Catalog No.:AA0000XK

1001264-89-6 | GDC-0068

Name: Name:GDC-0068
Brand: AABLOCKS
SKU: AA0000XK
Availability: InStock
Rating: 90 (10 reviews)

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1mg

≥98%

in stock

$79.00 $55.00

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5mg

99%

in stock

$90.00 $63.00

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10mg

99%

in stock

$129.00 $90.00

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50mg

99%

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$373.00 $261.00

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100mg

99%

in stock

$579.00 $405.00

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500mg

99%

in stock

$1,929.00 $1,350.00

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99%

in stock

$3,343.00 $2,340.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA0000XK

Chemical Name:

GDC-0068

CAS Number:

1001264-89-6

Molecular Formula:

C24H32ClN5O2

Molecular Weight:

457.9962

MDL Number:

MFCD22124514

SMILES:

CC(NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)C[C@H]2O)c1ccc(cc1)Cl)C

Properties

Computed Properties

Complexity:

622

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.5

Literature

Title: Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Journal: Journal of medicinal chemistry 20120927

Title: Blake JF, et al. Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem. 2012 Sep 27;55(18):8110-27.

Title: Lin J, et al. Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res. 2013 Apr 1;19(7):1760-72.

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SDS