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Home Fluorides 1223403-58-4
1223403-58-4,MFCD28902192
Catalog No.:AA00171P

1223403-58-4 | (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$9.00   $7.00
- +
5mg
98%
in stock  
$22.00   $15.00
- +
50mg
98%
in stock  
$86.00   $61.00
- +
1g
98%
in stock  
$974.00   $682.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00171P
Chemical Name:
(S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
CAS Number:
1223403-58-4
Molecular Formula:
C21H22F2N6O2
Molecular Weight:
428.4352
MDL Number:
MFCD28902192
SMILES:
O[C@H]1CCN(C1)C(=O)Nc1cnn2c1nc(cc2)N1CCC[C@@H]1c1cc(F)ccc1F
Properties
Computed Properties
 
Complexity:
659  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
1.7  

Downstream Synthesis Route

[1]Patent:WO2010/48314,2010,A1.Locationinpatent:Page/Pagecolumn59

[1]Patent:US2017/281632,2017,A1.Locationinpatent:Paragraph0382;0419;0420;0421;0422

[2]Patent:WO2010/48314,2010,A1.Locationinpatent:Page/Pagecolumn60

[1]CurrentPatentAssignee:ANQINGDUOHUIBIOTECHNOLOGY-CN111763211,2020,ALocationinpatent:Paragraph0044-0049

1223403-58-4   
(S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo1,5-apyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamidehydrogensulfate 

[1]Patent:US2016/137654,2016,A1.Locationinpatent:Paragraph0255

1223403-58-4   
(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidine-1-yl)pyrazolo1,5-apyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamidehydrochloride 

[1]Patent:US2016/137654,2016,A1.Locationinpatent:Paragraph0256

[2]Patent:US2017/281632,2017,A1.Locationinpatent:Paragraph0382;0423

Literature

Title: Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

Journal: The New England journal of medicine 20180222

Title: Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain.

Journal: Molecular pain 20100101

Title: Karyn Bouhana, et al. LOXO-101, a pan TRK inhibitor, For The Treatment Of TRK-driven Cancers.

Title: Nagasubramanian R, et al. Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101. Pediatr Blood Cancer. 2016 Aug;63(8):1468-70.

Title: Kathryn G, et al. Genetic Modeling and Therapeutic Targeting of ETV6-NTRK3 with Loxo-101in Acute Lymphoblastic Leukemia. Blood 2016 128:278.

Title: Doebele RC, et al. An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov. 2015 Oct;5(10):1049-57.

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Tags:1223403-58-4 Molecular Formula|1223403-58-4 MDL|1223403-58-4 SMILES|1223403-58-4 (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide