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1192491-61-4,MFCD29472268
Catalog No.:AA000ICY

1192491-61-4 | Avibactam sodium

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$7.00   $5.00
- +
10mg
98%
in stock  
$9.00   $7.00
- +
50mg
98%
in stock  
$12.00   $8.00
- +
100mg
98%
in stock  
$15.00   $11.00
- +
250mg
98%
in stock  
$19.00   $14.00
- +
1g
98%
in stock  
$62.00   $44.00
- +
5g
98%
in stock  
$148.00   $103.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000ICY
Chemical Name:
Avibactam sodium
CAS Number:
1192491-61-4
Molecular Formula:
C7H10N3NaO6S
Molecular Weight:
287.2256
MDL Number:
MFCD29472268
SMILES:
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)[O-].[Na+]
Properties
Computed Properties
 
Complexity:
462  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  

Downstream Synthesis Route

[1]Patent:US2012/323010,2012,A1

[2]Patent:US2012/323010,2012,A1

[3]Patent:US2012/323010,2012,A1

[4]Patent:EP2657234,2013,A1

[5]Patent:WO2014/135930,2014,A1

[6]OrganicProcessResearchandDevelopment,2016,vol.20,p.1799-1805

[7]Patent:CN106831772,2017,A

[8]Patent:CN106866668,2017,A

[9]OrganicProcessResearchandDevelopment,2018,vol.22,p.267-272

[10]JournalofMedicinalChemistry,2018,vol.61,p.10340-10344

[1]Patent:US2012/323010,2012,A1

[2]Patent:US2012/323010,2012,A1

[3]Patent:US2012/323010,2012,A1

[4]OrganicProcessResearchandDevelopment,2018,vol.22,p.267-272

[5]Patent:CN108239089,2018,A

[6]Patent:CN107880042,2018,A

[7]OrganicProcessResearchandDevelopment,2018,vol.22,p.1738-1744

[1]Patent:US2012/323010,2012,A1

[2]Patent:US2012/323010,2012,A1

[3]Patent:US2012/323010,2012,A1

[4]Patent:US2012/323010,2012,A1

[5]Patent:US2012/323010,2012,A1

[6]Patent:US2012/323010,2012,A1

[7]Patent:US2012/323010,2012,A1

[8]Patent:US2012/323010,2012,A1

[9]Patent:US2012/323010,2012,A1

[10]Patent:US2012/323010,2012,A1

[11]Patent:US2012/323010,2012,A1

[12]Patent:US2012/323010,2012,A1

[1]Patent:US2012/323010,2012,A1

[2]Patent:US2012/323010,2012,A1

[3]Patent:US2012/323010,2012,A1

[4]Patent:US2012/323010,2012,A1

[5]Patent:US2012/323010,2012,A1

[6]Patent:US2012/323010,2012,A1

[7]Patent:CN106866668,2017,A

Literature

Title: Role of the Outer Membrane and Porins in Susceptibility of β-Lactamase-Producing Enterobacteriaceae to Ceftazidime-Avibactam.

Journal: Antimicrobial agents and chemotherapy 20160301

Title: Kinetics of avibactam inhibition against Class A, C, and D β-lactamases.

Journal: The Journal of biological chemistry 20130927

Title: Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20120717

Title: Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole.

Journal: International journal of antimicrobial agents 20120601

Title: In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae.

Journal: International journal of antimicrobial agents 20120101

Title: New Delhi metallo-β-lactamase (NDM-1): an update.

Journal: Journal of chemotherapy (Florence, Italy) 20111001

Title: In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases.

Journal: The Journal of antimicrobial chemotherapy 20090801

Title: Ehmann DE, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

Title: Livermore DM, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8.

Title: Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304.

Title: Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.

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