107667-60-7,MFCD00870906
Catalog No.:AA007DTV

107667-60-7 | Polaprezinc

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Purity
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1g
97%
in stock  
$14.00   $10.00
- +
5g
97%
in stock  
$48.00   $34.00
- +
25g
97%
in stock  
$151.00   $106.00
- +
100g
97%
in stock  
$508.00   $356.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007DTV
Chemical Name:
Polaprezinc
CAS Number:
107667-60-7
Molecular Formula:
C9H11N4O3Zn
Molecular Weight:
288.5886
MDL Number:
MFCD00870906
SMILES:
[O-]1C(=O)C([N-]2[Zn+2]1NCCC2=O)Cc1cnc[nH]1
Properties
Computed Properties
 
Complexity:
265  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
-1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route

[1]Patent:KR2017/23417,2017,A.Locationinpatent:Paragraph0021;0022

Literature

Title: Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study.

Journal: BMC gastroenterology 20130101

Title: A comparison of the cellular actions of polaprezinc (zinc-L-carnosine) and ZnCl2.

Journal: Life sciences 20120627

Title: Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo.

Journal: American journal of veterinary research 20120501

Title: Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats.

Journal: Life sciences 20120116

Title: Oral zinc therapy for zinc deficiency-related telogen effluvium.

Journal: Dermatologic therapy 20120101

Title: [The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20111201

Title: Efficacy of polaprezinc for acute radiation proctitis in a rat model.

Journal: International journal of radiation oncology, biology, physics 20110701

Title: [Preventive effect of polaprezinc suspension dispersed in sodium alginate solution (P-AG) for stomatitis induced by Docetaxel/Cisplatin/Fluorouracil (DCF) chemotherapy in patients with head and neck cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20110501

Title: [Orally administered polaprezinc significantly improves taste disorders in ovarian cancer patient undergoing chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20110401

Title: The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line.

Journal: Mutation research 20110227

Title: Calcineurin inhibition by polaprezinc in rats with experimentally-induced colitis.

Journal: Life sciences 20110227

Title: Effects of zinc-L-carnosine and vitamin E on aspirin-induced gastroduodenal injury in dogs.

Journal: Journal of veterinary internal medicine 20110101

Title: Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats.

Journal: Journal of gastroenterology and hepatology 20101201

Title: Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer.

Journal: International journal of cancer 20101015

Title: Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20101001

Title: Effects of polaprezinc on morphological change of the tongue in zinc-deficient rats.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100901

Title: Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury.

Journal: Journal of gastroenterology 20100701

Title: Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment.

Journal: Auris, nasus, larynx 20100401

Title: Basal protrusion of ulcers induced by endoscopic submucosal dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc.

Journal: Hepato-gastroenterology 20100101

Title: Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats.

Journal: Life sciences 20091118

Title: A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study.

Journal: Acta oto-laryngologica 20091001

Title: Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection.

Journal: Journal of pharmacological sciences 20090701

Title: Induction of type 1 interferon receptor by zinc in U937 cells.

Journal: Cytokine 20090601

Title: Zinc deficiency anemia and effects of zinc therapy in maintenance hemodialysis patients.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20090601

Title: Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice.

Journal: European journal of pharmacology 20081214

Title: Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.

Journal: Journal of gastroenterology and hepatology 20081201

Title: Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells.

Journal: Journal of radiation research 20080701

Title: [Involvement of zinc in taste disturbance occurring during treatment for malignant tumor in the chest and the effects of polaprezinc oral disintegrating tablets (a retrospective study)].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20080601

Title: Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease.

Journal: Scandinavian journal of gastroenterology 20070901

Title: Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha-2b and ribavirin.

Journal: Journal of nutritional science and vitaminology 20070601

Title: Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes.

Journal: Gut 20070201

Title: Evaluation of topical external medicine for 5-fluorouracil-induced oral mucositis in hamsters.

Journal: European journal of pharmacology 20061203

Title: Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation.

Journal: Life sciences 20061110

Title: Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.

Journal: Biochemical and biophysical research communications 20061020

Title: Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins.

Journal: World journal of gastroenterology 20061014

Title: Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: a randomized controlled clinical trial.

Journal: World journal of gastroenterology 20060227

Title: Randomized controlled trial of consensus interferon with or without zinc for chronic hepatitis C patients with genotype 2.

Journal: World journal of gastroenterology 20060214

Title: Effect of polaprezinc on taste disorders in zinc-deficient rats.

