Home Thiazoles 1133819-87-0
1133819-87-0,MFCD28502493
Catalog No.:AA00IMMF

1133819-87-0 | 5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione

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10mg
≥95%
in stock  
$125.00   $87.00
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25mg
≥95%
in stock  
$276.00   $193.00
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50mg
≥95%
in stock  
$519.00   $363.00
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100mg
≥95%
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$912.00   $638.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IMMF
Chemical Name:
5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione
CAS Number:
1133819-87-0
Molecular Formula:
C19H17NO5S
Molecular Weight:
371.4070
MDL Number:
MFCD28502493
SMILES:
COc1cccc(c1)C(=O)COc1ccc(cc1)CC1SC(=O)NC1=O
Properties
Computed Properties
 
Complexity:
532  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.4  

Downstream Synthesis Route

[1]Tanis,StevenP.;Colca,JerryR.;Parker,TimothyT.;Artman,GeraldD.;Larsen,ScottD.;McDonald,WilliamG.;Gadwood,RobertC.;Kletzien,RolfF.;Zeller,JamesB.;Lee,PilH.;Adams,WadeJ.[BioorganicandMedicinalChemistry,2018,vol.26,#22,p.5870-5884]

[2]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-WO2009/38681,2009,A1Locationinpatent:Page/Pagecolumn40

[3]CurrentPatentAssignee:METABOLICSOLUTIONSDEVELOPMENTCOMAPNY,LLC-WO2010/105048,2010,A1Locationinpatent:Page/Pagecolumn63-64

[4]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-WO2014/93114,2014,A1Locationinpatent:Paragraph0399;0400

[5]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-US9126959,2015,B2Locationinpatent:Page/Pagecolumn109

[1]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-WO2011/133442,2011,A1Locationinpatent:Page/Pagecolumn33-34

[1]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-WO2012/21476,2012,A1

[2]Tanis,StevenP.;Colca,JerryR.;Parker,TimothyT.;Artman,GeraldD.;Larsen,ScottD.;McDonald,WilliamG.;Gadwood,RobertC.;Kletzien,RolfF.;Zeller,JamesB.;Lee,PilH.;Adams,WadeJ.[BioorganicandMedicinalChemistry,2018,vol.26,#22,p.5870-5884]

[1]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-WO2012/21476,2012,A1

[2]Tanis,StevenP.;Colca,JerryR.;Parker,TimothyT.;Artman,GeraldD.;Larsen,ScottD.;Gadwood,RobertC.;Zeller,JamesR.[TetrahedronLetters,2019,vol.60,#33]

[1]CurrentPatentAssignee:CIRIUSTHERAPEUTICS-WO2012/21476,2012,A1

Literature

Title: Chen Z, et al. Resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48.

Title: Vigueira PA, et al. The beneficial metabolic effects of sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 2017 Aug 1;102(8):985-999.

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Tags:1133819-87-0 Molecular Formula|1133819-87-0 MDL|1133819-87-0 SMILES|1133819-87-0 5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione