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115966-23-9,MFCD00076227
Catalog No.:AA000H5V

115966-23-9 | Urodilatin

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1mg
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  • Technical Information
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Technical Information
Catalog Number:
AA000H5V
Chemical Name:
Urodilatin
CAS Number:
115966-23-9
Molecular Formula:
C67H152N32O4
Molecular Weight:
1470.1358
MDL Number:
MFCD00076227
SMILES:
NCNCCC[CH]NC[CH]NC[CH]NC[C@H](CCCNC(=N)N)NCCNCCNC[CH]NC[CH]NC[C@@H](NC[C@@H](NC[C@@H](NC[C@@H](NC[C@H](CC(C)C)NC[C@@H](NC[C@@H](NC[C@@H]1CCCN1C[CH]NC[C@H]([C@H](O)C)N)CCCNC(=N)N)CO)CCCNC(=N)N)CCCNC(=N)N)CO)CO
Properties
Computed Properties
 
Complexity:
8140  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
29  
Heavy Atom Count:
244  
Hydrogen Bond Acceptor Count:
54  
Hydrogen Bond Donor Count:
60  
Rotatable Bond Count:
88  
XLogP3:
-17.1  

Literature

Title: [Natriuretic peptides in the therapy of acute decompensated heart failure].

Journal: Deutsche medizinische Wochenschrift (1946) 20110801

Title: Urodilatin increases renal dopamine uptake: intracellular network involved.

Journal: Journal of physiology and biochemistry 20110601

Title: A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.

Journal: Cardiovascular research 20101201

Title: Atrial natriuretic peptides and urodilatin modulate proximal tubule Na(+)-ATPase activity through activation of the NPR-A/cGMP/PKG pathway.

Journal: Peptides 20100501

Title: [Incretory function of the kidney].

Journal: Uspekhi fiziologicheskikh nauk 20100101

Title: Vasodilators in the treatment of acute heart failure: what we know, what we don't.

Journal: Heart failure reviews 20091201

Title: Role of guanylate cyclase modulators in decompensated heart failure.

Journal: Heart failure reviews 20091201

Title: Urodilatin and dopamine: a new interaction in the kidney.

Journal: Regulatory peptides 20090225

Title: Urodilatin and pentoxifylline prevent the early onset of Escherichia coli-induced acute renal failure in a model of isolated perfused rat kidney.

Journal: Kidney & blood pressure research 20090101

Title: Cardiac and kidney hormones cure up to 86% of human small-cell lung cancers in mice.

Journal: European journal of clinical investigation 20080801

Title: Renal effects of ularitide in patients with decompensated heart failure.

Journal: American heart journal 20080601

Title: Expression and purification of human urodilatin by small ubiquitin-related modifier fusion in Escherichia coli.

Journal: Applied microbiology and biotechnology 20080301

Title: Renal effects of urodilatin in healthy subjects are independent of blockade of the cyclooxygenase and angiotensin II receptor.

Journal: Scandinavian journal of clinical and laboratory investigation 20080101

Title: Expression, purification and characterization of human urodilatin in E. coli.

Journal: Protein expression and purification 20071001

Title: Urodilatin: a better natriuretic peptide?

Journal: Current heart failure reports 20070901

Title: Natriuretic peptides and therapeutic applications.

Journal: Heart failure reviews 20070601

Title: Effects of urodilatin on natriuresis in cirrhosis patients with sodium retention.

Journal: BMC gastroenterology 20070101

Title: Atrial natriuretic peptide and related peptides.

Journal: Clinical chemistry and laboratory medicine 20070101

Title: Emerging therapies for the management of decompensated heart failure: from bench to bedside.

Journal: Journal of the American College of Cardiology 20061219

Title: Haemodynamic and clinical effects of ularitide in decompensated heart failure.

Journal: European heart journal 20061201

Title: Urodilatin and four cardiac hormones decrease human renal carcinoma cell numbers.

Journal: European journal of clinical investigation 20061101

Title: ANP and urodilatin: who is who in the kidney.

Journal: European journal of medical research 20061027

Title: Urodilatin excretion and its correlation with sodium excretion in healthy full-term newborn infants.

Journal: Early human development 20061001

Title: Interaction of atrial natriuretic peptide, urodilatin, guanylin and uroguanylin in the isolated perfused rat kidney.

Journal: Regulatory peptides 20060911

Title: Management of acute decompensated heart failure: treatment, controversy, and future directions.

Journal: Pharmacotherapy 20060801

Title: [The cardiac natriuretic peptides].

Journal: Minerva medica 20060201

Title: Effects of the renal natriuretic peptide urodilatin (ularitide) in patients with decompensated chronic heart failure: a double-blind, placebo-controlled, ascending-dose trial.

Journal: American heart journal 20051201

Title: Equimolar doses of atrial and brain natriuretic peptides and urodilatin have differential renal actions in overt experimental heart failure.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050501

Title: Natriuretic peptide family: new aspects.

Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20050401

Title: Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501

Title: Ouabain-insensitive Na+-ATPase of proximal tubules is an effector for urodilatin and atrial natriuretic peptide.

Journal: Biochimica et biophysica acta 20040128

Title: Effect of ischemia on soluble and particulate guanylyl cyclase-mediated cGMP synthesis in cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020501

Title: Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20020501

Title: [Up to now no effect of urodilatin on acute kidney failure in intensive care patients has been shown].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020301

Title: [Up to now no effect of urodilatin on acute kidney failure in intensive care patients has been shown. Reply].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020301

Title: Effect of two oral contraceptives with different ethinyl estradiol and levonorgestrel concentrations on the urinary excretion of biochemical vasoactive markers.

Journal: Contraception 20011201

Title: Urodilatin attenuates sympathetic neurotransmission in the rabbit isolated vas deferens without activating guanylyl cyclase.

Journal: Life sciences 20011102

Title: Effects of posture and positive airway pressure on plasma atrial natriuretic peptide and renal urodilatin excretion.

Journal: Clinical nephrology 20011101

Title: The renal urodilatin system: clinical implications.

Journal: Cardiovascular research 20010815

Title: Cellular localization, membrane distribution, and possible function of guanylyl cyclases A and 1 in collecting ducts of rat.

Journal: Cardiovascular research 20010815

Title: Intravenous administration of the natriuretic peptide urodilatin at low doses during coronary reperfusion limits infarct size in anesthetized pigs.

Journal: Cardiovascular research 20010815

Title: Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.

Journal: American journal of respiratory cell and molecular biology 20010801

Title: Effect on biochemical vasoactive markers during postmenopausal hormone replacement therapy: estradiol versus estradiol/dienogest.

Journal: Maturitas 20010530

Title: Involvement of the renal natriuretic peptide urodilatin in body fluid regulation.

Journal: Seminars in nephrology 20010501

Title: Effects of angiotensin II and the AT(1) receptor antagonist losartan on the renal excretion of urodilatin.

Journal: Kidney & blood pressure research 20010101

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