[1]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1547-1552
[1]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1547-1552
[1]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1547-1552
[1]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1547-1552
[1]BioorganicandMedicinalChemistryLetters,1996,vol.6,p.1547-1552
Title: Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect.
Journal: Oncogene 20150806
Title: Anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile, a synthetic arvelexin derivative, on the macrophages through destabilizing mPGES-1 mRNA and suppressing NF-κB activation.
Journal: Chemico-biological interactions 20141205
Title: Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.
Journal: Toxicology 20141204
Title: Perfluorooctanoate suppresses spheroid attachment on endometrial epithelial cells through peroxisome proliferator-activated receptor alpha and down-regulation of Wnt signaling.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20131201
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.
Journal: Chemical research in toxicology 20130218
Title: Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells.
Journal: The Journal of toxicological sciences 20130101
Title: An inhibitor of leukotriene synthesis affects vasopressin secretion following osmotic stimulus in rats.
Journal: Regulatory peptides 20121110
Title: Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.
Journal: Journal of medicinal chemistry 20121025
Title: Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.
Journal: Bioorganic & medicinal chemistry 20120815
Title: Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.
Journal: European journal of medicinal chemistry 20120801
Title: Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120701
Title: Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Journal: Bioorganic & medicinal chemistry 20120615
Title: The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock.
Journal: Shock (Augusta, Ga.) 20120601
Title: Monascus-fermented metabolite monascin suppresses inflammation via PPAR-γ regulation and JNK inactivation in THP-1 monocytes.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: Lipopolysaccharide-induced stem cell factor messenger RNA expression and production in odontoblast-like cells.
Journal: Journal of endodontics 20120501
Title: Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells.
Journal: The British journal of nutrition 20120301
Title: Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells.
Journal: Biochemical and biophysical research communications 20120224
Title: Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1.
Journal: European journal of medicinal chemistry 20120201
Title: The role of transient receptor potential channel blockers in human gastric cancer cell viability.
Journal: Canadian journal of physiology and pharmacology 20120201
Title: Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated macrophages by a PPARγ-dependent pathway.
Journal: Molecular medicine reports 20120101
Title: Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
Journal: Journal of neuroinflammation 20120101
Title: Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha.
Journal: Journal of biomedical science 20120101
Title: A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Journal: PloS one 20120101
Title: 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Journal: Journal of medicinal chemistry 20111208
Title: Studies on the expression of fibroblast growth factor-2 from odontoblast-like cells.
Journal: Journal of endodontics 20111101
Title: MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis.
Journal: International journal of hematology 20111101
Title: Novel human mPGES-1 inhibitors identified through structure-based virtual screening.
Journal: Bioorganic & medicinal chemistry 20111015
Title: A facilitated approach to evaluate the inhibitor mode and potency of compounds targeting microsomal prostaglandin e synthase-1.
Journal: Assay and drug development technologies 20111001
Title: Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20111001
Title: Leukotriene synthesis inhibitor decreases vasopressin release in the early phase of sepsis.
Journal: Journal of neuroimmunology 20110915
Title: Cysteinyl leukotrienes synthesis is involved in aristolochic acid I-induced apoptosis in renal proximal tubular epithelial cells.
Journal: Toxicology 20110905
Title: Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Journal: Journal of natural products 20110826
Title: Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive prostaglandins.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20110801
Title: Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
Journal: Journal of medicinal chemistry 20110714
Title: Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20110701
Title: Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.
Journal: Pancreas 20110701
Title: 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells.
Journal: British journal of pharmacology 20110601
Title: Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.
Journal: Bioorganic & medicinal chemistry 20110601
Title: Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).
Journal: Journal of medicinal chemistry 20110512
Title: Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
Journal: Biological psychiatry 20110401
Title: Retinoic acids exhibit anti-fibrotic activity through the inhibition of 5-lipoxygenase expression in scleroderma fibroblasts.
Journal: The Journal of dermatology 20110401
Title: Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3.
Journal: The American journal of pathology 20110401
Title: Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.
Journal: Journal of medicinal chemistry 20110324
Title: A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo.
Journal: Biochemical pharmacology 20110115
Title: Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats.
Journal: Journal of cardiothoracic surgery 20110101
Title: Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells.
Journal: PPAR research 20110101
Title: Effects of thyroid hormone analogue and a leukotrienes pathway-blocker on renal ischemia/reperfusion injury in mice.
Journal: BMC nephrology 20110101
Title: Regulation of liver fatty acid binding protein expression by clofibrate in hepatoma cells.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20101201
Title: Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Journal: Nature neuroscience 20101001
Title: Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.
