110044-82-1,MFCD00065505
Catalog No.:AA007VVC

110044-82-1 | Mg-101

Pack Size
Purity
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1mg
≥95%
in stock  
$45.00   $31.00
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5mg
≥95%
in stock  
$88.00   $61.00
- +
10mg
≥95%
in stock  
$150.00   $105.00
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25mg
≥95%
in stock  
$315.00   $220.00
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100mg
95%
in stock  
$644.00   $451.00
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250mg
95%
in stock  
$1,130.00   $791.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007VVC
Chemical Name:
Mg-101
CAS Number:
110044-82-1
Molecular Formula:
C20H37N3O4
Molecular Weight:
383.5255
MDL Number:
MFCD00065505
SMILES:
CCCCC(NC(=O)C(NC(=O)C(NC(=O)C)CC(C)C)CC(C)C)C=O
Properties
Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
13  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:THEUNIVERSITYOFTOKYO;TOKYOUNIVERSITYOFSCIENCE-EP3312273,2018,A1Locationinpatent:Paragraph0132;0134

[2]CurrentPatentAssignee:TOKYOUNIVERSITYOFSCIENCE-EP3542821,2019,A1Locationinpatent:Paragraph0088;0154;0157

[3]CurrentPatentAssignee:TOKYOUNIVERSITYOFSCIENCE;THEUNIVERSITYOFTOKYO-EP3542824,2019,A1Locationinpatent:Paragraph0173-0174

110044-82-1   
CASUnavailable 

[1]CurrentPatentAssignee:THEUNIVERSITYOFTOKYO;TOKYOUNIVERSITYOFSCIENCE-EP3312273,2018,A1

Literature

Title: Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells.

Journal: Toxicology 20160715

Title: Vialinin A is a ubiquitin-specific peptidase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Anti-malarial activity of new N-acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLN) derivatives against Plasmodium falciparum.

Journal: Bioorganic & medicinal chemistry letters 20130301

Title: Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity.

Journal: Biochemical and biophysical research communications 20120622

Title: Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.

Journal: Molecular biology reports 20120601

Title: Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.

Journal: Journal of cell science 20120301

Title: Synthesis and evaluation of peptidyl α,β-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors.

Journal: Archives of pharmacal research 20120301

Title: IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.

Journal: Biochimica et biophysica acta 20120201

Title: Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation.

Journal: Archives of biochemistry and biophysics 20111215

Title: A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome.

Journal: Journal of cell science 20110815

Title: Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B.

Journal: Hepatology (Baltimore, Md.) 20110501

Title: Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Journal: Oncogene 20110217

Title: Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.

Journal: Stem cells (Dayton, Ohio) 20110201

Title: Inhibition of the ubiquitin-proteasome system sensitizes TRAIL-resistant prostate cancer cells by up-regulation of death receptor 5.

Journal: Molecular medicine reports 20110101

Title: Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton.

Journal: Reproduction (Cambridge, England) 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration.

Journal: Experimental eye research 20100901

Title: The production of 85 kDa N-terminal fragment of apolipoprotein B in mutant HepG2 cells generated by targeted modification of apoB gene occurs by ALLN-inhibitable protease cleavage during translocation.

Journal: Biochemical and biophysical research communications 20100806

Title: Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusion.

Journal: Canadian journal of physiology and pharmacology 20100501

Title: Targeted cancer stem cell therapies start with proper identification of the target.

Journal: Molecular cancer research : MCR 20100201

Title: Time-course correlation of early toxic events in three models of striatal damage: modulation by proteases inhibition.

Journal: Neurochemistry international 20100101

Title: Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain.

Journal: PloS one 20100101

Title: Hypoxic resistance to articular chondrocyte apoptosis--a possible mechanism of maintaining homeostasis of normal articular cartilage.

Journal: The FEBS journal 20091201

Title: The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.

Journal: Journal of pharmacological sciences 20091201

Title: Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Journal: Nature medicine 20091001

Title: Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.

