Home Other Building Blocks 117928-94-6
117928-94-6,MFCD12912477
Catalog No.:AA008TMO

117928-94-6 | Rapastinel

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Purity
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1mg
≥98%
in stock  
$173.00   $121.00
- +
5mg
≥98%
in stock  
$609.00   $426.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TMO
Chemical Name:
Rapastinel
CAS Number:
117928-94-6
Molecular Formula:
C18H31N5O6
Molecular Weight:
413.4686
MDL Number:
MFCD12912477
SMILES:
C[C@H]([C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](O)C)N)O
Properties
Computed Properties
 
Complexity:
659  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
7  
XLogP3:
-2.8  

Upstream Synthesis Route

[1]Patent:WO2017/136348,2017,A1,

[2]Molecules,2018,vol.23,#5,

[1]Molecules,2018,vol.23,#5,

[1]Patent:WO2017/136348,2017,A1,

[2]Patent:WO2017/136348,2017,A1,

[1]Patent:WO2017/136348,2017,A1,

[1]Patent:WO2017/136348,2017,A1,

Downstream Synthesis Route
117928-94-6   
C33H51N5O10 

[1]Patent:WO2015/65891,2015,A1

117928-94-6   
C31H47N5O10 

[1]Patent:WO2015/65891,2015,A1

117928-94-6   
C31H49N5O10 

[1]Patent:WO2015/65891,2015,A1

117928-94-6   
C26H41N5O8 

[1]Patent:WO2015/65891,2015,A1

117-99-7    117928-94-6   
C31H39N5O7 

[1]Patent:WO2015/65891,2015,A1.Locationinpatent:Paragraph00174;00175;00176

Literature

Title: A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism.

Journal: Neuroscience and biobehavioral reviews 20111001

Title: Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors.

Journal: Neuroscience 20110929

Title: The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats.

Journal: Neurobiology of aging 20110401

Title: Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13.

Journal: Neuroreport 20090826

Title: A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus.

Journal: Neuropharmacology 20081201

Title: Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist.

Journal: Neuroreport 20080702

Title: GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.

Journal: Neuropharmacology 20051201

Title: Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11.

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