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121034-89-7,MFCD09878250
Catalog No.:AA008SD4

121034-89-7 | IEM 1460

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10mg
≥98%
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$152.00   $106.00
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50mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SD4
Chemical Name:
IEM 1460
CAS Number:
121034-89-7
Molecular Formula:
C19H38Br2N2
Molecular Weight:
454.3264
MDL Number:
MFCD09878250
SMILES:
C[N+](CCCCCNCC12CC3CC(C2)CC(C1)C3)(C)C.Br.[Br-]
Properties
Computed Properties
 
Complexity:
301  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  

Literature

Title: Eppendorf finalist. Striatal interneurons: causes of or cures for movement disorders?

Journal: Science (New York, N.Y.) 20121005

Title: Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120613

Title: Functional evidence for D-serine inhibition of non-N-methyl-D-aspartate ionotropic glutamate receptors in retinal neurons.

Journal: The European journal of neuroscience 20120101

Title: Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111102

Title: Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease.

Journal: Journal of neurochemistry 20100701

Title: Ca2+-permeable AMPA receptors mediate induction of test pulse depression of naive synapses in rat visual cortical slices at early postnatal stage.

Journal: Neuroscience 20100203

Title: Synaptic scaling requires the GluR2 subunit of the AMPA receptor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090520

Title: Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II.

Journal: PloS one 20090101

Title: Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice.

Journal: Bulletin of experimental biology and medicine 20080701

Title: [Blockade of the alpha3alpha4 N-cholinoreceptors and GluR1 AMPA receptors eliminates clonic-tonic nicotinic and kainate seizures].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20080101

Title: Selective blockade of Ca2+ permeable AMPA receptors in CA1 area of rat hippocampus.

Journal: Neuroscience 20070105

Title: Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors.

Journal: British journal of pharmacology 20050701

Title: Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations.

Journal: Neuroscience and behavioral physiology 20030301

Title: Evaluation of GluR2 subunit involvement in AMPA receptor function of neonatal rat hypoglossal motoneurons.

Journal: The European journal of neuroscience 20020601

Title: [Comparison of anti-amnesia properties of NMDA-receptor 'fast' blockers and polyamines].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20020101

Title: [Structure of glutamate receptor ion channels and mechanisms of their blockade by organic cations].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010801

Title: Pharmacological analysis of the subunit composition of the AMPA receptor in hippocampal neurons.

Journal: Neuroscience and behavioral physiology 20010101

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