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480-54-6,MFCD00870195
Catalog No.:AA00D8R4

480-54-6 | RETRORSINE

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1mg
≥90%
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$182.00   $128.00
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5mg
≥90%
in stock  
$457.00   $320.00
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10mg
≥90%
in stock  
$754.00   $528.00
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25mg
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$1,256.00   $879.00
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50mg
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$2,200.00   $1,540.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00D8R4
Chemical Name:
RETRORSINE
CAS Number:
480-54-6
Molecular Formula:
C18H25NO6
Molecular Weight:
351.3942
MDL Number:
MFCD00870195
SMILES:
CC=C1CC(C)C(O)(CO)C(=O)OCC2=CCN3C2C(OC1=O)CC3
Properties
Computed Properties
 
Complexity:
627  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
0.6  

Literature

Title: Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline.

Journal: Chemical research in toxicology 20170220

Title: Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity.

Journal: Toxicology 20140801

Title: Hepatocyte senescence in vivo following preconditioning for liver repopulation.

Journal: Hepatology (Baltimore, Md.) 20120801

Title: Fetal liver-derived mesenchymal stromal cells augment engraftment of transplanted hepatocytes.

Journal: Cytotherapy 20120701

Title: Profiling of alkaloids and eremophilanes in miracle tea (Packera candidissima and P. bellidifolia) products.

Journal: Journal of natural products 20120525

Title: Growth ability and repopulation efficiency of transplanted hepatic stem cells, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers.

Journal: Cell transplantation 20120101

Title: HSQC-1,1-ADEQUATE and HSQC-1,n-ADEQUATE: enhanced methods for establishing adjacent and long-range 13C-13C connectivity networks.

Journal: Journal of natural products 20111128

Title: [Developmental toxicity of retrorsine on mouse embryos in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

Title: The growth pattern of transplanted normal and nodular hepatocytes.

Journal: Histochemistry and cell biology 20110601

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats.

Journal: Experimental and molecular pathology 20101001

Title: Cytokine-dependent activation of small hepatocyte-like progenitor cells in retrorsine-induced rat liver injury.

Journal: Experimental and molecular pathology 20100201

Title: Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4.

Journal: Chemico-biological interactions 20100105

Title: Endogenous and transplanted small hepatocytes in retrorsine-treated/partially hepatectomized rat liver show differences in growth, phenotype, and proximity to clusters of gamma-glutamyl transpeptidase-positive host hepatocytes.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20100101

Title: Hepatocyte transplantation and the differentiation fate of host oval cells in acute severe hepatic injury.

Journal: Cell transplantation 20100101

Title: Effects of bone marrow and hepatocyte transplantation on liver injury.

Journal: The Journal of surgical research 20091101

Title: Engraftment of syngeneic and allogeneic endothelial cells, hepatocytes and cholangiocytes into partially hepatectomized rats previously treated with mitomycin C.

Journal: Transplantation 20090827

Title: Generation of hepatocyte-like cells from in vitro transdifferentiated human fetal pancreas.

Journal: Cell transplantation 20090101

Title: Impaired hepatocyte regeneration in acute severe hepatic injury enhances effective repopulation by transplanted hepatocytes.

Journal: Cell transplantation 20090101

Title: Hepatocytes from fibrotic liver possess high growth potential in vivo.

Journal: Cell transplantation 20090101

Title: Direct in vivo cell lineage analysis in the retrorsine and 2AAF models of liver injury after genetic labeling in adult and newborn rats.

Journal: PloS one 20090101

Title: Low-dose recombinant human hepatocyte growth factor enhances effect of hepatocyte transplantation in rats treated with retrorsine.

Journal: Hepato-gastroenterology 20090101

Title: Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.

Journal: Toxicology letters 20080505

Title: Proliferation of L02 human hepatocytes in tolerized genetically immunocompetent rats.

Journal: World journal of gastroenterology 20080421

Title: Cells of origin of small hepatocyte-like progenitor cells in the retrorsine model of rat liver injury and regeneration.

Journal: Journal of hepatology 20080201

Title: Origin of small hepatocyte-like progenitor in retrorsine-treated rats.

Journal: Journal of hepatology 20080201

Title: Repopulation by endogenous hepatocytes does not reconstitute liver mass in rats treated with retrorsine.

Journal: Cell transplantation 20080101

Title: Bile duct destruction by 4,4'-diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats.

Journal: Hepatology (Baltimore, Md.) 20071101

Title: Senecio latifolius induces in vitro hepatocytotoxicity in a human cell line.

Journal: Canadian journal of physiology and pharmacology 20071101

Title: The toxicity of Senecio inaequidens DC.

Journal: Journal of the South African Veterinary Association 20070901

Title: Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats.

Journal: Journal of hepatology 20070601

Title: [The repopulation of human L02 hepatocytes in tolerant rats treated with retrorsine].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20070301

Title: Cholangiocyte marker-positive and -negative fetal liver cells differ significantly in their ability to regenerate the livers of adult rats exposed to retrorsine.

Journal: Development (Cambridge, England) 20061101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effects of retrorsine on mouse hepatocyte proliferation after liver injury.

Journal: World journal of gastroenterology 20060307

Title: Liver repopulation trial using bone marrow cells in a retrorsine-induced chronic hepatocellular injury model.

Journal: Gastroenterologie clinique et biologique 20060301

Title: Isolation and characterization of bipotent liver progenitor cells from adult mouse.

Journal: Stem cells (Dayton, Ohio) 20060201

Title: The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.

Journal: Hepatology (Baltimore, Md.) 20060201

Title: Cyclin D1 is up-regulated in hepatocytes in vivo following cell-cycle block induced by retrorsine.

Journal: Journal of hepatology 20050901

Title: Hepatic proliferation in Gunn rats transplanted with hepatocytes: effect of retrorsine and tri-iodothyronine.

Journal: Cell proliferation 20050601

Title: Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo.

Journal: International journal of environmental research and public health 20050501

Title: Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.

Journal: Toxicology letters 20050315

Title: GC/MS identification of toxic pyrrolizidine alkaloids in traditional remedies given to two sets of twins.

Journal: Annals of clinical biochemistry 20050301

Title: Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents.

Journal: Cell transplantation 20050101

Title: Mature hepatocytes are the source of small hepatocyte-like progenitor cells in the retrorsine model of liver injury.

Journal: Journal of hepatology 20041101

Title: Molecular mechanisms of apoptosis in the liver of rats after portal branch ligation with and without retrorsine.

Journal: Laboratory investigation; a journal of technical methods and pathology 20040501

Title: Liver repopulation by c-Met-positive stem/progenitor cells isolated from the developing rat liver.

Journal: Hepato-gastroenterology 20040101

Title: Bone marrow progenitors are not the source of expanding oval cells in injured liver.

Journal: Stem cells (Dayton, Ohio) 20040101

Title: Liver regeneration in a retrorsine/CCl4-induced acute liver failure model: do bone marrow-derived cells contribute?

Journal: Journal of hepatology 20030901

Title: Retrorsine: a kinetic study of its influence on rat liver regeneration in the portal branch ligation model.

Journal: Journal of hepatology 20030701

Title: [Proliferation of retrorsine-treated SD rat immortalized hepatocytes after intrasplenic transplantation].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030601

Title: Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth.

Journal: Journal of chemical ecology 20020901

Title: Liver repopulation after cell transplantation in mice treated with retrorsine and carbon tetrachloride.

Journal: Transplantation 20020615

Title: Isolation, short-term culture, and transplantation of small hepatocyte-like progenitor cells from retrorsine-exposed rats.

Journal: Transplantation 20020427

Title: Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells.

Journal: The American journal of pathology 20011001

Title: Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20010301

Title: Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine.

Journal: The American journal of pathology 20010201

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

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