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115956-12-2,MFCD00865542
Catalog No.:AA000H55

115956-12-2 | 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

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1mg
98%
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$11.00   $8.00
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5mg
98%
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$23.00   $16.00
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10mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000H55
Chemical Name:
1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer
CAS Number:
115956-12-2
Molecular Formula:
C19H20N2O3
Molecular Weight:
324.3737
MDL Number:
MFCD00865542
SMILES:
O=C1CN2[C@H]3C[C@H]1C[C@@H]2C[C@H](C3)OC(=O)c1c[nH]c2c1cccc2
Properties
Properties
 
Form:
Solid  
MP:
228-229˚C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
535  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.4  

Literature

Title: Optimization of sample pretreatment methods for simultaneous determination of dolasetron and hydrodolasetron in human plasma by HPLC-ESI-MS.

Journal: Journal of chromatographic science 20121001

Title: Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120501

Title: Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery.

Journal: Korean journal of anesthesiology 20120301

Title: A network meta-analysis on the efficacy of serotonin type 3 receptor antagonists used in adults during the first 24 hours for postoperative nausea and vomiting prophylaxis.

Journal: Clinical therapeutics 20120201

Title: A practical and direct comparison of intrinsic metabolic clearance of several non-CYP enzyme substrates in freshly isolated and cryopreserved hepatocytes.

Journal: Drug metabolism and pharmacokinetics 20120101

Title: Reduction in the incidence of shivering with perioperative dexmedetomidine: A randomized prospective study.

Journal: Journal of anaesthesiology, clinical pharmacology 20120101

Title: Reappraisal of the role of dolasetron in prevention and treatment of nausea and vomiting associated with surgery or chemotherapy.

Journal: Cancer management and research 20120101

Title: Cardiovascular events in cancer patients treated with highly or moderately emetogenic chemotherapy: results from a population-based study.

Journal: Journal of cancer epidemiology 20120101

Title: Impact of 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study.

Journal: BMC health services research 20120101

Title: Management of postoperative nausea and vomiting in women scheduled for breast cancer surgery.

Journal: Journal of anesthesia 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Single-dose palonosetron for prevention of chemotherapy-induced nausea and vomiting in patients with aggressive non-Hodgkin's lymphoma receiving moderately emetogenic chemotherapy containing steroids: results of a phase II study from the Gruppo Italiano per lo Studio dei Linfomi (GISL).

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20111001

Title: Retraction note to: Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110901

Title: Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following moderately emetogenic chemotherapy: a randomized, multicenter, phase III trial.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801

Title: Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT3R) in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110601

Title: Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy: Retraction.

Journal: European journal of anaesthesiology 20110601

Title: 5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities.

Journal: Journal of clinical anesthesia 20110601

Title: Combination treatment with intrahepatic arterial infusion and intratumoral injection chemotherapy in patients with far-advanced hepatocellular carcinoma and arterioportal or arteriovenous shunts: preliminary results.

Journal: The Korean journal of hepatology 20110601

Title: A randomised, double-blind, placebo-controlled trial of dolasetron, a 5-hydroxytryptamine 3 receptor antagonist, in patients with fibromyalgia.

Journal: European journal of pain (London, England) 20110501

Title: Dolasetron for preventing postanesthetic shivering: Retraction.

Journal: Anesthesia and analgesia 20110501

Title: Retraction Notice: Current review of ramosetron in the prevention of postoperative nausea and vomiting.

Journal: Current drug safety 20110401

Title: Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists.

Journal: Cancer chemotherapy and pharmacology 20110301

Title: Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Journal: Surgical endoscopy 20110301

Title: Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics.

Journal: International journal of clinical pharmacy 20110201

Title: Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma.

Journal: Core evidence 20110101

Title: BICEPP: an example-based statistical text mining method for predicting the binary characteristics of drugs.

Journal: BMC bioinformatics 20110101

Title: Genetic polymorphisms in the three malaysian races effect granisetron clinical antiemetic actions in breast cancer patients receiving chemotherapy.

Journal: Asian Pacific journal of cancer prevention : APJCP 20110101

Title: Short term non-invasive ventilation post-surgery improves arterial blood-gases in obese subjects compared to supplemental oxygen delivery - a randomized controlled trial.

Journal: BMC anesthesiology 20110101

Title: Palonosetron: A novel approach to control postoperative nausea and vomiting in day care surgery.

