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1173022-77-9,MFCD09878288
Catalog No.:AA01ENE5

1173022-77-9 | BRL 15572 monohydrochloride

Pack Size
Purity
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Price(USD)
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5mg
98%
in stock  
$236.00   $165.00
- +
10mg
98%
in stock  
$331.00   $232.00
- +
25mg
98%
in stock  
$674.00   $472.00
- +
50mg
98%
in stock  
$1,202.00   $842.00
- +
100mg
98%
in stock  
$2,116.00   $1,482.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01ENE5
Chemical Name:
BRL 15572 monohydrochloride
CAS Number:
1173022-77-9
Molecular Formula:
C25H28Cl2N2O
Molecular Weight:
443.4086
MDL Number:
MFCD09878288
SMILES:
C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl
Properties
Computed Properties
 
Complexity:
451  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Tachyphylaxis to the sumatriptan-induced contractile effect in the human uterine artery but not in human cerebral blood vessels: pharmacological demonstration of the 5-HT(1B) receptor functionality loss.

Journal: Pharmacology 20120101

Title: Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.

Journal: European journal of pharmacology 20090801

Title: Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart.

Journal: Clinical and experimental pharmacology & physiology 20071101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission.

Journal: Brain research 20051026

Title: Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.

Journal: Clinical and experimental pharmacology & physiology 20051001

Title: Autoradiographic characterisation of [35S]GTPgammaS binding stimulation mediated by 5-HT1B receptor in postmortem human brain.

Journal: Neuropharmacology 20050101

Title: Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors.

Journal: European journal of pharmacology 20041025

Title: Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis.

Journal: Brain research 20040917

Title: 5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040701

Title: 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.

Journal: Neuroscience research 20040301

Title: Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040201

Title: Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030701

Title: Multiple 5-HT(1) autoreceptor subtypes govern serotonin release in dorsal and median raphé nuclei.

Journal: Neuropharmacology 20010301

Title: Unravelling the pharmacological profile of the canine external carotid vasodilator '5-HT1-like' receptors: coexistence of sympatho-inhibitory 5-HT1B and postjunctional 5-HT7 receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010101

Title: SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970901

Title: Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20.

Title: Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279.

Title: Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74.

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