Home Nitro Compounds 1009817-63-3
1009817-63-3,MFCD26142662
Catalog No.:AA00039T

1009817-63-3 | 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-, (3E,5E)-

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Purity
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1mg
98%
in stock  
$18.00   $13.00
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5mg
98%
in stock  
$44.00   $31.00
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10mg
98%
in stock  
$73.00   $51.00
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25mg
98%
in stock  
$128.00   $89.00
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  • Technical Information
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  • Technical Information
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Technical Information
Catalog Number:
AA00039T
Chemical Name:
4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-, (3E,5E)-
CAS Number:
1009817-63-3
Molecular Formula:
C22H17N3O6
Molecular Weight:
419.3869
MDL Number:
MFCD26142662
SMILES:
C=CC(=O)N1C/C(=C\c2ccc(cc2)[N+](=O)[O-])/C(=O)/C(=C/c2ccc(cc2)[N+](=O)[O-])/C1
NSC Number:
687852
Properties
Computed Properties
 
Complexity:
750  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
3  
XLogP3:
3.3  

Literature

Title: Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.

Journal: European journal of medicinal chemistry 20080101

Title: A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.

Journal: Journal of medicinal chemistry 20010215

Title: D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17(12):1636-40.

Title: Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85(6):932-45.

Title: Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123(5):706-16.

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Tags:1009817-63-3 Molecular Formula|1009817-63-3 MDL|1009817-63-3 SMILES|1009817-63-3 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-, (3E,5E)-