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1062159-35-6,MFCD22419019
Catalog No.:AA008YUM

1062159-35-6 | Way-600

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$128.00   $89.00
- +
5mg
in stock  
$411.00   $288.00
- +
10mg
in stock  
$543.00   $380.00
- +
50mg
in stock  
$1,331.00   $932.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008YUM
Chemical Name:
Way-600
CAS Number:
1062159-35-6
Molecular Formula:
C28H30N8O
Molecular Weight:
494.5908
MDL Number:
MFCD22419019
SMILES:
O1CCN(CC1)c1nc(nc2c1cnn2C1CCN(CC1)Cc1cccnc1)c1ccc2c(c1)cc[nH]2
Properties
Computed Properties
 
Complexity:
744  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3  

Downstream Synthesis Route
1062159-35-6    164365-88-2   
C37H47N9O3 

[1]Patent:WO2018/204416,2018,A1.Locationinpatent:Paragraph00334

[2]Patent:WO2019/212991,2019,A1.Locationinpatent:Paragraph00438

1062159-35-6    164365-88-2    76-05-1   
4-(5-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo3,4-dpyrimidin-6-yl)-1H-indol-1-yl)butan-1-aminetrifluoroaceticacidsalt 

[1]Patent:WO2019/212991,2019,A1.Locationinpatent:Paragraph00438

Literature

Title: Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.

Journal: Journal of medicinal chemistry 20091126

Title: Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40.

Title: Wang K, et al. MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models. Biochem Biophys Res Commun. 2016 May 27;474(2):330-7.

Quotation Request
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SDS
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Tags:1062159-35-6 Molecular Formula|1062159-35-6 MDL|1062159-35-6 SMILES|1062159-35-6 Way-600
Catalog No.: AA008YUM
1062159-35-6,MFCD22419019
1062159-35-6 | Way-600
Pack Size： 1mg
Purity： ≥98%
in stock
$128.00 $89.00
Pack Size： 5mg
Purity：
in stock
$411.00 $288.00
Pack Size： 10mg
Purity：
in stock
$543.00 $380.00
Pack Size： 50mg
Purity：
in stock
$1,331.00 $932.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008YUM
Chemical Name: Way-600
CAS Number: 1062159-35-6
Molecular Formula: C28H30N8O
Molecular Weight: 494.5908
MDL Number: MFCD22419019
SMILES: O1CCN(CC1)c1nc(nc2c1cnn2C1CCN(CC1)Cc1cccnc1)c1ccc2c(c1)cc[nH]2
Properties
Complexity: 744  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 37  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3  
Downstream Synthesis Route
1062159-35-6    164365-88-2   
C37H47N9O3 

[1]Patent:WO2018/204416,2018,A1.Locationinpatent:Paragraph00334

[2]Patent:WO2019/212991,2019,A1.Locationinpatent:Paragraph00438

1062159-35-6    164365-88-2    76-05-1   
4-(5-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo3,4-dpyrimidin-6-yl)-1H-indol-1-yl)butan-1-aminetrifluoroaceticacidsalt 

[1]Patent:WO2019/212991,2019,A1.Locationinpatent:Paragraph00438

Literature fold

Title: Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.

Journal: Journal of medicinal chemistry20091126

Title: Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40.

Title: Wang K, et al. MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models. Biochem Biophys Res Commun. 2016 May 27;474(2):330-7.

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