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1210004-12-8,MFCD18382122
Catalog No.:AA008SP9

1210004-12-8 | JZL 195

Pack Size
Purity
Availability
Price(USD)
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5mg
≥98%
in stock  
$88.00   $61.00
- +
10mg
≥98%
in stock  
$160.00   $112.00
- +
50mg
≥98%
in stock  
$669.00   $468.00
- +
100mg
≥98%
in stock  
$1,166.00   $816.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SP9
Chemical Name:
JZL 195
CAS Number:
1210004-12-8
Molecular Formula:
C24H24ClN3O5
Molecular Weight:
469.9175
MDL Number:
MFCD18382122
SMILES:
O=C(N1CCN(CC1)Cc1cccc(c1)Oc1ccccc1)Oc1ccc(cc1)[N+](=O)[O-].Cl
Properties
Computed Properties
 
Complexity:
605  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
6  
XLogP3:
4.3  

Literature

Title: Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.

Journal: British journal of pharmacology 20160101

Title: Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.

Journal: The Journal of pharmacology and experimental therapeutics 20150801

Title: The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20150701

Title: A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.

Journal: Nature chemical biology 20140801

Title: Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.

Journal: Neuropharmacology 20140601

Title: Assay and inhibition of diacylglycerol lipase activity.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.

Journal: Journal of medicinal chemistry 20100225

Title: Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20091201

Title: Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.

Title: Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.

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