Journal: Saudi journal of anaesthesia 20110101

Title: Symptomatic sinus bradycardia: A rare adverse effect of intravenous ondansetron.

Journal: Saudi journal of anaesthesia 20110101

Title: Comparison of ondansetron and combination of ondansetron and dexamethasone as a prophylaxis for postoperative nausea and vomiting in adults undergoing elective laparoscopic surgery.

Journal: Journal of emergencies, trauma, and shock 20110101

Title: Prophylaxis of postoperative nausea and vomiting in adolescent patients: a review with emphasis on combination of fixed-dose ondansetron and transdermal scopolamine.

Journal: Journal of drug delivery 20110101

Title: Treating nausea and vomiting in palliative care: a review.

Journal: Clinical interventions in aging 20110101

Title: Current concepts in the management of postoperative nausea and vomiting.

Journal: Anesthesiology research and practice 20110101

Title: Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone.

Journal: Korean journal of anesthesiology 20101101

Title: Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.

Journal: Brain research 20100917

Title: Retraction Notice: Clinical Management of Postoperative Vomiting after Strabismus Surgery in Children.

Journal: Current drug safety 20100401

Title: Comparison of perioperative oral multimodal analgesia versus IV PCA for spine surgery.

Journal: Journal of spinal disorders & techniques 20100401

Title: Acute vomiting in cats: rational treatment selection.

Journal: Journal of feline medicine and surgery 20100301

Title: Effect of ramosetron on shivering during spinal anesthesia.

Journal: Korean journal of anesthesiology 20100301

Title: Optimizing emetic control in children receiving antineoplastic therapy: beyond the guidelines.

Journal: Paediatric drugs 20100101

Title: Other drugs acting on nervous system associated with QT-interval prolongation.

Journal: Current drug safety 20100101

Title: Safety and effectiveness of outpatient laparoscopic cholecystectomy in a teaching hospital: a prospective study of 110 consecutive patients.

Journal: BMC research notes 20100101

Title: Differences in efficacy and safety of pharmaceutical treatments between men and women: an umbrella review.

Journal: PloS one 20100101

Title: A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics.

Journal: American journal of therapeutics 20100101

Title: Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review.

Journal: Cancer management and research 20100101

Title: Acute gastroenteritis: from guidelines to real life.

Journal: Clinical and experimental gastroenterology 20100101

Title: Palonosetron: in the prevention of nausea and vomiting.

Journal: Drugs 20091112

Title: Effect of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of dolasetron and granisetron.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090901

Title: Impact of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of ondansetron and dexamethasone.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090901

Title: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

Journal: Current cardiology reviews 20090801

Title: Prophylactic granisetron vs pethidine for the prevention of postoperative shivering: a randomized control trial.

Journal: Indian journal of anaesthesia 20090601

Title: 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.

Journal: Journal of clinical medicine research 20090601

Title: Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial.

Journal: The Lancet. Oncology 20090201

Title: Retraction Notice: Current Management of Vomiting after Tonsillectomy in Children.

Journal: Current drug safety 20090101

Title: Management of postoperative nausea and vomiting: focus on palonosetron.

Journal: Therapeutics and clinical risk management 20090101

Title: Bilateral infraorbital nerve blocks decrease postoperative pain but do not reduce time to discharge following outpatient nasal surgery.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20090101

Title: Casopitant: a novel NK(1)-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting.

Journal: Therapeutics and clinical risk management 20090101

Title: Prevention of acute chemotherapy-induced nausea and vomiting: the role of palonosetron.

Journal: Cancer management and research 20090101

Title: Palonosetron for the prevention of chemotherapy-induced nausea and vomiting: approval and efficacy.

Journal: Cancer management and research 20090101

Title: Dolasetron and QT interval.

Journal: Emergency medicine journal : EMJ 20081001

Title: The acute effect of tropisetron on ECG parameters in cancer patients.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20080901

Title: Fatal metformin overdose presenting with progressive hyperglycemia.

Journal: The western journal of emergency medicine 20080801

Title: Ondansetron induced fatal ventricular tachycardia.

Journal: Indian journal of pharmacology 20080801

Title: Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080401

Title: Postoperative nausea and vomiting after surgery for prognathism: not only a question of patients' comfort. A placebo-controlled comparison of dolasetron and droperidol.

Journal: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20080401

Title: Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.

