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10285-06-0,MFCD09970420
Catalog No.:AA008WH2

10285-06-0 | INTERMEDINE

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008WH2
Chemical Name:
INTERMEDINE
CAS Number:
10285-06-0
Molecular Formula:
C15H25NO5
Molecular Weight:
299.3627
MDL Number:
MFCD09970420
SMILES:
O[C@@H]1CCN2[C@@H]1C(=CC2)COC(=O)[C@@]([C@H](O)C)(C(C)C)O
Properties
Computed Properties
 
Complexity:
436  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
-0.4  

Literature

Title: An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.

Journal: PLoS genetics 20120301

Title: Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.

Journal: PloS one 20120101

Title: The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.

Journal: Handbook of experimental pharmacology 20120101

Title: Detecting regulatory mechanisms in endocrine time series measurements.

Journal: PloS one 20120101

Title: Post-translational modifications of pro-opiomelanocrtin related hormones in medaka pituitary based on mass spectrometric analyses.

Journal: Peptides 20111001

Title: Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.

Journal: Biochimica et biophysica acta 20110901

Title: Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.

Journal: Domestic animal endocrinology 20110801

Title: Detection of high levels of pyrrolizidine-N-oxides in the endangered plant Cryptantha crassipes (Terlingua Creek cat's-eye) using HPLC-ESI-MS.

Journal: Phytochemical analysis : PCA 20110101

Title: Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

Journal: PloS one 20110101

Title: An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans.

Journal: Journal of obesity 20110101

Title: The prohormone theory and the proprotein convertases: it is all about serendipity.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: Solution structures and molecular interactions of selective melanocortin receptor antagonists.

Journal: Molecules and cells 20101201

Title: Metabolism, genotoxicity, and carcinogenicity of comfrey.

Journal: Journal of toxicology and environmental health. Part B, Critical reviews 20101001

Title: Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.

Journal: Biochemistry 20100608

Title: Comfrey (Symphytum Officinale. l.) and Experimental Hepatic Carcinogenesis: A Short-term Carcinogenesis Model Study.

Journal: Evidence-based complementary and alternative medicine : eCAM 20100601

Title: The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice.

Journal: Molecules (Basel, Switzerland) 20100303

Title: Chiral stationary phases for separation of intermedine and lycopsamine enantiomers from Symphytum uplandicum.

Journal: Journal of separation science 20100201

Title: Characterization of the sea bass melanocortin 5 receptor: a putative role in hepatic lipid metabolism.

Journal: The Journal of experimental biology 20091201

Title: [Staining and slide-preparing technique of mitotic chromosomes and application in karyotype determination of Ephedra].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: [Overview in 45 years of studies on peptide chemistry].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001

Title: Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte-stimulating hormone-induced anorexigenic pathway in chicks.

Journal: Neuroscience letters 20090724

Title: Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion.

Journal: Experimental dermatology 20090701

Title: Molecular cloning, tissue distribution and quantitative analysis of two proopiomelanocortin mRNAs in Japanese flounder (Paralichthys olivaceus).

Journal: BMB reports 20090430

Title: Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity?

Journal: Molecular and cellular endocrinology 20090305

Title: Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating hormone/melanocortin-4 receptor signaling.

Journal: Endocrinology 20090301

Title: Melanocortin-4 receptor mutations in obesity.

Journal: Advances in clinical chemistry 20090101

Title: Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study.

Journal: Pharmacological reports : PR 20090101

Title: Regulation of melanogenesis--controversies and new concepts.

Journal: Experimental dermatology 20080501

Title: Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks.

Journal: Journal of neuroendocrinology 20080201

Title: A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally.

Journal: Peptides 20080101

Title: Neuropeptide processing and its impact on melanocortin pathways.

Journal: Endocrinology 20070901

Title: Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070601

Title: cDNA cloning of proopiomelanocortin (POMC) and mass spectrometric identification of POMC-derived peptides from snake and alligator pituitaries.

