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100981-43-9,MFCD00869998
Catalog No.:AA008T0X

100981-43-9 | Ebrotidine

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Purity
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Price(USD)
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5mg
≥98%
in stock  
$322.00   $225.00
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10mg
≥98%
in stock  
$500.00   $350.00
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50mg
≥98%
in stock  
$1,165.00   $815.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008T0X
Chemical Name:
Ebrotidine
CAS Number:
100981-43-9
Molecular Formula:
C14H17BrN6O2S3
Molecular Weight:
477.4228
MDL Number:
MFCD00869998
SMILES:
NC(=N)Nc1scc(n1)CSCC/N=C/NS(=O)(=O)c1ccc(cc1)Br
Properties
Computed Properties
 
Complexity:
586  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
1.5  

Upstream Synthesis Route

[1]JournalofPharmaceuticalSciences,1994,vol.83,#2,p.252-254

Literature

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Determination of ebrotidine and its metabolites by micellar electrokinetic capillary chromatography.

Journal: Journal of chromatography. A 20021108

Title: [Prospect of the development of new bactericidal drugs against Helicobacter pylori for eradication therapy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: Determination of ebrotidine metabolites in overlapping peaks from capillary zone electrophoresis using chemometric methods.

Journal: Electrophoresis 20010101

Title: Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.

Journal: European journal of gastroenterology & hepatology 20000301

Title: Agut J, Sánchez JC, Sacristán A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9.

Title: Palop D, Agut J, Márquez M, Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.

Title: Konturek SJ, Kwiecien N, Sito E, Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans. Scand J Gastroenterol. 1993 Dec;28(12):1047-50.

Title: Piotrowski J, Yamaki K, Morita M, Ebrotidine--a new H2-receptor antagonist with mucosal strengthening activity. Biochem Int. 1992 Mar;26(4):659-67.

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SDS
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