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10537-47-0,MFCD00209853
Catalog No.:AA0084ZL

10537-47-0 | Tyrphostin 9 (RG-50872, Malonaben, SF 6847)

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5mg
≥98%
in stock  
$40.00   $28.00
- +
10mg
≥98%
in stock  
$72.00   $50.00
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25mg
>98.0%(GC)
in stock  
$79.00   $56.00
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100mg
≥98%
in stock  
$270.00   $189.00
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500mg
≥98%
in stock  
$1,029.00   $720.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0084ZL
Chemical Name:
Tyrphostin 9 (RG-50872, Malonaben, SF 6847)
CAS Number:
10537-47-0
Molecular Formula:
C18H22N2O
Molecular Weight:
282.3801
MDL Number:
MFCD00209853
SMILES:
N#CC(=Cc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)C#N
NSC Number:
242557
Properties
Computed Properties
 
Complexity:
459  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
5  

Literature

Title: A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation.

Journal: Biochemical and biophysical research communications 20110513

Title: A history of optogenetics: the development of tools for controlling brain circuits with light.

Journal: F1000 biology reports 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Establishment, characterization, and drug sensitivity of a new Ewing sarcoma cell line (SS-ES-1).

Journal: Journal of pediatric hematology/oncology 20101101

Title: Involvement of Ech hydrogenase in energy conservation of Methanosarcina mazei.

Journal: The FEBS journal 20100801

Title: The dopamine D4 receptor activates intracellular platelet-derived growth factor receptor beta to stimulate ERK1/2.

Journal: Cellular signalling 20100201

Title: Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.

Journal: Molecular brain 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.

Journal: Molecular immunology 20090201

Title: Electrochemical elucidation on the mechanism of uncoupling caused by hydrophobic weak acids.

Journal: Physical chemistry chemical physics : PCCP 20080814

Title: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080415

Title: Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

Journal: Arthritis and rheumatism 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20060201

Title: Modulation of intracellular calcium concentrations and T cell activation by prickly pear polyphenols.

Journal: Molecular and cellular biochemistry 20040501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: D-Aspartate is stored in secretory granules and released through a Ca(2+)-dependent pathway in a subset of rat pheochromocytoma PC12 cells.

Journal: The Journal of biological chemistry 20010713

Title: Ca2+-dependent exocytosis of L-glutamate by alphaTC6, clonal mouse pancreatic alpha-cells.

Journal: Diabetes 20010501

Title: Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts.

Journal: Journal of cell science 20010101

Title: Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

Journal: Journal of medicinal chemistry 19891001

Title: Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70.

Title: Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway. The Journal of Biological Chemistry, 2003, 278, 24577-24585.

Title: Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104(3):327-335.

Title: Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76(1): 33-42

Title: R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473

Title: Kumar N, et al. Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J Virol. 2011 Mar;85(6):2818-2

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