Journal: Journal of lipid research 20090901

Title: Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.

Journal: Molecular pharmacology 20090801

Title: Effects of dopamine on LC3-II activation as a marker of autophagy in a neuroblastoma cell model.

Journal: Neurotoxicology 20090701

Title: Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090601

Title: Antimalarial effect of N-acetyl-L-Leucyl-L-leucyl-L-norleucinal by the inhibition of Plasmodium falciparum Calpain.

Journal: Archives of pharmacal research 20090601

Title: Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.

Journal: Journal of neuroscience research 20090501

Title: Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.

Journal: Neuroscience letters 20090424

Title: Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Journal: Cellular signalling 20090401

Title: HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity.

Journal: Biochimica et biophysica acta 20090201

Title: An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.

Journal: Circulation research 20090102

Title: Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.

Journal: PloS one 20090101

Title: Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.

Journal: Environmental toxicology and pharmacology 20081101

Title: Glutamate alteration of glutamic acid decarboxylase (GAD) in GABAergic neurons: the role of cysteine proteases.

Journal: Experimental neurology 20080901

Title: Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position.

Journal: Bioorganic & medicinal chemistry letters 20080901

Title: Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells.

Journal: Cellular signalling 20080701

Title: Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein.

Journal: Tissue antigens 20080701

Title: Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.

Journal: Experimental cell research 20080501

Title: UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation.

Journal: Molecular cancer therapeutics 20080401

Title: Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways.

Journal: Clinical and vaccine immunology : CVI 20080201

Title: Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

Journal: Anti-cancer drugs 20080201

Title: Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors.

Journal: Journal of pharmacological sciences 20080101

Title: Multiplexing bioluminescent and fluorescent reporters to monitor live cells.

Journal: Current chemical genomics 20080101

Title: Modulation of proteasome activity by vitamin E in THP-1 monocytes.

Journal: IUBMB life 20071201

Title: Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.

Journal: Experimental parasitology 20071001

Title: Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.

Journal: Blood 20071001

Title: Estrogen attenuates cardiac ischemia-reperfusion injury via inhibition of calpain-mediated bid cleavage.

Journal: Archives of pharmacal research 20071001

Title: Endothelial gap junctions are down-regulated by arsenic trioxide.

Journal: European journal of pharmacology 20070813

Title: Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases.

Journal: Apoptosis : an international journal on programmed cell death 20070801

Title: Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.

Journal: Journal of hepatology 20070701

Title: Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation.

Journal: Biochemical and biophysical research communications 20070608

Title: Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages.

Journal: Cardiovascular research 20070601

Title: Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.

Journal: Journal of cellular physiology 20070501

Title: Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain.

Journal: Platelets 20070501

Title: Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.

Journal: Biochemical pharmacology 20070401

Title: Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.

Journal: Biochemical and biophysical research communications 20070216

Title: Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism.

Journal: Archives of biochemistry and biophysics 20070101

Title: The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.

Journal: Molecular cancer 20070101

Title: Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease.

Journal: Neuro-degenerative diseases 20070101

Title: Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.

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Title: [Effect of ubiquitin-proteasome pathway on inflammatory reaction in intestine and its barrier function in rats with postburn sepsis].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20061101

Title: Remodeling of connexin 43 in the diabetic rat heart.

Journal: Molecular and cellular biochemistry 20061001

Title: Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.

Journal: Kidney international 20061001

Title: Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts.

Journal: Experimental cell research 20060701

Title: In vivo heteromer formation. Expression of soluble betaA4-crystallin requires coexpression of a heteromeric partner.

Journal: The FEBS journal 20060701

Title: Secreted proteins from Mycobacterium tuberculosis gain access to the cytosolic MHC class-I antigen-processing pathway.

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Title: Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast.

Journal: Biological & pharmaceutical bulletin 20060601

Title: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.

Journal: The Journal of biological chemistry 20060331

Title: Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.

