Catalog No.:AA0000XK

1001264-89-6 | GDC-0068

Name: Name:GDC-0068
Brand: AABLOCKS
SKU: AA0000XK
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Rating: 90 (10 reviews)

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5mg

98%

in stock

$60.00 $42.00

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50mg

≥98%

in stock

$570.00 $399.00

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100mg

≥98%

in stock

$852.00 $597.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA0000XK

Chemical Name:

GDC-0068

CAS Number:

1001264-89-6

Molecular Formula:

C24H32ClN5O2

Molecular Weight:

457.9962

MDL Number:

MFCD22124514

SMILES:

CC(NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)C[C@H]2O)c1ccc(cc1)Cl)C

Properties

Computed Properties

Complexity:

622

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.5

Downstream Synthesis Route

1001270-64-9

1001264-89-6

[1]CurrentPatentAssignee:ROCHEHOLDINGAG;PFIZERINC-WO2008/6040,2008,A1Locationinpatent:Page/Pagecolumn105-106

[2]Remarchuk,Travis;St-Jean,Frederic;Carrera,Diane;Savage,Scott;Yajima,Herbert;Wong,Brian;Babu,Srinivasan;Deese,Alan;Stults,Jeffrey;Dong,MichaelW.;Askin,David;Lane,JonathanW.;Spencer,KeithL.[OrganicProcessResearchandDevelopment,2014,vol.18,#12,p.1652-1666]

1491129-84-0

1001264-89-6

[1]Remarchuk,Travis;St-Jean,Frederic;Carrera,Diane;Savage,Scott;Yajima,Herbert;Wong,Brian;Babu,Srinivasan;Deese,Alan;Stults,Jeffrey;Dong,MichaelW.;Askin,David;Lane,JonathanW.;Spencer,KeithL.[OrganicProcessResearchandDevelopment,2014,vol.18,#12,p.1652-1666]

1491895-99-8

1001264-89-6

1491896-03-7

1001264-89-6

1491896-05-9

1001264-89-6

Literature

Title: Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Journal: Journal of medicinal chemistry 20120927

Title: Blake JF, et al. Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem. 2012 Sep 27;55(18):8110-27.

Title: Lin J, et al. Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res. 2013 Apr 1;19(7):1760-72.

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SDS