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1191044-58-2,MFCD31618413
Catalog No.:AA00977D

1191044-58-2 | GSK1059865

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$339.00   $237.00
- +
10mg
98% by HPLC
in stock  
$534.00   $374.00
- +
25mg
98% by HPLC
in stock  
$1,059.00   $741.00
- +
50mg
98% by HPLC
in stock  
$1,759.00   $1,232.00
- +
100mg
98% by HPLC
in stock  
$2,998.00   $2,099.00
- +
500mg
98% by HPLC
in stock  
$9,538.00   $6,677.00
- +
1000mg
98% by HPLC
in stock  
$15,225.00   $10,658.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00977D
Chemical Name:
GSK1059865
CAS Number:
1191044-58-2
Molecular Formula:
C20H23BrFN3O2
Molecular Weight:
436.3179
MDL Number:
MFCD31618413
SMILES:
COc1c(F)cccc1C(=O)N1C[C@@H](C)CC[C@H]1CNc1ccc(cn1)Br
Properties
Computed Properties
 
Complexity:
498  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
4.4  

Literature

Title: Selective orexin receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20130901

Title: Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists.

Journal: PloS one 20110101

Title: Lopez MF, et al. The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice. Brain Res. 2016 Apr 1;1636:74-80.

Title: Piccoli L, et al. Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats. Neuropsychopharmacology. 2012 Aug;37(9):1999-2011.

Title: Gozzi A, et al. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology. 2013 Oct;38(11):2120-30.

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