Name: Name:(+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1
Brand: AABLOCKS
SKU: AA008RHA
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008RHA

Chemical Name: (+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1

CAS Number: 112137-89-0

Molecular Formula: C21H36O5

Molecular Weight: 368.5075

MDL Number: MFCD00869984

SMILES: CCCCC(CC=CC1C(O)CC(=O)C1CCCCCCC(=O)O)(O)C

Properties

Complexity: 473

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 3

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 26

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 13

Undefined Atom Stereocenter Count: 1

Undefined Bond Stereocenter Count: 0

XLogP3: 3.3

Downstream Synthesis Route

4846-21-3

112137-89-0

2641624-12-4

[1]CurrentPatentAssignee:YOOOOKJOON;LIFEXBIOLABS-US2021/139435,2021,A1Locationinpatent:Paragraph0171-0173

15457-50-8

112137-89-0

2641623-96-1

[1]CurrentPatentAssignee:YOOOOKJOON;LIFEXBIOLABS-US2021/139435,2021,A1Locationinpatent:Paragraph0147-0149

Literature fold

Title: Validated method for the determination of misoprostol acid in whole blood by ultra performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20121201

Title: Effect of bacterial vaginosis on the pharmacokinetics of misoprostol in early pregnancy.

Journal: Human reproduction (Oxford, England)20120201

Title: Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20110915

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Pharmacokinetics of repeated doses of misoprostol.

Journal: Human reproduction (Oxford, England)20090801

Title: Pharmacokinetic profiles up to 12 h after administration of vaginal, sublingual and slow-release oral misoprostol.

Journal: Human reproduction (Oxford, England)20070701

Title: Determination of misoprostol acid in human plasma by liquid chromatography coupled to tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070601

Title: The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration.

Journal: European journal of obstetrics, gynecology, and reproductive biology20030501

Title: The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.

Journal: Biochimica et biophysica acta20000117

Title: Vijaya Bharathi D, et al. Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2827-33.

Title: Schmidt-Hansen M, et al. Simultaneous compared to interval administration of mifepristone and misoprostol for medical abortion up to 10+0 weeks' gestation: a systematic review with meta-analyses. BMJ Sex Reprod Health. 2020 Feb 20. pii: bmjsrh-2019-200448.

112137-89-0 | (+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1