Journal: Cell biology international 20060301

Title: Changes in tight junctional resistance of the cervical epithelium are associated with modulation of content and phosphorylation of occludin 65-kilodalton and 50-kilodalton forms.

Journal: Endocrinology 20060201

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Journal: Veterinary immunology and immunopathology 20060115

Title: Degradation of perilipin is mediated through ubiquitination-proteasome pathway.

Journal: Biochimica et biophysica acta 20060101

Title: Involvement of calcium in 7beta -hydroxycholesterol and cholesterol-5beta,6beta -epoxide-induced apoptosis.

Journal: International journal of toxicology 20060101

Title: Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion.

Journal: The Journal of biological chemistry 20051202

Title: Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes.

Journal: Biochimica et biophysica acta 20051015

Title: Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

Journal: Gene therapy 20051001

Title: Activation of multiple pathways during photoreceptor apoptosis in the rd mouse.

Journal: Investigative ophthalmology & visual science 20051001

Title: Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells.

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Title: Regulation of polymeric immunoglobulin receptor expression by reovirus.

Journal: The Journal of general virology 20050801

Title: Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20050701

Title: Involvement of calpain in melanogenesis of mouse B16 melanoma cells.

Journal: Molecular and cellular biochemistry 20050701

Title: Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.

Journal: The Journal of biological chemistry 20050513

Title: Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

Journal: Endocrinology 20050401

Title: Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B.

Journal: Journal of pineal research 20050401

Title: Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation.

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Title: The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.

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Title: CD4 and CD8 T cell response to the rHSP60 from Klebsiella pneumoniae in peripheral blood mononuclear cells from patients with ankylosing spondylitis.

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Title: Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation.

Journal: Mechanisms of development 20041001

Title: Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.

Journal: The Journal of biological chemistry 20040813

Title: Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.

Journal: Archives of dermatological research 20040701

Title: Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.

Journal: Journal of cellular biochemistry 20040701

Title: Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.

Journal: Biochemical and biophysical research communications 20040611

Title: Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation.

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Title: Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040401

Title: Calpain inhibitors improve myocardial dysfunction and inflammation induced by endotoxin in rats.

Journal: Shock (Augusta, Ga.) 20040401

Title: Amino acid sequences within the beta1 domain of human apolipoprotein B can mediate rapid intracellular degradation.

Journal: Journal of lipid research 20040201

Title: Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.

Journal: The Journal of biological chemistry 20040102

Title: Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040101

Title: Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells.

Journal: Biochimica et biophysica acta 20031230

Title: Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes.

Journal: The Biochemical journal 20031215

Title: The mechanism of alphaB-crystallin gene expression by proteasome inhibition.

Journal: Biochemical and biophysical research communications 20031107

Title: Proteolysis of type I inositol 1,4,5-trisphosphate receptor in WB rat liver cells.

Journal: The Biochemical journal 20031101

Title: Inducible CD40 expression mediates NFkappaB activation and cytokine secretion in human colonic fibroblasts.

Journal: Gut 20031001

Title: Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20031001

Title: Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation.

Journal: FEBS letters 20030828

Title: Radiosensitization by inhibition of IkappaB-alpha phosphorylation in human glioma cells.

Journal: Radiation research 20030801

Title: Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells.

Journal: Journal of cellular biochemistry 20030801

Title: Effects of rewarming on nuclear factor-kappaB and interleukin 8 expression in cold-preserved alveolar epithelial cells.

Journal: Transplantation 20030727

Title: Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum.

Journal: Molecular and biochemical parasitology 20030701

Title: Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.

Journal: Molecular cancer research : MCR 20030701

Title: Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulum.

Journal: The Journal of biological chemistry 20030613

Title: TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.

Journal: Blood 20030501

Title: Modulation of ERG25 expression by LDL in vascular cells.

Journal: Cardiovascular research 20030401

Title: Factors affecting premature chromosome condensation of cumulus cell nuclei injected into rat oocytes.