Journal: AANA journal 20080201

Title: Chemotherapy-and cancer-related nausea and vomiting.

Journal: Current oncology (Toronto, Ont.) 20080101

Title: [Pharmacokinetic and pharmacodynamic features of palonosetron].

Journal: Tumori 20080101

Title: [Meta-analysis of phase III studies with palonosetron in the prevention of vomiting induced by moderately emetogenic chemotherapy].

Journal: Tumori 20080101

Title: [Palonosetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) in Italy: pharmacologic, clinical and economic aspects].

Journal: Tumori 20080101

Title: Retraction Notice: The Benefits and Risks of Different Therapies in Preventing Postoperative Nausea and Vomiting in Patients Undergoing Thyroid Surgery.

Journal: Current drug safety 20080101

Title: Mining clinical relationships from patient narratives.

Journal: BMC bioinformatics 20080101

Title: Dolasetron-induced torsades de pointes.

Journal: Journal of clinical anesthesia 20071201

Title: Palonosetron as an anti-emetic and anti-nausea agent in oncology.

Journal: Therapeutics and clinical risk management 20071201

Title: A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy-induced emesis.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20070901

Title: [Prevention of postoperative nausea and vomiting].

Journal: Ugeskrift for laeger 20070813

Title: The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting.

Journal: Anaesthesia 20070801

Title: Ondansetron oral disintegrating tablets for the prevention of postoperative vomiting in children undergoing strabismus surgery.

Journal: Therapeutics and clinical risk management 20070801

Title: Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review.

Journal: Emergency medicine journal : EMJ 20070701

Title: Antiemetic agents.

Journal: Oncology (Williston Park, N.Y.) 20070701

Title: [Prevention and treatment of postoperative nausea and vomiting in children. An evidence-based approach].

Journal: Annales francaises d'anesthesie et de reanimation 20070601

Title: Management of platinum-based chemotherapy-induced acute nausea and vomiting: is there a superior serotonin receptor antagonist?

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20070601

Title: Randomized comparison of two anti-emetic strategies in high-risk patients undergoing day-case gynaecological surgery.

Journal: British journal of anaesthesia 20070401

Title: Management of radiation-induced nausea and vomiting.

Journal: Experimental hematology 20070401

Title: Safety and efficacy of a continuous infusion, patient-controlled antiemetic pump for children receiving emetogenic chemotherapy.

Journal: Pediatric blood & cancer 20070301

Title: Tremor in multiple sclerosis.

Journal: Journal of neurology 20070201

Title: [Dolasetron and shivering. A prospective randomized placebo-controlled pharmaco-economic evaluation].

Journal: Der Anaesthesist 20070101

Title: Are all 5-HT3 receptor antagonists the same?

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20070101

Title: Management of postoperative nausea and vomiting in children.

Journal: Paediatric drugs 20070101

Title: Systemic anticancer therapy in gynecological cancer patients with renal dysfunction.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101

Title: Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting.

Journal: Paediatric drugs 20070101

Title: Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials.

Journal: BMC cancer 20070101

Title: Aprepitant: the evidence for its place in the prevention of chemotherapy-induced nausea and vomiting.

Journal: Core evidence 20070101

Title: Pharmacological prophylaxis and management of adult postoperative/postdischarge nausea and vomiting.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20061201

Title: Inspired oxygen fraction of 0.8 compared with 0.4 does not further reduce postoperative nausea and vomiting in dolasetron-treated patients undergoing laparoscopic cholecystectomy.

Journal: British journal of anaesthesia 20061101

Title: Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis.

Journal: British journal of anaesthesia 20061101

Title: Palonosetron: a second-generation 5-hydroxytryptamine receptor antagonist.

Journal: Future oncology (London, England) 20061001

Title: Dolasetron versus ondansetron as single-agent prophylaxis for patients at increased risk for postoperative nausea and vomiting: a prospective, double-blind, randomized trial.

Journal: Military medicine 20060901

Title: Ethics, marketing, and the medical literature.

Journal: Anesthesia and analgesia 20060801

Title: Drugs for preventing postoperative nausea and vomiting.

Journal: The Cochrane database of systematic reviews 20060719

Title: Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers.

