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103177-37-3,MFCD00864631
Catalog No.:AA008QYX

103177-37-3 | Pranlukast

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50mg
98%
in stock  
$6.00   $4.00
- +
100mg
98%
in stock  
$7.00   $5.00
- +
1g
98%
in stock  
$33.00   $23.00
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5g
98%
in stock  
$83.00   $58.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008QYX
Chemical Name:
Pranlukast
CAS Number:
103177-37-3
Molecular Formula:
C27H23N5O4
Molecular Weight:
481.5026
MDL Number:
MFCD00864631
SMILES:
O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1
Properties
Computed Properties
 
Complexity:
778  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
4.2  

Literature

Title: A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101

Title: Enhance the dissolution rate and oral bioavailability of pranlukast by preparing nanosuspensions with high-pressure homogenizing method.

Journal: Drug development and industrial pharmacy 20121101

Title: Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20120801

Title: Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development.

Journal: Pharmaceutical research 20120601

Title: Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation.

Journal: Respiratory medicine 20120401

Title: Pranlukast dry syrup inhibits symptoms of Japanese cedar pollinosis in children using OHIO Chamber.

Journal: Allergy and asthma proceedings 20120101

Title: A silica-induced pulmonary fibrosis model: are we closer to 'real life'?

Journal: International archives of allergy and immunology 20120101

Title: Pranlukast, a cysteinyl leukotriene type 1 receptor antagonist, attenuates the progression but not the onset of silica-induced pulmonary fibrosis in mice.

Journal: International archives of allergy and immunology 20120101

Title: Delay of onset of symptoms of Japanese cedar pollinosis by treatment with a leukotriene receptor antagonist.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20111201

Title: Successful multidrug treatment of a pediatric patient with severe Churg-Strauss syndrome refractory to prednisolone.

Journal: The Tohoku journal of experimental medicine 20111001

Title: Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20110801

Title: Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages.

Journal: Cytokine 20110701

Title: α-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization.

Journal: International journal of pharmaceutics 20110530

Title: Pranlukast attenuates hydrogen peroxide-induced necrosis in endothelial cells by inhibiting oxygen reactive species-mediated collapse of mitochondrial membrane potential.

Journal: Journal of cardiovascular pharmacology 20110401

Title: Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.

Journal: The Journal of pharmacy and pharmacology 20110401

Title: Effects of leukotriene receptor antagonists on peripheral eosinophil counts and serum IgE levels in children with food allergy.

Journal: Drugs in R&D 20100901

Title: Serum interleukin-5 levels correlate with disease activity of Churg-Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid.

Journal: Scandinavian journal of rheumatology 20100801

Title: Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.

Journal: Bioorganic & medicinal chemistry 20100801

Title: Colloid formation by drugs in simulated intestinal fluid.

Journal: Journal of medicinal chemistry 20100527

Title: Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.

Journal: Glia 20100401

Title: Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20100401

Title: Antileukotriene drugs in the treatment of asthma.

Journal: Polskie Archiwum Medycyny Wewnetrznej 20100301

Title: Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva).

Journal: European journal of pharmacology 20100225

Title: Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.

Journal: BMC structural biology 20100101

Title: Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability.

Journal: The Keio journal of medicine 20100101

Title: Functional expression of cysteinyl leukotriene receptors on human platelets.

Journal: Platelets 20100101

Title: Comparable effect of a leukotriene receptor antagonist and long-acting beta₂-adrenergic agonist in cough variant asthma.

Journal: Allergy and asthma proceedings 20100101

Title: Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Additional effects of pranlukast in salmeterol/fluticasone combination therapy for the asthmatic distal airway in a randomized crossover study.

Journal: Pulmonary pharmacology & therapeutics 20091201

Title: Targeting leukotrienes for the treatment of COPD?

Journal: Inflammation & allergy drug targets 20090901

Title: Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics.

Journal: Respirology (Carlton, Vic.) 20090801

Title: Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20090601

Title: Remodeling of nasal mucosa by allergen exposure in guinea pigs is suppressed by steroid and pranlukast.

Journal: Rhinology 20090601

Title: In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes.

Journal: Biological & pharmaceutical bulletin 20090401

Title: Molecular mechanism of the additive effects of leukotriene modifier in asthmatic patients receiving steroid therapy.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20090301

Title: Pharmacological analysis of antigen-induced late airway response in rats.

