Home Other Building Blocks 1094873-14-9
1094873-14-9,MFCD18782744
Catalog No.:AA008SQJ

1094873-14-9 | Jnj-31020028

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$29.00   $21.00
- +
10mg
98%
in stock  
$45.00   $32.00
- +
25mg
98%
in stock  
$74.00   $52.00
- +
50mg
98%
in stock  
$124.00   $87.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SQJ
Chemical Name:
Jnj-31020028
CAS Number:
1094873-14-9
Molecular Formula:
C34H36FN5O2
Molecular Weight:
565.6803
MDL Number:
MFCD18782744
SMILES:
CCN(C(=O)C(c1ccccc1)N1CCN(CC1)c1ccc(cc1F)NC(=O)c1ccccc1c1cccnc1)CC
Properties
Computed Properties
 
Complexity:
857  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.3  

Literature

Title: Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY(3-36).

Journal: Toxicology 20180601

Title: Role of Y(2) receptors in the regulation of gastric tone in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120401

Title: Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype.

Journal: Behavioural brain research 20110923

Title: The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Journal: Alcohol (Fayetteville, N.Y.) 20110901

Title: In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.

Journal: Psychopharmacology 20100201

Title: Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19750101

Title: Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4--(diethylamino)-2-oxo-1-phenylethylpiperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology (Berl). 2010 Feb;208(2):265-77.

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