Journal: Experimental physiology 20100801
Title: 5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase.
Journal: Free radical research 20100701
Title: Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth.
Journal: Cancer letters 20100628
Title: Nitric oxide mediates distinct effects of various LPS chemotypes on phagocytosis and leukotriene synthesis in human neutrophils.
Journal: The international journal of biochemistry & cell biology 20100601
Title: MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells.
Journal: Journal of neuro-oncology 20100501
Title: Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.
Journal: Biochemical pharmacology 20100315
Title: Bezafibrate induces myotoxicity in human rhabdomyosarcoma cells via peroxisome proliferator-activated receptor alpha signaling.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100201
Title: Connective tissue mast cells are the target of formaldehyde to induce tracheal hyperresponsiveness in rats: putative role of leukotriene B4 and nitric oxide.
Journal: Toxicology letters 20100201
Title: 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK.
Journal: Toxicology and applied pharmacology 20100115
Title: Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells.
Journal: Journal of endocrinological investigation 20100101
Title: Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.
Journal: Biochemistry 20091222
Title: Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
Journal: Bioorganic & medicinal chemistry 20091201
Title: Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091101
Title: Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury.
Journal: Journal of neurotrauma 20091101
Title: 5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway.
Journal: Molecular and cellular biochemistry 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery.
Journal: European journal of haematology 20090701
Title: Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.
Journal: Journal of medicinal chemistry 20090611
Title: Blocking central leukotrienes synthesis affects vasopressin release during sepsis.
Journal: Neuroscience 20090602
Title: Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells.
Journal: Basic & clinical pharmacology & toxicology 20090601
Title: Effect of montelukast and MK-886 on hepatic ischemia-reperfusion injury in rats.
Journal: The Journal of surgical research 20090501
Title: Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20090501
Title: MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.
Journal: European journal of pharmacology 20090417
Title: Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.
Journal: Journal of neuroscience research 20090301
Title: Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model.
Journal: Neuroscience letters 20090220
Title: Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.
Journal: Pharmacology 20090101
Title: Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Journal: Journal of medicinal chemistry 20081225
Title: Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.
Journal: Journal of photochemistry and photobiology. B, Biology 20081113
Title: Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
Journal: The Journal of pharmacology and experimental therapeutics 20080901
Title: Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT(1)R antagonism.
Journal: Journal of leukocyte biology 20080601
Title: Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice.
Journal: Neuroscience letters 20080509
Title: In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).
Journal: Molecular pharmacology 20080501
Title: Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation.
Journal: Stem cells (Dayton, Ohio) 20080501
Title: Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats.
Journal: Biochemical and biophysical research communications 20080418
Title: Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.
Journal: European journal of nutrition 20080301
Title: Cysteinyl leukotrienes mediate the enhancing effects of indomethacin and aspirin on eosinophil production in murine bone marrow cultures.
Journal: British journal of pharmacology 20080201
Title: Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080201
Title: Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells.
Journal: Cell biochemistry and function 20080101
Title: Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2.
Journal: Journal of leukocyte biology 20080101
Title: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Journal: Stem cells (Dayton, Ohio) 20080101
Title: Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080101
Title: Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4.
Journal: Clinical and experimental immunology 20071001
Title: The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
Journal: British journal of pharmacology 20071001
Title: Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
Journal: Journal of pharmacological sciences 20070901
Title: Effect of a leukotriene inhibitor (MK886) on nitric oxide and hydrogen peroxide production by macrophages of acutely and chronically stressed mice.
Journal: The Journal of pharmacy and pharmacology 20070901
Title: Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.
Journal: Toxicology and applied pharmacology 20070815
Title: The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy.
Journal: British journal of pharmacology 20070801
Title: 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo.
Journal: Brain research 20070525
Title: 3D-QSAR study of microsomal prostaglandin E2 synthase (mPGES-1) inhibitors.
Journal: Journal of molecular modeling 20070501
Title: Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis.
Journal: Microbes and infection 20070401
Title: Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070401
Title: Impact of MK886 on eosinophil counts and phenotypic features in toxocariasis.
Journal: Scandinavian journal of immunology 20070401
Title: Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070101
Title: Regulation of apoptosis in eicosapentaenoic acid-treated HL-60 cells.
Journal: The Journal of surgical research 20070101
Title: Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.
Journal: Toxicology and applied pharmacology 20070101
Title: Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines.
Journal: Journal of experimental therapeutics & oncology 20070101
Title: Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells.
Journal: Neoplasma 20070101
Title: Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation.
