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104931-87-5,MFCD00896451
Catalog No.:AA008SL0

104931-87-5 | ARBEKACIN SULPHATE

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SL0
Chemical Name:
ARBEKACIN SULPHATE
CAS Number:
104931-87-5
Molecular Formula:
C22H46N6O14S
Molecular Weight:
650.6974
MDL Number:
MFCD00896451
SMILES:
OS(=O)(=O)O.NCC[C@@H](C(=O)N[C@@H]1C[C@H](N)[C@H]([C@@H]([C@H]1O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)N)O)O)O[C@H]1O[C@H](CN)CC[C@H]1N)O
Properties
Computed Properties
 
Complexity:
839  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
19  
Hydrogen Bond Donor Count:
13  
Rotatable Bond Count:
10  

Literature

Title: Intrathoracic irrigation with arbekacin for methicillin-resistant Staphylococcus aureus empyema following lung resection.

Journal: Interactive cardiovascular and thoracic surgery 20120901

Title: The usefulness of arbekacin compared to vancomycin.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120701

Title: [The cutting-edge of medicine anti-MRSA agents; how to select and how to use].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20120410

Title: The efficacy and safety of high-dose arbekacin sulfate therapy (once-daily treatment) in patients with MRSA infection.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120401

Title: In vitro combination effects of aztreonam and aminoglycoside against multidrug-resistant Pseudomonas aeruginosa in Japan.

Journal: Japanese journal of infectious diseases 20120101

Title: Clinical efficacy of arbekacin for Gram-negative bacteria.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20111201

Title: Successful combination therapy with vancomycin and arbekacin against infective endocarditis caused by MRSA.

Journal: The Japanese journal of antibiotics 20111201

Title: [Influence of inoculum size on MICs for methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus].

Journal: The Japanese journal of antibiotics 20110801

Title: Staphylococcal scalded skin syndrome in an extremely low-birth-weight neonate: molecular characterization and rapid detection by multiplex and real-time PCR of methicillin-resistant Staphylococcus aureus.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20110401

Title: Perioperative antimicrobials in chest surgery patients positive for methicillin-resistant Staphylococcus aureus.

Journal: General thoracic and cardiovascular surgery 20101201

Title: [Evaluation of once a day of arbekacin administration to neonates as a new object of peak concentration].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20101101

Title: Mycobacterium abscessus corneal ulcer following sutured clear corneal cataract incision.

Journal: Japanese journal of ophthalmology 20100901

Title: Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.

Journal: The Journal of antibiotics 20100601

Title: Pharmacokinetics and pharmacodynamics of once-daily arbekacin during continuous venovenous hemodiafiltration in critically ill patients.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20091201

Title: Characterization of beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) in a patient with septicemia during long-term vancomycin administration.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20091001

Title: Effect of PEGylation of N-WASP181-200 on the inhibitory potency for renal aminoglycoside accumulation.

Journal: Bioconjugate chemistry 20090819

Title: MRSA-pyomyositis in a patient with acute myelogenous leukemia after intensive chemotherapy.

Journal: Anticancer research 20090801

Title: [Case with large abdominal abscess associated with a ventriculoperitoneal shunt].

Journal: No shinkei geka. Neurological surgery 20090401

Title: [Analysis of factors affecting long-term administration of anti-methicillin resistant Staphylococcus aureus (MRSA) drugs].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090301

Title: Recommended dose of arbekacin, an aminoglycoside against methicillin-resistant Staphylococcus aureus, does not achieve desired serum concentration in critically ill patients with lowered creatinine clearance.

Journal: Journal of clinical pharmacy and therapeutics 20081001

Title: [Appropriate use of anti-methicillin-resistant Staphylococcus aureus agents in a retrospective study].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080701

Title: Population pharmacokinetics of arbekacin in burn patients.

Journal: European journal of clinical pharmacology 20080601

Title: Evaluation of the clinical application of cystatin C, a new marker of the glomerular filtration rate, for the initial dose-setting of arbekacin.

Journal: Journal of clinical pharmacy and therapeutics 20080601

Title: Influences of dosage regimen and co-administration of low-molecular weight proteins and basic peptides on renal accumulation of arbekacin in mice.

Journal: The Journal of antimicrobial chemotherapy 20080301

Title: Microbiological and clinical study of methicillin-resistant Staphylococcus aureus (MRSA) carrying VraS mutation: changes in susceptibility to glycopeptides and clinical significance.

Journal: International journal of antimicrobial agents 20080101

Title: Prediction of aminoglycoside response against methicillin-resistant Staphylococcus aureus infection in burn patients by artificial neural network modeling.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080101

Title: [Analysis of factors in selecting anti-methicillin-resistant Staphylococcus aureus drugs by doctors].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080101

Title: Effect of varying the 4''-position of arbekacin derivatives on antibacterial activity against MRSA and Pseudomonas aeruginosa.

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: [In vitro activity of arbekacin against clinical isolates of Staphylococcus species and gram-negative bacilli].

Journal: The Korean journal of laboratory medicine 20070801

Title: Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: [Appropriate usage of antibiotics by therapeutic drug monitoring].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070601

Title: Trends in the gentamicin and arbekacin susceptibility of methicillin-resistant Staphylococcus aureus and the genes encoding aminoglycoside-modifying enzymes.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20070401

Title: 16S rRNA methylase-producing, gram-negative pathogens, Japan.

Journal: Emerging infectious diseases 20070401

Title: [Appropriate use of anti-MRSA drugs (discussion)].

Journal: The Japanese journal of antibiotics 20070201

Title: Comparative evaluation of the in vitro antimycobacterial activities of six aminoglycoside antibiotics using an agar dilution method.

