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103-76-4,MFCD00005970
Catalog No.:AA00357H

103-76-4 | 1-Piperazineethanol

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Purity
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25g
97%
in stock  
$11.00   $8.00
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100g
97%
in stock  
$16.00   $11.00
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500g
97%
in stock  
$26.00   $18.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00357H
Chemical Name:
1-Piperazineethanol
CAS Number:
103-76-4
Molecular Formula:
C6H14N2O
Molecular Weight:
130.1882
MDL Number:
MFCD00005970
SMILES:
OCCN1CCNCC1
Properties
Properties
 
BP:
246°C at 760 mmHg  
Form:
Liquid  
MP:
-38.5 °C  
Refractive Index:
n20/D 1.506(lit.)  
Storage:
Light sensitive;Room Temperature;  

Computed Properties
 
Complexity:
71.5  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
-1.1  

Upstream Synthesis Route

[1]Patent:US2860138,1956,,

[1]Patent:US2008/51397,2008,A1,.Locationinpatent:Page/Pagecolumn10;26

[2]Synthesis,2008,#7,p.1049-1060

[3]Patent:WO2009/71677,2009,A1,.Locationinpatent:Page/Pagecolumn23

[4]Patent:US2009/203695,2009,A1,.Locationinpatent:Page/Pagecolumn9

[5]Patent:US2009/281087,2009,A1,.Locationinpatent:Page/Pagecolumn10

[6]JournaloftheAmericanChemicalSociety,1948,vol.70,p.3098

[7]AustralianJournalofChemistry,1956,vol.9,p.89,92

[1]Patent:US6610729,2003,B1,

[1]OrganicProcessResearchandDevelopment,2015,vol.19,#10,p.1400-1410

[1]BulletinoftheKoreanChemicalSociety,2011,vol.32,#6,p.1907-1911

[2]BulletinoftheKoreanChemicalSociety,2016,vol.37,#10,p.1577-1581

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1954,vol.76,p.1126,1129

[2]Patent:US2541260,1949,

[1]Patent:US2008/51397,2008,A1.Locationinpatent:Page/Pagecolumn10;26

[2]Synthesis,2008,p.1049-1060

[3]Patent:WO2009/71677,2009,A1.Locationinpatent:Page/Pagecolumn23

[4]Patent:US2009/203695,2009,A1.Locationinpatent:Page/Pagecolumn9

[5]Patent:US2009/281087,2009,A1.Locationinpatent:Page/Pagecolumn10

[6]JournaloftheAmericanChemicalSociety,1948,vol.70,p.3098

[7]AustralianJournalofChemistry,1956,vol.9,p.89,92

[1]Patent:US2860138,1956,

[1]Journalofmedicinalchemistry,1972,vol.15,p.693-694

103-76-4    109-70-6    3433-74-7   
2-{4-3-(11<i>H</i>-dibenzo<i>b</i>,<i>e</i>1,4oxazepin-5-yl)-propyl-piperazin-1-yl}-ethanol 

[1]JournalofMedicinalChemistry,1970,vol.13,p.713-722

Literature

Title: N-{2-[4-(2-Hy-droxy-eth-yl)piperazin-1-yl]eth-yl}phthalimide.

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: Rapid room temperature synthesis of electrocatalytically active Au nanostructures.

Journal: Journal of colloid and interface science 20110115

Title: Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

Journal: PloS one 20110101

Title: Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin.

Journal: Dalton transactions (Cambridge, England : 2003) 20090507

Title: Synthesis and antimalarial activity of hydroxyethylpiperazine derivatives.

Journal: European journal of medicinal chemistry 20090301

Title: Use of a hydrolytic procedure and spectrometric methods in the structure elucidation of a thiocarbonyl analogue of sildenafil detected as an adulterant in an over-the-counter herbal aphrodisiac.

Journal: Journal of AOAC International 20090101

Title: Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals.

Journal: Purinergic signalling 20080601

Title: Calcium-dependent release of adenosine and uridine nucleotides from A549 cells.

Journal: Purinergic signalling 20080601

Title: Purinergic inhibition of Na⁺,K⁺,Cl⁻ cotransport in C11-MDCK cells: Role of stress-activated protein kinases.

Journal: Purinergic signalling 20080601

Title: Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection.

Journal: PloS one 20080101

Title: Autoregulation in PC12 cells via P2Y receptors: Evidence for non-exocytotic nucleotide release from neuroendocrine cells.

Journal: Purinergic signalling 20070901

Title: Lack of evidence for direct phosphorylation of recombinantly expressed P2X(2) and P2X (3) receptors by protein kinase C.

Journal: Purinergic signalling 20070901

Title: Ectonucleotidases in Müller glial cells of the rodent retina: Involvement in inhibition of osmotic cell swelling.

Journal: Purinergic signalling 20070901

Title: A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn.

Journal: Journal of clinical biochemistry and nutrition 20070701

Title: Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli.

Journal: Purinergic signalling 20070601

Title: Structure determination of new analogues of vardenafil and sildenafil in dietary supplements.

Journal: Food additives and contaminants 20070201

Title: Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents.

Journal: American journal of therapeutics 20060101

Title: Depot perphenazine decanoate and enanthate for schizophrenia.

Journal: The Cochrane database of systematic reviews 20050720

Title: Protein L-agarose for adsorption of autoantibodies: a potential tool for extracorporeal treatment.

Journal: Artificial organs 20050401

Title: Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

Journal: Bioorganic & medicinal chemistry 20041201

Title: Structure elucidation of sildenafil analogues in herbal products.

Journal: Food additives and contaminants 20040801

Title: Orally active antimalarials: hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin.

Journal: Journal of medicinal chemistry 20040311

Title: Kinetics and mechanism of the aminolysis of methyl 4-nitrophenyl, methyl 2,4-dinitrophenyl, and phenyl 2,4-dinitrophenyl carbonates.

Journal: The Journal of organic chemistry 20021213

Title: Kinetics and mechanisms of the reactions of 3-methoxyphenyl, 3-chlorophenyl, and 4-cyanophenyl 4-nitrophenyl thionocarbonates with alicyclic amines.

Journal: The Journal of organic chemistry 20010907

Title: Noninvasive picoliter volume thermometry based on backscatter interferometry.

Journal: Electrophoresis 20010601

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