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1062161-90-3,MFCD22417086
Catalog No.:AA008THV

1062161-90-3 | Wye-687

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$69.00   $48.00
- +
5mg
≥98%
in stock  
$181.00   $127.00
- +
10mg
≥98%
in stock  
$254.00   $178.00
- +
25mg
≥98%
in stock  
$472.00   $330.00
- +
50mg
≥98%
in stock  
$722.00   $505.00
- +
100mg
≥98%
in stock  
$1,120.00   $784.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008THV
Chemical Name:
Wye-687
CAS Number:
1062161-90-3
Molecular Formula:
C28H32N8O3
Molecular Weight:
528.6055
MDL Number:
MFCD22417086
SMILES:
COC(=O)Nc1ccc(cc1)c1nc(N2CCOCC2)c2c(n1)n(nc2)C1CCN(CC1)Cc1cccnc1
Properties
Computed Properties
 
Complexity:
785  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
2.4  

Literature

Title: Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.

Journal: Journal of medicinal chemistry 20091224

Title: ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.

Journal: Journal of medicinal chemistry 20090827

Title: Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40.

Title: Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.

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SDS
Tags:1062161-90-3 Molecular Formula|1062161-90-3 MDL|1062161-90-3 SMILES|1062161-90-3 Wye-687