Journal: General and comparative endocrinology 20070515

Title: Melanocortin receptor 4 is induced in nerve-injured motor and sensory neurons of mouse.

Journal: Journal of neurochemistry 20070501

Title: Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors.

Journal: Peptides 20070401

Title: Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

Journal: Current topics in medicinal chemistry 20070101

Title: Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.

Journal: Current topics in medicinal chemistry 20070101

Title: Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes.

Journal: BMC evolutionary biology 20070101

Title: The role of proopiomelanocortin (POMC) neurones in feeding behaviour.

Journal: Nutrition & metabolism 20070101

Title: A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice.

Journal: Endocrinology 20061201

Title: Unraveling the genetics of human obesity.

Journal: PLoS genetics 20061201

Title: The differential influences of melanocortins on nociception in the formalin and tail flick tests.

Journal: Pharmacology, biochemistry, and behavior 20061001

Title: Posttranslational processing of proopiomelanocortin family molecules in sea lamprey based on mass spectrometric and chemical analyses.

Journal: General and comparative endocrinology 20060801

Title: Role of the melanocortin system in inflammation.

Journal: Annals of the New York Academy of Sciences 20060801

Title: Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.

Journal: Biochemistry 20060613

Title: The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model.

Journal: Peptides 20060601

Title: Melanocortins in human melanocytes.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20060530

Title: Molecular cloning and characterization of preproopiomelanocortin (prePOMC) cDNA from the ostrich (Struthio camelus).

Journal: General and comparative endocrinology 20060501

Title: Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.

Journal: The Journal of clinical endocrinology and metabolism 20060501

Title: Expression of three proopiomelanocortin subtype genes and mass spectrometric identification of POMC-derived peptides in pars distalis and pars intermedia of barfin flounder pituitary.

Journal: General and comparative endocrinology 20060201

Title: Melanocortin-4 receptors, beta-MSH and leptin: key elements in the satiety pathway.

Journal: Peptides 20060201

Title: The molecular genetics of the melanocortin pathway and energy homeostasis.

Journal: Cell metabolism 20060201

Title: A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.

Journal: Cell metabolism 20060201

Title: A role for beta-melanocyte-stimulating hormone in human body-weight regulation.

Journal: Cell metabolism 20060201

Title: Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale).

Journal: BMC bioinformatics 20060101

Title: Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling.

Journal: Journal of neuroimmunology 20051201

Title: A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin.

Journal: The Journal of endocrinology 20051101

Title: Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV.

Journal: Peptides 20051001

Title: Inhibition of morphine tolerance by spinal melanocortin receptor blockade.

Journal: Pain 20051001

Title: Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: Trends in the evolution of the proopiomelanocortin gene.

Journal: General and comparative endocrinology 20050515

Title: Discovery of a beta-MSH-derived MC-4R selective agonist.

Journal: Journal of medicinal chemistry 20050505

Title: Nucleotide sequence and expression of three subtypes of proopiomelanocortin mRNA in barfin flounder.

Journal: General and comparative endocrinology 20050501

Title: Isolation and characterization of a novel proopiomelanocortin-derived peptide from hemofiltrate of chronic renal failure patients.

Journal: Endocrinology 20050401

Title: Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH.

Journal: Annals of the New York Academy of Sciences 20050401

Title: Differential utilization of pyrrolizidine alkaloids by males of a danaid butterfly, Parantica sita, for the production of danaidone in the alar scent organ.

Journal: Journal of chemical ecology 20050401

Title: Mutagenicity of comfrey (Symphytum Officinale) in rat liver.

Journal: British journal of cancer 20050314

Title: Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake.

Journal: Endocrinology 20040701

Title: The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs.

Journal: Molecular biology and evolution 20040301

Title: Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults.

Journal: The Journal of clinical endocrinology and metabolism 20040201

Title: Beta- and gamma-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain.