Journal: Biological & pharmaceutical bulletin 20090301

Title: Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation.

Journal: Journal of cardiovascular pharmacology 20090101

Title: Cedar and cypress pollinosis and allergic rhinitis: quality of life effects of early intervention with leukotriene receptor antagonists.

Journal: International archives of allergy and immunology 20090101

Title: Beneficial effects of leukotriene receptor antagonists in the prevention of cedar pollinosis in a community setting.

Journal: Journal of investigational allergology & clinical immunology 20090101

Title: A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20081201

Title: Two pharmacological phases in antigen-induced immediate airway response in rats.

Journal: Biological & pharmaceutical bulletin 20081201

Title: Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin.

Journal: International journal of pharmaceutics 20080122

Title: Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080101

Title: Role of regular treatment with inhaled corticosteroid or leukotriene receptor antagonist in mild intermittent asthma.

Journal: Allergy and asthma proceedings 20080101

Title: Correlations of health-related quality of life questionnaire results in asthma and allergic rhinitis: effects of a leukotriene receptor antagonist.

Journal: The Journal of international medical research 20080101

Title: Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists.

Journal: Respiration; international review of thoracic diseases 20080101

Title: Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers.

Journal: Drug metabolism and pharmacokinetics 20080101

Title: Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers.

Journal: European journal of pharmacology 20071208

Title: Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats.

Journal: Inflammopharmacology 20071201

Title: Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.

Journal: International immunopharmacology 20071101

Title: Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.

Journal: Journal of pharmacological sciences 20071101

Title: [Adverse effects of leukotriene-antagonists].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20070911

Title: Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.

Journal: Journal of pharmacological sciences 20070901

Title: Cysteinyl leukotriene receptor 1 partially mediates brain cryoinjury in mice.

Journal: Acta pharmacologica Sinica 20070701

Title: The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells.

Journal: Auris, nasus, larynx 20070601

Title: [Antileukotrienes and Churg-Strauss syndrome].

Journal: Presse medicale (Paris, France : 1983) 20070501

Title: Leukotriene synthesis inhibitors versus antagonists: the pros and cons.

Journal: Current allergy and asthma reports 20070501

Title: Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401

Title: Preparation of drug nanoparticles by co-grinding with cyclodextrin: formation mechanism and factors affecting nanoparticle formation.

Journal: Chemical & pharmaceutical bulletin 20070301

Title: [Effects of cysteinyl receptor agonist and antagonists on rat primary cortical neurons].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

Title: [Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

Title: Eosinophilic tumor in a patient with bronchial asthma receiving pranlukast.

Journal: European journal of pediatrics 20070201

Title: Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice.

Journal: The Journal of allergy and clinical immunology 20070101

Title: Comparative evaluation of the leukotriene receptor antagonist pranlukast versus the steroid inhalant fluticasone in the therapy of aged patients with mild bronchial asthma.

Journal: Arzneimittel-Forschung 20070101

Title: Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation.

Journal: Journal of leukocyte biology 20061201

Title: Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice.

Journal: Acta pharmacologica Sinica 20061201

Title: Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20061201

Title: Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, protects mice against brain cold injury.

Journal: European journal of pharmacology 20061107

Title: Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

Journal: The Journal of pharmacy and pharmacology 20061101

Title: Distribution of specific binding sites for cysteinyl leukotriene 1 receptor antagonist in human nasal mucosa.

Journal: Acta oto-laryngologica 20060901

Title: Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats.

Journal: Neuroscience 20060707

Title: Effects of anti-inflammatory therapies on recurrent and low-grade respiratory syncytial virus infections in a murine model of asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060701

Title: [Effect of Pranlukast on tissue remodeling in experimental guinea pig allergic rhinitis model].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20060701

Title: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.

Journal: Drug metabolism and pharmacokinetics 20060401

Title: Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice.

Journal: Acta pharmacologica Sinica 20060301

Title: Attenuation of cysteinyl leukotrienes induces human mesenchymal stem cell differentiation.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20060101

Title: CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.

Journal: Biochemical pharmacology 20051219

Title: Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers.

Journal: Prostaglandins & other lipid mediators 20051201

Title: Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast.

Journal: Clinical rheumatology 20051101

Title: Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050901

Title: Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice.

Journal: Brain research 20050816

Title: Effects of various anti-asthmatic agents on mite allergen-pulsed murine bone marrow-derived dendritic cells.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050701

Title: Delayed-type asthmatic response induced by repeated intratracheal exposure to toluene-2,4-diisocyanate in guinea pigs.

Journal: International archives of allergy and immunology 20050601

Title: Effect of pet removal on pet allergic asthma.

Journal: Chest 20050501

Title: ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.

Journal: Acta pharmacologica Sinica 20050401

Title: Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells.

Journal: Pharmacology 20050201

Title: Pranlukast, a leukotriene receptor antagonist, inhibits interleukin-5 production via a mechanism distinct from leukotriene receptor antagonism.

Journal: International archives of allergy and immunology 20050201

Title: Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.

Journal: Pharmacology 20050101

Title: Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils.

Journal: International archives of allergy and immunology 20050101

Title: Evaluation of theophylline or pranlukast, a cysteinyl leukotriene receptor 1 antagonist, as add-on therapy in uncontrolled asthmatic patients with a medium dose of inhaled corticosteroids.

Journal: Allergy and asthma proceedings 20050101

Title: A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20041115

Title: Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression.

Journal: The Journal of allergy and clinical immunology 20041101

Title: Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs.

Journal: Prostaglandins & other lipid mediators 20041001

Title: Urinary leukotriene E4 in Henoch-Schonlein purpura.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

Title: Pranlukast, a leukotriene receptor antagonist, prolongs the duration of the migrating motor complex in dogs.

Journal: Digestive diseases and sciences 20040801

Title: Pranlukast regulates tumour growth by attenuating IL-4 production in Kimura disease.

Journal: European journal of pediatrics 20040701

Title: Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma.

Journal: The Journal of allergy and clinical immunology 20040701

Title: Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients.

Journal: Chest 20040501

Title: Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040501

Title: The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma.

Journal: American journal of respiratory and critical care medicine 20040415

Title: [Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: Long-term follow-up of pulmonary function in bronchial asthma patients treated with pranlukast.

Journal: Lung 20040101

Title: [Effect of pranlukast on histamine release and leukotriene c4 (ltc4) generation from human peripheral basophils].

Journal: Arerugi = [Allergy] 20040101

Title: [Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040101

Title: The position of pranlukast, a cysteinyl leukotriene receptor antagonist, in the long-term treatment of asthma. 5-year follow-up study.

Journal: Respiration; international review of thoracic diseases 20040101

Title: Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig.

Journal: Experimental lung research 20040101

Title: Clinical evaluation of response to long-term treatment with Pranlukast in patients with bronchial asthma.

Journal: Journal of investigational allergology & clinical immunology 20040101

Title: [An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia].

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20031225

Title: Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats.

Journal: Acta pharmacologica Sinica 20031201

Title: Churg-Strauss syndrome (CSS) in a patient receiving pranlukast.

Journal: Clinical rheumatology 20031201

Title: Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.

Journal: Journal of pharmacological sciences 20031201

Title: Leukotriene receptor antagonist pranlukast suppresses eosinophil infiltration and cytokine production in human nasal mucosa of perennial allergic rhinitis.

Journal: The Annals of otology, rhinology, and laryngology 20031101

Title: Formation of fine drug particle by cogrinding with cyclodextrins. Part II. The influence of moisture condition during cogrinding process on fine particle formation.

Journal: International journal of pharmaceutics 20031020

Title: [Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20031001

Title: The Churg-Strauss syndrome after pranlukast treatment in a patient not receiving corticosteroids.

Journal: Annals of internal medicine 20030902

Title: gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo.

Journal: European journal of immunology 20030801

Title: Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma.

Journal: The Journal of allergy and clinical immunology 20030801

Title: [Expression of vascular cell adhesion molecule-1 in lung slices from antigen sensitized rats and pharmacological modulation].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20030801

Title: A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats.

Journal: The Journal of allergy and clinical immunology 20030701

Title: Churg-Strauss syndrome may be induced by leukotriene modifiers in severe asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030701

Title: Sputum eosinophilia and bronchial responsiveness in patients with chronic non-productive cough responsive to anti-asthma therapy.

