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1220-80-0,MFCD00026493
Catalog No.:AA0016HY

1220-80-0 | L-Leucine, N-[(4-methylphenyl)sulfonyl]-

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250mg
95% (GC)
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$404.00   $283.00
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  • Downstream Synthesis Route
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0016HY
Chemical Name:
L-Leucine, N-[(4-methylphenyl)sulfonyl]-
CAS Number:
1220-80-0
Molecular Formula:
C13H19NO4S
Molecular Weight:
285.3593
MDL Number:
MFCD00026493
SMILES:
CC(C[C@@H](C(=O)O)NS(=O)(=O)c1ccc(cc1)C)C
Properties
Computed Properties
 
Complexity:
391  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.6  

Downstream Synthesis Route
61-90-5    98-59-9   
(S)-4-methyl-2-(toluene-4-sulfonamido)pentanoicacid 

[1]Ugwu;Okoro;Ukoha;Okafor;Ibezim;Kumar[EuropeanJournalofMedicinalChemistry,2017,vol.135,p.349-369]

[2]Ugwu,DavidIzuchukwu;Okoro,UchechukwuChris;Mishra,NarendraKumar[PLoSONE,2018,vol.13,#1]

[3]Ahmad,Roshan;Jabeen,Rukhsana;Zia-Ul-Haq,Mohammad;Nadeem,Humaira;Duddeck,Helmut;Verspohl,EugenJ.[ZeitschriftfurNaturforschung,B:ChemicalSciences,2000,vol.55,#2,p.203-207]

[4]Kondratov,IvanS.;Logvinenko,IvanG.;Tolmachova,NataliyaA.;Morev,RomanN.;Kliachyna,MariaA.;Clausen,Florian;Daniliuc,ConstantinG.;Haufe,Günter[OrganicandBiomolecularChemistry,2017,vol.15,#3,p.672-679]

[5]Craig,Donald;Hyland,ChristopherJ.T.;Ward,SimonE.[ChemicalCommunications,2005,#27,p.3439-3441]

[6]Sdira,SofianeBen;Felix,CarolineP.;Giudicelli,Marie-BeatriceA.;Seigle-Ferrand,PascalF.;Perrin,Monique;Lamartine,RogerJ.[JournalofOrganicChemistry,2003,vol.68,#17,p.6632-6638]

[7]Sivaraman,Aneesh;Kim,DaeGyu;Bhattarai,Deepak;Kim,Minkyoung;Lee,HwaYoung;Lim,Semi;Kong,Jiwon;Goo,Ja-Il;Shim,Seunghwan;Lee,Seungbeom;Suh,Young-Ger;Choi,Yongseok;Kim,Sunghoon;Lee,Kyeong[JournalofMedicinalChemistry,2020,vol.63,#10,p.5139-5158]

[8]Yudasaka,Masaharu;Shimbo,Daisuke;Maruyama,Toshifumi;Tada,Norihiro;Itoh,Akichika[OrganicLetters,2019,vol.21,#4,p.1098-1102]

[9]Fischer,E.;Lipschitz[ChemischeBerichte,1915,vol.48,p.374]

[10]Karrer;Kehl[HelveticaChimicaActa,1930,vol.13,p.50,54]

[11]Achmatowicz,Osman;Pietraszkiewicz,Marek[PolishJournalofChemistry,1982,vol.56,#3,p.511-519]

[12]Burgess,Kevin;Liu,LeeT.;Pal,Biman[JournalofOrganicChemistry,1993,vol.58,#17,p.4758-4763]

[13]Nenajdenko,ValentineG;Karpov,AlexeiS;Balenkova,ElizabethS[TetrahedronAsymmetry,2001,vol.12,#18,p.2517-2527]

[14]Locationinpatent:experimentalpartZhang,Jinchao;Li,Luwei;Wang,Liwei;Zhang,Fangfang;Li,Xiaoliu[EuropeanJournalofMedicinalChemistry,2010,vol.45,#11,p.5337-5344]

[15]Locationinpatent:schemeortableBhattacharya,Debleena;Behera,Ashok;Hota,SandipK.;Chattopadhyay,Partha[Synthesis,2011,#4,p.585-592]

[16]Locationinpatent:schemeortableFan,YiChiao;Kwon,Ohyun[Molecules,2011,vol.16,#5,p.3802-3825]