Journal: Journal of leukocyte biology 20061201
Title: Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices.
Journal: Chemico-biological interactions 20061107
Title: Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.
Journal: Molecular cancer therapeutics 20061101
Title: PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060901
Title: Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643.
Journal: Free radical biology & medicine 20060815
Title: Effects of bezafibrate on the expression of endothelial nitric oxide synthase gene and its mechanisms in cultured bovine endothelial cells.
Journal: Atherosclerosis 20060801
Title: Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.
Journal: Journal of photochemistry and photobiology. B, Biology 20060801
Title: Mechanisms of N-acetylcysteine-driven enhancement of MK886-induced apoptosis.
Journal: Cell biology and toxicology 20060701
Title: MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis.
Journal: Cancer letters 20060618
Title: Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages.
Journal: Journal of leukocyte biology 20060601
Title: Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice.
Journal: European journal of clinical investigation 20060301
Title: Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-alpha.
Journal: Toxicology and applied pharmacology 20060201
Title: Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation.
Journal: International immunopharmacology 20060201
Title: Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices.
Journal: Acta pharmacologica Sinica 20060201
Title: Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats.
Journal: Journal of hypertension 20060101
Title: The cysteinyl-leukotriene-1 receptor antagonist zafirlukast is a potent secretagogue in rat and human airways.
Journal: European journal of pharmacology 20051219
Title: Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20051201
Title: Leukotrienes modulate cytokine release from dendritic cells.
Journal: Immunology 20051201
Title: The involvement of adhesion molecules and lipid mediators in the adhesion of human platelets to eosinophils.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201
Title: Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20051101
Title: Mast cell mediators in citric acid-induced airway constriction of guinea pigs.
Journal: Toxicology and applied pharmacology 20050815
Title: Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Journal: Bioorganic & medicinal chemistry letters 20050715
Title: Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species.
Journal: Biochimica et biophysica acta 20050610
Title: Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Journal: Cancer research 20050515
Title: Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20050201
Title: Reactive oxygen species and redox-induced programmed cell death due to MK 886: cells ('soil') 'trump' agent ('seed').
Journal: In vivo (Athens, Greece) 20050101
Title: P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia.
Journal: International journal of immunopathology and pharmacology 20050101
Title: P2X7 receptor activation in rat brain cultured astrocytes increases the biosynthetic release of cysteinyl leukotrienes.
Journal: International journal of immunopathology and pharmacology 20050101
Title: The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Journal: Inflammopharmacology 20050101
Title: Non-prostaglandin eicosanoids in fever and anapyrexia.
Journal: Frontiers in bioscience : a journal and virtual library 20040901
Title: Blockade of leukotriene B4 prevents articular incapacitation in rat zymosan-induced arthritis.
Journal: European journal of pharmacology 20040816
Title: Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner.
Journal: The Journal of pharmacology and experimental therapeutics 20040801
Title: Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway.
Journal: The Journal of biological chemistry 20040611
Title: Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
Journal: American journal of physiology. Heart and circulatory physiology 20040501
Title: Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501
Title: Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells.
Journal: Acta pharmacologica Sinica 20040501
Title: Inflammatory response of human tendon fibroblasts to cyclic mechanical stretching.
Journal: The American journal of sports medicine 20040301
Title: Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.
Journal: American journal of physiology. Cell physiology 20040201
Title: Leukotrienes-mediated effects of water extracts from Sargassum horneri, a marine brown alga, on Cl- absorption in isolated rat colon.
Journal: The Japanese journal of physiology 20040201
Title: Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.
Journal: The Journal of pharmacology and experimental therapeutics 20040101
Title: Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax.
Journal: Journal of gastroenterology and hepatology 20040101
Title: Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.
Journal: Arthritis research & therapy 20040101
Title: Acute changes in U937 nuclear Ca2+ preceding type 1 'apoptotic' programmed cell death due to MK 886.
Journal: Anticancer research 20040101
Title: Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs.
Journal: Biochemical and biophysical research communications 20031212
Title: Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Journal: The Journal of urology 20031101
Title: NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha.
Journal: The Journal of biological chemistry 20031003
Title: Inhibition of leukotriene synthesis with MK-886 prevents a rise in blood pressure and reduces noradrenaline-evoked contraction in L-NAME-treated rats.
Journal: British journal of pharmacology 20030901
Title: Caspase-dependent and -independent panc-1 cell death due to actinomycin D and MK 886 are additive but increase clonogenic survival.