Journal: The Journal of reproduction and development 20030401

Title: Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells.

Journal: The Journal of biological chemistry 20030314

Title: I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.

Journal: American journal of physiology. Heart and circulatory physiology 20030301

Title: Role of BRCA1 in heat shock response.

Journal: Oncogene 20030109

Title: Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030101

Title: Synergistic induction of apoptosis of rheumatoid arthritis synovial cells by H(2)O(2) and N-acetyl-leucyl-leucyl-norleucinal.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20030101

Title: Involvement of the proteasome in IL-1beta induced suppression of islets of Langerhans in the rat.

Journal: Upsala journal of medical sciences 20030101

Title: Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells.

Journal: Cancer biology & therapy 20030101

Title: Low-density lipoprotein upregulates low-density lipoprotein receptor-related protein expression in vascular smooth muscle cells: possible involvement of sterol regulatory element binding protein-2-dependent mechanism.

Journal: Circulation 20021210

Title: Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43.

Journal: Cytokine 20021124

Title: Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020915

Title: Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.

Journal: Journal of lipid research 20020901

Title: Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells.

Journal: The Biochemical journal 20020801

Title: Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation.

Journal: The Journal of biological chemistry 20020621

Title: Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest.

Journal: The Journal of biological chemistry 20020510

Title: The time course of cardiac NF-kappaB activation and TNF-alpha secretion by cardiac myocytes after burn injury: contribution to burn-related cardiac contractile dysfunction.

Journal: Shock (Augusta, Ga.) 20020401

Title: Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.

Journal: Biochemical and biophysical research communications 20020125

Title: Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.

Journal: EMBO reports 20020115

Title: Regulation of transformed state by calpastatin via PKCepsilon in NIH3T3 mouse fibroblasts.

Journal: Biochemical and biophysical research communications 20020111

Title: Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells.

Journal: Molecular and cellular biochemistry 20020101

Title: Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.

Journal: Neuron 20011220

Title: Activation of caspase-8 during N-(4-hydroxyphenyl)retinamide-induced apoptosis in Fas-defective hepatoma cells.

Journal: Hepatology (Baltimore, Md.) 20011201

Title: Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells.

Journal: International journal of oncology 20011001

Title: Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein.

Journal: The EMBO journal 20011001

Title: Evidence for the Involvement of annexin 6 in the trafficking between the endocytic compartment and lysosomes.

Journal: Experimental cell research 20010910

Title: Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.

Journal: FEBS letters 20010824

Title: Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.

Journal: Journal of neurobiology 20010801

Title: Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway.

Journal: The Journal of biological chemistry 20010629

Title: Impairment of the ubiquitin-proteasome system by protein aggregation.

Journal: Science (New York, N.Y.) 20010525

Title: The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010501

Title: 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010501

Title: Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.

Journal: Biochemical pharmacology 20010401

Title: Peptide transport by the multidrug resistance protein MRP1.

Journal: Cancer research 20010315

Title: A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.

Journal: Gastroenterology 20010301

Title: LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.

Journal: Circulation research 20010216

Title: Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance.

Journal: Circulation 20010102

Title: Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.

Journal: Neuroscience 20010101

Title: Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid.

Journal: Journal of lipid research 20001201

Title: Peptide aldehydes as inhibitors of HIV protease.

Journal: FEBS letters 19930322

Title: Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-á-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2.