[17]Locationinpatent:experimentalpartZhang,Jinchao;Li,Luwei;Ma,Lili;Zhang,Fangfang;Zhang,Zhilei;Wang,Shuxiang[EuropeanJournalofMedicinalChemistry,2011,vol.46,#11,p.5711-5716]

[18]Locationinpatent:experimentalpartZhang,JinChao;Li,Luwei;Ma,Lili;Zhang,Fangfang;Wang,Shuxiang[JournalofCoordinationChemistry,2011,vol.64,#10,p.1695-1706]

[19]Gharpure,SantoshJ.;Vijayasree;Reddy,S.RajaBhushan[OrganicandBiomolecularChemistry,2012,vol.10,#9,p.1735-1738]

[20]Locationinpatent:experimentalpartZhang,Jinchao;Ma,Lili;Zhang,Fangfang;Zhang,Zhilei;Li,Luwei;Wang,Shuxiang[JournalofCoordinationChemistry,2012,vol.65,#2,p.239-250]

[21]Ma,Lili;Zhang,Jinchao;Zhang,Fangfang;Chen,Chao;Li,Luwei;Wang,Shuxiang;Li,Shenghui[JournalofCoordinationChemistry,2012,vol.65,#18,p.3160-3173]

[22]Kishorevandavasi,Jaya;Hu,Wan-Ping;Chandrusenadi,Gopal;Chen,Hui-Ting;Chen,Hsing-Yin;Hsieh,Kuang-Chan;Wang,Jeh-Jeng[AdvancedSynthesisandCatalysis,2015,vol.357,#13,p.2788-2794]

[23]Ugwu,DavidIzuchukwu;Okoro,UchechukwuChris;Ahmad,Hilal[PLoSONE,2017,vol.12,#9]

[24]Kanyiva,KyaloStephen;Horiuchi,Masashi;Shibata,Takanori[EuropeanJournalofOrganicChemistry,2018,vol.2018,#8,p.1067-1070]

[25]Kanyiva,KyaloStephen;Tane,Marina;Shibata,Takanori[JournalofOrganicChemistry,2019,vol.84,#20,p.12773-12783]

[26]Eze,FlorenceUchenna;Okoro,UchechukwuChris;Ugwu,DavidIzuchukwu;Okafor,SundayN.[BioorganicChemistry,2019,vol.92]

[27]Michelet,Bastien;Castelli,Ugo;Appert,Emeline;Boucher,Maude;Vitse,Kassandra;Marrot,Jérôme;Guillard,Jérôme;Martin-Mingot,Agnès;Thibaudeau,Sébastien[OrganicLetters,2020,vol.22,#13,p.4944-4948]

[28]Craig,Donald;Spreadbury,SamuelR.J.;White,AndrewJ.P.[ChemicalCommunications,2020,vol.56,#68,p.9803-9806]

[29]CurrentPatentAssignee:DONGGUKUNIVERSITY;MEDICINALBIOCONVERGENCERESEARCHCENTER-EP3939968,2022,A1Locationinpatent:Paragraph0068-0070

[30]CurrentPatentAssignee:DONGGUKUNIVERSITY;MEDICINALBIOCONVERGENCERESEARCHCENTER-EP3939968,2022,A1Locationinpatent:Paragraph0068-0070

1220-80-0    16741-80-3   
Tos-L-Leu-L-Cys(Bzl)-OMe 

[1]JournaloftheIndianChemicalSociety,1983,vol.60,p.762-765

1220-80-0    6973-51-9   
(S)-4-Methyl-2-(toluene-4-sulfonylamino)-pentanoicacid(4-nitro-benzothiazol-2-yl)-amide 

[1]PakistanJournalofScientificandIndustrialResearch,1995,vol.38,p.246-248

1220-80-0    1643-39-6   
N-(p-toluenesulfonyl)-L-leucine-3,5-di-tert-butyl-2-phenolamide 

[1]HeteroatomChemistry,2004,vol.15,p.114-120

1220-80-0    2632-65-7   
(S)-4-methyl-2-(4-methylphenylsulfonamido)-N-(4-(pyrrolidin-1-yl)phenyl)pentanamide 

[1]JournalofMedicinalChemistry,2020,vol.63,p.5139-5158

Literature
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