Journal: Experimental biology and medicine (Maywood, N.J.) 20030901
Title: 5-Lipoxygenase is involved in the angiotensin II-induced NAD(P)H-oxidase activation.
Journal: Biochemical and biophysical research communications 20030829
Title: Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
Journal: The Journal of biological chemistry 20030808
Title: Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis.
Journal: Cell biology and toxicology 20030601
Title: Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.
Journal: The Biochemical journal 20030515
Title: Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030501
Title: Arachidonic acid in astrocytes blocks Ca(2+) oscillations by inhibiting store-operated Ca(2+) entry, and causes delayed Ca(2+) influx.
Journal: Cell calcium 20030401
Title: Neutrophil migration induced by IL-8-activated mast cells is mediated by CINC-1.
Journal: Cytokine 20030307
Title: Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis.
Journal: Toxicology letters 20030303
Title: Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Journal: Critical care medicine 20030301
Title: Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.
Journal: Journal of leukocyte biology 20030301
Title: Role of downstream metabolic processing of proinflammatory fatty acids by 5-lipoxygenase in HL-60 cell apoptosis.
Journal: The Journal of trauma 20030101
Title: An interaction between type 1 and type 2 programmed cell death and clonogenic survival.
Journal: Medical hypotheses 20030101
Title: Spermadhesin PSP-I/PSP-II heterodimer and its isolated subunits induced neutrophil migration into the peritoneal cavity of rats.
Journal: Biology of reproduction 20021201
Title: 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism.
Journal: Cancer research 20021201
Title: The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK.
Journal: Journal of cancer research and clinical oncology 20021001
Title: Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Journal: Critical care medicine 20021001
Title: Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors.
Journal: The Journal of biological chemistry 20020830
Title: Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.
Journal: Cancer research 20020801
Title: Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
Journal: Inflammation 20020401
Title: Increased cytosol Ca(2+) and type 1 programmed cell death in Bcl-2-positive U937 but not in Bcl-2-negative PC-3 and Panc-1 cells induced by the 5-lipoxygenase inhibitor MK 886.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20020401
Title: Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase.
Journal: The Journal of biological chemistry 20020301
Title: Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.
Journal: Journal of the American Society of Nephrology : JASN 20020301
Title: Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase.
Journal: The Journal of pharmacology and experimental therapeutics 20020301
Title: 5-Lipoxygenase and human pulmonary artery endothelial cell proliferation.
Journal: American journal of physiology. Heart and circulatory physiology 20020201
Title: Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.
Journal: Archives of dermatological research 20020201
Title: Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity.
Journal: Neurobiology of aging 20020101
Title: Mesalamine induces manganese superoxide dismutase in rat intestinal epithelial cell lines and in vivo.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20011001
Title: Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901
Title: Proteolytic loss of bcl-x(L) in FL5.12 Cells undergoing apoptosis induced by MK886.
Journal: Toxicology and applied pharmacology 20010801
Title: Production of leukotrienes in a model of focal cerebral ischaemia in the rat.
Journal: British journal of pharmacology 20010801
Title: Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.
Journal: The Biochemical journal 20010615
Title: SCF-induced airway hyperreactivity is dependent on leukotriene production.
Journal: American journal of physiology. Lung cellular and molecular physiology 20010601
Title: Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010515
Title: Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve.
Journal: British journal of pharmacology 20010401
Title: Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Journal: Journal of leukocyte biology 20010401
Title: Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas.
Journal: Carcinogenesis 20010301
Title: Peroxisomal bifunctional enzyme binds and activates the activation function-1 region of the peroxisome proliferator-activated receptor alpha.
Journal: The Biochemical journal 20010115
Title: Platelet-leukocyte cross talk in whole blood.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20001201
Title: Nordihydroguaiaretic acid blocks secretory and endocytic pathways in human dendritic cells.
Journal: Journal of leukocyte biology 19981201
Title: Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.
Journal: The American journal of physiology 19980601
Title: Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages.
Journal: The Biochemical journal 19980201
Title: Pharmacological modulation of human platelet leukotriene C4-synthase.
Journal: Biochemical pharmacology 19970321
Title: Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids.
Journal: The Journal of experimental medicine 19960401
Title: Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Journal: Toxicology 19950626
Title: Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19940816
Title: A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice.
Journal: Japanese journal of pharmacology 19940801
Title: The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.
Journal: European journal of pharmacology 19940523
Title: Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
Journal: Agents and actions 19930901
Title: Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
Journal: European journal of pharmacology 19930406
Title: Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds.
Journal: Biochemical pharmacology 19930107
Title: Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.
Journal: Nature 19900118