Journal: Endocrinology

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SDS
Tags:110044-82-1 Molecular Formula|110044-82-1 MDL|110044-82-1 SMILES|110044-82-1 Mg-101
Catalog No.: AA007VVC
110044-82-1,MFCD00065505
110044-82-1 | Mg-101
Pack Size: 1mg
Purity: ≥95%
in stock
$45.00 $31.00
Pack Size: 5mg
Purity: ≥95%
in stock
$88.00 $61.00
Pack Size: 10mg
Purity: ≥95%
in stock
$150.00 $105.00
Pack Size: 25mg
Purity: ≥95%
in stock
$315.00 $220.00
Pack Size: 100mg
Purity: 95%
in stock
$644.00 $451.00
Pack Size: 250mg
Purity: 95%
in stock
$1,130.00 $791.00
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Technical Information
Catalog Number: AA007VVC
Chemical Name: Mg-101
CAS Number: 110044-82-1
Molecular Formula: C20H37N3O4
Molecular Weight: 383.5255
MDL Number: MFCD00065505
SMILES: CCCCC(NC(=O)C(NC(=O)C(NC(=O)C)CC(C)C)CC(C)C)C=O
Properties
Complexity: 492  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 13  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3  
Downstream Synthesis Route
110044-82-1    148333-42-0 

[1]CurrentPatentAssignee:THEUNIVERSITYOFTOKYO;TOKYOUNIVERSITYOFSCIENCE-EP3312273,2018,A1Locationinpatent:Paragraph0132;0134

[2]CurrentPatentAssignee:TOKYOUNIVERSITYOFSCIENCE-EP3542821,2019,A1Locationinpatent:Paragraph0088;0154;0157

[3]CurrentPatentAssignee:TOKYOUNIVERSITYOFSCIENCE;THEUNIVERSITYOFTOKYO-EP3542824,2019,A1Locationinpatent:Paragraph0173-0174

110044-82-1   
CASUnavailable 

[1]CurrentPatentAssignee:THEUNIVERSITYOFTOKYO;TOKYOUNIVERSITYOFSCIENCE-EP3312273,2018,A1

Literature fold

Title: Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells.

Journal: Toxicology20160715

Title: Vialinin A is a ubiquitin-specific peptidase inhibitor.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Anti-malarial activity of new N-acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLN) derivatives against Plasmodium falciparum.

Journal: Bioorganic & medicinal chemistry letters20130301

Title: Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity.

Journal: Biochemical and biophysical research communications20120622

Title: Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.

Journal: Molecular biology reports20120601

Title: Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.

Journal: Journal of cell science20120301

Title: Synthesis and evaluation of peptidyl α,β-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors.

Journal: Archives of pharmacal research20120301

Title: IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.

Journal: Biochimica et biophysica acta20120201

Title: Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation.

Journal: Archives of biochemistry and biophysics20111215

Title: A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome.

Journal: Journal of cell science20110815

Title: Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B.

Journal: Hepatology (Baltimore, Md.)20110501

Title: Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Journal: Oncogene20110217

Title: Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.

Journal: Stem cells (Dayton, Ohio)20110201

Title: Inhibition of the ubiquitin-proteasome system sensitizes TRAIL-resistant prostate cancer cells by up-regulation of death receptor 5.

Journal: Molecular medicine reports20110101

Title: Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton.

Journal: Reproduction (Cambridge, England)20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration.

Journal: Experimental eye research20100901

Title: The production of 85 kDa N-terminal fragment of apolipoprotein B in mutant HepG2 cells generated by targeted modification of apoB gene occurs by ALLN-inhibitable protease cleavage during translocation.

Journal: Biochemical and biophysical research communications20100806

Title: Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusion.

Journal: Canadian journal of physiology and pharmacology20100501

Title: Targeted cancer stem cell therapies start with proper identification of the target.

Journal: Molecular cancer research : MCR20100201

Title: Time-course correlation of early toxic events in three models of striatal damage: modulation by proteases inhibition.

Journal: Neurochemistry international20100101

Title: Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain.

Journal: PloS one20100101

Title: Hypoxic resistance to articular chondrocyte apoptosis--a possible mechanism of maintaining homeostasis of normal articular cartilage.

Journal: The FEBS journal20091201

Title: The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.

Journal: Journal of pharmacological sciences20091201

Title: Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Journal: Nature medicine20091001

Title: Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.

Journal: Journal of lipid research20090901

Title: Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.

Journal: Molecular pharmacology20090801

Title: Effects of dopamine on LC3-II activation as a marker of autophagy in a neuroblastoma cell model.

Journal: Neurotoxicology20090701

Title: Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production.

Journal: American journal of physiology. Gastrointestinal and liver physiology20090601

Title: Antimalarial effect of N-acetyl-L-Leucyl-L-leucyl-L-norleucinal by the inhibition of Plasmodium falciparum Calpain.

Journal: Archives of pharmacal research20090601

Title: Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.

Journal: Journal of neuroscience research20090501

Title: Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.

Journal: Neuroscience letters20090424

Title: Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Journal: Cellular signalling20090401

Title: HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity.

Journal: Biochimica et biophysica acta20090201

Title: An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.

Journal: Circulation research20090102

Title: Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.

Journal: PloS one20090101

Title: Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.

Journal: Environmental toxicology and pharmacology20081101

Title: Glutamate alteration of glutamic acid decarboxylase (GAD) in GABAergic neurons: the role of cysteine proteases.

Journal: Experimental neurology20080901

Title: Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position.

Journal: Bioorganic & medicinal chemistry letters20080901

Title: Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells.

Journal: Cellular signalling20080701

Title: Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein.

Journal: Tissue antigens20080701

Title: Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.

Journal: Experimental cell research20080501

Title: UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation.

Journal: Molecular cancer therapeutics20080401

Title: Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways.

Journal: Clinical and vaccine immunology : CVI20080201

Title: Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

Journal: Anti-cancer drugs20080201

Title: Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors.

Journal: Journal of pharmacological sciences20080101

Title: Multiplexing bioluminescent and fluorescent reporters to monitor live cells.

Journal: Current chemical genomics20080101

Title: Modulation of proteasome activity by vitamin E in THP-1 monocytes.

Journal: IUBMB life20071201

Title: Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.

Journal: Experimental parasitology20071001

Title: Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.

Journal: Blood20071001

Title: Estrogen attenuates cardiac ischemia-reperfusion injury via inhibition of calpain-mediated bid cleavage.

Journal: Archives of pharmacal research20071001

Title: Endothelial gap junctions are down-regulated by arsenic trioxide.

Journal: European journal of pharmacology20070813

Title: Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases.

Journal: Apoptosis : an international journal on programmed cell death20070801

Title: Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.

Journal: Journal of hepatology20070701

Title: Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation.

Journal: Biochemical and biophysical research communications20070608

Title: Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages.

Journal: Cardiovascular research20070601

Title: Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.

Journal: Journal of cellular physiology20070501

Title: Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain.

Journal: Platelets20070501

Title: Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.

Journal: Biochemical pharmacology20070401

Title: Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.

Journal: Biochemical and biophysical research communications20070216

Title: Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism.

Journal: Archives of biochemistry and biophysics20070101

Title: The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.

Journal: Molecular cancer20070101

Title: Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease.

Journal: Neuro-degenerative diseases20070101

Title: Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20061108

Title: [Effect of ubiquitin-proteasome pathway on inflammatory reaction in intestine and its barrier function in rats with postburn sepsis].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue20061101

Title: Remodeling of connexin 43 in the diabetic rat heart.

Journal: Molecular and cellular biochemistry20061001

Title: Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.

Journal: Kidney international20061001

Title: Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts.

Journal: Experimental cell research20060701

Title: In vivo heteromer formation. Expression of soluble betaA4-crystallin requires coexpression of a heteromeric partner.

Journal: The FEBS journal20060701

Title: Secreted proteins from Mycobacterium tuberculosis gain access to the cytosolic MHC class-I antigen-processing pathway.

Journal: Journal of immunology (Baltimore, Md. : 1950)20060701

Title: Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast.

Journal: Biological & pharmaceutical bulletin20060601

Title: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.

Journal: The Journal of biological chemistry20060331

Title: Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.

Journal: Cell biology international20060301

Title: Changes in tight junctional resistance of the cervical epithelium are associated with modulation of content and phosphorylation of occludin 65-kilodalton and 50-kilodalton forms.

Journal: Endocrinology20060201

Title: Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic.

Journal: Journal of biochemistry20060201

Title: The selective inhibition of nitric oxide production in the avian macrophage cell line HD11.

Journal: Veterinary immunology and immunopathology20060115

Title: Degradation of perilipin is mediated through ubiquitination-proteasome pathway.

Journal: Biochimica et biophysica acta20060101

Title: Involvement of calcium in 7beta -hydroxycholesterol and cholesterol-5beta,6beta -epoxide-induced apoptosis.

Journal: International journal of toxicology20060101

Title: Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion.

Journal: The Journal of biological chemistry20051202

Title: Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes.

Journal: Biochimica et biophysica acta20051015

Title: Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

Journal: Gene therapy20051001

Title: Activation of multiple pathways during photoreceptor apoptosis in the rd mouse.

Journal: Investigative ophthalmology & visual science20051001

Title: Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells.

Journal: Human gene therapy20050901

Title: Regulation of polymeric immunoglobulin receptor expression by reovirus.

Journal: The Journal of general virology20050801

Title: Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20050701

Title: Involvement of calpain in melanogenesis of mouse B16 melanoma cells.

Journal: Molecular and cellular biochemistry20050701

Title: Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.

Journal: The Journal of biological chemistry20050513

Title: Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

Journal: Endocrinology20050401

Title: Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B.

Journal: Journal of pineal research20050401

Title: Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation.

Journal: Pigment cell research20050401

Title: Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand.

Journal: The Journal of general virology20050401

Title: Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.

Journal: Cancer research20050301

Title: Participation of the ubiquitin-proteasome pathway in rat oocyte activation.

Journal: Zygote (Cambridge, England)20050201

Title: The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.

Journal: BMC cancer20050101

Title: CD4 and CD8 T cell response to the rHSP60 from Klebsiella pneumoniae in peripheral blood mononuclear cells from patients with ankylosing spondylitis.

Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion20050101

Title: Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation.

Journal: Mechanisms of development20041001

Title: Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.

Journal: The Journal of biological chemistry20040813

Title: Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.

Journal: Archives of dermatological research20040701

Title: Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.

Journal: Journal of cellular biochemistry20040701

Title: Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.

Journal: Biochemical and biophysical research communications20040611

Title: Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation.

Journal: International journal of molecular medicine20040501

Title: Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040401

Title: Calpain inhibitors improve myocardial dysfunction and inflammation induced by endotoxin in rats.

Journal: Shock (Augusta, Ga.)20040401

Title: Amino acid sequences within the beta1 domain of human apolipoprotein B can mediate rapid intracellular degradation.

Journal: Journal of lipid research20040201

Title: Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.

Journal: The Journal of biological chemistry20040102

Title: Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.

Journal: Arteriosclerosis, thrombosis, and vascular biology20040101

Title: Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells.

Journal: Biochimica et biophysica acta20031230

Title: Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes.

Journal: The Biochemical journal20031215

Title: The mechanism of alphaB-crystallin gene expression by proteasome inhibition.

Journal: Biochemical and biophysical research communications20031107

Title: Proteolysis of type I inositol 1,4,5-trisphosphate receptor in WB rat liver cells.

Journal: The Biochemical journal20031101

Title: Inducible CD40 expression mediates NFkappaB activation and cytokine secretion in human colonic fibroblasts.

Journal: Gut20031001

Title: Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research20031001

Title: Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation.

Journal: FEBS letters20030828

Title: Radiosensitization by inhibition of IkappaB-alpha phosphorylation in human glioma cells.

Journal: Radiation research20030801

Title: Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells.

Journal: Journal of cellular biochemistry20030801

Title: Effects of rewarming on nuclear factor-kappaB and interleukin 8 expression in cold-preserved alveolar epithelial cells.

Journal: Transplantation20030727

Title: Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum.

Journal: Molecular and biochemical parasitology20030701

Title: Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.

