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Home Imidazoles 188860-26-6
188860-26-6,MFCD26143176
Catalog No.:AA002HCT

188860-26-6 | 2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
97%
in stock  
$493.00   $345.00
- +
25mg
97%
in stock  
$1,359.00   $952.00
- +
50mg
97%
in stock  
$2,400.00   $1,680.00
- +
100mg
97%
in stock  
$4,274.00   $2,992.00
- +
250mg
97%
in stock  
$9,543.00   $6,680.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002HCT
Chemical Name:
2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-
CAS Number:
188860-26-6
Molecular Formula:
C27H28N6O2
Molecular Weight:
468.5502
MDL Number:
MFCD26143176
SMILES:
COc1cc(ccc1OC)c1[nH]c2c(n1)cc(cc2)c1nc2c([nH]1)ccc(c2)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
705  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.3  

Downstream Synthesis Route

[1]Singh,Manish;Tandon,Vibha[EuropeanJournalofMedicinalChemistry,2011,vol.46,#2,p.659-669]

[1]Locationinpatent:experimentalpartSingh,Manish;Tandon,Vibha[EuropeanJournalofMedicinalChemistry,2011,vol.46,#2,p.659-669]

[1]Singh,Manish;Tandon,Vibha[EuropeanJournalofMedicinalChemistry,2011,vol.46,#2,p.659-669]

[1]Singh,Manish;Tandon,Vibha[EuropeanJournalofMedicinalChemistry,2011,vol.46,#2,p.659-669]

[1]Singh,Manish;Tandon,Vibha[EuropeanJournalofMedicinalChemistry,2011,vol.46,#2,p.659-669]

Literature

Title: Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles.

Journal: European journal of medicinal chemistry 20110201

Title: Old class but new dimethoxy analogue of benzimidazole: a bacterial topoisomerase I inhibitor.

Journal: International journal of antimicrobial agents 20100201

Title: Minor groove binding DNA ligands with expanded A/T sequence length recognition, selective binding to bent DNA regions and enhanced fluorescent properties.

Journal: Biochemistry 20031118

Title: Influence of phenyl ring disubstitution on bisbenzimidazole and terbenzimidazole cytotoxicity: synthesis and biological evaluation as radioprotectors.

Journal: Journal of medicinal chemistry 20030828

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SDS
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Tags:188860-26-6 Molecular Formula|188860-26-6 MDL|188860-26-6 SMILES|188860-26-6 2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)- |Heterocyclic_Building_Blocks