Title: Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20180901
Title: Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster.
Journal: Redox biology 20150801
Title: Glutathione S-transferase class μ regulation of apoptosis signal-regulating kinase 1 protein during VCD-induced ovotoxicity in neonatal rat ovaries.
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Title: An update on primary ovarian insufficiency.
Journal: Science China. Life sciences 20120801
Title: Analysis of second-harmonic-generation microscopy in a mouse model of ovarian carcinoma.
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Title: Modeling perimenopause in Sprague-Dawley rats by chemical manipulation of the transition to ovarian failure.
Journal: Comparative medicine 20120601
Title: Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
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Title: 4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity.
Journal: Systems biology in reproductive medicine 20120201
Title: Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling.
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Title: Inhibition of ovarian KIT phosphorylation by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.
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Title: Estradiol treatment, physical activity, and muscle function in ovarian-senescent mice.
Journal: Experimental gerontology 20110801
Title: 4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats.
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Title: Induction of a menopausal state alters the growth and histology of ovarian tumors in a mouse model of ovarian cancer.
Journal: Menopause (New York, N.Y.) 20110501
Title: Inhibition of PIK3 signaling pathway members by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.
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Title: Accelerated ovarian failure: a novel, chemically induced animal model of menopause.
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Title: Midkine, a heparin-binding protein, is increased in the diabetic mouse kidney postmenopause.
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Title: Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility.
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Title: Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity.
Journal: Toxicology and applied pharmacology 20101115
Title: Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis).
Journal: Comparative medicine 20101001
Title: Dual protective role for glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary.
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Title: Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis.
Journal: Cancer biology & therapy 20100901
Title: The cognitive effects of conjugated equine estrogens depend on whether menopause etiology is transitional or surgical.
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Title: 7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide.
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Title: Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice.
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Title: A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity.
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Title: Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.
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Title: Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome.
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Title: Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system.
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Title: Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS).
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Title: Ovarian neoplasm development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian failure.
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Title: Steroidogenic capacity of residual ovarian tissue in 4-vinylcyclohexene diepoxide-treated mice.
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Title: Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes.
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Title: Collaborative work on evaluation of ovarian toxicity. 4) Two- or four-week repeated dose study of 4-vinylcyclohexene diepoxide in female rats.
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Title: Collaborative work on evaluation of ovarian toxicity. 4) Effects of fertility study of 4-vinylcyclohexene diepoxide in female rats.
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Title: Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse.
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Title: Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure.
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Title: Correlation of serum anti-Müllerian hormone with accelerated follicle loss following 4-vinylcyclohexene diepoxide-induced follicle loss in mice.
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Title: Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.
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Title: Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice.
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Title: Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats.
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Title: Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice.
Journal: Toxicology and applied pharmacology 20080701
Title: Peer review and reflection continues forever.
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Title: Development of a sampling and analysis method for 4-vinyl-1-cyclohexene in air.
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Title: Effects of impending ovarian failure induced by 4-vinylcyclohexene diepoxide on fertility in C57BL/6 female mice.
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Title: Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause.
Journal: American journal of physiology. Renal physiology 20070701
Title: Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition.
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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
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Title: Recent female mouse models displaying advanced reproductive aging.
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Title: Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause.
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Title: Dual modality imaging of a novel rat model of ovarian carcinogenesis.
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Title: Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause.
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Title: Atherosclerotic lesion development in a novel ovary-intact mouse model of perimenopause.
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Title: Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss.
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Title: Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinylcyclohexene diepoxide.
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Title: The follicle-deplete mouse ovary produces androgen.
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Title: Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.
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Title: Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
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Title: Ovarian follicle counts--not as simple as 1, 2, 3.
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Title: In vivo exposure of female rats to toxicants may affect oocyte quality.
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Title: Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide.
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Title: Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats.
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Title: Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries.
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Title: 17beta-estradiol affords protection against 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in Fischer-344 rats.
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Title: Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide.
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Title: 4-Vinyl-1-cyclohexene diepoxide.
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Title: Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats.
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Title: Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries.
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Title: Evaluation of hepatic cytochrome P4502E1 in the species-dependent bioactivation of 4-vinylcyclohexene.
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Title: Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades.
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Title: Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model.
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Title: Mechanisms of ovotoxicity induced by environmental chemicals: 4-vinylcyclohexene diepoxide as a model chemical.
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Title: Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice.
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Title: Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat.
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Title: Irritant symptoms and immunologic responses to multiple chemicals: importance of clinical and immunologic correlations.
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