Journal: Respirology (Carlton, Vic.) 20030601

Title: Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, attenuates allergen-specific tumour necrosis factor alpha production and nuclear factor kappa B nuclear translocation in peripheral blood monocytes from atopic asthmatics.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601

Title: Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601

Title: Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078).

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20030601

Title: [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030101

Title: Pranlukast: a review of its use in the management of asthma.

Journal: Drugs 20030101

Title: Thromboxane antagonism and cough in chronic bronchitis.

Journal: Annals of medicine 20030101

Title: Sleep apnea due to Kimura's disease of the larynx. Report of a case.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20030101

Title: Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma.

Journal: Arzneimittel-Forschung 20030101

Title: Recent advances in the management of asthma using leukotriene modifiers.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20030101

Title: [Study on the effect of cysteinyl leukotriene antagonist, pranlukast hydrate, on adhesive interaction between eosinophils and pulmonary endothelial cells].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20021201

Title: Correlation between cysteinyl leukotriene release from leukocytes and clinical response to a leukotriene inhibitor.

Journal: Chest 20021101

Title: Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma.

Journal: Pharmacogenetics 20021001

Title: Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in rats.

Journal: Acta pharmacologica Sinica 20021001

Title: Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein.

Journal: Respirology (Carlton, Vic.) 20020901

Title: [The effectiveness of the long-term treatment with pranlukast in pediatric patients with mild to moderate asthma].

Journal: Arerugi = [Allergy] 20020501

Title: [Evaluation before and after pranlukast administration with the QOL questionnaire (revised version 2001) for pediatric patients with bronchial asthma and their parents or caregivers].

Journal: Arerugi = [Allergy] 20020501

Title: Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.

Journal: Biochemical pharmacology 20020415

Title: Experimental otitis media with effusion induced by leukotriene D4.

Journal: Auris, nasus, larynx 20020401

Title: Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020401

Title: Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.

Journal: Chest 20020101

Title: Evaluation of the combined effect of pranlukast during high-dose steroid inhalation.

Journal: Arzneimittel-Forschung 20020101

Title: The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.

Journal: Biochemical pharmacology 20011101

Title: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

Journal: Cancer research 20011001

Title: [Leukotriene modifiers].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011001

Title: Fulminant eosinophilic endomyocarditis in an asthmatic patient treated with pranlukast after corticosteroid withdrawal.

Journal: Heart (British Cardiac Society) 20010901

Title: Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010901

Title: Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a guinea pig model of allergic rhinitis.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010901

Title: Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells.

Journal: The Journal of investigative dermatology 20010801

Title: Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.

Journal: Internal medicine (Tokyo, Japan) 20010801

Title: Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderate or severe asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010801

Title: Efficacy and safety of long-term treatment of asthmatic patients with pranlukast, a cysteinyl-leukotriene-receptor antagonist: four-year followup study.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010701

Title: Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010701

Title: Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010701

Title: Churg-Strauss syndrome after reduction of inhaled corticosteroid in a patient treated with pranlukast for asthma.

Journal: Internal medicine (Tokyo, Japan) 20010501

Title: Clinical effects of pranlukast, an oral leukotriene receptor antagonist, in mild-to-moderate asthma: a 4 week randomized multicentre controlled trial.

Journal: Respirology (Carlton, Vic.) 20010301

Title: Antileukotrienes in asthma: present situation.

Journal: Expert opinion on pharmacotherapy 20010301

Title: Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells.

Journal: European journal of pharmacology 20010216

Title: Effects of pranlukast, a leukotriene receptor antagonist, on airway inflammation in mild asthmatics.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20010201

Title: [Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010201

Title: Zafirlukast: an update of its pharmacology and therapeutic efficacy in asthma.

Journal: Drugs 20010101

Title: Characterization of the human cysteinyl leukotriene 2 receptor.

Journal: The Journal of biological chemistry 20000929

Title: The protective effects of leukotriene modifiers in aspirin-induced asthma.

Journal: Postgraduate medicine 20000915

Title: A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma.

Journal: Molecular pharmacology 20000601

Title: Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.

Journal: Bioorganic & medicinal chemistry letters 19990920

Title: Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.

Journal: Molecular pharmacology 19990901

Title: Churg-Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast.

Journal: The Journal of allergy and clinical immunology 19990301

Title: Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers.

Journal: The Journal of biological chemistry 19990122

Title: Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 19981215

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