fragments containing isolated ligand binding sites.

Journal: Biochemistry20020312

Title: New lanostanoids from the fungus Ganoderma concinna.

Journal: Journal of natural products20020301

Title: Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals.

Journal: Chromosoma20020301

Title: Base-sequence specificity of Hoechst 33258 and DAPI binding to five (A/T)4 DNA sites with kinetic evidence for more than one high-affinity Hoechst 33258-AATT complex.

Journal: Journal of molecular biology20020201

Title: Visualization of complexes of Hoechst 33258 and DNA duplexes in solution by atomic force microscopy.

Journal: Chemical & pharmaceutical bulletin20020201

Title: Mechanism of tert-butylhydroperoxide induced apoptosis in rat hepatocytes: involvement of mitochondria and endoplasmic reticulum.

Journal: Biochimica et biophysica acta20020130

Title: Immunocytochemical analysis of neuronal differentiation.

Journal: Methods in molecular biology (Clifton, N.J.)20020101

Title: [A cross drug resistance of mammalian cells with a high efficiency of 'DNA clearing'].

Journal: Tsitologiia20020101

Title: NMR characterization of the DNA binding properties of a novel Hoechst 33258 analogue peptide building block.

Journal: Bioconjugate chemistry20020101

Title: Cooperativity in drug-DNA recognition: a molecular dynamics study.

Journal: Journal of the American Chemical Society20011219

Title: Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition.

Journal: Bioorganic & medicinal chemistry20011101

Title: Low-dose hypersensitivity in Chinese hamster V79 cells targeted with counted protons using a charged-particle microbeam.

Journal: Radiation research20011101

Title: Texture analysis of fluorescence lifetime images of AT- and GC-rich regions in nuclei.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society20011101

Title: Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells.

Journal: Journal of immunological methods20011001

Title: Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin.

Journal: International journal of oncology20011001

Title: Effects of humic substances on fluorometric DNA quantification and DNA hybridization.

Journal: Journal of microbiological methods20011001

Title: Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo.

Journal: Carcinogenesis20011001

Title: Effect of homologous preovulatory follicular fluid on in vitro maturation of equine cumulus-oocyte complexes.

Journal: Theriogenology20010915

Title: Dentate granule neuron apoptosis and glia activation in murine hippocampus induced by trimethyltin exposure.

Journal: Brain research20010907

Title: In situ staining with DNA-binding fluorescent dye, Hoechst 33258, to detect microorganisms in the epithelial cells of oral leukoplakia.

Journal: Oral oncology20010901

Title: Significance of ligand tails for interaction with the minor groove of B-DNA.

Journal: Biophysical journal20010901

Title: Combined prostaglandin and nitric oxide inhibition produces anatomic remodeling and closure of the ductus arteriosus in the premature newborn baboon.

Journal: Pediatric research20010901

Title: Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells.

Journal: Free radical biology & medicine20010901

Title: Synergistic effects of nicotine on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology20010901

Title: Effect of antioxidants on preservation of motility,viability and acrosomal integrity of equine spermatozoa during storage at 5 degrees C.

Journal: Theriogenology20010901

Title: Experimental precedent for the need to involve the primary hydration layer of DNA in lead drug design.

Journal: Journal of medicinal chemistry20010802

Title: Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma.

Journal: Cancer gene therapy20010801

Title: Synthesis of a dA-dT base pair analogue and its effects on DNA-ligand binding.

Journal: Bioorganic chemistry20010801

Title: Implication of the small GTPase Rac1 in the apoptosis induced by UV in Rat-2 fibroblasts.

Journal: Biochemical and biophysical research communications20010720

Title: Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E(2) production and neurodegeneration in cortical and hippocampal cell cultures.

Journal: Brain research20010720

Title: A simple method for classification of cell death by use of thin layer collagen gel for the detection of apoptosis and/or necrosis after cancer chemotherapy.

Journal: Japanese journal of cancer research : Gann20010701

Title: A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.

Journal: Journal of the American Chemical Society20010627

Title: The protective role of HSP90 against 3-hydroxykynurenine-induced neuronal apoptosis.

Journal: Biochemical and biophysical research communications20010608

Title: Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death.

Journal: Biochemical and biophysical research communications20010601

Title: DNA minor-groove recognition by small molecules.

Journal: Natural product reports20010601

Title: Double-stranded DNA binding characteristics and subcellular distribution of a minor groove binding diphenyl ether bisbenzimidazole.

Journal: Biochemistry20010529

Title: Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20010501

Title: Witness to a miracle: the initial cortisone trial: an interview with Richard Freyberg, MD. Interview by Mary Ellen Warner.

Journal: Mayo Clinic proceedings20010501

Title: Analysis of sister-chromatid exchanges.

Journal: Current protocols in human genetics20010501

Title: Quantitation of DNA and RNA with absorption and fluorescence spectroscopy.

Journal: Current protocols in immunology20010501

Title: Serpin protein CrmA suppresses hypoxia-mediated apoptosis of ventricular myocytes.

Journal: Circulation20010417

Title: Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs.

Journal: Molecular pharmacology20010401

Title: Recent developments in sequence selective minor groove DNA effectors.

Journal: Current medicinal chemistry20010401

Title: DNA minor groove alkylating agents.

Journal: Current medicinal chemistry20010401

Title: Direct and sensitized photoprocesses of bis-benzimidazole dyes and the effects of surfactants and DNA.

Journal: Photochemistry and photobiology20010401

Title: Hoechst 33342-induced apoptosis is associated with decreased immunoreactive topoisomerase I and topoisomerase I-DNA complex formation.

Journal: Annals of clinical and laboratory science20010401

Title: Recognition of nine base pairs in the minor groove of DNA by a tripyrrole peptide-Hoechst conjugate.

Journal: Journal of the American Chemical Society20010321

Title: Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro.

Journal: Clinical oral investigations20010301

Title: Synthesis, crystal structure, spectral studies, and catechol oxidase activity of trigonal bipyramidal Cu(II) complexes derived from a tetradentate diamide bisbenzimidazole ligand.

Journal: Inorganic chemistry20010226

Title: Cytotoxicity of fluoride on human pulp cell cultures in vitro.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics20010201

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