Journal: Journal of clinical pharmacology 20060701

Title: Relative efficacy of ondansetron, granisetron, dolasetron and palonosetron in controlling acute nausea and vomiting associated with platinum-based chemotherapy.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20060601

Title: Meta-analysis of the safety of 5-HT3 antagonists with dexamethasone or droperidol for prevention of PONV.

Journal: The Annals of pharmacotherapy 20060501

Title: Meta-analysis of the use of rescue antiemetics following PONV prophylactic failure with 5-HT3 antagonist/dexamethasone versus single-agent therapies.

Journal: The Annals of pharmacotherapy 20060501

Title: Paravertebral blocks provide superior same-day recovery over general anesthesia for patients undergoing inguinal hernia repair.

Journal: Anesthesia and analgesia 20060401

Title: Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype.

Journal: Anesthesia and analgesia 20060401

Title: Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy-induced emesis.

Journal: Supportive cancer therapy 20060401

Title: Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060301

Title: New antiemetic drugs.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060301

Title: Measuring the maintenance of daily life activities using the functional living index-emesis (FLIE) in patients receiving moderately emetogenic chemotherapy.

Journal: The journal of supportive oncology 20060101

Title: The role of 5-HT3 receptor antagonists in preventing postoperative nausea and vomiting.

Journal: AORN journal 20060101

Title: Laparoscopic cholecystectomy and management of biliary tract stones in a freestanding ambulatory surgery center.

Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons 20060101

Title: Anesthesiologists' practice patterns for treatment of postoperative nausea and vomiting in the ambulatory Post Anesthesia Care Unit.

Journal: BMC anesthesiology 20060101

Title: New approaches to chemotherapy-induced nausea and vomiting: from neuropharmacology to clinical investigations.

Journal: Cancer journal (Sudbury, Mass.) 20060101

Title: Prophylaxis of postoperative nausea and vomiting in patients scheduled for breast surgery.

Journal: Clinical drug investigation 20060101

Title: Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room - implications for the treatment of PONV and related clinical trials.

Journal: BMC anesthesiology 20060101

Title: Treatment of postoperative nausea and vomiting with dolasetron versus ondansetron: is there a conflict of interest?

Journal: Anesthesia and analgesia 20051201

Title: Employment of substandard antiemetic prophylaxis in recent trials of chemotherapy-induced nausea and vomiting.

Journal: The Annals of pharmacotherapy 20051101

Title: Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: a randomized, double-blinded, placebo-controlled study.

Journal: Anesthesia and analgesia 20051101

Title: Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20051001

Title: Dolasetron and peri-operative cardiac arrhythmia.

Journal: Anaesthesia 20050901

Title: Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors.

Journal: Anesthesia and analgesia 20050901

Title: 5HT3-receptor antagonists as antiemetics in cancer.

Journal: Drug and therapeutics bulletin 20050801

Title: Update on anti-emetics for chemotherapy-induced emesis.

Journal: Internal medicine journal 20050801

Title: 5-hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis: can we safely reduce the dose of administered agents?

Journal: Cancer 20050701

Title: Prevention and treatment of postoperative nausea and vomiting.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050615

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Pharmacokinetics of palonosetron in combination with aprepitant in healthy volunteers.

Journal: Current medical research and opinion 20050401

Title: Docetaxel (Taxotere), cisplatin, UFT, and leucovorin combination chemotherapy in advanced gastric cancer.

Journal: British journal of cancer 20050314

Title: Acute emesis: moderately emetogenic chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20050201

Title: Dolasetron versus ondansetron for the treatment of postoperative nausea and vomiting.

Journal: Anesthesia and analgesia 20050201

Title: Coronary vasospasm leading to an acute myocardial infarction after the administration of dolasetron.

Journal: Journal of clinical anesthesia 20050201

Title: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same?

Journal: CNS drugs 20050101

Title: The utility of antiemetics in the prevention and treatment of postoperative nausea and vomiting in patients scheduled for laparoscopic cholecystectomy.

Journal: Current pharmaceutical design 20050101

Title: The Breast Journal regrettably is retracting a manuscript entitled, ' Dolasetron decreases postoperative nausea and vomiting after breast surgery'.

Journal: The breast journal 20050101

Title: A randomized, multicenter, open-label comparison of the antiemetic efficacy of dolasetron versus ondansetron for the prevention of nausea and vomiting during high-dose myeloablative chemotherapy.

Journal: Supportive cancer therapy 20050101

Title: Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol.

