Title: Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901
Title: Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation.
Journal: Journal of biochemistry 20121101
Title: Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6.
Journal: Chemico-biological interactions 20111115
Title: Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex.
Journal: The Journal of pharmacology and experimental therapeutics 20110901
Title: Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.
Journal: Biochemistry 20110607
Title: Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.
Journal: Journal of veterinary pharmacology and therapeutics 20101201
Title: A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.
Journal: Nature protocols 20100901
Title: Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.28, except CYP2B6.22).
Journal: Pharmacogenetics and genomics 20100701
Title: Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners.
Journal: Biochimica et biophysica acta 20100601
Title: Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: a study of cell viability, morphology and drug metabolism.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100601
Title: Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100201
Title: Functional expression in Bacillus subtilis of mammalian NADPH-cytochrome P450 oxidoreductase and its spore-display.
Journal: Protein expression and purification 20090101
Title: Amino acid positions 69-132 of UGT1A9 are involved in the C-glucuronidation of phenylbutazone.
Journal: Archives of biochemistry and biophysics 20081001
Title: Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.
Journal: The Journal of biological chemistry 20080801
Title: Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Journal: Molecular pharmacology 20071101
Title: Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.
Journal: Chemical research in toxicology 20071101
Title: Mutation of a single residue (K262R) in P450 2B6 leads to loss of mechanism-based inactivation by phencyclidine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801
Title: Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
Journal: Archives of biochemistry and biophysics 20070215
Title: Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201
Title: Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.
Journal: Archives of biochemistry and biophysics 20061101
Title: Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms.
Journal: The Journal of pharmacology and experimental therapeutics 20060701
Title: Biochemical analysis of a chlorfenapyr-selected resistant strain of Tetranychus urticae Koch.
Journal: Pest management science 20060501
Title: Improvement in the expression of CYP2B6 by co-expression with molecular chaperones GroES/EL in Escherichia coli.
Journal: Protein expression and purification 20060401
Title: Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes.
Journal: Methods in molecular biology (Clifton, N.J.) 20060101
Title: Expression and activity of CYP2E1 in circulating lymphocytes are not altered in diabetic individuals.
Journal: Pharmacological research 20050601
Title: Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
Journal: The Journal of biological chemistry 20050520
Title: Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae.
Journal: Pest management science 20050501
Title: Functional role of residues in the helix B' region of cytochrome P450 2B1.
Journal: Archives of biochemistry and biophysics 20050301
Title: Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2.
Journal: Biochemistry 20050222
Title: EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme.
Journal: Biochemistry 20041123
Title: Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.
Journal: The Journal of pharmacology and experimental therapeutics 20041001
Title: Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040901
Title: Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix.
Journal: Archives of biochemistry and biophysics 20040315
Title: Mechanistic studies with N-benzyl-1-aminobenzotriazole-inactivated CYP2B1: differential effects on the metabolism of 7-ethoxy-4-(trifluoromethyl)coumarin, testosterone, and benzphetamine.
Journal: Archives of biochemistry and biophysics 20040315
Title: Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivation.
Journal: The Journal of pharmacology and experimental therapeutics 20030801
Title: Functional characterization of cytochrome P450 2B6 allelic variants.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401
Title: Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5.
Journal: Journal of inorganic biochemistry 20030115
Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Journal: Archives of biochemistry and biophysics 20030101
Title: Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.
Journal: The Journal of pharmacology and experimental therapeutics 20030101
Title: Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.
Journal: Chemical research in toxicology 20021101
Title: Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.
Journal: The Journal of pharmacology and experimental therapeutics 20020601
Title: Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020101
Title: Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity.
Journal: Anticancer research 20020101
Title: A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function.
Journal: Archives of biochemistry and biophysics 20011101
Title: Examination of purported probes of human CYP2B6.
Journal: Pharmacogenetics 19970601