Journal: BioFactors (Oxford, England) 20060101

Title: Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice.

Journal: Scandinavian journal of gastroenterology 20051101

Title: Taste disorders: a survey of the examination methods and treatments used in Japan.

Journal: Acta oto-laryngologica 20051101

Title: New synthetic method of zinc(II) complexes based on mixing.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051001

Title: Effect of beta-alanyl-L-histidinato zinc on the differentiation of C2C12 cells.

Journal: Life sciences 20041217

Title: Effect of beta-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells.

Journal: Life sciences 20040402

Title: [A case of polaprezinc-induced pneumonitis].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20030801

Title: Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils.

Journal: Helicobacter 20021201

Title: Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine.

Journal: Digestive diseases and sciences 20021201

Title: Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20021101

Title: Effect of zinc-carnosine complex on muscular function in frail distrophin-deficient (mdx) mice.

Journal: The Japanese journal of physiology 20021001

Title: [Efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis].

Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 20020301

Title: [Chaperon-induction therapy for peptic ulcers].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: [Polaprezinc].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: Effect of zinc-carnosine chelate compound on muscle function in mdx mouse.

Journal: The Japanese journal of physiology 20020201

Title: Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C.

Journal: Journal of viral hepatitis 20010901

Title: Cell culture model for antiulcerogenic agents.

Journal: Microscopy research and technique 20010615

Title: Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils--a study using intravital videomicroscopy.

Journal: Alimentary pharmacology & therapeutics 20010501

Title: Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury.

Journal: Digestive diseases and sciences 20010401

Title: Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats--role of insulin-like growth factors (IGF)-1.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101

Title: Protection by polaprezinc, an anti-ulcer drug, against indomethacin-induced apoptosis in rat gastric mucosal cells.

Journal: Japanese journal of pharmacology 20000901

Title: Effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor I.

Journal: Biochemical pharmacology 19990715

Title: Odawara S, et al. Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice. Mol Clin Oncol. 2016 Oct;5(4):377-381.

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Tags:107667-60-7 Molecular Formula|107667-60-7 MDL|107667-60-7 SMILES|107667-60-7 Polaprezinc
Catalog No.: AA007DTV
107667-60-7,MFCD00870906
107667-60-7 | Polaprezinc
Pack Size: 1g
Purity: 97%
in stock
$14.00 $10.00
Pack Size: 5g
Purity: 97%
in stock
$48.00 $34.00
Pack Size: 25g
Purity: 97%
in stock
$151.00 $106.00
Pack Size: 100g
Purity: 97%
in stock
$508.00 $356.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA007DTV
Chemical Name: Polaprezinc
CAS Number: 107667-60-7
Molecular Formula: C9H11N4O3Zn
Molecular Weight: 288.5886
MDL Number: MFCD00870906
SMILES: [O-]1C(=O)C([N-]2[Zn+2]1NCCC2=O)Cc1cnc[nH]1
Properties
Complexity: 265  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: -1  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
5970-45-6    305-84-0    107667-60-7 

[1]Patent:KR2017/23417,2017,A.Locationinpatent:Paragraph0021;0022

Literature fold

Title: Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study.

Journal: BMC gastroenterology20130101

Title: A comparison of the cellular actions of polaprezinc (zinc-L-carnosine) and ZnCl2.

Journal: Life sciences20120627

Title: Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo.

Journal: American journal of veterinary research20120501

Title: Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats.

Journal: Life sciences20120116

Title: Oral zinc therapy for zinc deficiency-related telogen effluvium.

Journal: Dermatologic therapy20120101

Title: [The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20111201

Title: Efficacy of polaprezinc for acute radiation proctitis in a rat model.

Journal: International journal of radiation oncology, biology, physics20110701

Title: [Preventive effect of polaprezinc suspension dispersed in sodium alginate solution (P-AG) for stomatitis induced by Docetaxel/Cisplatin/Fluorouracil (DCF) chemotherapy in patients with head and neck cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20110501

Title: [Orally administered polaprezinc significantly improves taste disorders in ovarian cancer patient undergoing chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20110401

Title: The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line.

Journal: Mutation research20110227

Title: Calcineurin inhibition by polaprezinc in rats with experimentally-induced colitis.

Journal: Life sciences20110227

Title: Effects of zinc-L-carnosine and vitamin E on aspirin-induced gastroduodenal injury in dogs.

Journal: Journal of veterinary internal medicine20110101

Title: Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats.

Journal: Journal of gastroenterology and hepatology20101201

Title: Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer.

Journal: International journal of cancer20101015

Title: Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20101001

Title: Effects of polaprezinc on morphological change of the tongue in zinc-deficient rats.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology20100901

Title: Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury.

Journal: Journal of gastroenterology20100701

Title: Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment.

Journal: Auris, nasus, larynx20100401

Title: Basal protrusion of ulcers induced by endoscopic submucosal dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc.

Journal: Hepato-gastroenterology20100101

Title: Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats.

Journal: Life sciences20091118

Title: A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study.

Journal: Acta oto-laryngologica20091001

Title: Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection.

Journal: Journal of pharmacological sciences20090701

Title: Induction of type 1 interferon receptor by zinc in U937 cells.

Journal: Cytokine20090601

Title: Zinc deficiency anemia and effects of zinc therapy in maintenance hemodialysis patients.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy20090601

Title: Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice.

Journal: European journal of pharmacology20081214

Title: Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.

Journal: Journal of gastroenterology and hepatology20081201

Title: Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells.

Journal: Journal of radiation research20080701

Title: [Involvement of zinc in taste disturbance occurring during treatment for malignant tumor in the chest and the effects of polaprezinc oral disintegrating tablets (a retrospective study)].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20080601

Title: Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease.

Journal: Scandinavian journal of gastroenterology20070901

Title: Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha-2b and ribavirin.

Journal: Journal of nutritional science and vitaminology20070601

Title: Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes.

Journal: Gut20070201

Title: Evaluation of topical external medicine for 5-fluorouracil-induced oral mucositis in hamsters.

Journal: European journal of pharmacology20061203

Title: Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation.

Journal: Life sciences20061110

Title: Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.

Journal: Biochemical and biophysical research communications20061020

Title: Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins.

Journal: World journal of gastroenterology20061014

Title: Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: a randomized controlled clinical trial.

Journal: World journal of gastroenterology20060227

Title: Randomized controlled trial of consensus interferon with or without zinc for chronic hepatitis C patients with genotype 2.

Journal: World journal of gastroenterology20060214

Title: Effect of polaprezinc on taste disorders in zinc-deficient rats.

Journal: BioFactors (Oxford, England)20060101

Title: Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice.

Journal: Scandinavian journal of gastroenterology20051101

Title: Taste disorders: a survey of the examination methods and treatments used in Japan.

Journal: Acta oto-laryngologica20051101

Title: New synthetic method of zinc(II) complexes based on mixing.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20051001

Title: Effect of beta-alanyl-L-histidinato zinc on the differentiation of C2C12 cells.

Journal: Life sciences20041217

Title: Effect of beta-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells.

Journal: Life sciences20040402

Title: [A case of polaprezinc-induced pneumonitis].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20030801

Title: Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils.

Journal: Helicobacter20021201

Title: Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine.

Journal: Digestive diseases and sciences20021201

Title: Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie20021101

Title: Effect of zinc-carnosine complex on muscular function in frail distrophin-deficient (mdx) mice.

Journal: The Japanese journal of physiology20021001

Title: [Efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis].

Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica20020301

Title: [Chaperon-induction therapy for peptic ulcers].

Journal: Nihon rinsho. Japanese journal of clinical medicine20020201

Title: [Polaprezinc].

Journal: Nihon rinsho. Japanese journal of clinical medicine20020201

Title: Effect of zinc-carnosine chelate compound on muscle function in mdx mouse.

Journal: The Japanese journal of physiology20020201

Title: Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C.

Journal: Journal of viral hepatitis20010901

Title: Cell culture model for antiulcerogenic agents.

Journal: Microscopy research and technique20010615

Title: Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils--a study using intravital videomicroscopy.

Journal: Alimentary pharmacology & therapeutics20010501

Title: Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury.

Journal: Digestive diseases and sciences20010401

Title: Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats--role of insulin-like growth factors (IGF)-1.

Journal: Medical science monitor : international medical journal of experimental and clinical research20010101

Title: Protection by polaprezinc, an anti-ulcer drug, against indomethacin-induced apoptosis in rat gastric mucosal cells.

Journal: Japanese journal of pharmacology20000901

Title: Effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor I.

Journal: Biochemical pharmacology19990715

Title: Odawara S, et al. Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice. Mol Clin Oncol. 2016 Oct;5(4):377-381.

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