Journal: Journal of chemotherapy (Florence, Italy) 20061201

Title: [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2004). I. Susceptibility distribution].

Journal: The Japanese journal of antibiotics 20060601

Title: Synergy of arbekacin-based combinations against vancomycin hetero-intermediate Staphylococcus aureus.

Journal: Journal of Korean medical science 20060401

Title: Trends of arbekacin-resistant MRSA strains in Japanese hospitals (1979 to 2000).

Journal: The Journal of antibiotics 20060401

Title: Synergistic effect of [10]-gingerol and aminoglycosides against vancomycin-resistant enterococci (VRE).

Journal: Biological & pharmaceutical bulletin 20060301

Title: Factors influencing neonatal therapeutic effect of anti-MRSA drugs.

Journal: International journal of clinical pharmacology and therapeutics 20050701

Title: Global spread of multiple aminoglycoside resistance genes.

Journal: Emerging infectious diseases 20050601

Title: [Combination effect of pazufloxacin and anti-mrsa drugs against beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR)].

Journal: The Japanese journal of antibiotics 20050201

Title: Synergistic effect of fosfomycin and arbekacin on a methicillin-resistant Staphylococcus aureus-induced biofilm in a rat model.

Journal: International journal of antimicrobial agents 20050101

Title: Dosage regimen of arbekacin for methicillin-resistant Staphylococcus aureus infection in newborns and infants.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20041201

Title: Clinical glycopeptide-intermediate staphylococci tested against arbekacin, daptomycin, and tigecycline.

Journal: Diagnostic microbiology and infectious disease 20041001

Title: Characterization of a bifunctional aminoglycoside-modifying enzyme with novel substrate specificity and its gene from a clinical isolate of methicillin-resistant Staphylococcus aureus with high arbekacin resistance.

Journal: The Journal of antibiotics 20041001

Title: Effect of arbekacin on a methicillin-resistant Staphylococcus aureus-induced biofilm in a rat model.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20041001

Title: [Combined effects of arbekacin with biapenem against in vitro and in vivo model of a mixture of MRSA and Pseudomonas aeruginosa].

Journal: The Japanese journal of antibiotics 20040601

Title: Artificial neural network modeling to predict the plasma concentration of aminoglycosides in burn patients.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20040501

Title: [Epidemiological study of Arbekacin-resistant, methicillin resistant Staphylococcus aureus in Saitama Medical School Hospital].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20040401

Title: [Sensitivity of MRSA isolated in our hospital to various antibacterial agents: changes over 5 years].

Journal: The Japanese journal of antibiotics 20040401

Title: Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides.

Journal: Antimicrobial agents and chemotherapy 20040201

Title: Application of artificial neural network modelling to identify severely ill patients whose aminoglycoside concentrations are likely to fall below therapeutic concentrations.

Journal: Journal of clinical pharmacy and therapeutics 20031001

Title: Molecular mechanism for the enhancement of arbekacin resistance in a methicillin-resistant Staphylococcus aureus.

Journal: FEBS letters 20030710

Title: Arbekacin is actively secreted in the rat intestine via a different efflux system from P-glycoprotein.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030601

Title: Efficacy and safety of arbekacin for staphylococcal infection in the NICU.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20030601

Title: Pharmacokinetics and dosing of arbekacin in preterm and term newborn infants.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20030401

Title: [Relationship between arbekacin-susceptibility and aminoglycoside-resistant gene of methicillin-resistant Staphylococcus aureus (MRSA)].

Journal: The Japanese journal of antibiotics 20030201

Title: [Attenuation of arbekacin-induced nephrotoxicity in rats by pazufloxacin mesilate].

Journal: The Japanese journal of antibiotics 20030201

Title: Treatment outcome of two-stage revision total hip arthroplasty for infected hip arthroplasty using antibiotic-impregnated cement spacer.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20030101

Title: [Survey of susceptibility of methicillin-resistant Staphylococcus aureus to antimicrobial agents in Hokusetsu General Hospital].

Journal: The Japanese journal of antibiotics 20021201

Title: Contact dermatitis from arbekacin sulfate: report of a case.

Journal: The Journal of dermatology 20021001

Title: Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea.

Journal: Cornea 20021001

Title: [Arbekacin resistant gene, aacA/aphD, in Staphylococcus aureus is lost during in vitro passage].

Journal: Rinsho byori. The Japanese journal of clinical pathology 20020101

Title: Mechanical properties of the femur after injection of calcium phosphate cement containing arbekacin sulfate and polylactic acid in a rat model of experimental osteoporosis.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20020101

Title: Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1.

Journal: Journal of basic microbiology 20020101

Title: [MRSA].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011101

Title: [Effect of arbekacin on the production of toxic shock syndrome toxin 1 by methicillin-resistant Staphylococcus aureus].

Journal: The Japanese journal of antibiotics 20010701

Title: In vitro antimicrobial activity of the aminoglycoside arbekacin tested against oxacillin-resistant Staphylococcus aureus isolated in Brazilian hospitals.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20010601

Title: [Combination effect of arbekacin and cefepime on mixed culture of MRSA and P. aeruginosa].

Journal: The Japanese journal of antibiotics 20010201

Title: Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit.

Journal: Pharmacology 20010101

Title: Antimicrobial activity of arbekacin, a new aminoglycoside antibiotic, against methicillin-resistant Staphylococcus aureus.

Journal: Drugs under experimental and clinical research 19940101

Title: [Habekacin: a new aminoglycoside. Study of nephrotoxicity in rats in comparison with gentamicin, netilmicin and amikacin].

Journal: Pathologie-biologie 19880601

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