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1429882-07-4,MFCD28502224
Catalog No.:AA01EO65

1429882-07-4 | MRX-2843

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$70.00   $49.00
- +
5mg
≥95%
in stock  
$256.00   $179.00
- +
25mg
98%
in stock  
$426.00   $298.00
- +
100mg
98%
in stock  
$1,220.00   $854.00
- +
1g
98%
in stock  
$5,823.00   $4,076.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EO65
Chemical Name:
MRX-2843
CAS Number:
1429882-07-4
Molecular Formula:
C29H40N6O
Molecular Weight:
488.6675
MDL Number:
MFCD28502224
SMILES:
O[C@@H]1CC[C@H](CC1)n1cc(c2c1nc(NCCC1CC1)nc2)c1ccc(cc1)CN1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
681  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.2  

Downstream Synthesis Route
938043-30-2   
5-bromo-7-(trans-4-((tertbutyldimethylsilyl)oxy)cyclohexyl)-N-(2-cyclopropylethyl)-7H-pyrrolo2,3-dpyrimidin-2-amine 
 
trans-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo2,3-dpyrimidin-7-yl)cyclohexan-1-ol 

[1]JournalofMedicinalChemistry,2014,vol.57,p.7031-7041

CASUnavailable 
  1429882-07-4 

[1]Zhang,Weihe;Deryckere,Deborah;Hunter,Debra;Liu,Jing;Stashko,MichaelA.;Minson,KatherineA.;Cummings,ChristopherT.;Lee,Minjung;Glaros,TrevorG.;Newton,DianneL.;Sather,Susan;Zhang,Dehui;Kireev,Dmitri;Janzen,WilliamP.;Earp,H.Shelton;Graham,DouglasK.;Frye,StephenV.;Wang,Xiaodong[JournalofMedicinalChemistry,2014,vol.57,#16,p.7031-7041]

[1]CurrentPatentAssignee:UNIVERSITYOFNORTHCAROLINASYSTEM;MERYXINC;BEDAPHARMACY;MERIXSHARE;BETTAPHARMACEUTICALSCOLTD;BRANCHSCHOOLOFTANGTANSHANOFNORTHCORONAUNIV-WO2020/205967,2020,A1Locationinpatent:Page/Pagecolumn19;21

2408505-63-3   
CASUnavailable 
  1429882-07-4 

[1]CurrentPatentAssignee:UNIVERSITYOFNORTHCAROLINASYSTEM;MERYXINC;BEDAPHARMACY;MERIXSHARE;BETTAPHARMACEUTICALSCOLTD;BRANCHSCHOOLOFTANGTANSHANOFNORTHCORONAUNIV-WO2020/205967,2020,A1Locationinpatent:Page/Pagecolumn19-21

[1]CurrentPatentAssignee:UNIVERSITYOFNORTHCAROLINASYSTEM;MERYXINC;BEDAPHARMACY;MERIXSHARE;BETTAPHARMACEUTICALSCOLTD;BRANCHSCHOOLOFTANGTANSHANOFNORTHCORONAUNIV-WO2020/205967,2020,A1

Literature

Title: Minson KA, et al. The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI Insight. 2016 Mar;1(3):e85630.

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SDS
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Tags:1429882-07-4 Molecular Formula|1429882-07-4 MDL|1429882-07-4 SMILES|1429882-07-4 MRX-2843
Catalog No.: AA01EO65
1429882-07-4,MFCD28502224
1429882-07-4 | MRX-2843
Pack Size： 1mg
Purity： ≥95%
in stock
$70.00 $49.00
Pack Size： 5mg
Purity： ≥95%
in stock
$256.00 $179.00
Pack Size： 25mg
Purity： 98%
in stock
$426.00 $298.00
Pack Size： 100mg
Purity： 98%
in stock
$1,220.00 $854.00
Pack Size： 1g
Purity： 98%
in stock
$5,823.00 $4,076.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EO65
Chemical Name: MRX-2843
CAS Number: 1429882-07-4
Molecular Formula: C29H40N6O
Molecular Weight: 488.6675
MDL Number: MFCD28502224
SMILES: O[C@@H]1CC[C@H](CC1)n1cc(c2c1nc(NCCC1CC1)nc2)c1ccc(cc1)CN1CCN(CC1)C
Properties
Complexity: 681  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 36  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.2  
Downstream Synthesis Route
938043-30-2   
5-bromo-7-(trans-4-((tertbutyldimethylsilyl)oxy)cyclohexyl)-N-(2-cyclopropylethyl)-7H-pyrrolo2,3-dpyrimidin-2-amine 
 
trans-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo2,3-dpyrimidin-7-yl)cyclohexan-1-ol 

[1]JournalofMedicinalChemistry,2014,vol.57,p.7031-7041

CASUnavailable 
  1429882-07-4 

[1]Zhang,Weihe;Deryckere,Deborah;Hunter,Debra;Liu,Jing;Stashko,MichaelA.;Minson,KatherineA.;Cummings,ChristopherT.;Lee,Minjung;Glaros,TrevorG.;Newton,DianneL.;Sather,Susan;Zhang,Dehui;Kireev,Dmitri;Janzen,WilliamP.;Earp,H.Shelton;Graham,DouglasK.;Frye,StephenV.;Wang,Xiaodong[JournalofMedicinalChemistry,2014,vol.57,#16,p.7031-7041]

1429882-07-4    2498541-94-7 

[1]CurrentPatentAssignee:UNIVERSITYOFNORTHCAROLINASYSTEM;MERYXINC;BEDAPHARMACY;MERIXSHARE;BETTAPHARMACEUTICALSCOLTD;BRANCHSCHOOLOFTANGTANSHANOFNORTHCORONAUNIV-WO2020/205967,2020,A1Locationinpatent:Page/Pagecolumn19;21

2408505-63-3   
CASUnavailable 
  1429882-07-4 

[1]CurrentPatentAssignee:UNIVERSITYOFNORTHCAROLINASYSTEM;MERYXINC;BEDAPHARMACY;MERIXSHARE;BETTAPHARMACEUTICALSCOLTD;BRANCHSCHOOLOFTANGTANSHANOFNORTHCORONAUNIV-WO2020/205967,2020,A1Locationinpatent:Page/Pagecolumn19-21

1630906-40-9    1429882-07-4 

[1]CurrentPatentAssignee:UNIVERSITYOFNORTHCAROLINASYSTEM;MERYXINC;BEDAPHARMACY;MERIXSHARE;BETTAPHARMACEUTICALSCOLTD;BRANCHSCHOOLOFTANGTANSHANOFNORTHCORONAUNIV-WO2020/205967,2020,A1

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