Journal: Brain research 20040102

Title: Molecular cloning of proopiomelanocortin cDNA in the ratfish, a holocephalan.

Journal: General and comparative endocrinology 20040101

Title: [Protein hormones, receptors, and other proteins in mechanisms of hormonal regulation].

Journal: Biomeditsinskaia khimiia 20040101

Title: Identification of two proopiomelanocortin genes in zebrafish (Danio rerio).

Journal: Brain research. Molecular brain research 20031212

Title: Characterizing a proopiomelanocortin cDNA cloned from the brain of the Bichir, Polypterus senegalus: evaluating phylogenetic relationships among ray-finned fish.

Journal: General and comparative endocrinology 20031201

Title: Alcoholism and obesity: overlapping neuropeptide pathways?

Journal: Neuropeptides 20031201

Title: Melanocortins and their receptors and antagonists.

Journal: Current drug targets 20031001

Title: Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.

Journal: Journal of medicinal chemistry 20030814

Title: Presence of the delta-MSH sequence in a proopiomelanocortin cDNA cloned from the pituitary of the galeoid shark, Heterodontus portusjacksoni.

Journal: General and comparative endocrinology 20030801

Title: The role of melanocortins and their receptors in inflammatory processes, nerve regeneration and nociception.

Journal: Life sciences 20030704

Title: Evaluating the radiation of the POMC gene in teleosts: characterization of American eel POMC.

Journal: General and comparative endocrinology 20030701

Title: Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake.

Journal: Endocrinology 20030601

Title: Detection and characterization of methionine oxidation in peptides by collision-induced dissociation and electron capture dissociation.

Journal: Journal of the American Society for Mass Spectrometry 20030601

Title: Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors.

Journal: Annals of the New York Academy of Sciences 20030601

Title: Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival.

Journal: Annals of the New York Academy of Sciences 20030601

Title: Biochemical processing of plant acquired pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi.

Journal: Insect biochemistry and molecular biology 20030501

Title: The pro-opiomelanocortin gene of the zebrafish (Danio rerio).

Journal: Biochemical and biophysical research communications 20030418

Title: Molecular cloning of proopiomelanocortin (POMC) cDNA from mud turtle, Pelodiscus sinensis.

Journal: General and comparative endocrinology 20030401

Title: Inverse agonist activity of agouti and agouti-related protein.

Journal: Peptides 20030401

Title: beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R?

Journal: Peptides 20030301

Title: Identification of proopiomelanocortin-related peptides in the rostral pars distalis of the pituitary in coelacanth: evolutional implications.

Journal: General and comparative endocrinology 20030215

Title: Sequestration and metabolism of protoxic pyrrolizidine alkaloids by larvae of the leaf beetle Platyphora boucardi and their transfer via pupae into defensive secretions of adults.

Journal: Journal of chemical ecology 20030201

Title: The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

Journal: European journal of pharmacology 20020816

Title: A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

Journal: Human molecular genetics 20020815

Title: Toxic pyrrolyzidine alkaloids from three mongolian plants. a possible risk for cattle poisoning.

Journal: Journal of natural toxins 20020801

Title: Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor.

Journal: Peptides 20020601

Title: Pyrrolizidine alkaloids in Pulmonaria obscura.

Journal: Planta medica 20020501

Title: The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

Journal: European journal of pharmacology 20020412

Title: Sequestration, metabolism and partial synthesis of tertiary pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi.

Journal: Insect biochemistry and molecular biology 20011001

Title: Medical mystery: the answer.

Journal: The New England journal of medicine 20010524

Title: Differential effects of alpha-, beta- and gamma(2)-melanocyte-stimulating hormones on hypothalamic neuronal activation and feeding in the fasted rat.

Journal: Neuroscience 20010101

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Tags:10285-06-0 Molecular Formula|10285-06-0 MDL|10285-06-0 SMILES|10285-06-0 INTERMEDINE