Catalog No.:AA01EO12

1825352-65-5 | Risdiplam

Name: Name:Risdiplam
Brand: AABLOCKS
SKU: AA01EO12
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

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Price(USD)

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1mg

≥98%

in stock

$53.00 $37.00

- +

5mg

≥98%

in stock

$166.00 $116.00

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10mg

≥98%

in stock

$305.00 $213.00

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25mg

≥98%

in stock

$505.00 $353.00

- +

97%

in stock

$1,534.00 $1,074.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01EO12

Chemical Name:

Risdiplam

CAS Number:

1825352-65-5

Molecular Formula:

C22H23N7O

Molecular Weight:

401.4643

MDL Number:

MFCD31657372

SMILES:

Cc1cn2c(n1)c(C)cc(n2)c1cc(=O)n2c(n1)ccc(c2)N1CCNC2(C1)CC2

Properties

Computed Properties

Complexity:

886

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

0.5

Downstream Synthesis Route

19064-64-3

1825352-65-5

[1]CurrentPatentAssignee:ROCHEHOLDINGAG;PTCTHERAPEUTICSINC-WO2015/173181,2015,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/81111,2017,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/80967,2017,A1

[4]Ratni,Hasane;Ebeling,Martin;Baird,John;Bendels,Stefanie;Bylund,Johan;Chen,KarenS.;Denk,Nora;Feng,Zhihua;Green,Luke;Guerard,Melanie;Jablonski,Philippe;Jacobsen,Bjoern;Khwaja,Omar;Kletzl,Heidemarie;Ko,Chien-Ping;Kustermann,Stefan;Marquet,Anne;Metzger,Friedrich;Mueller,Barbara;Naryshkin,NikolaiA.;Paushkin,SergeyV.;Pinard,Emmanuel;Poirier,Agnès;Reutlinger,Michael;Weetall,Marla;Zeller,Andreas;Zhao,Xin;Mueller,Lutz[JournalofMedicinalChemistry,2018,vol.61,#15,p.6501-6517]

[5]CurrentPatentAssignee:PTCTHERAPEUTICSINC;ROCHEHOLDINGAG;PTCTHERANENTICS-US2019/315773,2019,A1

17412-23-6

1825352-65-5

[1]CurrentPatentAssignee:ROCHEHOLDINGAG;PTCTHERAPEUTICSINC-WO2015/173181,2015,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/81111,2017,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/80967,2017,A1

[5]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2019/57740,2019,A1

[6]CurrentPatentAssignee:PTCTHERAPEUTICSINC;ROCHEHOLDINGAG;PTCTHERANENTICS-US2019/315773,2019,A1

1825352-86-0

1825352-65-5

[1]CurrentPatentAssignee:ROCHEHOLDINGAG;PTCTHERAPEUTICSINC-WO2015/173181,2015,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/81111,2017,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/80967,2017,A1

[4]CurrentPatentAssignee:PTCTHERAPEUTICSINC;ROCHEHOLDINGAG;PTCTHERANENTICS-US2019/315773,2019,A1

2-(2,8-dimethylimidazo1,2-bpyridazin-6-yl)-7-fluoro-pyrido1,2-apyrimidin-4-one

145122-56-1

7-(4,7-diazaspiro2.5octan-7-yl)-2-(2,8-dimethylimidazo1,2-bpyridazin-6-yl)pyrido1,2-apyrimidin-4-one

[1]Patent:WO2015/173181,2015,A1.Locationinpatent:Page/Pagecolumn46-47

[2]Patent:WO2017/81111,2017,A1.Locationinpatent:Page/Pagecolumn46;47

[3]Patent:WO2017/80967,2017,A1.Locationinpatent:Page/Pagecolumn68-69

[4]JournalofMedicinalChemistry,2018,vol.61,p.6501-6517

[5]Patent:US2019/315773,2019,A1.Locationinpatent:Paragraph0312-0313

1449598-86-0

1825352-65-5

[1]CurrentPatentAssignee:ROCHEHOLDINGAG;PTCTHERAPEUTICSINC-WO2015/173181,2015,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/81111,2017,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/80967,2017,A1

[4]CurrentPatentAssignee:PTCTHERAPEUTICSINC;ROCHEHOLDINGAG;PTCTHERANENTICS-US2019/315773,2019,A1

Literature

Title: Poirier A, et al. Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. Pharmacol Res Perspect. 2018 Nov 29;6(6):e00447.

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SDS