Home Other Building Blocks 1174018-99-5
1174018-99-5,MFCD28502833
Catalog No.:AA008TMP

1174018-99-5 | Relebactam

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
98%
in stock  
$148.00   $104.00
- +
25mg
98%
in stock  
$402.00   $282.00
- +
50mg
95%
in stock  
$522.00   $365.00
- +
250mg
98%
in stock  
$2,172.00   $1,520.00
- +
1g
98%
in stock  
$4,235.00   $2,965.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TMP
Chemical Name:
Relebactam
CAS Number:
1174018-99-5
Molecular Formula:
C12H20N4O6S
Molecular Weight:
348.3754
MDL Number:
MFCD28502833
SMILES:
O=C([C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O)NC1CCNCC1
Properties
Computed Properties
 
Complexity:
585  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
-3.6  

Downstream Synthesis Route

[1]Miller,StevenP.;Zhong,Yong-Li;Liu,Zhijian;Simeone,Michael;Yasuda,Nobuyoshi;Limanto,John;Chen,Zheng;Lynch,Joseph;Capodanno,Vincent[OrganicLetters,2014,vol.16,#1,p.174-177]

[2]CurrentPatentAssignee:MERCK&COINC-WO2009/91856,2009,A2Locationinpatent:Page/Pagecolumn71-72

[3]CurrentPatentAssignee:ARIXAPHARMACEUTICALSINC-US10085999,2018,B1Locationinpatent:Page/Pagecolumn129

[4]CurrentPatentAssignee:WOCKHARDTLIMITED-WO2015/33191,2015,A1Locationinpatent:Page/Pagecolumn9;10

[5]CurrentPatentAssignee:MERCK&COINC-WO2009/91856,2009,A2Locationinpatent:Page/Pagecolumn61

[6]Blizzard,TimothyA.;Chen,Helen;Kim,Seongkon;Wu,Jane;Bodner,Rena;Gude,Candido;Imbriglio,Jason;Young,Katherine;Park,Young-Whan;Ogawa,Aimie;Raghoobar,Susan;Hairston,Nichelle;Painter,RonaldE.;Wisniewski,Doug;Scapin,Giovanna;Fitzgerald,Paula;Sharma,Nandini;Lu,Jun;Ha,Sookhee;Hermes,Jeff;Hammond,MiltonL.[BioorganicandMedicinalChemistryLetters,2014,vol.24,#3,p.780-785]

[7]CurrentPatentAssignee:MERCK&COINC-WO2014/200786,2014,A1Locationinpatent:Page/Pagecolumn27

[1]CurrentPatentAssignee:MERCK&COINC-WO2009/91856,2009,A2Locationinpatent:Page/Pagecolumn72-73

[1]CurrentPatentAssignee:MERCK&COINC-WO2009/91856,2009,A2Locationinpatent:Page/Pagecolumn62-63

[2]Mangion,IanK.;Ruck,RebeccaT.;Rivera,Nelo;Huffman,MarkA.;Shevlin,Michael[OrganicLetters,2011,vol.13,#20,p.5480-5483]

[1]OrganicLetters,2011,vol.13,p.5480-5483

[1]Mangion,IanK.;Ruck,RebeccaT.;Rivera,Nelo;Huffman,MarkA.;Shevlin,Michael[OrganicLetters,2011,vol.13,#20,p.5480-5483]

Literature

Title: A concise synthesis of a β-lactamase inhibitor.

Journal: Organic letters 20111021

Title: Lapuebla A, et al. Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Antimicrob Agents Chemother. 2015 Aug;59(8):5029-31.

Title: Bush K. A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents. 2015 Nov;46(5):483-93.

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SDS
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