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105404-65-7,MFCD24038928
Catalog No.:AA0039UO

105404-65-7 | Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

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Purity
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Price(USD)
Quantity
  
100mg
95%
in stock  
$411.00   $288.00
- +
250mg
95%
in stock  
$809.00   $567.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0039UO
Chemical Name:
Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate
CAS Number:
105404-65-7
Molecular Formula:
C19H22FN3O3
Molecular Weight:
359.3947
MDL Number:
MFCD24038928
SMILES:
CCOC(=O)c1cn(C2CC2)c2c(c1=O)cc(c(c2)N1CCNCC1)F
Properties
Computed Properties
 
Complexity:
601  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
1.3  

Downstream Synthesis Route
479069-85-7    105404-65-7   
CASUnavailable 

[1]Zhi,Chengxin;Long,Zheng-Yu;Manikowski,Andrzej;Comstock,Jeanne;Xu,Wei-Chu;Brown,NealC.;TarantinoJr.,PaulM.;Holm,KarstenA.;Dix,EdwardJ.;Wright,GeorgeE.;Barnes,MarjorieH.;Butler,MichelleM.;Foster,KimberlyA.;LaMarr,WilliamA.;Bachand,Benoit;Bethell,Richard;Cadilhac,Caroline;Charron,Sylvie;Lamothe,Serge;Motorina,Irina;Storer,Richard[JournalofMedicinalChemistry,2006,vol.49,#4,p.1455-1465]

CASUnavailable 
  105404-65-7    479069-78-8 

[1]Zhi,Chengxin;Long,Zheng-Yu;Manikowski,Andrzej;Comstock,Jeanne;Xu,Wei-Chu;Brown,NealC.;TarantinoJr.,PaulM.;Holm,KarstenA.;Dix,EdwardJ.;Wright,GeorgeE.;Barnes,MarjorieH.;Butler,MichelleM.;Foster,KimberlyA.;LaMarr,WilliamA.;Bachand,Benoit;Bethell,Richard;Cadilhac,Caroline;Charron,Sylvie;Lamothe,Serge;Motorina,Irina;Storer,Richard[JournalofMedicinalChemistry,2006,vol.49,#4,p.1455-1465]

[1]Zhi,Chengxin;Long,Zheng-Yu;Manikowski,Andrzej;Comstock,Jeanne;Xu,Wei-Chu;Brown,NealC.;TarantinoJr.,PaulM.;Holm,KarstenA.;Dix,EdwardJ.;Wright,GeorgeE.;Barnes,MarjorieH.;Butler,MichelleM.;Foster,KimberlyA.;LaMarr,WilliamA.;Bachand,Benoit;Bethell,Richard;Cadilhac,Caroline;Charron,Sylvie;Lamothe,Serge;Motorina,Irina;Storer,Richard[JournalofMedicinalChemistry,2006,vol.49,#4,p.1455-1465]

[1]Zhi,Chengxin;Long,Zheng-Yu;Manikowski,Andrzej;Comstock,Jeanne;Xu,Wei-Chu;Brown,NealC.;TarantinoJr.,PaulM.;Holm,KarstenA.;Dix,EdwardJ.;Wright,GeorgeE.;Barnes,MarjorieH.;Butler,MichelleM.;Foster,KimberlyA.;LaMarr,WilliamA.;Bachand,Benoit;Bethell,Richard;Cadilhac,Caroline;Charron,Sylvie;Lamothe,Serge;Motorina,Irina;Storer,Richard[JournalofMedicinalChemistry,2006,vol.49,#4,p.1455-1465]

[1]Zhi,Chengxin;Long,Zheng-Yu;Manikowski,Andrzej;Comstock,Jeanne;Xu,Wei-Chu;Brown,NealC.;TarantinoJr.,PaulM.;Holm,KarstenA.;Dix,EdwardJ.;Wright,GeorgeE.;Barnes,MarjorieH.;Butler,MichelleM.;Foster,KimberlyA.;LaMarr,WilliamA.;Bachand,Benoit;Bethell,Richard;Cadilhac,Caroline;Charron,Sylvie;Lamothe,Serge;Motorina,Irina;Storer,Richard[JournalofMedicinalChemistry,2006,vol.49,#4,p.1455-1465]

Literature

Title: Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

Journal: Journal of medicinal chemistry 20110113

Title: From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.

Journal: Journal of medicinal chemistry 20100610

Title: Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach.

Journal: Journal of medicinal chemistry 20091224

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Tags:105404-65-7 Molecular Formula|105404-65-7 MDL|105404-65-7 SMILES|105404-65-7 Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate