Home Other Building Blocks 1220646-23-0
1220646-23-0,MFCD31544338
Catalog No.:AA01EOAV

1220646-23-0 | AVN-492

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
98% by HPLC
in stock  
$194.00   $136.00
- +
10mg
98% by HPLC
in stock  
$283.00   $198.00
- +
25mg
98% by HPLC
in stock  
$528.00   $370.00
- +
50mg
98% by HPLC
in stock  
$854.00   $598.00
- +
100mg
98% by HPLC
in stock  
$1,431.00   $1,002.00
- +
500mg
98% by HPLC
in stock  
$4,477.00   $3,134.00
- +
1000mg
98% by HPLC
in stock  
$7,126.00   $4,988.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EOAV
Chemical Name:
AVN-492
CAS Number:
1220646-23-0
Molecular Formula:
C17H21N5O2S
Molecular Weight:
359.4459
MDL Number:
MFCD31544338
SMILES:
CNc1nn2c(c1S(=O)(=O)c1ccccc1)nc(c(c2C)N(C)C)C
Properties
Computed Properties
 
Complexity:
558  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:IVASHCHENKO;ALLACHEMLLC-US2011/178078,2011,A1Locationinpatent:Page/Pagecolumn23;85;94

[1]Locationinpatent:experimentalpartIvachtchenko,AlexandreV.;Golovina,ElenaS.;Kadieva,MadinaG.;Kysil,VolodymyrM.;Mitkin,OlegD.;Tkachenko,SergeyE.;Okun,IlyaM.[JournalofMedicinalChemistry,2011,vol.54,#23,p.8161-8173]

Literature

Title: Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

Journal: Journal of medicinal chemistry 20111208

Title: Ivachtchenko AV, et al. AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation. J Alzheimers Dis. 2017;58(4):1043-1063.

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SDS
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