Journal: The Journal of pharmacy and pharmacology 20041201

Title: Open-label, randomized comparison of the efficacy of intravenous dolasetron mesylate and ondansetron in the prevention of acute and delayed cisplatin-induced emesis in cancer patients.

Journal: Cancer research and treatment : official journal of Korean Cancer Association 20041201

Title: 5-HT3 receptor antagonists for prevention of late acute-onset emesis.

Journal: The Annals of pharmacotherapy 20041001

Title: Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials.

Journal: Anesthesia and analgesia 20040901

Title: Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy.

Journal: Ophthalmology 20040801

Title: Timing of administration of dolasetron affects dose necessary to prevent postoperative nausea and vomiting.

Journal: Journal of clinical anesthesia 20040801

Title: A comparison of infraclavicular nerve block versus general anesthesia for hand and wrist day-case surgeries.

Journal: Anesthesiology 20040701

Title: Granisetron vs dolasetron for acute chemotherapy-induced nausea and vomiting (CINV) in high and moderately high emetogenic chemotherapy: an open-label pilot study.

Journal: Current medical research and opinion 20040601

Title: Palonosetron: a unique 5-HT3 receptor antagonist indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting.

Journal: Clinical advances in hematology & oncology : H&O 20040501

Title: Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results.

Journal: British journal of cancer 20040405

Title: Ondansetron versus dolasetron: a comparison study in the prevention of postoperative nausea and vomiting in patients undergoing gynecological procedures.

Journal: AANA journal 20040401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040101

Title: Palonosetron.

Journal: Drugs 20040101

Title: Is amiodarone a safe antiarrhythmic to use in supraventricular tachyarrhythmias after lung cancer surgery?

Journal: BMC surgery 20040101

Title: Same old story? Do we need to modify our supportive care treatment of elderly cancer patients? Focus on antiemetics.

Journal: Drugs & aging 20040101

Title: Spectrum of use and tolerability of 5-HT3 receptor antagonists.

Journal: Scandinavian journal of rheumatology. Supplement 20040101

Title: Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron.

Journal: Cancer 20031201

Title: Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis.

Journal: Expert opinion on pharmacotherapy 20031201

Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

Journal: British journal of cancer 20031117

Title: Randomized, double-blind trial of dolasetron versus droperidol for prophylaxis of postoperative nausea and vomiting in patients undergoing TRAM flap breast reconstruction surgery.

Journal: Annals of plastic surgery 20031101

Title: [Blocking nociceptive afferents by retrobulbar bupivacaine does not decrease nausea and vomiting after propofol-remifentanil anaesthesia].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20031101

Title: Stability of dolasetron in two oral liquid vehicles.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031101

Title: Comparison of oral dolasetron and ondansetron in the prophylaxis of postoperative nausea and vomiting in children.

Journal: European journal of anaesthesiology 20031001

Title: Double-blind crossover study with dolasetron mesilate, a 5-HT3 receptor antagonist in cerebellar syndrome secondary to multiple sclerosis.

Journal: Journal of neurology 20031001

Title: Electrocardiographic and cardiovascular effects of the 5-hydroxytryptamine3 receptor antagonists.

Journal: The Annals of pharmacotherapy 20030901

Title: Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting.

Journal: Expert opinion on pharmacotherapy 20030901

Title: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: A comparison of the costs and efficacy of ondansetron and dolasetron in the prophylaxis of postoperative vomiting in pediatric patients undergoing ambulatory surgery.

Journal: Anesthesia and analgesia 20030801

Title: Dolasetron for the prevention of postoperative vomiting in children undergoing strabismus surgery.

Journal: Paediatric anaesthesia 20030701

Title: Cost-effectiveness of antiemetics use during cancer chemotherapy.

Journal: Expert review of pharmacoeconomics & outcomes research 20030601

Title: Patient outcomes after therapeutic interchange of dolasetron for granisetron.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030515

Title: Arrhythmogenic potential of antiemetics: perspectives on risk-benefits.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030301

Title: Dolasetron prophylaxis reduces nausea and postanaesthesia recovery time after remifentanil infusion during monitored anaesthesia care for extracorporeal shock wave lithotripsy.

Journal: British journal of anaesthesia 20030201

Title: Antiemetic prophylaxis for office-based surgery: are the 5-HT3 receptor antagonists beneficial?

Journal: Anesthesiology 20030201

Title: [Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone].

Journal: Der Anaesthesist 20030201

Title: The efficacy and cost-effectiveness of prophylactic 5-hydroxytryptamine3 receptor antagonists: tropisetron, ondansetron and dolasetron.

Journal: Anaesthesia and intensive care 20030201

Title: Benefits and risks of newer treatments for chemotherapy-induced and postoperative nausea and vomiting.

Journal: Drug safety 20030101

Title: Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy.

Journal: Health and quality of life outcomes 20030101

Title: Writers challenge points made in article about antiemetic therapy.

Journal: Oncology nursing forum 20030101

Title: QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.

Journal: American journal of therapeutics 20030101

Title: Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models.

Journal: Journal of receptor and signal transduction research 20030101

Title: A systematic approach to the management of postoperative nausea and vomiting.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20021201

Title: Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20021201

Title: Ondansetron and dolasetron provide equivalent postoperative vomiting control after ambulatory tonsillectomy in dexamethasone-pretreated children.

Journal: Anesthesia and analgesia 20021101

Title: Pharmacological prevention of postanesthetic shivering.

Journal: Anesthesia and analgesia 20021001

Title: [Dolasetron reduces pain on injection of propofol].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020901

Title: Progress in preventing chemotherapy-induced nausea and vomiting.

Journal: Cleveland Clinic journal of medicine 20020801

Title: Probable serotonin syndrome variant in a patient receiving a selective serotonin reuptake inhibitor and a 5-HT3 receptor antagonist.

Journal: Journal of psychopharmacology (Oxford, England) 20020601

Title: Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy.

Journal: Anesthesiology 20020601

Title: Granisetron vs ondansetron: is it a question of duration of 5-HT3 receptor blockade?

Journal: British journal of cancer 20020520

Title: The effect of anaesthetic technique on postoperative nausea and vomiting after day-case gynaecological laparoscopy.

Journal: Anaesthesia and intensive care 20020401

Title: Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin.

Journal: British journal of cancer 20020121

Title: Dolasetron for preventing postanesthetic shivering.

Journal: Anesthesia and analgesia 20020101

Title: [Prophylaxis of Postoperative Nausea and Vomiting FollowingGynaecological Laparoscopy].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020101

Title: The cardiotoxic potential of the 5-HT(3) receptor antagonist antiemetics: is there cause for concern?

Journal: The oncologist 20020101

Title: Dolasetron decreases postoperative nausea and vomiting after breast surgery.

Journal: The breast journal 20020101

Title: 5-HT(3)-receptor antagonists for the treatment of nausea and vomiting: a reappraisal of their side-effect profile.

Journal: The oncologist 20020101

Title: 5-HT3-receptor antagonists and the cytochrome P450 system: clinical implications.

Journal: Cancer journal (Sudbury, Mass.) 20020101

Title: Compatibility and stability of 5-HT3 receptor antagonists: a pharmacology review.

Journal: Oncology nursing forum 20020101

Title: Implementing evidence based antiemetic guidelines in the oncology setting: results of a 4-month prospective intervention study.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20011101

Title: The effect of timing of dolasetron administration on its efficacy as a prophylactic antiemetic in the ambulatory setting.

Journal: Anesthesia and analgesia 20011001

Title: [Prophylaxis of nausea and vomiting after thyroid surgery: comparison of oral and intravenous dolasetron with intravenous droperidol and placebo].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20010701

Title: Efficacy of single-dose intravenous dolasetron versus ondansetron in the prevention of postoperative nausea and vomiting.

Journal: Clinical therapeutics 20010601

Title: Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy.

Journal: European journal of anaesthesiology 20010401

Title: Dolasetron for chemo nausea.

Journal: RN 20010301

Title: Randomized open-label trial of dolasetron for the control of nausea and vomiting associated with high-dose chemotherapy with hematopoietic stem cell transplantation.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20010101

Title: 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy.

Journal: Drugs 19980201

Title: Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery.

Journal: Drugs 19970801

Title: A double-blind, multicentre comparison of intravenous dolasetron mesilate and metoclopramide in the prevention of nausea and vomiting in cancer patients receiving high-dose cisplatin chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 19970101

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Title: Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer. 2014 Feb;22(2):469-77.

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Tags:115956-12-2 Molecular Formula|115956-12-2 MDL|115956-12-2 SMILES|115956-12-2 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer