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1103926-82-4,MFCD28396414
Catalog No.:AA0097DG

1103926-82-4 | TM 5275

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$45.00   $32.00
- +
2mg
98%
in stock  
$72.00   $50.00
- +
5mg
98%
in stock  
$135.00   $95.00
- +
10mg
98%
in stock  
$175.00   $123.00
- +
25mg
98%
in stock  
$228.00   $160.00
- +
50mg
98%
in stock  
$296.00   $207.00
- +
100mg
98%
in stock  
$384.00   $269.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0097DG
Chemical Name:
TM 5275
CAS Number:
1103926-82-4
Molecular Formula:
C28H28ClN3NaO5+
Molecular Weight:
544.9818
MDL Number:
MFCD28396414
SMILES:
O=C(Nc1ccc(cc1C(=O)O)Cl)COCC(=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1.[Na+]
Properties
Computed Properties
 
Complexity:
752  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  

Downstream Synthesis Route

[1]Yamaoka,Nagahisa;Kodama,Hidehiko;Izuhara,Yuko;Miyata,Toshio;Meguro,Kanji[ChemicalandPharmaceuticalBulletin,2011,vol.59,#2,p.215-224]

[1]Yamaoka,Nagahisa;Kodama,Hidehiko;Izuhara,Yuko;Miyata,Toshio;Meguro,Kanji[ChemicalandPharmaceuticalBulletin,2011,vol.59,#2,p.215-224]

C12H11Cl2NO5 
  1103926-82-4 

[1]Yamaoka,Nagahisa;Kodama,Hidehiko;Izuhara,Yuko;Miyata,Toshio;Meguro,Kanji[ChemicalandPharmaceuticalBulletin,2011,vol.59,#2,p.215-224]

[1]Locationinpatent:experimentalpartYamaoka,Nagahisa;Kodama,Hidehiko;Izuhara,Yuko;Miyata,Toshio;Meguro,Kanji[ChemicalandPharmaceuticalBulletin,2011,vol.59,#2,p.215-224]

Literature

Title: Izuhara Y, et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J Cereb Blood Flow Metab. 2010 May;30(5):904-12.

Title: Yasui H, et al. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells. Thromb Res. 2013 Jul;132(1):100-5.

Title: Mashiko S, et al. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biol Ther. 2015;16(2):253-60.

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SDS
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