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1629869-44-8,MFCD31382121
Catalog No.:AA01EN1K

1629869-44-8 | Pimodivir

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$209.00   $146.00
- +
25mg
95%
in stock  
$366.00   $257.00
- +
100mg
95%
in stock  
$1,319.00   $923.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EN1K
Chemical Name:
Pimodivir
CAS Number:
1629869-44-8
Molecular Formula:
C20H19F2N5O2
Molecular Weight:
399.3940
MDL Number:
MFCD31382121
SMILES:
OC(=O)[C@H]1C2CCC([C@@H]1Nc1nc(ncc1F)c1c[nH]c3c1cc(F)cn3)CC2
Properties
Computed Properties
 
Complexity:
620  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
3.8  

Literature

Title: Smee DF, et al. Activities of JNJ63623872 and GS 4071 against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50.

Title: Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31.

Title: Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25(9):1990-4.

Title: Byrn RA, et al. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82.

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SDS
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