Journal: Molecular cancer research : MCR20030701

Title: Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulum.

Journal: The Journal of biological chemistry20030613

Title: TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.

Journal: Blood20030501

Title: Modulation of ERG25 expression by LDL in vascular cells.

Journal: Cardiovascular research20030401

Title: Factors affecting premature chromosome condensation of cumulus cell nuclei injected into rat oocytes.

Journal: The Journal of reproduction and development20030401

Title: Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells.

Journal: The Journal of biological chemistry20030314

Title: I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.

Journal: American journal of physiology. Heart and circulatory physiology20030301

Title: Role of BRCA1 in heat shock response.

Journal: Oncogene20030109

Title: Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion.

Journal: Journal of immunology (Baltimore, Md. : 1950)20030101

Title: Synergistic induction of apoptosis of rheumatoid arthritis synovial cells by H(2)O(2) and N-acetyl-leucyl-leucyl-norleucinal.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association20030101

Title: Involvement of the proteasome in IL-1beta induced suppression of islets of Langerhans in the rat.

Journal: Upsala journal of medical sciences20030101

Title: Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells.

Journal: Cancer biology & therapy20030101

Title: Low-density lipoprotein upregulates low-density lipoprotein receptor-related protein expression in vascular smooth muscle cells: possible involvement of sterol regulatory element binding protein-2-dependent mechanism.

Journal: Circulation20021210

Title: Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43.

Journal: Cytokine20021124

Title: Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES.

Journal: Journal of immunology (Baltimore, Md. : 1950)20020915

Title: Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.

Journal: Journal of lipid research20020901

Title: Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells.

Journal: The Biochemical journal20020801

Title: Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation.

Journal: The Journal of biological chemistry20020621

Title: Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest.

Journal: The Journal of biological chemistry20020510

Title: The time course of cardiac NF-kappaB activation and TNF-alpha secretion by cardiac myocytes after burn injury: contribution to burn-related cardiac contractile dysfunction.

Journal: Shock (Augusta, Ga.)20020401

Title: Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.

Journal: Biochemical and biophysical research communications20020125

Title: Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.

Journal: EMBO reports20020115

Title: Regulation of transformed state by calpastatin via PKCepsilon in NIH3T3 mouse fibroblasts.

Journal: Biochemical and biophysical research communications20020111

Title: Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells.

Journal: Molecular and cellular biochemistry20020101

Title: Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.

Journal: Neuron20011220

Title: Activation of caspase-8 during N-(4-hydroxyphenyl)retinamide-induced apoptosis in Fas-defective hepatoma cells.

Journal: Hepatology (Baltimore, Md.)20011201

Title: Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells.

Journal: International journal of oncology20011001

Title: Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein.

Journal: The EMBO journal20011001

Title: Evidence for the Involvement of annexin 6 in the trafficking between the endocytic compartment and lysosomes.

Journal: Experimental cell research20010910

Title: Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.

Journal: FEBS letters20010824

Title: Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.

Journal: Journal of neurobiology20010801

Title: Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway.

Journal: The Journal of biological chemistry20010629

Title: Impairment of the ubiquitin-proteasome system by protein aggregation.

Journal: Science (New York, N.Y.)20010525

Title: The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells.

Journal: Journal of immunology (Baltimore, Md. : 1950)20010501

Title: 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation.

Journal: Arteriosclerosis, thrombosis, and vascular biology20010501

Title: Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.

Journal: Biochemical pharmacology20010401

Title: Peptide transport by the multidrug resistance protein MRP1.

Journal: Cancer research20010315

Title: A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.

Journal: Gastroenterology20010301

Title: LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.

Journal: Circulation research20010216

Title: Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance.

Journal: Circulation20010102

Title: Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.

Journal: Neuroscience20010101

Title: Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid.

Journal: Journal of lipid research20001201

Title: Peptide aldehydes as inhibitors of HIV protease.

Journal: FEBS letters19930322

Title: Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-á-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2.

Journal: Endocrinology

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